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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
For additional species annotation, visit the Alliance of Genome Resources.


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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMH anti-Mullerian hormone JBrowse link 19 2,249,323 2,252,073 RGD:2315639
G BMP4 bone morphogenetic protein 4 JBrowse link 14 53,949,736 53,956,891 RGD:1643593
G CCND2 cyclin D2 JBrowse link 12 4,273,762 4,305,353 RGD:2289157
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:2296066
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 9 22,002,903 22,009,313 RGD:2296066
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 12 108,288,044 108,339,347 RGD:11554173
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:1643593
RGD:13592920
G FANCF FA complementation group F JBrowse link 11 22,622,533 22,625,823 RGD:2298508
RGD:11049141
G FHIT fragile histidine triad diadenosine triphosphatase JBrowse link 3 59,747,277 61,251,461 RGD:2298508
G FSHR follicle stimulating hormone receptor JBrowse link 2 48,953,161 49,154,527 RGD:2289157
G GNAI2 G protein subunit alpha i2 JBrowse link 3 50,227,068 50,259,362 RGD:8554872
G KIT KIT proto-oncogene, receptor tyrosine kinase JBrowse link 4 54,657,928 54,740,715 RGD:2302173
G LEPR leptin receptor JBrowse link 1 65,420,652 65,641,559 RGD:11554173
G LHCGR luteinizing hormone/choriogonadotropin receptor JBrowse link 2 48,686,774 48,755,724 RGD:2302176
RGD:2289157
G MGMT O-6-methylguanine-DNA methyltransferase JBrowse link 10 129,467,241 129,770,983 RGD:2317693
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 7 107,044,705 107,161,811 RGD:2289157
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:2289157
G RARRES2 retinoic acid receptor responder 2 JBrowse link 7 150,338,329 150,341,685 RGD:11554173
G SGK1 serum/glucocorticoid regulated kinase 1 JBrowse link 6 134,169,246 134,318,112 RGD:2289157
G SMAD1 SMAD family member 1 JBrowse link 4 145,481,306 145,559,176 RGD:2299978
G SMAD5 SMAD family member 5 JBrowse link 5 136,132,845 136,182,734 RGD:2299978
G ST14 suppression of tumorigenicity 14 JBrowse link 11 130,159,782 130,210,362 RGD:2315091
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:2315463
G WIF1 WNT inhibitory factor 1 JBrowse link 12 65,050,626 65,121,305 RGD:1643593
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GNAI2 G protein subunit alpha i2 JBrowse link 3 50,227,068 50,259,362 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16645
    disease of anatomical entity 15627
      endocrine system disease 4941
        endocrine gland cancer 1572
          ovarian cancer 231
            granulosa cell tumor 24
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 0
Path 2
Term Annotations click to browse term
  disease 16645
    disease of anatomical entity 15627
      Urogenital Diseases 4336
        Female Urogenital Diseases and Pregnancy Complications 1888
          Female Urogenital Diseases 1581
            female reproductive system disease 1577
              Adnexal Diseases 679
                ovarian disease 673
                  Ovarian Neoplasms 391
                    ovarian cancer 231
                      granulosa cell tumor 24
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.