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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:acute kidney failure
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Accession:DOID:3021 term browser browse the term
Definition:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Synonyms:exact_synonym: Acute Kidney Failures;   Acute Kidney Injuries;   Acute Kidney Injury;   Acute Kidney Insufficiencies;   Acute Kidney Insufficiency;   Acute Renal Failure;   Acute Renal Failures;   Acute Renal Injuries;   Acute Renal Injury;   Acute Renal Insufficiencies;   Acute Renal Insufficiency
 primary_id: MESH:D058186;   RDO:0001702
For additional species annotation, visit the Alliance of Genome Resources.



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acute kidney failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:24502693 RGD:11039053 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
JBrowse link
G ADRB2 adrenoceptor beta 2 treatment ISO associated with Bacteremia;
associated with Endotoxemia;
associated with endotoxemia; protein:increased expression:kidney
RGD PMID:14747378 PMID:19020966 PMID:19887504 RGD:7175276 RGD:7175281 RGD:7175283 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G AFM afamin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr13:62,212,230...62,235,136
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21811803 RGD:7243868 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129
JBrowse link
G AHSG alpha 2-HS glycoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr34:19,221,034...19,228,866
Ensembl chr34:19,221,107...19,228,716
JBrowse link
G ALAD aminolevulinate dehydratase ISO protein:decreased activity:kidney (rat) RGD PMID:19484701 RGD:4144146 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321
JBrowse link
G ALB albumin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:2048579 PMID:21259293 PMID:24361871 PMID:28885000 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:19194548 RGD:2317536 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:8963945 PMID:28885000 RGD:6904218 NCBI chr11:68,338,644...68,353,366
Ensembl chr11:68,338,389...68,351,994
JBrowse link
G AMN amnion associated transmembrane protein ISO CTD Direct Evidence: therapeutic CTD PMID:20514524 NCBI chr 8:70,800,435...70,807,835 JBrowse link
G ANXA1 annexin A1 treatment ISO RGD PMID:22101490 RGD:7421583 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
JBrowse link
G AR androgen receptor ISO RGD PMID:24503548 RGD:11570523 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
G ARG1 arginase 1 ISO mRNA:decreased expression:renal tubule (rat) RGD PMID:12371970 RGD:631989 NCBI chr12:242,717...255,736
Ensembl chr12:242,714...255,305
JBrowse link
G ARG2 arginase 2 ISO mRNA:decreased expression:renal tubule (rat) RGD PMID:12371970 RGD:631989 NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402
JBrowse link
G ATP5F1B ATP synthase F1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25666834 NCBI chr10:870,405...876,937
Ensembl chr10:870,392...909,161
JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2139164 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
G AVPR1A arginine vasopressin receptor 1A ISO RGD PMID:17347933 RGD:2300348 NCBI chr10:6,266,217...6,269,662
Ensembl chr10:6,265,998...6,269,662
JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding disease_progression ISO RGD PMID:23849457 RGD:153350150 NCBI chr 6:9,622,991...9,629,154
Ensembl chr 6:9,622,992...9,629,154
JBrowse link
G B2M beta-2-microglobulin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:2689182 PMID:19536607 PMID:22005293 PMID:28885000 RGD:6482685 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
JBrowse link
G B9D2 B9 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10469268 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO RGD PMID:20037173 RGD:10053672 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:20037173 PMID:20623750 RGD:10053672 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BCL2L1 BCL2 like 1 ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BDKRB2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24975837 NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407
JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761
JBrowse link
G CAPN1 calpain 1 treatment ISO associated with Rhabdomyolysis; RGD PMID:24158126 RGD:13792553 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (mouse) RGD PMID:19508392 RGD:4889990 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055553 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
JBrowse link
G CD44 CD44 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:kidney RGD PMID:16557226 RGD:2293624 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906
JBrowse link
G CLU clusterin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:urine
CTD
RGD
PMID:20118187 PMID:20623750 PMID:22005293 PMID:22581811 PMID:23052191 More... RGD:7245501 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
JBrowse link
G CP ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369
JBrowse link
G CRP C-reactive protein ISO associated with Myocardial Infarction;
protein:increased expression:serum
RGD PMID:22551254 PMID:22694718 RGD:6903282 RGD:6906888 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
JBrowse link
G CSF1 colony stimulating factor 1 ISO RGD PMID:23143303 RGD:7257565 NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371
JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 treatment ISO RGD PMID:18495746 PMID:19890363 RGD:7257732 RGD:7257735 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 treatment ISO RGD PMID:18495746 PMID:23981375 RGD:7257727 RGD:7257735 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO RGD PMID:6223803 RGD:2307326 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 treatment ISO RGD PMID:24412858 PMID:24717297 RGD:14700914 RGD:14700920 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO Protein:increased expression:renal tubule epithelium RGD PMID:15476864 RGD:1599736 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G ECE1 endothelin converting enzyme 1 ISO RGD PMID:10073607 PMID:11043448 RGD:7244180 RGD:7244185 NCBI chr 2:77,732,645...77,793,950
