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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:bipolar disorder
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Accession:DOID:3312 term browser browse the term
Definition:A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Synonyms:exact_synonym: BPAD;   Bipolar and Related Disorders;   Mania;   Manias;   Manic Depressive Psychosis;   Manic Disorder;   bipolar affective disorder;   bipolar affective psychoses;   bipolar affective psychosis;   bipolar depression;   bipolar disorder manic phase;   bipolar disorders;   depressive-manic psych.;   manic bipolar I disorder;   manic bipolar affective disorder;   manic depression;   manic depressive disorder;   manic disorders;   manic state;   manic states;   manic-depressive psychoses;   mixed bipolar disorder
 related_synonym: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
 primary_id: MESH:D000068105;   MESH:D001714
 xref: GARD:10249;   ICD10CM:F31;   ICD9CM:296.40;   ICD9CM:296.60;   ICD9CM:296.80;   NCI:C34423;   NCI:C34424;   NCI:C34805
For additional species annotation, visit the Alliance of Genome Resources.


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bipolar disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY2 adenylate cyclase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr16:74,305,729...74,729,999
Ensembl chr16:74,305,745...74,524,295
JBrowse link
G ADD3 adducin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr14:120,451,421...120,583,725
Ensembl chr14:120,451,573...120,583,723
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma RGD PMID:22137759 RGD:5686381 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO DNA:SNP, haplotype: :multiple (human) RGD PMID:20214684 RGD:5509071
G ANK3 ankyrin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18711365, PMID:21926974, PMID:31043756 NCBI chr14:63,416,154...63,809,220 JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO RGD PMID:9646882 RGD:1358437 NCBI chr 6:49,905,851...49,927,437 JBrowse link
G AVPR1B arginine vasopressin receptor 1B ISO DNA:SNP: :rs28536160 (human) RGD PMID:24012103 RGD:14700651 NCBI chr 9:66,769,472...66,776,916
Ensembl chr 9:66,772,591...66,776,931
JBrowse link
G BDNF brain derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030, PMID:19018715 NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,623,268...32,679,164
JBrowse link
G BHLHE40 basic helix-loop-helix family member e40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25395965 NCBI chr13:61,526,121...61,533,686
Ensembl chr13:61,526,197...61,533,686
JBrowse link
G BRD1 bromodomain containing 1 susceptibility ISO DNA,SNP,haplotype:3'UTR: RGD PMID:16924267 RGD:9586096 NCBI chr 5:774,307...808,016
Ensembl chr 5:770,654...808,006
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18711365, PMID:21926972, PMID:21926974, PMID:31043756 NCBI chr 5:69,016,954...69,448,428 JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO CTD Direct Evidence: marker/mechanism CTD PMID:28194001 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662
JBrowse link
G CBS cystathionine beta-synthase ISO ClinVar Annotator: match by term: Bipolar affective disorder ClinVar PMID:1301198, PMID:2056790, PMID:6711564, PMID:7506602, PMID:7611293, PMID:7635485, PMID:7762555, PMID:8554066, PMID:8803779, PMID:8940271, PMID:9708897, PMID:9864922, PMID:10328723, PMID:10338090, PMID:10364517, PMID:10807759, PMID:11230183, PMID:11359213, PMID:11434706, PMID:12552044, PMID:14722927, PMID:15146473, PMID:16375773, PMID:17072863, PMID:17540596, PMID:18201569, PMID:18805305, PMID:19819175, PMID:20506325, PMID:20567906, PMID:22069143, PMID:22267502, PMID:23592311, PMID:24033266, PMID:25516723, PMID:25741868, PMID:26750749, PMID:28492532, PMID:28583326, PMID:30311386 NCBI chr13:206,205,942...206,231,363 JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO RGD PMID:15034225 RGD:1358456 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CD47 CD47 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr13:151,427,933...151,488,064
Ensembl chr13:151,429,288...151,502,164
JBrowse link
