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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:acute kidney failure
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Accession:DOID:3021 term browser browse the term
Definition:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Synonyms:exact_synonym: Acute Kidney Failures;   Acute Kidney Injuries;   Acute Kidney Injury;   Acute Kidney Insufficiencies;   Acute Kidney Insufficiency;   Acute Renal Failure;   Acute Renal Failures;   Acute Renal Injuries;   Acute Renal Injury;   Acute Renal Insufficiencies;   Acute Renal Insufficiency
 narrow_synonym: post-operative acute kidney injury;   postoperative acute kidney injury
 primary_id: MESH:D058186;   RDO:0001702
 xref: EFO:0009955
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
acute kidney failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:24502693 RGD:11039053 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADRB2 adrenoceptor beta 2 treatment ISO associated with endotoxemia; protein:increased expression:kidney
associated with Bacteremia;
associated with Endotoxemia;		 RGD PMID:14747378 PMID:19020966 PMID:19887504 RGD:7175276 RGD:7175281 RGD:7175283 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G AFM afamin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 4:50,691,556...50,714,140
Ensembl chr 4:56,519,389...56,545,974 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21811803 RGD:7243868 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AHSG alpha 2-HS glycoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915 		JBrowse link
G ALAD aminolevulinate dehydratase ISO protein:decreased activity:kidney (rat) RGD PMID:19484701 RGD:4144146 NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784 		JBrowse link
G ALB albumin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:2048579 PMID:21259293 PMID:24361871 PMID:28885000 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:19194548 RGD:2317536 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:8963945 PMID:28885000 RGD:6904218 NCBI chr 9:85,157,680...85,176,253
Ensembl chr 9:113,525,835...113,543,422 		JBrowse link
G AMN amnion associated transmembrane protein ISO CTD Direct Evidence: therapeutic CTD PMID:20514524 NCBI chr14:83,541,891...83,550,346
Ensembl chr14:103,356,773...103,365,352 		JBrowse link
G ANXA1 annexin A1 treatment ISO RGD PMID:22101490 RGD:7421583 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G AR androgen receptor ISO RGD PMID:24503548 RGD:11570523 NCBI chr  X:56,722,828...56,909,004
Ensembl chr  X:66,791,081...66,969,357 		JBrowse link
G ARG1 arginase 1 ISO mRNA:decreased expression:renal tubule (rat) RGD PMID:12371970 RGD:631989 NCBI chr 6:129,372,747...129,383,880
Ensembl chr 6:133,479,966...133,491,162 		JBrowse link
G ARG2 arginase 2 ISO mRNA:decreased expression:renal tubule (rat) RGD PMID:12371970 RGD:631989 NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962 		JBrowse link
G ATP5F1B ATP synthase F1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25666834 NCBI chr12:32,264,570...32,272,419
Ensembl chr12:32,519,749...32,527,753 		JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2139164 NCBI chr20:3,169,094...3,172,900 JBrowse link
G AVPR1A arginine vasopressin receptor 1A ISO RGD PMID:17347933 RGD:2300348 NCBI chr12:25,793,633...25,803,026
Ensembl chr12:26,065,882...26,075,972 		JBrowse link
G B2M beta-2-microglobulin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum		 CTD
RGD		 PMID:2689182 PMID:19536607 PMID:22005293 PMID:28885000 RGD:6482685 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO RGD PMID:20037173 RGD:10053672 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20037173 PMID:20623750 RGD:10053672 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BCL2L1 BCL2 like 1 ISO protein:increased expression:kidney RGD PMID:20037173 RGD:10053672 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G BDKRB2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24975837 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CAPN1 calpain 1 treatment ISO associated with Rhabdomyolysis; RGD PMID:24158126 RGD:13792553 NCBI chr11:60,545,837...60,576,631
Ensembl chr11:63,886,015...63,916,021 		JBrowse link
G CASP1 caspase 1 ISO RGD PMID:16557226 RGD:2293624 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (mouse) RGD PMID:19508392 RGD:4889990 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055553 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CCT7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chr2A:73,287,026...73,305,792
Ensembl chr2A:74,775,781...74,794,515 		JBrowse link
G CD44 CD44 molecule (IN blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:kidney RGD PMID:16557226 RGD:2293624 NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541 		JBrowse link
G CLU clusterin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:urine		 CTD
RGD		 PMID:20118187 PMID:20623750 PMID:22005293 PMID:22581811 PMID:23052191 More... RGD:7245501 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G CP ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 3:146,180,527...146,239,833
Ensembl chr 3:153,764,830...153,817,544 		JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum
associated with Myocardial Infarction;		 RGD PMID:22551254 PMID:22694718 RGD:6903282 RGD:6906888 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CSF1 colony stimulating factor 1 ISO RGD PMID:23143303 RGD:7257565 NCBI chr 1:112,555,755...112,575,894
Ensembl chr 1:127,764,916...127,781,943 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr 5:145,478,725...145,537,858
Ensembl chr 5:151,483,572...151,517,415 		JBrowse link
G CST3 cystatin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:22005293 PMID:28885000 NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 treatment ISO RGD PMID:18495746 PMID:19890363 RGD:7257732 RGD:7257735 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 treatment ISO RGD PMID:18495746 PMID:23981375 RGD:7257727 RGD:7257735 NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO RGD PMID:6223803 RGD:2307326 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chr10:91,547,865...91,598,918