Ensembl chr 2:77,678,686...77,792,114
JBrowse link
G EDN1 endothelin 1 ISO mRNA, protein:increased expression:kidney (mouse)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9788586 PMID:19967049 RGD:4144852 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G EGF epidermal growth factor ISO RGD PMID:20482449 RGD:6906908 NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295
JBrowse link
G EGFR epidermal growth factor receptor ISO mRNA:increased expression:kidney
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:11340354 PMID:14638913 RGD:10395241 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 4:8,053,486...8,110,791
Ensembl chr 4:8,053,837...8,109,325
JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 8:12,873,755...12,901,728
Ensembl chr 8:12,875,387...12,901,709
JBrowse link
G EPAS1 endothelial PAS domain protein 1 treatment ISO RGD PMID:16762988 RGD:10395386 NCBI chr10:48,550,836...48,636,776
Ensembl chr10:48,551,410...48,634,844
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26165641 NCBI chr25:30,045,040...30,107,110
Ensembl chr25:30,045,291...30,107,110
JBrowse link
G EPO erythropoietin treatment ISO CTD Direct Evidence: therapeutic CTD
RGD
PMID:21847101 PMID:22209169 PMID:22235348 PMID:24561306 RGD:10400913 RGD:11041660 NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144
JBrowse link
G FAS Fas cell surface death receptor ISO protein:increased expression:renal tubule (rat) RGD PMID:21374789 RGD:8663469 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FGA fibrinogen alpha chain ISO mRNA:increased expression:kidney (rat) RGD PMID:15805072 RGD:9685024 NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975
JBrowse link
G FIS1 fission, mitochondrial 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chr 6:8,642,014...8,645,812
Ensembl chr 6:8,642,039...8,648,851
JBrowse link
G FN1 fibronectin 1 ISO protein:increased expression:kidney RGD PMID:11768240 PMID:12884040 RGD:7205684 RGD:729934 NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
JBrowse link
G FSTL1 follistatin like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20861081 NCBI chr33:23,892,317...23,914,406
Ensembl chr33:23,894,573...23,933,779
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:602954 PMID:734759 PMID:4794122 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G GAS6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19564549 NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875
JBrowse link
G GATM glycine amidinotransferase ISO protein:decreased activity:kidney (rat) RGD PMID:2752493 RGD:1599823 NCBI chr30:11,724,446...11,742,214
Ensembl chr30:11,723,519...11,742,214
JBrowse link
G GC GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929
JBrowse link
G GFER growth factor, augmenter of liver regeneration treatment ISO protein:increased expression:cortex of kidney,renal medulla:
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:20030531 RGD:9685736 NCBI chr 6:38,948,927...38,951,300
Ensembl chr 6:38,949,484...38,951,703
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:19625378 RGD:7242430 NCBI chr20:8,092,921...8,097,512
Ensembl chr20:8,092,957...8,097,510
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO protein:decreased activity:kidney (rat) RGD PMID:23924727 RGD:13506245 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
G GPNMB glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr14:36,919,184...36,947,023
Ensembl chr14:36,919,296...36,946,643
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22785175 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G GSR glutathione-disulfide reductase ISO protein:decreased activity:kidney:
glycerol-induced
RGD PMID:1870354 PMID:22286819 RGD:7257559 RGD:7257585 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:20623750 PMID:20798258 RGD:6903954 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine
protein:increased expression:urine:
CTD Direct Evidence: marker/mechanism
associated with Pyelonephritis;protein:increased expression:urine:
RGD
CTD
PMID:20118187 PMID:21259293 PMID:21835770 PMID:22005293 PMID:23019274 More... RGD:7244370 RGD:7245472 RGD:7245495 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952
JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:kidney
CTD
RGD
PMID:7635938 PMID:11340354 RGD:10395241 NCBI chr 2:35,551,248...35,563,310
Ensembl chr 2:35,551,250...35,563,043
JBrowse link
G HDAC2 histone deacetylase 2 treatment ISO associated with sepsis; RGD PMID:22933299 RGD:9590257 NCBI chr12:70,053,822...70,083,491
Ensembl chr12:70,053,297...70,103,578
JBrowse link
G HDAC3 histone deacetylase 3 ISO RGD PMID:21416250 RGD:10047111 NCBI chr 2:36,583,283...36,598,121
Ensembl chr 2:36,583,283...36,597,682
JBrowse link
G HDAC5 histone deacetylase 5 treatment ISO associated with sepsis; RGD PMID:21416250 PMID:22933299 RGD:10047111 RGD:9590257 NCBI chr 9:19,261,075...19,297,669
Ensembl chr 9:19,260,893...19,297,623
JBrowse link
G HES1 hes family bHLH transcription factor 1 ISO protein:increased expression:kidney tubule (rat)
mRNA:increased expression:kidney collecting duct (rat)
RGD PMID:24325066 PMID:24397211 RGD:9685383 RGD:9685389
G HEXB hexosaminidase subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22005293 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment ISO mRNA:increased expression:renal cortex (rat) RGD PMID:15673301 PMID:16762988 PMID:18593636 RGD:10395376 RGD:10395386 RGD:9068894 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO associated with Sepsis RGD PMID:16557230 RGD:5508471 NCBI chr 3:30,970,037...30,988,987
Ensembl chr 3:30,970,037...30,990,294
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO CTD Direct Evidence: therapeutic
