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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMH anti-Mullerian hormone JBrowse link 20 56,785,960 56,788,815 RGD:9068941
G BMP4 bone morphogenetic protein 4 JBrowse link 8 29,997,563 30,254,307 RGD:9068941
G CCND2 cyclin D2 JBrowse link 27 40,563,306 40,593,362 RGD:9068941
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 11 41,259,627 41,264,832 RGD:9068941
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 26 18,487,700 18,539,678 RGD:9068941
G CTNNB1 catenin beta 1 JBrowse link 23 10,559,722 10,572,933 RGD:9068941
G FANCF FA complementation group F JBrowse link 21 44,253,308 44,256,221 RGD:9068941
G FHIT fragile histidine triad diadenosine triphosphatase JBrowse link 20 29,735,380 31,113,859 RGD:9068941
G FSHR follicle stimulating hormone receptor JBrowse link 10 50,765,591 50,938,643 RGD:9068941
G GNAI2 G protein subunit alpha i2 JBrowse link 20 39,075,085 39,094,697 RGD:9068941
G KIT KIT proto-oncogene, receptor tyrosine kinase JBrowse link 13 47,108,442 47,190,935 RGD:9068941
G LEPR leptin receptor JBrowse link 5 44,684,118 44,775,626 RGD:9068941
G LHCGR luteinizing hormone/choriogonadotropin receptor JBrowse link 10 50,540,706 50,594,336 RGD:9068941
G MGMT O-6-methylguanine-DNA methyltransferase JBrowse link 28 38,204,611 38,427,482 RGD:9068941
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 18 13,375,216 13,467,811 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 7 19,668,079 19,674,903 RGD:9068941
G RARRES2 retinoic acid receptor responder 2 JBrowse link 16 14,671,345 14,675,000 RGD:9068941
G SGK1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 27,086,431 27,196,601 RGD:9068941
G SMAD1 SMAD family member 1 JBrowse link 15 44,093,491 44,171,177 RGD:9068941
G SMAD5 SMAD family member 5 JBrowse link 11 24,027,603 24,082,673 RGD:9068941
G ST14 suppression of tumorigenicity 14 JBrowse link 5 4,652,493 4,666,728 RGD:9068941
G VEGFA vascular endothelial growth factor A JBrowse link 12 12,209,032 12,224,978 RGD:9068941
G WIF1 WNT inhibitory factor 1 JBrowse link 10 7,659,277 7,726,175 RGD:9068941
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GNAI2 G protein subunit alpha i2 JBrowse link 20 39,075,085 39,094,697 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12222
    disease of anatomical entity 11877
      endocrine system disease 4248
        endocrine gland cancer 1468
          ovarian cancer 219
            granulosa cell tumor 23
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 0
Path 2
Term Annotations click to browse term
  disease 12222
    disease of anatomical entity 11877
      Urogenital Diseases 3537
        Female Urogenital Diseases and Pregnancy Complications 1709
          Female Urogenital Diseases 1422
            female reproductive system disease 1418
              Adnexal Diseases 636
                ovarian disease 630
                  Ovarian Neoplasms 367
                    ovarian cancer 219
                      granulosa cell tumor 23
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.