G CDC42 cell division cycle 42 ISO RGD PMID:18391128 RGD:5688274 NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,122...80,089,233
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 ISO DNA:SNP: :rs324650 (human)
protein:decreased expression:cerebral cortex
RGD PMID:19103464, PMID:20351719 RGD:5509579, RGD:5509584 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,150...12,600,249
JBrowse link
G COMT catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11772685 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G CPLX1 complexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 8:197,876...231,721
Ensembl chr 8:197,881...232,038
JBrowse link
G CPLX2 complexin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 2:81,732,527...81,813,189
Ensembl chr 2:81,732,528...81,813,271
JBrowse link
G DDC dopa decarboxylase ISO DNA:deletions:5' utr, intron:g.-601delG, g.722_725delGAGA (human) RGD PMID:12555230 RGD:1358586 NCBI chr 9:136,496,364...136,571,220
Ensembl chr 9:136,495,891...136,571,197
JBrowse link
G DISC1 DISC1 scaffold protein susceptibility ISO DNA:SNPs: :multiple
DNA:SNPs: :rs1538979, rs821577, rs821633 (human)
DNA;SNPs: :rs2738864,rs16841582 (human)
RGD PMID:15386212, PMID:18317464, PMID:21222298 RGD:5509829, RGD:5509833, RGD:5509836 NCBI chr14:58,606,441...58,963,954
Ensembl chr14:58,604,784...59,058,289
JBrowse link
G DIXDC1 DIX domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr 9:39,666,454...39,734,909 JBrowse link
G DRD1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19153942 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,188,936...49,193,709
JBrowse link
G DRD5 dopamine receptor D5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 8:6,180,221...6,182,575
Ensembl chr 8:6,180,221...6,181,636
JBrowse link
G FADS2 fatty acid desaturase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:9,633,941...9,666,666
Ensembl chr 2:9,629,422...9,666,676
JBrowse link
G FSTL5 follistatin like 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 8:50,264,272...51,052,933
Ensembl chr 8:50,264,272...51,052,864
JBrowse link
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 ISO RGD PMID:11840313 RGD:1358391 NCBI chr  X:123,456,952...123,684,814
Ensembl chr  X:123,456,952...123,684,821
JBrowse link
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 ISO RGD PMID:9514592 RGD:1358630 NCBI chr 1:140,486,107...140,568,204
Ensembl chr 1:140,486,103...140,567,893
JBrowse link
G GAD1 glutamate decarboxylase 1 ISO protein:decreased expression:prefrontal cortex layers 2-5
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15560956, PMID:18534564 RGD:6480428 NCBI chr15:76,991,863...77,034,819
Ensembl chr15:76,991,928...77,034,817
JBrowse link
G GAD2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15560956 NCBI chr10:49,316,682...49,391,013
Ensembl chr10:49,313,641...49,390,926
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO DNA:polymorphism RGD PMID:15909293 RGD:1601281 NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,202,007...184,257,315
JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18332879 NCBI chr 1:68,052,086...68,680,448
Ensembl chr 1:68,057,737...68,679,278
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO CTD Direct Evidence: marker/mechanism
DNA:repeat:promoter:(GT)18-33 (human)
CTD
RGD
PMID:12809987, PMID:31043756 RGD:1358644 NCBI chr 3:32,749,329...33,149,350
Ensembl chr 3:32,752,351...33,143,499
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO DNA:polymorphism:multiple RGD PMID:16549338 RGD:1642201 NCBI chr 5:58,477,862...58,948,735
Ensembl chr 5:58,480,526...58,927,583
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO mRNA, protein:decreased expression:frontal cortex (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12808434, PMID:19400979 RGD:5685029 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,985
JBrowse link
G GRN granulin precursor ISO protein:decreased expression:plasma RGD PMID:24581833 RGD:10401641 NCBI chr12:18,893,772...18,900,444
Ensembl chr12:18,893,770...18,900,446
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20357757 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,700,735