associated with Sepsis
CTD
RGD
PMID:21048024 PMID:23807243 RGD:10755583 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G HPX hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr21:29,749,913...29,759,176
Ensembl chr21:29,719,589...29,759,046
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO protein:increased expression:kidney, lysosome (rat) RGD PMID:14966137 RGD:7242786 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797
JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:22659586 RGD:7175102 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO mRNA: decreased expression: kidney: both cortex and medulla RGD PMID:9767523 RGD:7242908 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chr16:1,037,169...1,040,996
Ensembl chr16:1,037,162...1,167,094
JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18460982 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL18 interleukin 18 ISO RGD PMID:11342578 RGD:6893450 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:21716595 RGD:6907069 NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
JBrowse link
G IL1B interleukin 1 beta ISO mRNA:increased expression:kidney, liver, spleen (mouse)
protein:increased expression:kidney (rat)
RGD PMID:21677145 PMID:22286667 PMID:22659586 PMID:22750969 RGD:7175094 RGD:7175102 RGD:7175258 RGD:7175314 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO associated with Asphyxia; rat model treated with human protein
associated with Sepsis
RGD PMID:14610321 PMID:16259926 PMID:16763508 RGD:6907360 RGD:6907369 RGD:6907375 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329
JBrowse link
G IL20 interleukin 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18496552 NCBI chr 7:6,019,879...6,022,707
Ensembl chr 7:6,019,442...6,023,219
JBrowse link
G IL6 interleukin 6 ISO associated with Acute Lung Injury;protein:increased expression:plasma
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:18074478 PMID:21570986 RGD:5128661 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12243603 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G JAK2 Janus kinase 2 treatment ISO associated with Carcinoma, Lewis Lung, human cells in mouse model RGD PMID:31250048 RGD:149735351 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G KLK1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18227104 NCBI chr 1:106,009,125...106,028,331
Ensembl chr 1:105,963,564...106,028,331
JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: therapeutic CTD PMID:513486 PMID:3015452 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081
JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:urine
associated with open cardiac surgeries;protein:increased expression:urine:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:20623750 PMID:22005293 PMID:23052191 PMID:23336369 PMID:23683031 More... RGD:125973912 RGD:126781714 RGD:7244370 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
JBrowse link
G LGALS3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
JBrowse link
G LOC100856782 T-complex protein 1 subunit eta ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chr34:37,026,053...37,027,839 JBrowse link
G LOC477072 serotransferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
JBrowse link
G LOC477699 alpha-2-macroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr27:36,654,328...36,695,775 JBrowse link
G LOC485255 hemoglobin subunit epsilon-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:562503 PMID:851170 NCBI chr21:28,193,163...28,194,746 JBrowse link
G LOC607874 cystatin-C-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:22005293 PMID:28885000 NCBI chr23:49,562...53,618 JBrowse link
G LRG1 leucine rich alpha-2-glycoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chr20:55,177,777...55,180,382
Ensembl chr20:55,177,824...55,180,369
JBrowse link
G LRP2 LDL receptor related protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chr36:13,910,450...14,107,081
Ensembl chr36:13,911,865...14,107,546
JBrowse link
G MB myoglobin ISO protein: increased expression: serum RGD PMID:9822635 PMID:23497406 RGD:7244253 RGD:7244259 NCBI chr10:28,573,819...28,583,526
Ensembl chr10:28,552,749...28,583,522
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:renal parenchyma (rat) RGD PMID:17940345 RGD:2317469 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
JBrowse link
G MFN1 mitofusin 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chr34:12,785,799...12,816,881
Ensembl chr34:12,785,856...12,815,994
JBrowse link
G MIR10A microRNA mir-10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr 9:24,842,171...24,842,233
Ensembl chr 9:24,842,145...24,842,248
JBrowse link
G MIR122 microRNA mir-122 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr 1:17,593,858...17,593,915
Ensembl chr 1:17,593,837...17,593,929
JBrowse link
G MIR140 microRNA mir-140 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr 5:79,814,256...79,814,316
Ensembl chr 5:79,814,246...79,814,326
JBrowse link
G MIR143 microRNA mir-143 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594
JBrowse link
G MIR146B microRNA mir-146b ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr28:14,940,550...14,940,610
Ensembl chr28:14,940,550...14,940,610
JBrowse link
G MIR148A microRNA mir-148a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr14:39,301,847...39,301,906
Ensembl chr14:39,301,843...39,301,920
JBrowse link
G MIR151 microRNA mir-151 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr13:35,353,689...35,353,744
Ensembl chr13:35,353,689...35,353,744
JBrowse link
G MIR152 microRNA mir-152 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32583487 NCBI chr 9:24,335,161...24,335,219
Ensembl chr 9:24,335,146...24,335,225
JBrowse link
G MIR192 microRNA mir-192 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr18:52,281,129...52,281,193
Ensembl chr18:52,281,129...52,281,193
JBrowse link
G MIR23A microRNA mir-23a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr20:48,620,335...48,620,386