Ensembl chr10:95,022,482...95,105,653 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 treatment ISO RGD PMID:24412858 PMID:24717297 RGD:14700914 RGD:14700920 Ensembl chr10:134,839,025...134,852,719 JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO Protein:increased expression:renal tubule epithelium RGD PMID:15476864 RGD:1599736 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 ameliorates ISO RGD PMID:19828677 RGD:155663373 NCBI chr15:19,871,584...19,881,817
Ensembl chr15:38,121,574...38,129,471 		JBrowse link
G ECE1 endothelin converting enzyme 1 ISO RGD PMID:10073607 PMID:11043448 RGD:7244180 RGD:7244185 NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909 		JBrowse link
G EDN1 endothelin 1 ISO mRNA, protein:increased expression:kidney (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9788586 PMID:19967049 RGD:4144852 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G EGF epidermal growth factor ISO mRNA:decreased expression:kidney RGD PMID:11340354 PMID:20482449 RGD:10395241 RGD:6906908 NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460 		JBrowse link
G EGFR epidermal growth factor receptor ISO mRNA:increased expression:kidney
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:11340354 PMID:14638913 RGD:10395241 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 1:206,915,541...206,976,656 JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr14:14,689,398...14,716,301
Ensembl chr14:32,880,324...32,907,241 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 treatment ISO RGD PMID:16762988 RGD:10395386 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26165641 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G EPO erythropoietin treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21847101 PMID:22209169 PMID:22235348 PMID:24561306 RGD:10400913 RGD:11041660 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G FAS Fas cell surface death receptor ISO protein:increased expression:renal tubule (rat) RGD PMID:21374789 RGD:8663469 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FGA fibrinogen alpha chain ISO mRNA:increased expression:kidney (rat) RGD PMID:15805072 RGD:9685024 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FIS1 fission, mitochondrial 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683 		JBrowse link
G FN1 fibronectin 1 ISO protein:increased expression:kidney RGD PMID:11768240 PMID:12884040 RGD:7205684 RGD:729934 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003 		JBrowse link
G FSTL1 follistatin like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20861081 NCBI chr 3:117,508,772...117,564,254
Ensembl chr 3:124,422,968...124,475,431 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:602954 PMID:734759 PMID:4794122 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674 		JBrowse link
G GAS6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19564549 Ensembl chr13:113,968,843...114,009,562 JBrowse link
G GATM glycine amidinotransferase ISO protein:decreased activity:kidney (rat) RGD PMID:2752493 RGD:1599823 NCBI chr15:24,309,045...24,326,673
Ensembl chr15:42,639,597...42,657,209 		JBrowse link
G GC GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073 		JBrowse link
G GFER growth factor, augmenter of liver regeneration treatment ISO CTD Direct Evidence: therapeutic
protein:increased expression:cortex of kidney,renal medulla:		 RGD
CTD		 PMID:20030531 RGD:9685736 NCBI chr16:716,640...720,196
Ensembl chr16:2,073,064...2,076,592 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:19625378 RGD:7242430 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO protein:decreased activity:kidney (rat) RGD PMID:23924727 RGD:13506245 NCBI chr16:38,995,770...39,022,750
Ensembl chr16:58,120,781...58,147,378 		JBrowse link
G GPNMB glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr 7:23,931,220...23,959,687
Ensembl chr 7:23,539,928...23,568,624 		JBrowse link
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:22209169 RGD:10400913 Ensembl chr 8:144,259,991...144,263,737 JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:kidney RGD PMID:36583727 RGD:401827125 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GPX4 glutathione peroxidase 4 treatment ISO RGD PMID:29548851 RGD:401827911 NCBI chr19:20,904...23,828 JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22785175 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G GSR glutathione-disulfide reductase ISO protein:decreased activity:kidney:
glycerol-induced		 RGD PMID:1870354 PMID:22286819 RGD:7257559 RGD:7257585 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20623750 PMID:20798258 RGD:6903954 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine:
CTD Direct Evidence: marker/mechanism
associated with Pyelonephritis;protein:increased expression:urine:		 RGD
CTD		 PMID:20118187 PMID:21259293 PMID:21835770 PMID:22005293 PMID:23019274 More... RGD:7244370 RGD:7245472 RGD:7245495 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:kidney		 CTD
RGD		 PMID:7635938 PMID:11340354 RGD:10395241 NCBI chr 5:135,699,553...135,713,366
Ensembl chr 5:141,816,402...141,830,531 		JBrowse link
G HDAC2 histone deacetylase 2 treatment ISO associated with sepsis; RGD PMID:22933299 RGD:9590257 NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004 		JBrowse link
G HDAC3 histone deacetylase 3 ISO RGD PMID:21416250 RGD:10047111 NCBI chr 5:136,981,790...136,997,786
Ensembl chr 5:143,094,406...143,110,322 		JBrowse link
G HDAC5 histone deacetylase 5 treatment ISO associated with sepsis; RGD PMID:21416250 PMID:22933299 RGD:10047111 RGD:9590257 NCBI chr17:13,273,052...13,319,695
Ensembl chr17:13,446,836...13,479,140 		JBrowse link
G HES1 hes family bHLH transcription factor 1 ISO mRNA:increased expression:kidney collecting duct (rat)
protein:increased expression:kidney tubule (rat)		 RGD PMID:24325066 PMID:24397211 RGD:9685383 RGD:9685389 NCBI chr 3:191,432,513...191,435,387
