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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:acute kidney failure
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Accession:DOID:3021 term browser browse the term
Definition:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Synonyms:exact_synonym: Acute Kidney Failures;   Acute Kidney Injuries;   Acute Kidney Injury;   Acute Kidney Insufficiencies;   Acute Kidney Insufficiency;   Acute Renal Failure;   Acute Renal Failures;   Acute Renal Injuries;   Acute Renal Injury;   Acute Renal Insufficiencies;   Acute Renal Insufficiency
 primary_id: MESH:D058186;   RDO:0001702
For additional species annotation, visit the Alliance of Genome Resources.


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acute kidney failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 treatment ISO associated with endotoxemia; protein:increased expression:kidney
associated with Endotoxemia;
associated with Bacteremia;
RGD PMID:14747378 PMID:19020966 PMID:19887504 RGD:7175276 RGD:7175281 RGD:7175283 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO RGD PMID:21811803 RGD:7243868 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ahsg alpha 2-HS glycoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936578:3,332,934...3,339,903 JBrowse link
G Alad aminolevulinate dehydratase ISO protein:decreased activity:kidney (rat) RGD PMID:19484701 RGD:4144146 NCBI chrNW_004936559:226,481...237,258 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:19194548 RGD:2317536 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:8963945 PMID:28885000 RGD:6904218 NCBI chrNW_004936487:3,399,792...3,412,088 JBrowse link
G Amn amnion associated transmembrane protein ISO CTD Direct Evidence: therapeutic CTD PMID:20514524 NCBI chrNW_004936835:961,840...970,287 JBrowse link
G Anxa1 annexin A1 treatment ISO RGD PMID:22101490 RGD:7421583 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Ar androgen receptor ISO RGD PMID:24503548 RGD:11570523 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Arg2 arginase 2 ISO mRNA:decreased expression:renal tubule (rat) RGD PMID:12371970 RGD:631989 NCBI chrNW_004936495:11,004,296...11,045,467 JBrowse link
G Atp5f1b ATP synthase F1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25666834 NCBI chrNW_004936646:951,236...958,907 JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:17347933 RGD:2300348 NCBI chrNW_004936545:1,788,995...1,795,842 JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding disease_progression ISO RGD PMID:23849457 RGD:153350150 NCBI chrNW_004936543:105,983...113,475 JBrowse link
G B2m beta-2-microglobulin ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:2689182 PMID:19536607 PMID:22005293 PMID:28885000 RGD:6482685 NCBI chrNW_004936471:7,646,504...7,655,656 JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO RGD PMID:20037173 RGD:10053672 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:20037173 PMID:20623750 RGD:10053672 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bcl2l1 BCL2 like 1 ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24975837 NCBI chrNW_004936604:548,844...551,031 JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Capn1 calpain 1 treatment ISO associated with Rhabdomyolysis; RGD PMID:24158126 RGD:13792553 NCBI chrNW_004936599:4,178,963...4,201,037 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (mouse) RGD PMID:19508392 RGD:4889990 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chrNW_004936491:17,017,687...17,033,526 JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:kidney RGD PMID:16557226 RGD:2293624 NCBI chrNW_004936587:4,573,166...4,578,480 JBrowse link
G Clu clusterin ISO protein:increased expression:urine
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:20118187 PMID:20623750 PMID:22005293 PMID:22581811 PMID:23052191 More... RGD:7245501 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936519:6,431,156...6,473,183 JBrowse link
G Crp C-reactive protein ISO associated with Myocardial Infarction;
protein:increased expression:serum
RGD PMID:22551254 PMID:22694718 RGD:6903282 RGD:6906888 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Csf1 colony stimulating factor 1 ISO RGD PMID:23143303 RGD:7257565 NCBI chrNW_004936704:1,372,137...1,393,355 JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chrNW_004936504:4,898,947...4,927,195 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO Protein:increased expression:renal tubule epithelium RGD PMID:15476864 RGD:1599736 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:10073607 PMID:11043448 RGD:7244180 RGD:7244185 NCBI chrNW_004936474:7,034,134...7,083,005 JBrowse link
G Edn1 endothelin 1 ISO mRNA, protein:increased expression:kidney (mouse)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9788586 PMID:19967049 RGD:4144852 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Egf epidermal growth factor ISO RGD PMID:20482449 RGD:6906908 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: therapeutic
mRNA:increased expression:kidney
CTD
RGD