Ensembl chr20:48,620,323...48,620,397
JBrowse link
G MIR25 microRNA mir-25 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr 6:9,498,993...9,499,051
Ensembl chr 6:9,498,993...9,499,051
JBrowse link
G MIR26A-1 microRNA mir-26a-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr23:7,747,073...7,747,133
Ensembl chr23:7,747,064...7,747,140
JBrowse link
G MIR30A microRNA mir-30a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961
JBrowse link
G MIR30D microRNA mir-30d ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr13:30,910,306...30,910,365
Ensembl chr13:30,910,306...30,910,365
JBrowse link
G MIR486 microRNA mir-486 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:30682439 PMID:35279909 NCBI chr16:23,958,963...23,959,026
Ensembl chr16:23,958,963...23,959,026
JBrowse link
G MIR99A-1 microRNA mir-99a-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30682439 NCBI chr31:13,258,782...13,258,840
Ensembl chr31:13,258,782...13,258,840
JBrowse link
G MPO myeloperoxidase ISO DNA:haplotye: :
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19793022 PMID:20623750 PMID:22739978 RGD:6909168 RGD:6909185 NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17387702 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:23022334 RGD:7245507 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114
JBrowse link
G MUC20 mucin 20, cell surface associated ISO RGD PMID:14565953 RGD:7364790 NCBI chr33:29,044,104...29,055,583
Ensembl chr33:29,045,880...29,055,479
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor susceptibility ISO protein:decreased phosphorylation:kidney (mouse) RGD PMID:23228991 RGD:7207407 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 RGD:13801199 NCBI chr28:13,249,067...13,253,670
Ensembl chr28:13,249,070...13,253,619
JBrowse link
G NES nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chr 7:41,296,395...41,305,641
Ensembl chr 7:41,295,989...41,303,736
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:24291173 PMID:24958931 RGD:10412697 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:14531809 RGD:13825139 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9810145 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
JBrowse link
G NOS3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism
in females;mRNA:increased expression:cortex of kidney (rat)
CTD
RGD
PMID:9788586 PMID:28947737 RGD:13450947 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NPPA natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:kidney
CTD
RGD
PMID:1825077 PMID:2948068 PMID:19298916 PMID:22209992 RGD:7247715 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G NPPB natriuretic peptide B ISO associated with Myocardial Infarction;protein:increased expression:serum:
associated with lung diseases;protein:increased expression:serum:
mRNA:increased expression:kidney
associated with Pneumonia;protein:increased expression:serum:
RGD PMID:22209992 PMID:23192919 PMID:23415693 PMID:23837838 RGD:7247620 RGD:7247622 RGD:7247624 RGD:7247715 NCBI chr 2:84,395,844...84,397,473 JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:26723870 PMID:28230744 RGD:13440091 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
JBrowse link
G OCLN occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19766176 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO RGD PMID:21884784 RGD:5510015 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO protein:altered localization RGD PMID:12089381 RGD:7175293 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438
JBrowse link
G PLAT plasminogen activator, tissue type ISO protein:increased expression:plasma (human) RGD PMID:9767551 RGD:11541071 NCBI chr16:23,469,590...23,496,013 JBrowse link
G PLG plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 1:49,497,229...49,535,260
Ensembl chr 1:49,497,229...49,535,260
JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: therapeutic CTD PMID:17216604 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:17494862 PMID:20623750 PMID:24011919 PMID:24433871 RGD:8553020 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO associated with Endotoxemia; mRNA:decreased expression:kidney (mouse) RGD PMID:21881206 RGD:7242026 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269
JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:19092124 RGD:11250410 NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563
JBrowse link
G PROCR protein C receptor treatment ISO associated with Sepsis RGD PMID:23807243 RGD:10755583 NCBI chr24:24,184,063...24,188,452
Ensembl chr24:24,184,370...24,187,910
JBrowse link
G PTAFR platelet activating factor receptor treatment ISO associated with Endotoxemia RGD PMID:2538527 RGD:10043182 NCBI chr 2:72,225,386...72,256,353
Ensembl chr 2:72,225,386...72,256,352
JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:16871242 RGD:10003092 NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21893983 RGD:5508181 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21745194 NCBI chr27:6,993,452...7,030,372
Ensembl chr27:6,993,452...7,017,316
JBrowse link
G RB1 RB transcriptional corepressor 1 ISO associated with Sepsis;protein:increased phosphorylation:kidney RGD PMID:19428114 RGD:8547990 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726
JBrowse link
G REN renin exacerbates ISO Associated with toxic shock syndrome;protein:increased expression:blood plasma (human) RGD PMID:30407370 RGD:125097506 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO associated with LPS induced endotoxemia RGD PMID:18824919 RGD:2313129 NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482
JBrowse link
G SERPINA1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435
JBrowse link
G SERPINC1 serpin family C member 1 ISO associated with heart failure; protein:decreased activity:plasma: RGD PMID:26108065 RGD:11354006 NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987
JBrowse link