Ensembl chr 3:201,749,044...201,754,257 		JBrowse link
G HEXB hexosaminidase subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:22005293 NCBI chr 5:40,589,448...40,625,176
Ensembl chr 5:41,199,681...41,232,693 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment ISO mRNA:increased expression:renal cortex (rat) RGD PMID:15673301 PMID:16762988 PMID:18593636 RGD:10395376 RGD:10395386 RGD:9068894 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36052886 NCBI chr 1:88,579,603...88,627,988
Ensembl chr 1:123,633,134...123,677,714 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO associated with Sepsis RGD PMID:16557230 RGD:5508471 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO associated with Sepsis
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:21048024 PMID:23807243 RGD:10755583 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HPX hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr11:6,558,279...6,572,946
Ensembl chr11:6,246,392...6,256,410 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12690470 PMID:19546256 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO protein:increased expression:kidney, lysosome (rat) RGD PMID:14966137 RGD:7242786 NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:22659586 RGD:7175102 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO mRNA: decreased expression: kidney: both cortex and medulla RGD PMID:9767523 RGD:7242908 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7540432 NCBI chr 7:46,538,566...46,545,536
Ensembl chr 7:46,658,097...46,662,584 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18460982 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:11342578 RGD:6893450 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:21716595 RGD:6907069 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:kidney (rat)
mRNA:increased expression:kidney, liver, spleen (mouse)		 RGD PMID:21677145 PMID:22286667 PMID:22659586 PMID:22750969 RGD:7175094 RGD:7175102 RGD:7175258 RGD:7175314 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO associated with Asphyxia; rat model treated with human protein
associated with Sepsis		 RGD PMID:14610321 PMID:16259926 PMID:16763508 RGD:6907360 RGD:6907369 RGD:6907375 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL20 interleukin 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18496552 NCBI chr 1:182,468,571...182,472,440
Ensembl chr 1:186,747,086...186,750,952 		JBrowse link
G IL6 interleukin 6 ISO associated with Acute Lung Injury;protein:increased expression:plasma
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:18074478 PMID:21570986 RGD:5128661 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12243603 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666 		JBrowse link
G JAK2 Janus kinase 2 treatment ISO associated with Carcinoma, Lewis Lung, human cells in mouse model RGD PMID:31250048 RGD:149735351 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G KLK1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18227104 NCBI chr19:47,784,368...47,789,004
Ensembl chr19:56,677,579...56,682,216 		JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: therapeutic CTD PMID:513486 PMID:3015452 NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149 		JBrowse link
G LCN2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:urine
associated with open cardiac surgeries;protein:increased expression:urine:		 CTD
RGD		 PMID:20623750 PMID:22005293 PMID:23052191 PMID:23336369 PMID:23683031 More... RGD:125973912 RGD:126781714 RGD:7244370 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LGALS3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412 		JBrowse link
G LOC100972354 interferon alpha-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12810204 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736 		JBrowse link
G LOC100976904 growth-regulated alpha protein ISO mRNA:increased expression:kidney, liver, spleen RGD PMID:21677145 RGD:7175314 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474 		JBrowse link
G LOC100979149 hemoglobin subunit gamma-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:562503 PMID:851170 NCBI chr11:5,402,198...5,407,442 JBrowse link
G LOC100979269 alpha-2-macroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979 		JBrowse link
G LOC100980965 zinc-alpha-2-glycoprotein disease_progression ISO RGD PMID:23849457 RGD:153350150 NCBI chr 7:91,999,717...92,009,066
Ensembl chr 7:105,432,782...105,442,219 		JBrowse link
G LOC100982214 plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 6:158,662,192...158,713,413
Ensembl chr 6:163,673,464...163,736,777 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chr22:23,022,449...23,031,627 JBrowse link
G LRG1 leucine rich alpha-2-glycoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chr19:3,557,079...3,560,193
Ensembl chr19:4,504,704...4,507,790 		JBrowse link
G LRP2 LDL receptor related protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chr2B:56,407,871...56,640,471
Ensembl chr2B:173,873,767...174,103,697 		JBrowse link
G MB myoglobin ISO protein: increased expression: serum RGD PMID:9822635 PMID:23497406 RGD:7244253 RGD:7244259 NCBI chr22:16,612,519...16,645,333
Ensembl chr22:34,452,451...34,463,224 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:renal parenchyma (rat) RGD PMID:17940345 RGD:2317469 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159 		JBrowse link
G MFN1 mitofusin 1 ISO protein:decreased expression:kidney (rat) RGD PMID:26480480 RGD:12910862 NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763 		JBrowse link
G MPO myeloperoxidase ISO DNA:haplotye: :
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19793022 PMID:20623750 PMID:22739978 RGD:6909168 RGD:6909185 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17387702 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:23022334 RGD:7245507 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor susceptibility ISO protein:decreased phosphorylation:kidney (mouse) RGD PMID:23228991 RGD:7207407 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 RGD:13801199 NCBI chr10:97,123,826...97,129,919