PMID:11340354 PMID:14638913 RGD:10395241 NCBI chrNW_004936678:365,005...560,546 JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Egln3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chrNW_004936494:8,240,272...8,267,487 JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment ISO RGD PMID:16762988 RGD:10395386 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Ephx2 epoxide hydrolase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26165641 NCBI chrNW_004936675:350,357...392,919 JBrowse link
G Epo erythropoietin treatment ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:21847101 PMID:22209169 PMID:22235348 PMID:24561306 RGD:10400913 RGD:11041660 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:renal tubule (rat) RGD PMID:21374789 RGD:8663469 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Fga fibrinogen alpha chain ISO mRNA:increased expression:kidney (rat) RGD PMID:15805072 RGD:9685024 NCBI chrNW_004936576:1,322,406...1,329,743 JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chrNW_004936543:1,112,746...1,116,521 JBrowse link
G Fn1 fibronectin 1 ISO protein:increased expression:kidney RGD PMID:11768240 PMID:12884040 RGD:7205684 RGD:729934 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Fstl1 follistatin like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20861081 NCBI chrNW_004936536:7,132,369...7,186,951 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:602954 PMID:734759 PMID:4794122 NCBI chrNW_004936809:1,269,900...1,285,853 JBrowse link
G Gas6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19564549 NCBI chrNW_004936472:27,116...57,158 JBrowse link
G Gatm glycine amidinotransferase ISO protein:decreased activity:kidney (rat) RGD PMID:2752493 RGD:1599823 NCBI chrNW_004936471:8,017,611...8,032,703 JBrowse link
G Gc GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment ISO CTD Direct Evidence: therapeutic
protein:increased expression:cortex of kidney,renal medulla:
CTD
RGD
PMID:20030531 RGD:9685736 NCBI chrNW_004936694:2,051,362...2,053,812 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO RGD PMID:19625378 RGD:7242430 NCBI chrNW_004936602:3,037,862...3,044,863 JBrowse link
G Gpnmb glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chrNW_004936478:397,200...425,663 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22785175 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Gsr glutathione-disulfide reductase ISO glycerol-induced
protein:decreased activity:kidney:
RGD PMID:1870354 PMID:22286819 RGD:7257559 RGD:7257585 NCBI chrNW_004936792:531,076...579,083 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:20623750 PMID:20798258 RGD:6903954 NCBI chrNW_004936599:2,197,681...2,200,642 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:urine:
associated with Pyelonephritis;protein:increased expression:urine:
CTD
RGD
PMID:20118187 PMID:21259293 PMID:21835770 PMID:22005293 PMID:23019274 More... RGD:7244370 RGD:7245472 RGD:7245495 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Hbegf heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:kidney
CTD
RGD
PMID:7635938 PMID:11340354 RGD:10395241 NCBI chrNW_004936531:9,332,939...9,345,039 JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO associated with sepsis; RGD PMID:22933299 RGD:9590257 NCBI chrNW_004936679:2,448,676...2,474,641 JBrowse link
G Hdac3 histone deacetylase 3 ISO RGD PMID:21416250 RGD:10047111 NCBI chrNW_004936504:12,530,546...12,546,556 JBrowse link
G Hdac5 histone deacetylase 5 treatment ISO associated with sepsis; RGD PMID:21416250 PMID:22933299 RGD:10047111 RGD:9590257 NCBI chrNW_004936541:561,721...598,915 JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO protein:increased expression:kidney tubule (rat)
mRNA:increased expression:kidney collecting duct (rat)
RGD PMID:24325066 PMID:24397211 RGD:9685383 RGD:9685389 NCBI chrNW_004936711:640,002...642,580 JBrowse link
G Hexb hexosaminidase subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22005293 NCBI chrNW_004936549:1,918,482...1,943,665 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment ISO mRNA:increased expression:renal cortex (rat) RGD PMID:15673301 PMID:16762988 PMID:18593636 RGD:10395376 RGD:10395386 RGD:9068894 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO associated with Sepsis RGD PMID:16557230 RGD:5508471 NCBI chrNW_004936549:1,378,536...1,400,501 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO associated with Sepsis
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:21048024 PMID:23807243 RGD:10755583 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hpx hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936842:485,515...495,684 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO protein:increased expression:kidney, lysosome (rat) RGD PMID:14966137 RGD:7242786 NCBI chrNW_004936542:7,577,192...7,581,598 JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:22659586 RGD:7175102 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Igf1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO mRNA: decreased expression: kidney: both cortex and medulla RGD PMID:9767523 RGD:7242908 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chrNW_004936478:20,494,190...20,499,001 JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18460982 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il18 interleukin 18 ISO RGD PMID:11342578 RGD:6893450 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:21716595 RGD:6907069 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:kidney (rat)
