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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:acinar cell carcinoma
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Accession:DOID:3025 term browser browse the term
Definition:A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Synonyms:exact_synonym: Acinar Carcinomas;   Acinar Cell Adenocarcinoma;   Acinar Cell Adenocarcinomas;   Acinar Cell Carcinomas;   Acinic Cell Adenocarcinoma;   Acinic Cell Adenocarcinomas;   Acinic Cell Carcinoma;   Acinic Cell Carcinomas;   Acinic Cell Tumor;   Acinic Cell Tumors;   acinar carcinoma;   serous acinar adenoma
 primary_id: MESH:D018267
 alt_id: RDO:0007150
 xref: GARD:8568;   NCI:C3768
For additional species annotation, visit the Alliance of Genome Resources.


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acinar cell carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO DNA:mutations (human) RGD PMID:11891193 RGD:2317200 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
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pancreatic acinar cell adenocarcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO DNA:missense mutation, gene fusions:multiple (human) RGD PMID:25266736 RGD:13462041 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17014
    disease of cellular proliferation 6936
      cancer 4887
        cell type cancer 3390
          carcinoma 2909
            adenocarcinoma 1467
              acinar cell carcinoma 2
                acinic cell breast carcinoma 0
                pancreatic acinar cell adenocarcinoma + 1
paths to the root