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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:oligodendroglioma
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Accession:DOID:3181 term browser browse the term
Definition:A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Synonyms:exact_synonym: oligodendroblastoma;   oligodendroblastomas;   oligodendroglial neoplasm;   oligodendroglial tumor;   oligodendrogliomas;   well differentiated oligodendroglioma;   well-differentiated oligodendrogliomas
 narrow_synonym: Mixed Oligodendroglioma Astrocytoma;   Mixed Oligodendroglioma Ependymoma;   mixed oligodendroglioma-astrocytomas;   mixed oligodendroglioma-ependymomas
 primary_id: MESH:D009837
 xref: EFO:0000631;   EFO:0000632;   GARD:9953;   NCI:C129319;   NCI:C3288;   NCI:C6960
For additional species annotation, visit the Alliance of Genome Resources.

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oligodendroglioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX chromatin remodeler ISO ClinVar Annotator: match by term: Oligodendroglioma ClinVar NCBI chrNW_004955557:947,368...1,252,701
Ensembl chrNW_004955557:947,167...1,252,724 		JBrowse link
G Camk2b calcium/calmodulin dependent protein kinase II beta disease_progression ISO RGD PMID:15750623 RGD:13702479 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207 		JBrowse link
G Cic capicua transcriptional repressor ISO ClinVar Annotator: match by term: Oligodendroglioma ClinVar NCBI chrNW_004955555:613,549...641,587
Ensembl chrNW_004955555:613,665...638,369 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chrNW_004955482:9,416,456...9,447,265
Ensembl chrNW_004955482:9,417,116...9,446,239 		JBrowse link
G Egf epidermal growth factor susceptibility ISO DNA:polymorphism:promoter:GG genotypes were associated with increased risk. RGD PMID:17473192 RGD:13702474 NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19138852 NCBI chrNW_004955426:22,386,613...22,412,324
Ensembl chrNW_004955426:22,386,450...22,412,324 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chrNW_004955420:14,565,921...14,568,447
Ensembl chrNW_004955420:14,564,283...14,568,447 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chrNW_004955444:1,498,444...1,502,099
Ensembl chrNW_004955444:1,498,675...1,500,945 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Oligodendroglioma ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:21446021 More... NCBI chrNW_004955457:6,851,542...6,869,452
Ensembl chrNW_004955457:6,851,517...6,872,367 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20160062 NCBI chrNW_004955416:15,197,611...15,212,919
Ensembl chrNW_004955416:15,197,366...15,223,363 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypermethylation:promoter (human) RGD PMID:15455350 RGD:2317688 NCBI chrNW_004955477:7,103,035...7,375,073
Ensembl chrNW_004955477:7,102,977...7,376,530 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO protein:increased expression:brain cortex, white matter (human) RGD PMID:19347995 RGD:5688067 NCBI chrNW_004955458:4,203,075...4,209,967
Ensembl chrNW_004955458:4,203,076...4,209,910 		JBrowse link
G Rb1 RB transcriptional corepressor 1 disease_progression ISO RGD PMID:15970925 RGD:13782064 NCBI chrNW_004955431:1,960,765...2,124,576
Ensembl chrNW_004955431:1,960,661...2,124,576 		JBrowse link
anaplastic oligodendroglioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cic capicua transcriptional repressor ISO ClinVar Annotator: match by term: Anaplastic oligodendroglioma ClinVar NCBI chrNW_004955555:613,549...641,587
Ensembl chrNW_004955555:613,665...638,369 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      cancer 4843
        cell type cancer 3304
          high grade glioma 630
            oligodendroglioma 13
              adult oligodendroglioma 0
              anaplastic oligodendroglioma + 1
              brain oligodendroglioma + 0
              childhood oligodendroglioma 0
              spinal cord oligodendroglioma 0
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      nervous system disease 12088
        central nervous system disease 10855
          Central Nervous System Neoplasms 1292
            Brain Neoplasms 1248
              brain cancer 682
                high grade glioma 630
                  oligodendroglioma 13
                    adult oligodendroglioma 0
                    anaplastic oligodendroglioma + 1
                    brain oligodendroglioma + 0
                    childhood oligodendroglioma 0
                    spinal cord oligodendroglioma 0
paths to the root