Ensembl chr10:100,604,914...100,611,016 		JBrowse link
G NES nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chr 1:132,012,273...132,020,907
Ensembl chr 1:135,835,456...135,844,094 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:24291173 PMID:24958931 RGD:10412697 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29286200 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:14531809 RGD:13825139 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9810145 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism
in females;mRNA:increased expression:cortex of kidney (rat)		 CTD
RGD		 PMID:9788586 PMID:28947737 RGD:13450947 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NPPA natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:kidney		 CTD
RGD		 PMID:1825077 PMID:2948068 PMID:19298916 PMID:22209992 RGD:7247715 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NPPB natriuretic peptide B ISO mRNA:increased expression:kidney
associated with Myocardial Infarction;protein:increased expression:serum:
associated with lung diseases;protein:increased expression:serum:
associated with Pneumonia;protein:increased expression:serum:		 RGD PMID:22209992 PMID:23192919 PMID:23415693 PMID:23837838 RGD:7247620 RGD:7247622 RGD:7247624 RGD:7247715 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:26723870 PMID:28230744 RGD:13440091 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G OCLN occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19766176 NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342 		JBrowse link
G ORM1 orosomucoid 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 9:85,421,254...85,424,659 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO RGD PMID:21884784 RGD:5510015 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO protein:altered localization RGD PMID:12089381 RGD:7175293 NCBI chr 4:80,295,243...80,365,271
Ensembl chr 4:91,019,734...91,086,775 		JBrowse link
G PLAT plasminogen activator, tissue type ISO protein:increased expression:plasma (human) RGD PMID:9767551 RGD:11541071 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: therapeutic CTD PMID:17216604 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:17494862 PMID:20623750 PMID:24011919 PMID:24433871 RGD:8553020 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO associated with Endotoxemia RGD PMID:21881206 RGD:7242026 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:19092124 RGD:11250410 NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625 		JBrowse link
G PROCR protein C receptor treatment ISO associated with Sepsis RGD PMID:23807243 RGD:10755583 NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320 		JBrowse link
G PTAFR platelet activating factor receptor treatment ISO associated with Endotoxemia RGD PMID:2538527 RGD:10043182 NCBI chr 1:27,405,880...27,436,184
Ensembl chr 1:28,447,833...28,448,861 		JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:16871242 RGD:10003092 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21893983 RGD:5508181 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21745194 NCBI chr12:40,974,756...40,999,471
Ensembl chr12:41,848,785...41,873,252 		JBrowse link
G RB1 RB transcriptional corepressor 1 ISO associated with Sepsis;protein:increased phosphorylation:kidney RGD PMID:19428114 RGD:8547990 NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575 		JBrowse link
G REN renin exacerbates ISO Associated with toxic shock syndrome;protein:increased expression:blood plasma (human) RGD PMID:30407370 RGD:125097506 NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO associated with LPS induced endotoxemia RGD PMID:18824919 RGD:2313129 NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873 		JBrowse link
G SERPINA1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419 		JBrowse link
G SERPINC1 serpin family C member 1 ISO associated with heart failure; protein:decreased activity:plasma: RGD PMID:26108065 RGD:11354006 NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369 		JBrowse link
G SIRT1 sirtuin 1 severity ISO protein:increased expression:kidney (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:21416250 RGD:10047111 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 treatment ISO RGD PMID:22414646 RGD:7243179 NCBI chr 6:158,004,545...158,046,428
Ensembl chr 6:163,014,663...163,054,681 		JBrowse link
G SLC22A12 solute carrier family 22 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14655203 NCBI chr11:59,944,311...59,956,102
Ensembl chr11:63,290,329...63,299,047 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 susceptibility
treatment		 ISO mRNA:decreased expression:kidney
DNA:SNP: :808G>T (rs316019) human		 RGD PMID:18612803 PMID:19625999 PMID:22414646 RGD:7243179 RGD:7243880 RGD:7243884 NCBI chr 6:158,058,226...158,150,917
Ensembl chr 6:163,065,317...163,158,931 		JBrowse link
G SLC22A24 solute carrier family 22 member 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23649842 PMID:26230185 NCBI chr11:58,431,450...58,497,875 JBrowse link
G SLC34A1 solute carrier family 34 member 1 disease_progression ISO associated with Sepsis; protein:decreased expression:renal proximal tubule (mouse) RGD PMID:19729856 RGD:7242943 NCBI chr 5:172,685,862...172,700,440
Ensembl chr 5:179,748,492...179,762,975 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11274264 PMID:20623750 PMID:22863853 RGD:6903264 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935 		JBrowse link
G TBX1 T-box transcription factor 1 ISO mRNA:increased expression:kidney (rat) RGD PMID:24817956 RGD:155882498 NCBI chr22:2,521,080...2,541,267 JBrowse link
G TF transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476 		JBrowse link
G TFF3 trefoil factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr21:28,627,191...28,631,341
Ensembl chr21:41,948,696...41,952,268 		JBrowse link