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16397405, PMID:17357145, PMID:20357757 RGD:1641929, RGD:1641931 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,574
JBrowse link
G HDAC5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr12:19,077,910...19,119,463
Ensembl chr12:19,077,997...19,123,140
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr11:20,555,939...20,620,225
Ensembl chr11:20,555,961...20,619,629
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO DNA:missense mutation:cds:p.C23S (human) RGD PMID:8823764 RGD:1358737 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
G IMPA2 inositol monophosphatase 2 susceptibility ISO DNA:SNPs:promoter:-461C>T, -207T>C(human) RGD PMID:9322233, PMID:11673796, PMID:14699425 RGD:6480265, RGD:6480267, RGD:6480269 NCBI chr 6:97,280,008...97,309,729 JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:5506046 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr13:34,892,335...34,906,378
Ensembl chr13:34,892,339...34,924,812
JBrowse link
G KAT6B lysine acetyltransferase 6B ISO DNA:mutations:multiple (human) RGD PMID:24444492 RGD:9588521 NCBI chr14:77,390,790...77,597,674
Ensembl chr14:77,375,758...77,597,674
JBrowse link
G L1CAM L1 cell adhesion molecule ISO associated with Depressive Disorder; mRNA:increased expression:blood (human) RGD PMID:18430502 RGD:6483084 NCBI chr  X:124,595,649...124,618,292
Ensembl chr  X:124,595,651...124,618,307
JBrowse link
G LMAN2L lectin, mannose binding 2 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 3:56,879,301...56,902,356
Ensembl chr 3:56,878,940...56,936,319
JBrowse link
G LOC100515171 sodium channel protein type 2 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr15:71,864,753...71,999,219
Ensembl chr15:71,864,739...71,999,212
JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:haplotype: : RGD PMID:24856568 RGD:12910826 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,894...97,108,936
JBrowse link
G MRPS33 mitochondrial ribosomal protein S33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr18:8,883,439...8,894,473
Ensembl chr18:8,883,458...8,897,975
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO DNA:missense mutation:cds:m.3644T>C (human) RGD PMID:15533721 RGD:5490261 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17074966 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO DNA:snps:introns:IVS6+32T>C, IVS7+11G>C, IVS12+21C>A (human) RGD PMID:15050861 RGD:1358750 NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,750...40,960,608
JBrowse link
G NCAN neurocan ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:58,638,808...58,669,757
Ensembl chr 2:58,638,805...58,669,705
JBrowse link
G NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:20368511 RGD:6484696 NCBI chr 2:77,080,311...77,087,141 JBrowse link
G NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19135101 NCBI chr 6:98,819,156...98,852,561
Ensembl chr 6:98,815,882...98,852,576
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,937...144,956,095
JBrowse link
G NRG1 neuregulin 1 ISO DNA:SNP:enhancer: (rs35753505) RGD PMID:18585932 RGD:39131291 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,627,334...53,688,332
JBrowse link
G NTNG1 netrin G1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17507910 NCBI chr 4:112,280,899...112,615,782
Ensembl chr 4:112,287,043...112,614,544
JBrowse link
G NTNG2 netrin G2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17507910 NCBI chr 1:272,007,513...272,077,105
Ensembl chr 1:272,011,948...272,077,018
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:cerebellum
CTD
RGD
PMID:19018715, PMID:21612826 RGD:5684549 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
G PACS1 phosphofurin acidic cluster sorting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:6,138,345...6,277,309
Ensembl chr 2:6,138,348...6,211,684
JBrowse link
G PC pyruvate carboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:5,566,608...5,587,797
Ensembl chr 2:5,518,430...5,587,797
JBrowse link
G PDE4B phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18394866 NCBI chr 6:146,167,262...146,720,105
Ensembl chr 6:146,166,681...146,720,127
JBrowse link