mRNA:increased expression:kidney, liver, spleen (mouse)
RGD PMID:21677145 PMID:22286667 PMID:22659586 PMID:22750969 RGD:7175094 RGD:7175102 RGD:7175258 RGD:7175314 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO associated with Sepsis
associated with Asphyxia; rat model treated with human protein
RGD PMID:14610321 PMID:16259926 PMID:16763508 RGD:6907360 RGD:6907369 RGD:6907375 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il20 interleukin 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18496552 NCBI chrNW_004936557:5,749,419...5,751,776 JBrowse link
G Il6 interleukin 6 ISO associated with Acute Lung Injury;protein:increased expression:plasma
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:18074478 PMID:21570986 RGD:5128661 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Ins insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12243603 NCBI chrNW_004936816:1,002,137...1,003,357 JBrowse link
G Jak2 Janus kinase 2 treatment ISO associated with Carcinoma, Lewis Lung, human cells in mouse model RGD PMID:31250048 RGD:149735351 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G Klk1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18227104 NCBI chrNW_004936889:534,127...537,913 JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: therapeutic CTD PMID:513486 PMID:3015452 NCBI chrNW_004936578:3,255,335...3,281,296 JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:urine
associated with open cardiac surgeries;protein:increased expression:urine:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:20623750 PMID:22005293 PMID:23052191 PMID:23336369 PMID:23683031 More... RGD:125973912 RGD:126781714 RGD:7244370 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Lgals3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chrNW_004936697:20,861...38,568 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12690470 PMID:19546256 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G LOC101959212 alpha-2-macroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G LOC101961588 cytochrome P450 2D17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chrNW_004936718:153,340...157,966 JBrowse link
G LOC101968920 eotaxin ISO protein:increased expression:kidney RGD PMID:22778179 RGD:7247739 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G LOC101968921 angiotensin-converting enzyme treatment ISO RGD PMID:24502693 RGD:11039053 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
G LOC101969148 cytochrome P450 1A1 treatment ISO RGD PMID:18495746 PMID:19890363 RGD:7257732 RGD:7257735 NCBI chrNW_004936471:33,682,730...33,688,332 JBrowse link
G LOC101969421 cytochrome P450 1A2 treatment ISO RGD PMID:18495746 PMID:23981375 RGD:7257727 RGD:7257735 NCBI chrNW_004936471:33,704,616...33,709,455 JBrowse link
G LOC101970831 serotransferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936529:6,917,762...6,947,512 JBrowse link
G LOC101973029 cytochrome P450 2E1 treatment ISO RGD PMID:24412858 PMID:24717297 RGD:14700914 RGD:14700920 NCBI chrNW_004936486:19,691,822...19,702,684 JBrowse link
G LOC101973720 rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21745194 NCBI chrNW_004936512:5,636,197...5,659,606 JBrowse link
G LOC101976500 haptoglobin ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:19270397 PMID:28885000 RGD:11041863 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial ISO RGD PMID:6223803 RGD:2307326 NCBI chrNW_004936646:1,899,686...1,904,104 JBrowse link
G Lrg1 leucine rich alpha-2-glycoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chrNW_004936588:2,638,597...2,640,856 JBrowse link
G Lrp2 LDL receptor related protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chrNW_004936469:10,245,001...10,438,933 JBrowse link
G Mb myoglobin ISO protein: increased expression: serum RGD PMID:9822635 PMID:23497406 RGD:7244253 RGD:7244259 NCBI chrNW_004936492:4,890,871...4,897,665 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:renal parenchyma (rat) RGD PMID:17940345 RGD:2317469 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chrNW_004936566:3,737,315...3,775,894 JBrowse link
G Mpo myeloperoxidase ISO DNA:haplotye: :
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19793022 PMID:20623750 PMID:22739978 RGD:6909168 RGD:6909185 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17387702 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:23022334 RGD:7245507 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Muc20 mucin 20, cell surface associated ISO RGD PMID:14565953 RGD:7364790 NCBI chrNW_004936784:482,605...511,233 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor susceptibility ISO protein:decreased phosphorylation:kidney (mouse) RGD PMID:23228991 RGD:7207407 NCBI chrNW_004936470:20,480,844...20,485,955 JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 RGD:13801199 NCBI chrNW_004936600:5,122,004...5,126,776 JBrowse link