G TGFA transforming growth factor alpha ISO mRNA:increased expression:kidney RGD PMID:11340354 RGD:10395241 NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10469268 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34677723 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
G THBD thrombomodulin treatment ISO RGD PMID:17804460 PMID:19176699 RGD:5684994 RGD:5685010 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TLR2 toll like receptor 2 ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:22655058 PMID:29286200 RGD:7207898 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16638912 PMID:22266601 PMID:22655058 PMID:29286200 RGD:6892690 RGD:7207898 RGD:7241084 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16595132 PMID:18460982 PMID:20623750 PMID:21150875 RGD:7245548 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23052191 NCBI chr16:1,962,179...1,964,223
Ensembl chr16:3,134,577...3,136,581 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A susceptibility ISO associated with Endotoxemia
associated with Shock, Septic;protein:increased expression:serum
associated with Acute Lung Injury		 RGD PMID:12023385 PMID:12500222 PMID:18074478 PMID:21150875 RGD:5128661 RGD:7245534 RGD:7245535 RGD:7245548 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO associated with Acute Lung Injury
associated with Shock, Septic;protein:increased expression:serum		 RGD PMID:12500222 PMID:12865254 PMID:18074478 RGD:5128661 RGD:7245532 RGD:7245534 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20603111 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TTR transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28885000 NCBI chr18:24,809,707...24,816,713
Ensembl chr18:28,407,893...28,414,960 		JBrowse link
G UTS2R urotensin 2 receptor ISO RGD PMID:15146030 RGD:2306847 NCBI chr17:76,783,432...76,788,639
Ensembl chr17:82,592,312...82,593,702 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:20943766 PMID:22808199 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G WNT4 Wnt family member 4 ISO RGD PMID:12707392 RGD:727218 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Reperfusion Injury RGD PMID:18539378 PMID:19628223 PMID:22571266 RGD:7247641 RGD:7247650 RGD:7247656 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G ZNF644 zinc finger protein 644 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36052886 NCBI chr 1:93,573,781...93,686,786
Ensembl chr 1:92,322,540...92,348,120 		JBrowse link
acute kidney tubular necrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK4 adenylate kinase 4 ISO protein:decreased expression:kidney (rat) RGD PMID:21152904 RGD:5134352 NCBI chr 1:64,394,898...64,479,536
Ensembl chr 1:66,283,102...66,361,230 		JBrowse link
G BMP7 bone morphogenetic protein 7 ISO associated with Kidney Reperfusion Injury;protein:increased expression:kidney RGD PMID:16284088 RGD:1601494 NCBI chr20:53,509,484...53,606,889
Ensembl chr20:54,788,974...54,885,021 		JBrowse link
G CCT7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chr2A:73,287,026...73,305,792
Ensembl chr2A:74,775,781...74,794,515 		JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO mRNA:increased expression:kidney RGD PMID:9422398 RGD:7242901 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485 		JBrowse link
G FABP1 fatty acid binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18368030 NCBI chr2A:87,256,032...87,303,505
Ensembl chr2A:89,165,315...89,170,448 		JBrowse link
G GSR glutathione-disulfide reductase ISO protein:decreased activity:renal cortex: RGD PMID:12885594 PMID:17078987 RGD:7257555 RGD:7257573 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:kidney tubule, urine: RGD PMID:12081583 RGD:7245970 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G NOG noggin ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr17:50,669,186...50,671,081
Ensembl chr17:55,532,394...55,533,092 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4358912 PMID:6254450 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19834340 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19917352 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G TEK TEK receptor tyrosine kinase ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572 		JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chr 9:32,157,763...32,225,116
Ensembl chr 9:32,967,993...33,035,177 		JBrowse link
G ALB albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G CCN2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077 		JBrowse link
G CLU clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G CS citrate synthase treatment ISO RGD PMID:20005400 RGD:243048470 NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854 		JBrowse link
G MMP3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354 		JBrowse link
G MMP7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099 		JBrowse link
G PDGFA platelet derived growth factor subunit A ISO RGD PMID:11889420 RGD:11080974 NCBI chr 7:648,722...672,023 JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA:increased expression:kidney: RGD PMID:11889420 PMID:15785371 RGD:10449491 RGD:11080974 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:11889420 RGD:11080974 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PLAU plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600 RGD:13208601 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
Contrast-Induced Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CRP C-reactive protein ISO associated with coronary disease; RGD PMID:23102387 RGD:6909166 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G DDIT3 DNA damage inducible transcript 3 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701 		JBrowse link
G ECE1 endothelin converting enzyme 1 ISO mRNA,protein:increased expression:kidney medulla RGD PMID:18385664 RGD:7243946 NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23335628 RGD:7245471 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458 		JBrowse link