G PLEKHO1 pleckstrin homology domain containing O1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 4:98,924,115...98,934,610
Ensembl chr 4:98,923,996...98,934,371
JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2843795, PMID:9664777 NCBI chr 3:113,661,712...113,668,558 JBrowse link
G POU3F2 POU class 3 homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:65,835,375...65,842,872 JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B ISO DNA, mRNA:SNPs, haplotype, splice variant:multiple RGD PMID:23295814 RGD:13515076 NCBI chr12:22,681,244...22,690,978
Ensembl chr12:22,654,924...22,690,953
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO mRNA, protein:decreased expression:prefrontal cortex RGD PMID:20038946 RGD:5688160 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO mRNA, protein:increased expression:prefrontal cortex RGD PMID:20038946 RGD:5688160 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G PVALB parvalbumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 5:10,953,559...10,973,300
Ensembl chr 5:10,955,491...10,973,289
JBrowse link
G RAP1GAP RAP1 GTPase activating protein ISO mRNA, protein:increased expression:dorsolateral prefrontal cortex (human) RGD PMID:16687443 RGD:5490162 NCBI chr 6:79,664,486...79,735,361
Ensembl chr 6:79,664,485...79,735,363
JBrowse link
G RELN reelin ISO protein:decreased expression:hippocampus (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11126396, PMID:14708030, PMID:15560956 RGD:2324681 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,857...103,963,965
JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:51,785,140...52,246,456
Ensembl chr 1:51,785,495...52,244,934
JBrowse link
G RPS6KA2 ribosomal protein S6 kinase A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:2,203,825...2,522,604
Ensembl chr 1:2,203,605...2,522,604
JBrowse link
G S100B S100 calcium binding protein B ISO protein:increased expression:cerebrospinal fluid
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15581912, PMID:16476148 RGD:5508853
G SERPINA1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,604,285...115,614,633
JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:2,517,853...3,016,959
Ensembl chr 2:2,503,181...3,016,433
JBrowse link
G SLA-DRA MHC class II DR-alpha ISO RGD PMID:16687443 RGD:5490162 NCBI chr 7:24,825,037...24,830,650
Ensembl chr 7:24,825,053...24,835,160
JBrowse link
G SLC18A1 solute carrier family 18 member A1 ISO DNA:SNPs:5' utr, cds:g.-584A>G (rs988713), p.T136I (rs1390938) (human) RGD PMID:16936705 RGD:5131197 NCBI chr14:4,243,553...4,279,341
Ensembl chr14:4,243,557...4,278,989
JBrowse link
G SLC5A3 solute carrier family 5 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16420717 NCBI chr13:197,688,632...197,723,323
Ensembl chr13:197,688,631...197,718,696
JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism
DNA:repeats:promoter:
CTD
RGD
PMID:10484962, PMID:11772685, PMID:16395126 RGD:36947381 NCBI chr12:46,285,995...46,328,377
Ensembl chr12:46,285,997...46,314,378
JBrowse link
G SNAP25 synaptosome associated protein 25 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr17:19,096,115...19,227,580
Ensembl chr17:19,096,140...19,227,576
JBrowse link
G SNCA synuclein alpha ISO RGD PMID:19198857 RGD:6478716 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,388,307
JBrowse link
G SP4 Sp4 transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19401786 NCBI chr 9:90,337,355...90,410,529
Ensembl chr 9:90,336,690...90,410,295
JBrowse link
G SRPK2 SRSF protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 9:105,009,550...105,264,689
Ensembl chr 9:105,006,986...105,265,595
JBrowse link
G SRSF3 serine and arginine rich splicing factor 3 ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:18281098 RGD:11039413 NCBI chr 7:32,289,464...32,298,652
Ensembl chr 7:32,289,480...32,298,589
JBrowse link
G SSBP2 single stranded DNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:89,960,133...90,263,290
Ensembl chr 2:89,948,773...90,263,286
JBrowse link
G SSTR5 somatostatin receptor 5 ISO DNA:SNP, missense mutations, haplotype: :573G>A, p.L48M, p.P335L (human) RGD PMID:12192619 RGD:1358589 NCBI chr 3:40,756,465...40,758,111