G Nes nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chrNW_004936580:5,837,949...5,847,499 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:24291173 PMID:24958931 RGD:10412697 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chrNW_004936520:733,760...850,563 JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:14531809 RGD:13825139 NCBI chrNW_004936558:5,162,471...5,302,488 JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9810145 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Nos3 nitric oxide synthase 3 ISO in females;mRNA:increased expression:cortex of kidney (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9788586 PMID:28947737 RGD:13450947 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Nppa natriuretic peptide A ISO mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:1825077 PMID:2948068 PMID:19298916 PMID:22209992 RGD:7247715 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nppb natriuretic peptide B ISO associated with lung diseases;protein:increased expression:serum:
associated with Myocardial Infarction;protein:increased expression:serum:
associated with Pneumonia;protein:increased expression:serum:
mRNA:increased expression:kidney
RGD PMID:22209992 PMID:23192919 PMID:23415693 PMID:23837838 RGD:7247620 RGD:7247622 RGD:7247624 RGD:7247715 NCBI chrNW_004936474:683,325...684,662 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:26723870 PMID:28230744 RGD:13440091 NCBI chrNW_004936475:19,771,384...19,785,034 JBrowse link
G Ocln occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19766176 NCBI chrNW_004936480:99,516...152,834 JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO RGD PMID:21884784 RGD:5510015 NCBI chrNW_004936526:3,102,468...3,147,601 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO protein:altered localization RGD PMID:12089381 RGD:7175293 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Plat plasminogen activator, tissue type ISO protein:increased expression:plasma (human) RGD PMID:9767551 RGD:11541071 NCBI chrNW_004936785:476,200...503,371 JBrowse link
G Plg plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936489:11,775,243...11,808,482 JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: therapeutic CTD PMID:17216604 NCBI chrNW_004936493:7,060,747...7,065,276 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:17494862 PMID:20623750 PMID:24011919 PMID:24433871 RGD:8553020 NCBI chrNW_004936602:1,230,907...1,368,588 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO associated with Endotoxemia; mRNA:decreased expression:kidney (mouse) RGD PMID:21881206 RGD:7242026 NCBI chrNW_004936477:4,881,230...5,488,208 JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:19092124 RGD:11250410 NCBI chrNW_004936469:43,841,989...43,850,322 JBrowse link
G Procr protein C receptor treatment ISO associated with Sepsis RGD PMID:23807243 RGD:10755583 NCBI chrNW_004936561:5,557,640...5,562,981 JBrowse link
G Ptafr platelet activating factor receptor treatment ISO associated with Endotoxemia RGD PMID:2538527 RGD:10043182 NCBI chrNW_004936474:12,333,905...12,337,140 JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment ISO RGD PMID:16871242 RGD:10003092 NCBI chrNW_004936518:1,903,636...1,916,746 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21893983 RGD:5508181 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO associated with Sepsis;protein:increased phosphorylation:kidney RGD PMID:19428114 RGD:8547990 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link
G Ren renin exacerbates ISO Associated with toxic shock syndrome;protein:increased expression:blood plasma (human) RGD PMID:30407370 RGD:125097506 NCBI chrNW_004936567:598,044...607,628 JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO associated with LPS induced endotoxemia RGD PMID:18824919 RGD:2313129 NCBI chrNW_004936581:798,738...801,614 JBrowse link
G Serpinc1 serpin family C member 1 ISO associated with heart failure; protein:decreased activity:plasma: RGD PMID:26108065 RGD:11354006 NCBI chrNW_004936481:13,981,014...13,993,750 JBrowse link
G Sirt1 sirtuin 1 severity ISO protein:increased expression:kidney (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:21416250 RGD:10047111 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Slc22a1 solute carrier family 22 member 1 treatment ISO RGD PMID:22414646 RGD:7243179 NCBI chrNW_004936489:11,534,095...11,556,759 JBrowse link
G Slc22a12 solute carrier family 22 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14655203 NCBI chrNW_004936599:4,693,493...4,698,556 JBrowse link
G Slc22a2 solute carrier family 22 member 2 treatment
susceptibility
ISO mRNA:decreased expression:kidney
DNA:SNP: :808G>T (rs316019) human
RGD PMID:18612803 PMID:19625999 PMID:22414646 RGD:7243179 RGD:7243880 RGD:7243884 NCBI chrNW_004936489:11,605,403...11,627,786 JBrowse link
