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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMH anti-Mullerian hormone JBrowse link 19 2,231,984 2,236,130 RGD:9068941
G BMP4 bone morphogenetic protein 4 JBrowse link 14 52,821,872 52,828,781 RGD:9068941
G CCND2 cyclin D2 JBrowse link 12 4,309,272 4,340,893 RGD:9068941
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 22,420,748 22,447,243 RGD:9068941
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 9 22,455,662 22,462,156 RGD:9068941
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 12 109,256,329 109,307,526 RGD:9068941
G CTNNB1 catenin beta 1 JBrowse link 3 41,372,368 41,414,030 RGD:9068941
G FANCF FA complementation group F JBrowse link 11 22,542,426 22,546,147 RGD:9068941
G FHIT fragile histidine triad diadenosine triphosphatase JBrowse link 3 61,069,947 62,568,700 RGD:9068941
G FSHR follicle stimulating hormone receptor JBrowse link 2A 50,008,328 50,207,258 RGD:9068941
G GNAI2 G protein subunit alpha i2 JBrowse link 3 51,398,981 51,422,000 RGD:9068941
G KIT KIT proto-oncogene, receptor tyrosine kinase JBrowse link 4 75,761,946 75,844,473 RGD:9068941
G LEPR leptin receptor JBrowse link 1 66,651,994 66,764,768 RGD:9068941
G LHCGR luteinizing hormone/choriogonadotropin receptor JBrowse link 2A 49,728,994 49,798,780 RGD:9068941
G MGMT O-6-methylguanine-DNA methyltransferase JBrowse link 10 130,305,459 130,609,532 RGD:9068941
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 7 111,748,463 111,866,044 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 166,355,845 166,364,517 RGD:9068941
G RARRES2 retinoic acid receptor responder 2 JBrowse link 7 154,106,275 154,109,635 RGD:9068941
G SGK1 serum/glucocorticoid regulated kinase 1 JBrowse link 6 136,033,851 136,180,121 RGD:9068941
G SMAD1 SMAD family member 1 JBrowse link 4 149,481,819 149,558,135 RGD:9068941
G SMAD5 SMAD family member 5 JBrowse link 5 137,663,558 137,713,130 RGD:9068941
G ST14 suppression of tumorigenicity 14 JBrowse link 11 128,890,780 128,913,559 RGD:9068941
G VEGFA vascular endothelial growth factor A JBrowse link 6 44,651,855 44,666,353 RGD:9068941
G WIF1 WNT inhibitory factor 1 JBrowse link 12 24,299,354 24,370,591 RGD:9068941
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GNAI2 G protein subunit alpha i2 JBrowse link 3 51,398,981 51,422,000 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12058
    disease of anatomical entity 11718
      endocrine system disease 4074
        endocrine gland cancer 1420
          ovarian cancer 219
            granulosa cell tumor 24
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 0
Path 2
Term Annotations click to browse term
  disease 12058
    disease of anatomical entity 11718
      Urogenital Diseases 3496
        Female Urogenital Diseases and Pregnancy Complications 1698
          Female Urogenital Diseases 1418
            female reproductive system disease 1414
              Adnexal Diseases 632
                ovarian disease 626
                  Ovarian Neoplasms 368
                    ovarian cancer 219
                      granulosa cell tumor 24
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.