G IL1B interleukin 1 beta ISO associated with Diabetes Mellitus, Experimental RGD PMID:22094062 RGD:7175334 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G LCN2 lipocalin 2 ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:urine
protein:increased expression:urine:		 RGD PMID:23085980 PMID:23335628 RGD:7245471 RGD:7245484 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 treatment ISO RGD PMID:27781957 RGD:13782262 NCBI chr10:45,806,748...45,936,362 JBrowse link
G MPO myeloperoxidase ISO RGD PMID:20722568 RGD:6909183 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:19298916 RGD:7247719 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NPPB natriuretic peptide B ISO associated with Heart Failure RGD PMID:20438292 RGD:7248591 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995 		JBrowse link
hepatorenal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7967349 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21253390 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G SOD1 superoxide dismutase 1 ISO RGD PMID:15531919 RGD:1581228 NCBI chr21:18,029,831...18,037,526 JBrowse link
G TLR4 toll like receptor 4 ISO mRNA, protein:increased expression:kidney RGD PMID:18093430 RGD:4144102 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:plasma RGD PMID:18093430 RGD:4144102 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO RGD PMID:21680852 RGD:6893484 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891 		JBrowse link
G ACTA1 actin alpha 1, skeletal muscle ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 1:204,975,646...204,978,523
Ensembl chr 1:210,007,622...210,010,469 		JBrowse link
G ACVR2B activin A receptor type 2B treatment ISO human construct in rat model RGD PMID:27732750 RGD:329322881 NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:22015440 RGD:13703100 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 ISO RGD PMID:11967014 RGD:10047130 NCBI chr 8:38,939,413...39,034,142
Ensembl chr 8:36,448,201...36,542,784 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO RGD PMID:18272597 RGD:9684850 NCBI chr21:13,270,668...13,279,217
Ensembl chr21:26,656,370...26,665,485 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ADM adrenomedullin treatment ISO protein:increased expression:serum: RGD PMID:20538296 RGD:7364948 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO RGD PMID:31089212 RGD:27226686 NCBI chr 1:44,853,867...44,871,764
Ensembl chr 1:46,211,859...46,230,072 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member ISO RGD PMID:22022451 RGD:7241603 NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471 		JBrowse link
G ANXA1 annexin A1 treatment ISO RGD PMID:20953576 RGD:7421585 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G ANXA5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:26362957 RGD:13703110 NCBI chr12:96,224,515...96,311,246
Ensembl chr12:99,637,622...99,726,939 		JBrowse link
G APOA1 apolipoprotein A1 treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G ATM ATM serine/threonine kinase ISO protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:18221257 PMID:29285062 RGD:13792599 RGD:2293026 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:18725957 RGD:7241559 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BECN1 beclin 1 treatment ISO RGD PMID:26412257 RGD:11561958 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr10:22,477,755...22,487,894
Ensembl chr10:22,857,776...22,863,479 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634 		JBrowse link
G C3 complement C3 treatment ISO RGD PMID:19691975 RGD:7411689 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CALCA calcitonin related polypeptide alpha ISO RGD PMID:19194162 RGD:7204479 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP7 caspase 7 ISO RGD PMID:17596683 RGD:5684536 NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment
ameliorates		 ISO mRNA, protein:increased expression:kidney, lung, serum RGD PMID:18650485 PMID:20396927 PMID:24920753 RGD:11526113 RGD:329845564 RGD:4891433 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCN1 cellular communication network factor 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147 		JBrowse link
G CD14 CD14 molecule ISO mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:25993320 RGD:11251055 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CFB complement factor B ISO RGD PMID:12538716 PMID:16467447 RGD:7242709 RGD:7242734 NCBI chr 6:31,606,716...31,612,782 JBrowse link
G CFH complement factor H treatment ISO protein:decreased expression:serum: RGD PMID:20538296 RGD:7364948 NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521 		JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO RGD PMID:14569092 RGD:7242896 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485 		JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr  X:61,537,949...61,543,545
Ensembl chr  X:71,621,785...71,625,702 		JBrowse link
G COL1A1 collagen type I alpha 1 chain ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677 		JBrowse link
G COL3A1 collagen type III alpha 1 chain ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr2B:76,285,115...76,322,703
Ensembl chr2B:194,204,613...194,242,956 		JBrowse link
G CSF1 colony stimulating factor 1 ISO mRNA:increased expression:kidney RGD PMID:19196448 PMID:23143303 RGD:7257565 RGD:7257570 NCBI chr 1:112,555,755...112,575,894
Ensembl chr 1:127,764,916...127,781,943 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr 5:145,478,725...145,537,858
Ensembl chr 5:151,483,572...151,517,415 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:9407517 PMID:22189844 RGD:7204675 RGD:7204727 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:20038794 RGD:7257679 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 treatment ISO RGD PMID:23552495 RGD:7244372 NCBI chr15:30,152,924...30,282,854
Ensembl chr15:48,486,688...48,521,554 		JBrowse link
G DAXX death domain associated protein ISO protein:increased expression:kidney: RGD PMID:18480747 RGD:9587836 NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 ISO protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chr 6:30,625,871...30,645,066