G Slc34a1 solute carrier family 34 member 1 disease_progression ISO associated with Sepsis; protein:decreased expression:renal proximal tubule (mouse) RGD PMID:19729856 RGD:7242943 NCBI chrNW_004936597:1,667,700...1,684,533 JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11274264 PMID:20623750 PMID:22863853 RGD:6903264 NCBI chrNW_004936905:148,956...156,023 JBrowse link
G Tgfa transforming growth factor alpha ISO mRNA:increased expression:kidney RGD PMID:11340354 RGD:10395241 NCBI chrNW_004936491:14,659,089...14,758,614 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10469268 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chrNW_004936524:7,656,523...7,680,043 JBrowse link
G Thbd thrombomodulin treatment ISO RGD PMID:17804460 PMID:19176699 RGD:5684994 RGD:5685010 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Tlr2 toll like receptor 2 ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:22655058 PMID:29286200 RGD:7207898 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Sepsis
RGD
CTD
PMID:16638912 PMID:22266601 PMID:22655058 PMID:29286200 RGD:6892690 RGD:7207898 RGD:7241084 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor susceptibility ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16595132 PMID:18460982 PMID:20623750 PMID:21150875 RGD:7245548 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chrNW_004936694:1,149,169...1,151,098 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A susceptibility ISO associated with Acute Lung Injury
associated with Shock, Septic;protein:increased expression:serum
associated with Endotoxemia
RGD PMID:12023385 PMID:12500222 PMID:18074478 PMID:21150875 RGD:5128661 RGD:7245534 RGD:7245535 RGD:7245548 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO associated with Acute Lung Injury
associated with Shock, Septic;protein:increased expression:serum
RGD PMID:12500222 PMID:12865254 PMID:18074478 RGD:5128661 RGD:7245532 RGD:7245534 NCBI chrNW_004936474:908,414...935,765 JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20603111 NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Ttr transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chrNW_004936682:1,628,489...1,635,495 JBrowse link
G Uts2r urotensin 2 receptor ISO RGD PMID:15146030 RGD:2306847 NCBI chrNW_004936923:24,952...31,083 JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:20943766 PMID:22808199 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Wnt4 Wnt family member 4 ISO RGD PMID:12707392 RGD:727218 NCBI chrNW_004936474:7,623,462...7,635,416 JBrowse link
G Xdh xanthine dehydrogenase treatment ISO associated with Reperfusion Injury RGD PMID:18539378 PMID:19628223 PMID:22571266 RGD:7247641 RGD:7247650 RGD:7247656 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link
acute kidney tubular necrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak4 adenylate kinase 4 ISO protein:decreased expression:kidney (rat) RGD PMID:21152904 RGD:5134352 NCBI chrNW_004936692:2,593,409...2,654,583 JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO associated with Kidney Reperfusion Injury;protein:increased expression:kidney RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936530:71,965...143,940 JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chrNW_004936491:17,017,687...17,033,526 JBrowse link
G Ciita class II major histocompatibility complex transactivator ISO mRNA:increased expression:kidney RGD PMID:9422398 RGD:7242901 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Fabp1 fatty acid binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18368030 NCBI chrNW_004936712:738,361...743,073 JBrowse link
G Gsr glutathione-disulfide reductase ISO protein:decreased activity:renal cortex: RGD PMID:12885594 PMID:17078987 RGD:7257555 RGD:7257573 NCBI chrNW_004936792:531,076...579,083 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:kidney tubule, urine: RGD PMID:12081583 RGD:7245970 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Nog noggin ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936490:6,262,651...6,264,069 JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4358912 PMID:6254450 NCBI chrNW_004936493:7,060,747...7,065,276 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19834340 NCBI chrNW_004936629:3,672,445...3,725,645 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19917352 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Tek TEK receptor tyrosine kinase ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936611:2,420,176...2,531,726 JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chrNW_004936524:1,081,672...1,134,971 JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chrNW_004936560:42,561...45,748 JBrowse link
G Clu clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chrNW_004936551:5,388,456...5,395,071 JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO RGD PMID:11889420 RGD:11080974 NCBI chrNW_004936754:808,894...828,554 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO mRNA:increased expression:kidney: RGD PMID:11889420 PMID:15785371 RGD:10449491 RGD:11080974 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO RGD PMID:11889420 RGD:11080974 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chrNW_004936602:1,230,907...1,368,588 JBrowse link
