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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:laryngeal squamous cell carcinoma
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Accession:DOID:2876 term browser browse the term
Definition:A laryngeal carcinoma that has_material_basis_in squamous cells. (DO)
Synonyms:exact_synonym: epidermoid carcinoma of the larynx;   squamous cell carcinoma of larynx
 xref: NCI:C4044;   ORDO:494550
For additional species annotation, visit the Alliance of Genome Resources.



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laryngeal squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN1A cyclin dependent kinase inhibitor 1A ISO RGD PMID:15646812 RGD:8662837 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G EGFR epidermal growth factor receptor disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,431,656...21,496,279
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,973,037...114,696,375
JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 severity ISO associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human) RGD PMID:19513509 RGD:150429781 NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,240
JBrowse link
G MLH1 mutL homolog 1 disease_progression ISO mRNA:decreased expression:larynx RGD PMID:23787767 RGD:126848783 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:17786346 RGD:5130203 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G MSH2 mutS homolog 2 disease_progression ISO mRNA:decreased expression:larynx RGD PMID:23787767 RGD:126848783 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit severity ISO associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human) RGD PMID:19513509 RGD:150429781 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13619
    disease of cellular proliferation 6536
      cancer 4708
        cell type cancer 3231
          carcinoma 2761
            squamous cell carcinoma 489
              laryngeal squamous cell carcinoma 10
                larynx verrucous carcinoma + 0
Path 2
Term Annotations click to browse term
  disease 13619
    disease of anatomical entity 13284
      nervous system disease 10999
        sensory system disease 5104
          Otorhinolaryngologic Diseases 1226
            Otorhinolaryngologic Neoplasms 200
              Laryngeal Neoplasms 22
                larynx cancer 14
                  laryngeal carcinoma 10
                    laryngeal squamous cell carcinoma 10
                      larynx verrucous carcinoma + 0
paths to the root