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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:brain glioblastoma multiforme
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Accession:DOID:3073 term browser browse the term
Definition:A brain glioma that has_material_basis_in abnormally proliferating cells derives_from glial cells, has_symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems. (DO)
Synonyms:exact_synonym: brain glioblastoma;   glioblastoma multiforme of brain
 xref: EFO:0000515;   EFO:0006545;   NCI:C4642
For additional species annotation, visit the Alliance of Genome Resources.


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brain glioblastoma multiforme term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef2 eukaryotic translation elongation factor 2 ISO protein:increased expression:brain (human) RGD PMID:24589652 RGD:153297816 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Mir139 microRNA 139 ISO RNA:decreased expression:brain: RGD PMID:26449464 RGD:13838722 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 disease_progression ISO RGD PMID:20219118 RGD:40924672 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling IEP human, rat, and/or mouse glioma cells in a mouse model RGD PMID:30790292 RGD:150573813 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      cancer 5483
        cell type cancer 3731
          high grade glioma 670
            brain glioma 32
              brain glioblastoma multiforme 4
Path 2
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      Neoplasms by Site 7121
        Nervous System Neoplasms 1615
          Central Nervous System Neoplasms 1413
            Brain Neoplasms 1364
              Supratentorial Neoplasms 475
                supratentorial cancer 475
                  cerebrum cancer 422
                    malignant astrocytoma 418
                      glioblastoma 169
                        brain glioblastoma multiforme 4
paths to the root