G Serpine1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600 RGD:13208601 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
Contrast-Induced Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Crp C-reactive protein ISO associated with coronary disease; RGD PMID:23102387 RGD:6909166 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Ddit3 DNA damage inducible transcript 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Ece1 endothelin converting enzyme 1 ISO mRNA,protein:increased expression:kidney medulla RGD PMID:18385664 RGD:7243946 NCBI chrNW_004936474:7,034,134...7,083,005 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23335628 RGD:7245471 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chrNW_004936487:13,348,465...13,352,717 JBrowse link
G Il1b interleukin 1 beta ISO associated with Diabetes Mellitus, Experimental RGD PMID:22094062 RGD:7175334 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:urine:
associated with Diabetes Mellitus, Experimental; protein:increased expression:urine
RGD PMID:23085980 PMID:23335628 RGD:7245471 RGD:7245484 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chrNW_004936728:1,775,746...1,893,895 JBrowse link
G Mpo myeloperoxidase ISO RGD PMID:20722568 RGD:6909183 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:19298916 RGD:7247719 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nppb natriuretic peptide B ISO associated with Heart Failure RGD PMID:20438292 RGD:7248591 NCBI chrNW_004936474:683,325...684,662 JBrowse link
hepatorenal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7967349 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21253390 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Sod1 superoxide dismutase 1 ISO RGD PMID:15531919 RGD:1581228 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA, protein:increased expression:kidney RGD PMID:18093430 RGD:4144102 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:plasma RGD PMID:18093430 RGD:4144102 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 ISO mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G Adam17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:22015440 RGD:13703100 NCBI chrNW_004936532:5,864,851...5,904,005 JBrowse link
G Adam2 ADAM metallopeptidase domain 2 ISO RGD PMID:11967014 RGD:10047130 NCBI chrNW_004936675:393,160...451,851 JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO RGD PMID:18272597 RGD:9684850 NCBI chrNW_004936640:959,405...967,305 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Adm adrenomedullin treatment ISO protein:increased expression:serum: RGD PMID:20538296 RGD:7364948 NCBI chrNW_004936528:8,005,223...8,007,586 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO RGD PMID:31089212 RGD:27226686 NCBI chrNW_004936474:26,680,736...26,696,996 JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:22022451 RGD:7241603 NCBI chrNW_004936558:4,362,693...4,387,705 JBrowse link
G Anxa1 annexin A1 treatment ISO RGD PMID:20953576 RGD:7421585 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Anxa5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chrNW_004936662:926,302...959,964 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:26362957 RGD:13703110 NCBI chrNW_004936492:14,818,561...14,902,231 JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chrNW_004936542:2,111,055...2,112,626 JBrowse link
G Atm ATM serine/threonine kinase ISO protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:18221257 PMID:29285062 RGD:13792599 RGD:2293026 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:18725957 RGD:7241559 NCBI chrNW_004936604:551,774...567,014 JBrowse link
G Becn1 beclin 1 treatment ISO RGD PMID:26412257 RGD:11561958 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G C3 complement C3 treatment ISO RGD PMID:19691975 RGD:7411689 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Calca calcitonin related polypeptide alpha ISO RGD PMID:19194162 RGD:7204479 NCBI chrNW_004936528:3,800,801...3,806,000 JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17596683 RGD:5684536 NCBI chrNW_004936486:4,082,664...4,114,942 JBrowse link
G Cd14 CD14 molecule ISO mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chrNW_004936531:9,572,392...9,575,771 JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:25993320 RGD:11251055 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cfb complement factor B ISO RGD PMID:12538716 PMID:16467447 RGD:7242709 RGD:7242734 NCBI chrNW_004936727:1,595,872...1,602,274 JBrowse link