Ensembl chr 6:31,496,047...31,513,455 		JBrowse link
G DHFR dihydrofolate reductase treatment ISO mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G DRD3 dopamine receptor D3 treatment ISO RGD PMID:25989500 RGD:13506961 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403 		JBrowse link
G EED embryonic ectoderm development ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr11:81,295,068...81,330,321
Ensembl chr11:84,902,330...84,937,906 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 1:206,915,541...206,976,656 JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr14:14,689,398...14,716,301
Ensembl chr14:32,880,324...32,907,241 		JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO RGD PMID:16980042 RGD:10450580 NCBI chr19:276,499...280,598 JBrowse link
G ENG endoglin ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 RGD:7248779 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641 		JBrowse link
G EP300 E1A binding protein p300 ISO protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077 RGD:11041698 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050 		JBrowse link
G FAS Fas cell surface death receptor treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G FCGR1A Fc gamma receptor Ia treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220 		JBrowse link
G FGA fibrinogen alpha chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FGB fibrinogen beta chain treatment ISO mRNA, protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 exacerbates
ameliorates		 ISO protein:increased phosphorylation:kidney (mouse) RGD PMID:20591940 PMID:22688984 PMID:29344510 PMID:32523960 RGD:155663667 RGD:155782882 RGD:155782904 RGD:155882537 NCBI chr10:118,055,854...118,175,440
Ensembl chr10:121,469,735...121,588,815 		JBrowse link
G FGG fibrinogen gamma chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:11352844 RGD:7205629 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:19095962 RGD:7242184 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G GFER growth factor, augmenter of liver regeneration treatment ISO protein:increased expression:kidney: RGD PMID:20332418 RGD:9685723 NCBI chr16:716,640...720,196
Ensembl chr16:2,073,064...2,076,592 		JBrowse link
G GLO1 glyoxalase I ISO RGD PMID:19211689 RGD:7242566 NCBI chr 6:38,247,881...38,275,098
Ensembl chr 6:39,434,746...39,461,971 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:kidney
mRNA:decreased expression:kidney		 RGD PMID:22442209 PMID:37033969 RGD:401827821 RGD:401827906 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24630969 RGD:10401866 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:29137244 RGD:158014894 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HAS1 hyaluronan synthase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr19:48,657,165...48,668,130
Ensembl chr19:57,537,049...57,547,804 		JBrowse link
G HAS2 hyaluronan synthase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 8:118,313,186...118,342,160
Ensembl chr 8:121,072,154...121,089,365 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:23019274 PMID:23085062 PMID:23552495 RGD:7244372 RGD:7245489 RGD:7245495 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment
severity		 ISO RGD PMID:17519789 PMID:22432008 RGD:1626334 RGD:9068883 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:21291499 RGD:10755580 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HSF1 heat shock transcription factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:7569112 RGD:7242788 NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773 		JBrowse link
G HYAL1 hyaluronidase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 3:50,228,491...50,238,798
Ensembl chr 3:51,463,239...51,467,286 		JBrowse link
G HYAL2 hyaluronidase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 3:50,243,926...50,248,972
Ensembl chr 3:51,479,020...51,482,551 		JBrowse link
G IFNG interferon gamma treatment ISO RGD PMID:28355607 RGD:14975115 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:19546526 RGD:7495779 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:24079335 PMID:28664613 RGD:14975137 RGD:7364864 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL12B interleukin 12B ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381 		JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:22089199 RGD:8655971 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta ameliorates ISO RGD PMID:20030532 PMID:24920753 RGD:329845564 RGD:7175501 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO rat model treated with human protein
mouse model treated with human protein		 RGD PMID:9555664 PMID:16849996 PMID:18363573 RGD:6907101 RGD:6907359 RGD:6909149 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL6 interleukin 6 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INHBB inhibin subunit beta B ISO protein:increased expression:serum (rat) RGD PMID:27732750 RGD:329322881 NCBI chr2B:7,278,944...7,284,632 JBrowse link
G ITGB2 integrin subunit beta 2 ISO Associated with renal transplant patients RGD PMID:11007822 PMID:20504838 RGD:6907049 RGD:6907073 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729 		JBrowse link
G KL klotho treatment ISO mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 RGD:10403064 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO protein:increased expression:kidney (mouse) RGD PMID:31570196 RGD:155888490 NCBI chr11:113,273,198...113,364,404
Ensembl chr11:117,204,820...117,290,100 		JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:urine:
mRNA,protein:increased expression:kidney,urine
mRNA,protein:increased expression:kidney:		 RGD PMID:20181666 PMID:23085062 PMID:23364806 PMID:27800610 RGD:126779563 RGD:126790572 RGD:7245469 RGD:7245489 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LEP leptin resistance ISO RGD PMID:22969992 RGD:6909133 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G LGALS3 galectin 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412 		JBrowse link