G SIRT1 sirtuin 1 severity ISO protein:increased expression:kidney (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:21416250 RGD:10047111 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr37:25,039,203...25,047,461
Ensembl chr37:25,038,360...25,047,282
JBrowse link
G SLC22A1 solute carrier family 22 member 1 treatment ISO RGD PMID:22414646 RGD:7243179 NCBI chr 1:49,268,978...49,296,522 JBrowse link
G SLC22A12 solute carrier family 22 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14655203 NCBI chr18:52,541,820...52,550,037
Ensembl chr18:52,542,497...52,549,655
JBrowse link
G SLC22A2 solute carrier family 22 member 2 susceptibility
treatment
ISO mRNA:decreased expression:kidney
DNA:SNP: :808G>T (rs316019) human
RGD PMID:18612803 PMID:19625999 PMID:22414646 RGD:7243179 RGD:7243880 RGD:7243884 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
JBrowse link
G SLC34A1 solute carrier family 34 member 1 disease_progression ISO associated with Sepsis; protein:decreased expression:renal proximal tubule (mouse) RGD PMID:19729856 RGD:7242943 NCBI chr 4:35,961,394...35,973,733
Ensembl chr 4:35,961,958...35,973,657
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11274264 PMID:20623750 PMID:22863853 RGD:6903264 NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069
JBrowse link
G TFF3 trefoil factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr31:36,638,762...36,641,696 JBrowse link
G TGFA transforming growth factor alpha ISO mRNA:increased expression:kidney RGD PMID:11340354 RGD:10395241 NCBI chr10:68,915,671...68,957,027 JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594
JBrowse link
G THBD thrombomodulin treatment ISO RGD PMID:17804460 PMID:19176699 RGD:5684994 RGD:5685010 NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649
JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism
associated with Sepsis
CTD
RGD
PMID:22655058 PMID:29286200 RGD:7207898 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241
JBrowse link
G TLR4 toll like receptor 4 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Sepsis
RGD
CTD
PMID:16638912 PMID:22266601 PMID:22655058 PMID:29286200 RGD:6892690 RGD:7207898 RGD:7241084 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TLR9 toll like receptor 9 ISO associated with Sepsis RGD PMID:23548820 RGD:7245966 NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114
JBrowse link
G TNF tumor necrosis factor susceptibility ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16595132 PMID:18460982 PMID:20623750 PMID:21150875 RGD:7245548 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr 6:38,166,160...38,168,189
Ensembl chr 6:38,166,160...38,168,189
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A susceptibility ISO associated with Acute Lung Injury
associated with Shock, Septic;protein:increased expression:serum
associated with Endotoxemia
RGD PMID:12023385 PMID:12500222 PMID:18074478 PMID:21150875 RGD:5128661 RGD:7245534 RGD:7245535 RGD:7245548 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO associated with Shock, Septic;protein:increased expression:serum
associated with Acute Lung Injury
RGD PMID:12500222 PMID:12865254 PMID:18074478 RGD:5128661 RGD:7245532 RGD:7245534 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20603111 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TTR transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link
G UOX urate oxidase ISO CTD Direct Evidence: therapeutic CTD PMID:16313266 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478
JBrowse link
G UTS2R urotensin 2 receptor ISO RGD PMID:15146030 RGD:2306847
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:20943766 PMID:22808199 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
JBrowse link
G WNT4 Wnt family member 4 ISO RGD PMID:12707392 RGD:727218 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Reperfusion Injury RGD PMID:18539378 PMID:19628223 PMID:22571266 RGD:7247641 RGD:7247650 RGD:7247656 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935
JBrowse link
acute kidney tubular necrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP7 bone morphogenetic protein 7 ISO associated with Kidney Reperfusion Injury;protein:increased expression:kidney RGD PMID:16284088 RGD:1601494 NCBI chr24:42,203,183...42,294,105
Ensembl chr24:42,204,823...42,294,653
JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO mRNA:increased expression:kidney RGD PMID:9422398 RGD:7242901 NCBI chr 6:31,774,486...31,837,025
Ensembl chr 6:31,774,609...31,836,820
JBrowse link
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 ISO protein:decreased expression:kidney (rat) RGD PMID:21152904 RGD:5134352 NCBI chr 5:45,055,294...45,119,595
Ensembl chr 5:44,884,283...45,120,203
JBrowse link
G FABP1 fatty acid binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18368030 NCBI chr17:38,242,119...38,247,969
Ensembl chr17:38,242,119...38,247,962
JBrowse link
G GSR glutathione-disulfide reductase ISO protein:decreased activity:renal cortex: RGD PMID:12885594 PMID:17078987 RGD:7257555 RGD:7257573 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:kidney tubule, urine: RGD PMID:12081583 RGD:7245970 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952
JBrowse link
G LOC100856782 T-complex protein 1 subunit eta ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chr34:37,026,053...37,027,839 JBrowse link
G NOG noggin ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4358912 PMID:6254450 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19834340 NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19917352 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G TEK TEK receptor tyrosine kinase ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr11:45,278,375...45,377,300
Ensembl chr11:45,278,891...45,409,093
JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chr11:49,699,072...49,758,783
Ensembl chr11:49,699,109...49,923,257
JBrowse link
G ALB albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G CCN2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145
