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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amh anti-Mullerian hormone JBrowse link NW_004955495 5,893,375 5,896,152 RGD:9068941
G Bmp4 bone morphogenetic protein 4 JBrowse link NW_004955409 9,432,835 9,439,680 RGD:9068941
G Ccnd2 cyclin D2 JBrowse link NW_004955413 2,083,351 2,108,450 RGD:9068941
G Cdkn2b cyclin dependent kinase inhibitor 2B JBrowse link NW_004955472 12,275,613 12,280,141 RGD:9068941
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link NW_004955455 9,587,421 9,638,602 RGD:9068941
G Ctnnb1 catenin beta 1 JBrowse link NW_004955420 29,030,716 29,047,447 RGD:9068941
G Fancf FA complementation group F JBrowse link NW_004955476 3,067,491 3,069,637 RGD:9068941
G Fhit fragile histidine triad diadenosine triphosphatase JBrowse link NW_004955430 221,518 508,094 RGD:9068941
G Fshr follicle stimulating hormone receptor JBrowse link NW_004955441 15,422,190 15,585,446 RGD:9068941
G Gnai2 G protein subunit alpha i2 JBrowse link NW_004955532 2,059,038 2,079,120 RGD:9068941
G Kit KIT proto-oncogene, receptor tyrosine kinase JBrowse link NW_004955447 16,149,014 16,226,151 RGD:9068941
G Lepr leptin receptor JBrowse link NW_004955423 25,108,897 25,185,315 RGD:9068941
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link NW_004955441 15,205,883 15,263,617 RGD:9068941
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link NW_004955477 7,103,035 7,375,073 RGD:9068941
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link NW_004955410 11,529,530 11,620,085 RGD:9068941
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link NW_004955406 25,077,988 25,086,259 RGD:9068941
G Rarres2 retinoic acid receptor responder 2 JBrowse link NW_004955491 4,954,809 4,957,724 RGD:9068941
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link NW_004955439 2,399,992 2,406,587 RGD:9068941
G Smad1 SMAD family member 1 JBrowse link NW_004955428 1,357,398 1,429,521 RGD:9068941
G Smad5 SMAD family member 5 JBrowse link NW_004955408 31,183,727 31,228,355 RGD:9068941
G St14 suppression of tumorigenicity 14 JBrowse link NW_004955412 31,091,313 31,129,050 RGD:9068941
G Vegfa vascular endothelial growth factor A JBrowse link NW_004955437 9,527,445 9,541,908 RGD:9068941
G Wif1 WNT inhibitory factor 1 JBrowse link NW_004955458 11,755,147 11,834,047 RGD:9068941
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gnai2 G protein subunit alpha i2 JBrowse link NW_004955532 2,059,038 2,079,120 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11416
    disease of anatomical entity 11089
      endocrine system disease 3933
        endocrine gland cancer 1380
          ovarian cancer 213
            granulosa cell tumor 23
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 0
Path 2
Term Annotations click to browse term
  disease 11416
    disease of anatomical entity 11089
      Urogenital Diseases 3359
        Female Urogenital Diseases and Pregnancy Complications 1651
          Female Urogenital Diseases 1385
            female reproductive system disease 1381
              Adnexal Diseases 625
                ovarian disease 619
                  Ovarian Neoplasms 360
                    ovarian cancer 213
                      granulosa cell tumor 23
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.