G Ciita class II major histocompatibility complex transactivator ISO RGD PMID:14569092 RGD:7242896 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Csf1 colony stimulating factor 1 ISO mRNA:increased expression:kidney RGD PMID:19196448 PMID:23143303 RGD:7257565 RGD:7257570 NCBI chrNW_004936704:1,372,137...1,393,355 JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chrNW_004936504:4,898,947...4,927,195 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:9407517 PMID:22189844 RGD:7204675 RGD:7204727 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Daxx death domain associated protein ISO protein:increased expression:kidney: RGD PMID:18480747 RGD:9587836 NCBI chrNW_004936476:25,546,091...25,550,390 JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chrNW_004936837:523,227...538,799 JBrowse link
G Dhfr dihydrofolate reductase ISO mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Drd3 dopamine receptor D3 treatment ISO RGD PMID:25989500 RGD:13506961 NCBI chrNW_004936536:1,580,732...1,616,726 JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Egln3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chrNW_004936494:8,240,272...8,267,487 JBrowse link
G Eng endoglin ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 RGD:7248779 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Ep300 E1A binding protein p300 ISO protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077 RGD:11041698 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chrNW_004936537:4,637,028...4,647,915 JBrowse link
G Fas Fas cell surface death receptor treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chrNW_004936580:115,552...144,970 JBrowse link
G Fga fibrinogen alpha chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chrNW_004936576:1,322,406...1,329,743 JBrowse link
G Fgb fibrinogen beta chain treatment ISO mRNA, protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chrNW_004936576:1,306,076...1,313,485 JBrowse link
G Fgg fibrinogen gamma chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chrNW_004936576:1,343,657...1,352,085 JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:11352844 RGD:7205629 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:19095962 RGD:7242184 NCBI chrNW_004936488:4,384,710...4,388,118 JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment ISO protein:increased expression:kidney: RGD PMID:20332418 RGD:9685723 NCBI chrNW_004936694:2,051,362...2,053,812 JBrowse link
G Glo1 glyoxalase I ISO RGD PMID:19211689 RGD:7242566 NCBI chrNW_004936476:20,910,696...20,928,583 JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO RGD PMID:24630969 RGD:10401866 NCBI chrNW_004936792:531,076...579,083 JBrowse link
G Has1 hyaluronan synthase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chrNW_004937026:125,622...132,141 JBrowse link
G Has2 hyaluronan synthase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chrNW_004936470:25,418,069...25,443,332 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23019274 PMID:23085062 PMID:23552495 RGD:7244372 RGD:7245489 RGD:7245495 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha severity
treatment
ISO RGD PMID:17519789 PMID:22432008 RGD:1626334 RGD:9068883 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:21291499 RGD:10755580 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hsf1 heat shock transcription factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chrNW_004936470:7,927,734...7,950,805 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:7569112 RGD:7242788 NCBI chrNW_004936542:7,577,192...7,581,598 JBrowse link
G Hyal1 hyaluronidase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chrNW_004936529:1,838,212...1,842,399 JBrowse link
G Hyal2 hyaluronidase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chrNW_004936529:1,845,445...1,851,106 JBrowse link
G Ifng interferon gamma treatment ISO RGD PMID:28355607 RGD:14975115 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:19546526 RGD:7495779 NCBI chrNW_004936785:358,128...406,751 JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:24079335 PMID:28664613 RGD:14975137 RGD:7364864 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il18 interleukin 18 treatment ISO RGD PMID:22089199 RGD:8655971 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:20030532 RGD:7175501 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein
mouse model treated with human protein
RGD PMID:9555664 PMID:16849996 PMID:18363573 RGD:6907101 RGD:6907359 RGD:6909149 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Itgb2 integrin subunit beta 2 ISO Associated with renal transplant patients RGD PMID:11007822 PMID:20504838 RGD:6907049 RGD:6907073 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chrNW_004936528:1,685,015...1,688,220 JBrowse link
G Kl klotho treatment ISO mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 RGD:10403064 NCBI chrNW_004936472:27,604,681...27,649,613 JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:urine:
mRNA,protein:increased expression:kidney,urine
mRNA,protein:increased expression:kidney:
RGD PMID:20181666 PMID:23085062 PMID:23364806 PMID:27800610 RGD:126779563 RGD:126790572 RGD:7245469 RGD:7245489 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Lep leptin resistance ISO RGD PMID:22969992 RGD:6909133 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G Lgals3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chrNW_004936697:20,861...38,568 JBrowse link