JBrowse link
G CLU clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
JBrowse link
G MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) ISO RGD PMID:22845765 RGD:7241226 NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222
JBrowse link
G MMP7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153
JBrowse link
G PDGFA platelet derived growth factor subunit A ISO RGD PMID:11889420 RGD:11080974 NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA:increased expression:kidney: RGD PMID:11889420 PMID:15785371 RGD:10449491 RGD:11080974 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:11889420 RGD:11080974 NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283
JBrowse link
G PLAU plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600 RGD:13208601 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link
Contrast-Induced Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP12 caspase 12 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CRP C-reactive protein ISO associated with coronary disease; RGD PMID:23102387 RGD:6909166 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
JBrowse link
G DDIT3 DNA damage inducible transcript 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G ECE1 endothelin converting enzyme 1 ISO mRNA,protein:increased expression:kidney medulla RGD PMID:18385664 RGD:7243946 NCBI chr 2:77,732,645...77,793,950
Ensembl chr 2:77,678,686...77,792,114
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23335628 RGD:7245471 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G IL1B interleukin 1 beta ISO associated with Diabetes Mellitus, Experimental RGD PMID:22094062 RGD:7175334 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:urine:
associated with Diabetes Mellitus, Experimental; protein:increased expression:urine
RGD PMID:23085980 PMID:23335628 RGD:7245471 RGD:7245484 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MIR188 microRNA mir-188 ISO RNA:increased expression:plasma
RNA:increased expression:plasma, kidney
RGD PMID:27528406 RGD:35673289 NCBI chr  X:42,775,058...42,775,143
Ensembl chr  X:42,775,058...42,775,143
JBrowse link
G MIR30A microRNA mir-30a ISO RNA:increased expression:plasma RGD PMID:27528406 RGD:35673289 NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961
JBrowse link
G MIR30E microRNA mir-30e ISO RNA:increased expression:plasma RGD PMID:27528406 RGD:35673289 NCBI chr15:2,283,306...2,283,369
Ensembl chr15:2,283,306...2,283,369
JBrowse link
G MPO myeloperoxidase ISO RGD PMID:20722568 RGD:6909183 NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:19298916 RGD:7247719 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G NPPB natriuretic peptide B ISO associated with Heart Failure RGD PMID:20438292 RGD:7248591 NCBI chr 2:84,395,844...84,397,473 JBrowse link
hepatorenal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7967349 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21253390 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G SOD1 superoxide dismutase 1 ISO RGD PMID:15531919 RGD:1581228 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
G TLR4 toll like receptor 4 ISO mRNA, protein:increased expression:kidney RGD PMID:18093430 RGD:4144102 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:plasma RGD PMID:18093430 RGD:4144102 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO RGD PMID:21680852 RGD:6893484 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:22015440 RGD:13703100 NCBI chr17:6,589,874...6,638,788
Ensembl chr17:6,589,878...6,638,731
JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 ISO RGD PMID:11967014 RGD:10047130 NCBI chr16:25,781,508...25,912,988
Ensembl chr16:25,782,267...25,912,891
JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO RGD PMID:18272597 RGD:9684850 NCBI chr31:22,169,821...22,178,879
Ensembl chr31:22,170,381...22,178,945
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844
JBrowse link
G ADM adrenomedullin treatment ISO protein:increased expression:serum: RGD PMID:20538296 RGD:7364948 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO RGD PMID:31089212 RGD:27226686 NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member ISO RGD PMID:22022451 RGD:7241603 NCBI chr26:9,319,109...9,361,021 JBrowse link
G ANXA1 annexin A1 treatment ISO RGD PMID:20953576 RGD:7421585 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
JBrowse link
G ANXA5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chr19:18,419,936...18,450,088
Ensembl chr19:18,407,587...18,570,378
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:26362957 RGD:13703110 NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987
JBrowse link
G APOA1 apolipoprotein A1 treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943
JBrowse link
G ATM ATM serine/threonine kinase ISO protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:18221257 PMID:29285062 RGD:13792599 RGD:2293026 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:18725957 RGD:7241559 NCBI chr 8:65,017,655...65,028,899 JBrowse link
G BECN1 beclin 1 treatment ISO RGD PMID:26412257 RGD:11561958 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236
JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G C3 complement C3 treatment ISO RGD PMID:19691975 RGD:7411689 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CASP7 caspase 7 ISO RGD PMID:17596683 RGD:5684536 NCBI chr28:24,599,866...24,630,018
Ensembl chr28:24,599,493...24,628,668
JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment ISO mRNA, protein:increased expression:kidney, lung, serum RGD PMID:18650485 PMID:20396927 RGD:11526113 RGD:4891433 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CD14 CD14 molecule ISO mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chr 2:35,790,505...35,792,967 JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:25993320 RGD:11251055 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301
JBrowse link