Ensembl chr 3:40,756,519...40,758,111
JBrowse link
G STARD9 StAR related lipid transfer domain containing 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:128,656,375...128,808,951 JBrowse link
G STK4 serine/threonine kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr17:47,387,594...47,475,705
Ensembl chr17:47,376,115...47,475,718
JBrowse link
G SYNE1 spectrin repeat containing nuclear envelope protein 1 susceptibility ISO DNA:SNPs:promoter,intron: RGD PMID:28178086 RGD:13209005 NCBI chr 1:13,715,644...14,201,711 JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15845098 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
G TACR1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,728
JBrowse link
G TENM4 teneurin transmembrane protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21926972 NCBI chr 9:13,040,615...13,826,957 JBrowse link
G TGM6 transglutaminase 6 ISO ClinVar Annotator: match by term: Bipolar affective disorder ClinVar PMID:25741868, PMID:30311386 NCBI chr17:33,106,974...33,142,548
Ensembl chr17:33,108,569...33,155,069
JBrowse link
G THSD7A thrombospondin type 1 domain containing 7A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 9:81,071,840...81,518,200
Ensembl chr 9:81,076,062...81,518,228
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO protein:increased expression:plasma RGD PMID:20861651 RGD:7205488 NCBI chr 4:19,850,212...19,879,132 JBrowse link
G TPH2 tryptophan hydroxylase 2 ISO mRNA:increased expression:frontal association cortex
ClinVar Annotator: match by term: Bipolar affective disorder, susceptibility to
RGD
ClinVar
PMID:16240163, PMID:17905754, PMID:19319927 RGD:5686358 NCBI chr 5:35,917,159...36,016,981
Ensembl chr 5:35,918,569...36,017,514
JBrowse link
G TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr13:21,913,400...22,023,165
Ensembl chr13:21,913,275...22,023,156
JBrowse link
G TRPC3 transient receptor potential cation channel subfamily C member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23602965 NCBI chr 8:102,129,539...102,206,512
Ensembl chr 8:102,129,457...102,206,951
JBrowse link
G TRPM2 transient receptor potential cation channel subfamily M member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23602965 NCBI chr13:207,212,339...207,263,313
Ensembl chr13:207,211,952...207,264,982
JBrowse link
G TSHB thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:6455462 NCBI chr 4:105,553,070...105,558,769
Ensembl chr 4:105,553,070...105,558,683
JBrowse link
G VWF von Willebrand factor ISO protein:increased expression:plasma RGD PMID:19839997 RGD:7207027 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,098
JBrowse link
G ZCCHC2 zinc finger CCHC-type containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:158,964,816...159,022,143
Ensembl chr 1:158,962,511...159,022,072
JBrowse link
G ZNF592 zinc finger protein 592 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 7:52,731,690...52,793,950
Ensembl chr 7:52,546,406...52,793,927
JBrowse link
Major Affective Disorder 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XBP1 X-box binding protein 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Major affective disorder 7
OMIM
CTD
ClinVar
NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12618
    disease of anatomical entity 12151
      nervous system disease 9917
        central nervous system disease 8392
          brain disease 7764
            disease of mental health 5683
              cognitive disorder 1710
                mood disorder 231
                  bipolar disorder 109
                    Major Affective Disorder 3 0
                    Major Affective Disorder 4 0
                    Major Affective Disorder 5 0
                    Major Affective Disorder 6 0
                    Major Affective Disorder 7 1
                    Major Affective Disorder 8 0
                    Major Affective Disorder 9 0
                    Mental Health Wellness 1 0
                    Mental Health Wellness 2 0
                    bipolar I disorder 0
                    bipolar ll disorder 0
                    cyclothymic disorder 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.