G LOC100974886 uncharacterized LOC100974886 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G LOC100994157 histone H2AX treatment ISO RGD PMID:23726287 RGD:8693706 NCBI chr11:113,932,078...113,933,679 JBrowse link
G LOC103785028 polycomb protein SUZ12 ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr17:24,790,921...24,853,790 JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha treatment ISO RGD PMID:20075199 PMID:26412257 RGD:11561916 RGD:11561958 NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:23952292 RGD:10412647 NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727 		JBrowse link
G MC1R melanocortin 1 receptor ISO protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chr16:70,676,447...70,697,636 JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:kidney RGD PMID:18055546 PMID:22950848 RGD:6909167 RGD:7174699 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G MUC1 mucin 1, cell surface associated treatment ISO RGD PMID:22019164 RGD:7245959 NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:22160772 PMID:24096033 RGD:13801197 RGD:13801199 NCBI chr10:97,123,826...97,129,919
Ensembl chr10:100,604,914...100,611,016 		JBrowse link
G NES nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chr 1:132,012,273...132,020,907
Ensembl chr 1:135,835,456...135,844,094 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:31089916 RGD:155882543 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NOS2 nitric oxide synthase 2 treatment ISO RGD PMID:18408363 RGD:11040540 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO RGD PMID:18408363 PMID:29291552 RGD:11040540 RGD:13504682 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NOX1 NADPH oxidase 1 treatment ISO RGD PMID:34244746 RGD:329955363 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192 		JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:20471588 RGD:7247717 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:21545725 RGD:11035217 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 severity ISO mRNA:increased expression:kidney RGD PMID:22343121 RGD:14700869 NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO RGD PMID:12531391 RGD:2317150 NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335 		JBrowse link
G PAX2 paired box 2 ISO mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO mRNA:increased expression:kidney RGD PMID:10550325 PMID:12819032 RGD:1580850 RGD:8554477 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PEG10 paternally expressed 10 ISO mRNA:increased expression:kidney (mouse) RGD PMID:16778176 RGD:401851077 NCBI chr 7:86,606,249...86,619,580 JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chr 4:80,295,243...80,365,271
Ensembl chr 4:91,019,734...91,086,775 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha treatment ISO RGD PMID:24918615 RGD:10059636 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO mRNA:increased expression:kidney (mouse) RGD PMID:30413885 RGD:401959745 NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO RGD PMID:23393318 RGD:7327166 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G SERPINA1 serpin family A member 1 treatment ISO RGD PMID:28235038 RGD:14695051 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419 		JBrowse link
G SERPINC1 serpin family C member 1 severity ISO RGD PMID:26108065 RGD:11354006 NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369 		JBrowse link
G SERPINE1 serpin family E member 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G SIRT1 sirtuin 1 treatment ISO RGD PMID:22324445 RGD:9495930 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SIX2 SIX homeobox 2 ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr2A:45,109,414...45,113,887
Ensembl chr2A:46,039,582...46,044,035 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO RGD PMID:21835768 RGD:7243877 NCBI chr 6:158,004,545...158,046,428
Ensembl chr 6:163,014,663...163,054,681 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO RGD PMID:21835768 RGD:7243877 NCBI chr 6:158,058,226...158,150,917
Ensembl chr 6:163,065,317...163,158,931 		JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chr 5:172,685,862...172,700,440
Ensembl chr 5:179,748,492...179,762,975 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:12819032 RGD:1580850 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 severity ISO RGD PMID:12709397 RGD:7244143 Ensembl chr12:32,068,679...32,085,099 JBrowse link
G TFPI tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384 		JBrowse link
G TGFB1 transforming growth factor beta 1 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TLR2 toll like receptor 2 treatment
severity		 ISO RGD PMID:11801667 PMID:20130923 PMID:22750071 PMID:23023072 PMID:23239000 RGD:7207892 RGD:7207894 RGD:7207896 RGD:7240552 RGD:7241087 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:11801667 PMID:20130923 PMID:23239000 RGD:7207892 RGD:7240552 RGD:7241087 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ameliorates ISO protein:increased expression:serum RGD PMID:19925291 PMID:24920753 RGD:2315112 RGD:329845564 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732 		JBrowse link
G VWF von Willebrand factor ISO protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153 		JBrowse link
G WT1 WT1 transcription factor ISO mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:20616412 PMID:22995295 RGD:7247637 RGD:7247695 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G ZNF667 zinc finger protein 667 ameliorates ISO RGD PMID:24920753 RGD:329845564 NCBI chr19:53,465,103...53,502,535
Ensembl chr19:62,260,060...62,291,197 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      Urogenital Diseases 4727
        urinary system disease 2403
          kidney disease 2174
            kidney failure 508
              acute kidney failure 289
                Contrast-Induced Nephropathy 12
                Crome Syndrome 0
                Kidney Reperfusion Injury + 155
                acute kidney tubular necrosis 12
                hepatorenal syndrome 5
paths to the root