G CFB complement factor B ISO RGD PMID:12538716 PMID:16467447 RGD:7242709 RGD:7242734 NCBI chr12:1,400,143...1,406,267 JBrowse link
G CFH complement factor H treatment ISO protein:decreased expression:serum: RGD PMID:20538296 RGD:7364948 NCBI chr38:2,878,677...2,956,226 JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO RGD PMID:14569092 RGD:7242896 NCBI chr 6:31,774,486...31,837,025
Ensembl chr 6:31,774,609...31,836,820
JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 ISO RGD PMID:19194162 RGD:7204479 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645
JBrowse link
G CSF1 colony stimulating factor 1 ISO mRNA:increased expression:kidney RGD PMID:19196448 PMID:23143303 RGD:7257565 RGD:7257570 NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371
JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:9407517 PMID:22189844 RGD:7204675 RGD:7204727 NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:20038794 RGD:7257679 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 treatment ISO RGD PMID:23552495 RGD:7244372 NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353
JBrowse link
G DAXX death domain associated protein ISO protein:increased expression:kidney: RGD PMID:18480747 RGD:9587836 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 ISO protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543
JBrowse link
G DHFR dihydrofolate reductase ISO mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chr 3:26,521,214...26,556,065 JBrowse link
G DRD3 dopamine receptor D3 treatment ISO RGD PMID:25989500 RGD:13506961 NCBI chr33:18,369,362...18,414,465
Ensembl chr33:18,372,865...18,412,277
JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 4:8,053,486...8,110,791
Ensembl chr 4:8,053,837...8,109,325
JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 8:12,873,755...12,901,728
Ensembl chr 8:12,875,387...12,901,709
JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO RGD PMID:16980042 RGD:10450580 NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932
JBrowse link
G ENG endoglin ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 RGD:7248779 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064
JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077 RGD:11041698 NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144
JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607
JBrowse link
G FAS Fas cell surface death receptor treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chr17:59,073,139...59,102,023
Ensembl chr17:59,092,933...59,102,015
JBrowse link
G FGA fibrinogen alpha chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975
JBrowse link
G FGB fibrinogen beta chain treatment ISO mRNA, protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr15:52,220,690...52,228,526
Ensembl chr15:52,220,611...52,228,250
JBrowse link
G FGG fibrinogen gamma chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr15:52,261,215...52,270,077
Ensembl chr15:52,261,217...52,269,964
JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:11352844 RGD:7205629 NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:19095962 RGD:7242184 NCBI chr 8:48,330,856...48,334,273
Ensembl chr 8:48,331,026...48,333,467
JBrowse link
G GFER growth factor, augmenter of liver regeneration treatment ISO protein:increased expression:kidney: RGD PMID:20332418 RGD:9685723 NCBI chr 6:38,948,927...38,951,300
Ensembl chr 6:38,949,484...38,951,703
JBrowse link
G GLO1 glyoxalase I ISO RGD PMID:19211689 RGD:7242566 NCBI chr12:7,584,141...7,609,615
Ensembl chr12:7,585,531...7,609,550
JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24630969 RGD:10401866 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G H2AX H2A.X variant histone treatment ISO RGD PMID:23726287 RGD:8693706 NCBI chr 5:14,765,625...14,766,590
Ensembl chr 5:14,766,126...14,766,557
JBrowse link
G HAS1 hyaluronan synthase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 1:105,376,091...105,386,043
Ensembl chr 1:105,376,536...105,385,134
JBrowse link
G HAS2 hyaluronan synthase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr13:20,310,946...20,342,647
Ensembl chr13:20,309,872...20,341,636
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23019274 PMID:23085062 PMID:23552495 RGD:7244372 RGD:7245489 RGD:7245495 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment
severity
ISO RGD PMID:17519789 PMID:22432008 RGD:1626334 RGD:9068883 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:21291499 RGD:10755580 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G HSF1 heat shock transcription factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chr13:37,724,741...37,745,259
Ensembl chr13:37,724,759...37,745,252
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:7569112 RGD:7242788 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797
JBrowse link
G HYAL1 hyaluronidase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr20:39,035,924...39,040,443
Ensembl chr20:39,038,514...39,040,368
JBrowse link
G HYAL2 hyaluronidase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr20:39,029,426...39,034,451
Ensembl chr20:39,031,735...39,034,130
JBrowse link
G IFNG interferon gamma treatment ISO RGD PMID:28355607 RGD:14975115 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:19546526 RGD:7495779 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075
JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:24079335 PMID:28664613 RGD:14975137 RGD:7364864 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:22089199 RGD:8655971 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:20030532 RGD:7175501 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO rat model treated with human protein
mouse model treated with human protein
RGD PMID:9555664 PMID:16849996 PMID:18363573 RGD:6907101 RGD:6907359 RGD:6909149 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329
JBrowse link
G ITGB2 integrin subunit beta 2 ISO Associated with renal transplant patients RGD PMID:11007822 PMID:20504838 RGD:6907049 RGD:6907073 NCBI chr31:38,520,733...38,547,003
