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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amh anti-Mullerian hormone JBrowse link 10 80,805,240 80,807,679 RGD:2315639
G Bmp4 bone morphogenetic protein 4 JBrowse link 14 46,383,525 46,390,669 RGD:1643593
G Ccnd2 cyclin D2 JBrowse link 6 127,125,162 127,152,188 RGD:2289157
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:2296066
G Cdkn2b cyclin dependent kinase inhibitor 2B JBrowse link 4 89,306,289 89,311,032 RGD:2296066
G Cmklr1 chemokine-like receptor 1 JBrowse link 5 113,612,355 113,650,475 RGD:11554173
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:1643593
RGD:13592920
G Fancf Fanconi anemia, complementation group F JBrowse link 7 51,860,577 51,862,267 RGD:2298508
RGD:11049141
G Fhit fragile histidine triad gene JBrowse link 14 9,550,092 11,162,061 RGD:2298508
G Fshr follicle stimulating hormone receptor JBrowse link 17 88,984,952 89,200,675 RGD:2289157
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 JBrowse link 9 107,614,125 107,635,391 RGD:8554872
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 5 75,574,987 75,656,722 RGD:2302173
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:11554173
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 17 88,716,384 88,792,059 RGD:2302176
RGD:2289157
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 7 136,894,463 137,128,193 RGD:2317693
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta JBrowse link 12 31,958,450 32,061,648 RGD:2289157
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:2289157
G Rarres2 retinoic acid receptor responder (tazarotene induced) 2 JBrowse link 6 48,569,696 48,572,845 RGD:11554173
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 10 21,882,184 21,999,903 RGD:2289157
G Smad1 SMAD family member 1 JBrowse link 8 79,338,395 79,399,428 RGD:2299978
G Smad5 SMAD family member 5 JBrowse link 13 56,703,010 56,742,378 RGD:2299978
G St14 suppression of tumorigenicity 14 (colon carcinoma) JBrowse link 9 31,088,590 31,131,811 RGD:2315091
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:2315463
G Wif1 Wnt inhibitory factor 1 JBrowse link 10 121,034,004 121,100,642 RGD:1643593
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 JBrowse link 9 107,614,125 107,635,391 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12767
    disease of anatomical entity 12382
      endocrine system disease 4461
        endocrine gland cancer 1514
          ovarian cancer 229
            granulosa cell tumor 24
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 0
Path 2
Term Annotations click to browse term
  disease 12767
    disease of anatomical entity 12382
      Urogenital Diseases 3667
        Female Urogenital Diseases and Pregnancy Complications 1759
          Female Urogenital Diseases 1469
            female reproductive system disease 1465
              Adnexal Diseases 656
                ovarian disease 650
                  Ovarian Neoplasms 380
                    ovarian cancer 229
                      granulosa cell tumor 24
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.