RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: endometrial adenocarcinoma
Accession: DOID:2870
browse the term
Definition: An endometrial carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms: exact_synonym: EEC; Type I endometrial carcinoma; adenocarcinoma of endometrium; adenocarcinoma of the endometrium; adenocarcinoma of uterus; endometrial adenoacanthoma; endometrial endometrioid adenocarcinoma; endometrial endometrioid carcinoma; endometrioid adenoma or carcinoma; endometrioid carcinoma of endometrium
narrow_synonym: ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA, VARIANT WITH SQUAMOUS DIFFERENTIATION; endometrial endometrioid adenocarcinoma with squamous differentiation
broad_synonym: endometrioid adenomas and carcinomas; endometrioid endometrial cancer
xref: EFO:0005232 ; EFO:1000233 ; EFO:1001514 ; EFO:1001953 ; NCI:C3769 ; NCI:C6287 ; NCI:C6290 ; NCI:C63961 ; NCI:C7359
For additional species annotation, visit the
Alliance of Genome Resources .
G
ANGPT1
angiopoietin 1
ISO
protein:increased expression:endometrium epithelium
RGD
PMID:17295646
RGD:2293852
NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618
G
ANGPT2
angiopoietin 2
ISO
protein:increased expression:endometrium epithelium
RGD
PMID:17295646
RGD:2293852
NCBI chr16:58,404,049...58,458,344
Ensembl chr16:58,405,259...58,457,701
G
ARID1A
AT-rich interaction domain 1A
treatment
ISO
human cell in mouse model
RGD
PMID:21900401
RGD:126725086
NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102
G
AXIN2
axin 2
ISO
RGD
PMID:11940574
RGD:13432156
NCBI chr 9:14,559,476...14,588,950
Ensembl chr 9:14,559,388...14,588,530
G
BET1L
Bet1 golgi vesicular membrane trafficking protein like
disease_progression
ISO
RGD
PMID:28654152
RGD:14394612
NCBI chr18:25,358,517...25,361,944
Ensembl chr18:25,360,636...25,361,299
G
CD55
CD55 molecule
ISO
RGD
PMID:11506079
RGD:2326173
NCBI chr 7:6,361,037...6,396,063
Ensembl chr 7:6,360,964...6,386,226
G
EBAG9
estrogen receptor binding site associated antigen 9
ISO
protein:increased expression:endometrium
RGD
PMID:16112719
RGD:2289850
NCBI chr13:10,081,700...10,099,737
Ensembl chr13:10,081,695...10,099,501
G
FOXO3
forkhead box O3
severity
ISO
associated with Obesity;protein:decreased expression:endometrium (human)
RGD
PMID:26045339
RGD:11530998
NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
G
GPX3
glutathione peroxidase 3
ISO
mRNA:decreased expression:endometrium (rat)
RGD
PMID:19426485
RGD:2312621
NCBI chr 4:58,200,671...58,209,010
Ensembl chr 4:58,200,672...58,209,010
G
IRF1
interferon regulatory factor 1
ISO
DNA:deletions (rat)
RGD
PMID:19075038
RGD:5128782
NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608
G
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
no_association
ISO
protein, mRNA::endometrial epithelium and stroma:no correlation between expression and type of tissue or cancer stage or grade
RGD
PMID:10684716
RGD:2290482
NCBI chr 5:50,966,698...50,968,939
G
KRAS
KRAS proto-oncogene, GTPase
ISO
DNA:point mutation:CDS:p.G12D, p.G12S, p.Q61H (rat)
RGD
PMID:10775052
RGD:1600499
NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369
G
MAPK1
mitogen-activated protein kinase 1
treatment
ISO
protein:decreased phosphorylation:endometrium (human) human tumor in a mouse model
RGD
PMID:14760076 PMID:23402905
RGD:13703125 RGD:13703137
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
G
MAPK3
mitogen-activated protein kinase 3
treatment
ISO
human tumor in a mouse model protein:decreased phosphorylation:endometrium (human)
RGD
PMID:14760076 PMID:23402905
RGD:13703125 RGD:13703137
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
G
PDCD10
programmed cell death 10
disease_progression
ISO
protein:increased expression:endometrium (human)
RGD
PMID:32186778
RGD:401827111
NCBI chr34:32,512,109...32,553,524
Ensembl chr34:32,512,112...32,553,445
G
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
ISO
DNA:mutations:multiple (human)
RGD
PMID:21478295
RGD:13441595
NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
G
PTEN
phosphatase and tensin homolog
ameliorates
ISO
RGD
PMID:32843721
RGD:127285600
NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
G
PTGES
prostaglandin E synthase
ISO
protein:increased expression:endometrium
RGD
PMID:11592775
RGD:2300089
NCBI chr 9:54,071,472...54,082,232
Ensembl chr 9:54,071,472...54,082,232
G
RRM2
ribonucleotide reductase regulatory subunit M2
ISO
DNA:amplification (rat)
RGD
PMID:15942940
RGD:2324953
NCBI chr17:7,106,515...7,113,868
Ensembl chr17:7,104,961...7,122,939
G
TGFBR3
transforming growth factor beta receptor 3
ISO
mRNA:decreased expression:endometrium
RGD
PMID:15745937
RGD:1579943
NCBI chr 6:57,025,096...57,220,240
Ensembl chr 6:57,025,112...57,217,121
G
TP53
tumor protein p53
disease_progression
ISO
DNA:missense mutations protein:increased expression:endometrium
RGD
PMID:1540970
RGD:2290541
NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
G
TSG101
tumor susceptibility 101
ISO
mRNA:alternative forms
RGD
PMID:10027311
RGD:2291854
NCBI chr21:40,910,870...40,952,922
Ensembl chr21:40,910,874...40,952,808
G
ATM
ATM serine/threonine kinase
ISO
ClinVar Annotator: match by term: Endometrial serous adenocarcinoma
ClinVar
NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
G
BRCA2
BRCA2 DNA repair associated
susceptibility
ISO
DNA:deletion: :6174delT
RGD
PMID:16650962
RGD:2289045
NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all