Ensembl chr31:38,521,103...38,547,018
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chr21:39,953,461...39,957,615
Ensembl chr21:39,955,551...39,956,723
JBrowse link
G KL klotho treatment ISO mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 RGD:10403064 NCBI chr25:7,154,359...7,201,744
Ensembl chr25:7,156,620...7,199,558
JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:urine:
mRNA,protein:increased expression:kidney:
mRNA,protein:increased expression:kidney,urine
RGD PMID:20181666 PMID:23085062 PMID:23364806 PMID:27800610 RGD:126779563 RGD:126790572 RGD:7245469 RGD:7245489 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
JBrowse link
G LEP leptin resistance ISO RGD PMID:22969992 RGD:6909133 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395
JBrowse link
G LGALS3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha treatment ISO RGD PMID:20075199 PMID:26412257 RGD:11561916 RGD:11561958 NCBI chr24:23,672,343...23,673,937
Ensembl chr24:23,633,579...23,673,921
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:23952292 RGD:10412647 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503
JBrowse link
G MC1R melanocortin 1 receptor ISO protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chr 5:63,694,296...63,695,249 JBrowse link
G MIR381 microRNA mir-381 ISO RNA:decreased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr 8:69,274,983...69,275,057 JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:kidney RGD PMID:18055546 PMID:22950848 RGD:6909167 RGD:7174699 NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
JBrowse link
G MUC1 mucin 1, cell surface associated treatment ISO RGD PMID:22019164 RGD:7245959 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 PMID:24096033 RGD:13801197 RGD:13801199 NCBI chr28:13,249,067...13,253,670
Ensembl chr28:13,249,070...13,253,619
JBrowse link
G NES nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chr 7:41,296,395...41,305,641
Ensembl chr 7:41,295,989...41,303,736
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO RGD PMID:29291552 RGD:13504682 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:20471588 RGD:7247717 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:21545725 RGD:11035217 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 severity ISO mRNA:increased expression:kidney RGD PMID:22343121 RGD:14700869 NCBI chr27:2,947,729...2,965,045
Ensembl chr27:2,891,053...2,955,655
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO RGD PMID:12531391 RGD:2317150 NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264
JBrowse link
G PAX2 paired box 2 ISO mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chr28:13,442,894...13,519,853
Ensembl chr28:13,442,893...13,532,094
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO mRNA:increased expression:kidney RGD PMID:10550325 PMID:12819032 RGD:1580850 RGD:8554477 NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha treatment ISO RGD PMID:24918615 RGD:10059636 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269
JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO RGD PMID:23393318 RGD:7327166 NCBI chr26:38,137,662...38,413,666
Ensembl chr26:38,083,371...38,414,033
JBrowse link
G SERPINA1 serpin family A member 1 treatment ISO RGD PMID:28235038 RGD:14695051 NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435
JBrowse link
G SERPINC1 serpin family C member 1 severity ISO RGD PMID:26108065 RGD:11354006 NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987
JBrowse link
G SHH sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903
JBrowse link
G SIRT1 sirtuin 1 treatment ISO RGD PMID:22324445 RGD:9495930 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO RGD PMID:21835768 RGD:7243877 NCBI chr 1:49,268,978...49,296,522 JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO RGD PMID:21835768 RGD:7243877 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chr 4:35,961,394...35,973,733
Ensembl chr 4:35,961,958...35,973,657
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:12819032 RGD:1580850 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
JBrowse link
G STAT6 signal transducer and activator of transcription 6 severity ISO RGD PMID:12709397 RGD:7244143 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075
JBrowse link
G TFPI tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310
JBrowse link
G TLR2 toll like receptor 2 severity
treatment
ISO RGD PMID:11801667 PMID:20130923 PMID:22750071 PMID:23023072 PMID:23239000 RGD:7207892 RGD:7207894 RGD:7207896 RGD:7240552 RGD:7241087 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241
JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:11801667 PMID:20130923 PMID:23239000 RGD:7207892 RGD:7240552 RGD:7241087 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum RGD PMID:19925291 RGD:2315112 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933
JBrowse link
G VWF von Willebrand factor ISO protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chr27:38,834,812...38,972,614
Ensembl chr27:38,833,837...39,320,142
JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:20616412 PMID:22995295 RGD:7247637 RGD:7247695 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935
JBrowse link
G ZC3H7B zinc finger CCCH-type containing 7B ISO protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr10:23,882,379...23,944,850
Ensembl chr10:23,884,981...23,920,131
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14795
    disease of anatomical entity 14477
      Urogenital Diseases 4239
        urinary system disease 1981
          kidney disease 1764
            kidney failure 458
              acute kidney failure 273
                Contrast-Induced Nephropathy 16
                Crome Syndrome 0
                Kidney Reperfusion Injury + 128
                acute kidney tubular necrosis 12
                hepatorenal syndrome 5
paths to the root