G LOC101954950 aromatase treatment ISO RGD PMID:23552495 RGD:7244372 NCBI chrNW_004936471:13,107,603...13,136,910 JBrowse link
G LOC101966907 histone H2AX treatment ISO RGD PMID:23726287 RGD:8693706 NCBI chrNW_004936542:4,046,930...4,049,017 JBrowse link
G LOC101968920 eotaxin treatment ISO RGD PMID:22160777 RGD:7247742 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:21680852 RGD:6893484 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
G Map1lc3a microtubule associated protein 1 light chain 3 alpha treatment ISO RGD PMID:20075199 PMID:26412257 RGD:11561916 RGD:11561958 NCBI chrNW_004936561:6,104,748...6,106,348 JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:23952292 RGD:10412647 NCBI chrNW_004936560:3,988,696...4,197,953 JBrowse link
G Mc1r melanocortin 1 receptor ISO protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chrNW_004936641:193,885...198,730 JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:kidney RGD PMID:18055546 PMID:22950848 RGD:6909167 RGD:7174699 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Muc1 mucin 1, cell surface associated treatment ISO RGD PMID:22019164 RGD:7245959 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chrNW_004936470:20,480,844...20,485,955 JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 PMID:24096033 RGD:13801197 RGD:13801199 NCBI chrNW_004936600:5,122,004...5,126,776 JBrowse link
G Nes nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chrNW_004936580:5,837,949...5,847,499 JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO RGD PMID:29291552 RGD:13504682 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:20471588 RGD:7247717 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:21545725 RGD:11035217 NCBI chrNW_004936475:19,771,384...19,785,034 JBrowse link
G Nr4a1 nuclear receptor subfamily 4 group A member 1 severity ISO mRNA:increased expression:kidney RGD PMID:22343121 RGD:14700869 NCBI chrNW_004936512:9,486,096...9,508,338 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO RGD PMID:12531391 RGD:2317150 NCBI chrNW_004936602:3,411,106...3,418,826 JBrowse link
G Pax2 paired box 2 ISO mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chrNW_004936600:4,850,594...4,939,010 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO mRNA:increased expression:kidney RGD PMID:10550325 PMID:12819032 RGD:1580850 RGD:8554477 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment ISO RGD PMID:24918615 RGD:10059636 NCBI chrNW_004936477:4,881,230...5,488,208 JBrowse link
G Rnls renalase, FAD dependent amine oxidase ISO RGD PMID:23393318 RGD:7327166 NCBI chrNW_004936735:659,826...1,048,135 JBrowse link
G Serpinc1 serpin family C member 1 severity ISO RGD PMID:26108065 RGD:11354006 NCBI chrNW_004936481:13,981,014...13,993,750 JBrowse link
G Shh sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
G Sirt1 sirtuin 1 treatment ISO RGD PMID:22324445 RGD:9495930 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Slc22a1 solute carrier family 22 member 1 ISO RGD PMID:21835768 RGD:7243877 NCBI chrNW_004936489:11,534,095...11,556,759 JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO RGD PMID:21835768 RGD:7243877 NCBI chrNW_004936489:11,605,403...11,627,786 JBrowse link
G Slc34a1 solute carrier family 34 member 1 ISO protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chrNW_004936597:1,667,700...1,684,533 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:12819032 RGD:1580850 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO RGD PMID:12709397 RGD:7244143 NCBI chrNW_004936646:1,297,530...1,312,508 JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chrNW_004936506:10,103,120...10,172,800 JBrowse link
G Tlr2 toll like receptor 2 treatment
severity
ISO RGD PMID:11801667 PMID:20130923 PMID:22750071 PMID:23023072 PMID:23239000 RGD:7207892 RGD:7207894 RGD:7207896 RGD:7240552 RGD:7241087 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 treatment ISO RGD PMID:11801667 PMID:20130923 PMID:23239000 RGD:7207892 RGD:7240552 RGD:7241087 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum RGD PMID:19925291 RGD:2315112 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chrNW_004936748:785,491...802,791 JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chrNW_004936709:1,578,137...1,741,877 JBrowse link
G Xdh xanthine dehydrogenase treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:20616412 PMID:22995295 RGD:7247637 RGD:7247695 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link

Term paths to the root
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  disease 13774
    disease of anatomical entity 13507
      Urogenital Diseases 4036
        urinary system disease 1879
          kidney disease 1674
            kidney failure 421
              acute kidney failure 239
                Contrast-Induced Nephropathy 12
                Crome Syndrome 0
                Kidney Reperfusion Injury + 121
                acute kidney tubular necrosis 12
                hepatorenal syndrome 5
paths to the root