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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:asthma
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Accession:DOID:2841 term browser browse the term
Definition:A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Synonyms:exact_synonym: AS1;   asthmas;   bronchial asthma
 narrow_synonym: ASTHMA, DIMINISHED RESPONSE TO ANTILEUKOTRIENE TREATMENT IN;   adult onset asthma;   airway hyperresponsiveness
 related_synonym: ASRT1;   ASRT2;   ASRT3;   ASRT4;   ASRT5;   ASRT6;   ASRT7;   ASRT8;   Asthma-Related Traits, Susceptibility To, 1;   Asthma-Related Traits, Susceptibility To, 2;   Asthma-Related Traits, Susceptibility To, 3;   Asthma-Related Traits, Susceptibility To, 4;   Asthma-Related Traits, Susceptibility To, 5;   Asthma-Related Traits, Susceptibility To, 6;   Asthma-Related Traits, Susceptibility To, 7;   Asthma-Related Traits, Susceptibility To, 8;   allergic airway inflammation;   asthma and allergic rhinitis, susceptibility to;   asthma and atopy, susceptibility to;   asthma, protection against;   asthma, susceptibility to;   asthma-traits, susceptibility to asthma, protection against;   beta-2-adrenoreceptor agonist, reduced response to;   childhood athma, susceptibility to;   rhinoconjunctivitis, susceptibility to
 primary_id: MESH:D001249
 alt_id: MIM:600807;   MIM:601690;   MIM:607277;   MIM:608584;   MIM:609958;   MIM:610906;   MIM:611064;   MIM:611403;   MIM:611960;   MIM:613207
 xref: EFO:0000270;   EFO:0005414;   EFO:1002011;   GARD:10246;   ICD10CM:J45;   ICD9CM:493;   MONDO:0004979;   NCI:C28397
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A ISO protein:increased expression:blood, lymphocyte RGD PMID:19484671 RGD:4890020 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 IMP RGD PMID:18931056 RGD:5128825 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase no_association ISO RGD PMID:16008680 PMID:19771478 RGD:5128831, RGD:5128835 NCBI chr 2:26,732,508...26,754,973
Ensembl chr 2:26,732,515...26,754,991 		JBrowse link
G Ace angiotensin I converting enzyme susceptibility ISO DNA:polymorphism (human) RGD PMID:19383228 PMID:19484664 RGD:4140919, RGD:4140913 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 ISO DNA:hypermethylation:promoter RGD PMID:19221603 RGD:13831295 NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460 		JBrowse link
G Ada adenosine deaminase susceptibility ISO DNA:polymorphisms (human) RGD PMID:16754522 RGD:5128848 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adam33 a disintegrin and metallopeptidase domain 33 susceptibility
no_association
disease_progression		 ISO
IEP		 DNA:SNPs: :multiple (human)
DNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human)
mRNA:increased expression:bronchus
DNA:polymorphism: :p.M764T (human)
mRNA:increased expression:lung
DNA:SNPs (human)		 RGD
GAD		 PMID:18778489 PMID:15118671 PMID:16893396 PMID:17339047 PMID:17961406 More... RGD:4145378, RGD:1331525, RGD:4145382, RGD:4145380, RGD:4145379, RGD:4145360, RGD:4145359 NCBI chr 2:130,892,739...130,905,734
Ensembl chr 2:130,892,511...130,905,734 		JBrowse link
G Adam8 a disintegrin and metallopeptidase domain 8 severity ISO
IEP
IMP		 mRNA:increased expression:bronchus
mRNA:increased expression:respiratory tract		 RGD PMID:17339047 PMID:19373511 PMID:20194813 RGD:4145380, RGD:5128878, RGD:5128872 NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475 		JBrowse link
G Adcy2 adenylate cyclase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21912604 NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660 		JBrowse link
G Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21059121 NCBI chr 6:55,428,486...55,478,440
Ensembl chr 6:55,428,963...55,478,436 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide susceptibility ISO
IMP		 protein:increased expression:respiratory system fluid/secretion
DNA:SNPs: :rs1154404, rs28730619 (human)		 RGD PMID:19514054 PMID:19395503 PMID:17543375 PMID:15919956 RGD:5128890, RGD:5128891, RGD:5128882, RGD:5128892 NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IMP RGD PMID:19168697 RGD:5686821 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adora1 adenosine A1 receptor ISO
IMP		 DNA:SNPs: :1405C>T (human)
protein:increased expression:bronchus		 RGD PMID:19019667 PMID:20400685 PMID:17959644 RGD:4890386, RGD:4145444, RGD:5129097 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Adora2a adenosine A2a receptor ISO
IEP
IDA
IMP		 DNA:SNP (human)
mRNA:decreased expression:aorta		 RGD PMID:19019667 PMID:18310516 PMID:16339780 PMID:17293374 RGD:4890386, RGD:4890366, RGD:4890385, RGD:4890380 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 susceptibility ISO
IMP		 DNA:SNP: :p.Q27E (human)
DNA:polymorphism: :p.R16G (human)
DNA:SNPs:promoter:multiple (human)
DNA:SNPs: :p.R16G, p.Q27E (human)
DNA:SNP: :-1023A>G (human)
ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to		 ClinVar
RGD		 PMID:8383511 PMID:15284533 PMID:16596417 PMID:1655856 PMID:19423772 More... RGD:5129113, RGD:4145107, RGD:4145096, RGD:4145061, RGD:4145105, RGD:4145108, RGD:4145092, RGD:4145094, RGD:4145081, RGD:1331525 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment
onset		 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:lung (rat)		 CTD
RGD		 PMID:23304218 PMID:33075463 PMID:21920897 PMID:23304218 RGD:7244279, RGD:6767554, RGD:7244279 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP
ISO		 RGD PMID:17877756 PMID:19080339 RGD:5147452, RGD:5147457 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO mRNA, protein:increased expression:lung RGD PMID:19080339 RGD:5147457 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:9600491 PMID:11506308 PMID:15118671 RGD:1331525 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase IEP
IMP		 protein:increased expression:lung RGD PMID:19628725 PMID:18692885 RGD:5509605, RGD:5509784 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase no_association
severity
treatment		 ISO
IDA
IEP
IMP		 DNA:polymorphism:promoter (human)
DNA:polymorphism:cds:p.E254K (human)
DNA:repeat:promoter (human)
protein:increased expression:lung
mRNA:increased expression:blood, leukocyte
CTD Direct Evidence: marker/mechanism		 CTD
OMIM
RGD		 PMID:20128419 PMID:17394438 PMID:18204779 PMID:16364163 PMID:19033731 More... RGD:4890407, RGD:4890413, RGD:4890410, RGD:4890415, RGD:4890408, RGD:4890422, RGD:5147462, RGD:5147465, RGD:5147467, RGD:734557 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein susceptibility
no_association		 ISO
IMP
IEP		 DNA:SNP: :rs10507391 (human)
mRNA:increased expression:blood, leukocyte
DNA:repeat:promoter:-169(A)21 (human)
DNA:substitution, repeat:promoter:-336G>A, -169(A)19-23 (human)
DNA:polymorphisms:intron:IVS2+12C>A, IVS2+105T>C (human)
protein:increased expression:lung
DNA:polymorphism:promoter (human)
DNA:SNPs (human)		 RGD PMID:20067482 PMID:9642160 PMID:10527888 PMID:12911785 PMID:15784112 More... RGD:4890405, RGD:5147467, RGD:5147466, RGD:5147465, RGD:5147464, RGD:5147462, RGD:4890422, RGD:4890407, RGD:4890409 NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963 		JBrowse link
G Ambp alpha 1 microglobulin/bikunin precursor ISO protein:increased expression:serum RGD PMID:14621078 RGD:6904149 NCBI chr 4:63,061,512...63,072,409
Ensembl chr 4:63,061,512...63,073,036 		JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 severity ISO protein:increased expression:sputum RGD PMID:16478840 RGD:6892719 NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466 		JBrowse link
G Anxa1 annexin A1 IMP RGD PMID:22092555 RGD:7421657 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15696081 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Arg1 arginase, liver ISO
IEP		 DNA:SNP: :rs2781667 (human)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung, mononuclear cell (human)
mRNA:increased expression:lung (mouse)		 CTD
RGD		 PMID:19281908 PMID:19800904 PMID:20124949 PMID:12813022 PMID:12813022 RGD:5129205, RGD:4143187, RGD:4143187 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Arg2 arginase type II severity
susceptibility		 ISO
IEP		 DNA:SNP: :rs3742879, rs17249437 (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (mouse)
DNA:SNPs (human)		 CTD
RGD		 PMID:19281908 PMID:20124949 PMID:12813022 PMID:16387594 RGD:5129205, RGD:4143187, RGD:5129207 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18357729 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 onset ISO DNA:polymorphism:exon (human)
protein:increased expression:blood, eosinophil		 RGD PMID:11517947 PMID:8856156 PMID:14727005 PMID:19038786 RGD:4890456, RGD:4891042, RGD:4890454, RGD:4891028 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G Bdnf brain derived neurotrophic factor susceptibility
severity		 ISO protein:decreased expression:blood, eosinophil
DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
DNA:polymorphisms: :p.V66M, -270C>T (human)
protein:increased expression:plasma
DNA:polymorphisms: :p.V66M (rs6265) (human)		 RGD PMID:12752594 PMID:21723144 PMID:17584309 PMID:20874832 PMID:19895626 More... RGD:4891122, RGD:8655967, RGD:4891067, RGD:4891063, RGD:4891117, RGD:4891123 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:8429434 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor, type 1B ISO protein:decreased expression:bronchus RGD PMID:18292470 RGD:5129470 NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO protein:decreased expression:bronchus RGD PMID:18292470 RGD:5129470 NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173 		JBrowse link
G C3 complement component 3 severity IMP
ISO
IEP		 protein:increased expression:serum
DNA:SNP:intron:rs11569562 (human)
DNA:SNP: :4896C>T (human)
protein:increased expression:respiratory system fluid/secretion
Interaction with IL4RA
DNA:SNPs: :multiple (human)		 RGD PMID:11591733 PMID:20589464 PMID:18566738 PMID:15278436 PMID:20802484 More... RGD:5129517, RGD:5129519, RGD:5129501, RGD:5129512, RGD:5129681, RGD:5129537, RGD:5129538, RGD:5129505 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C3ar1 complement component 3a receptor 1 severity ISO
IMP
IEP		 mRNA:increased expression:lung
protein:increased expression:lung, leukocyte		 RGD PMID:15278436 PMID:20802484 PMID:20045013 PMID:17544263 PMID:15940127 More... RGD:5129512, RGD:5129681, RGD:5129686, RGD:5129560, RGD:5129561, RGD:5129560 NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120 		JBrowse link
G C5ar1 complement component 5a receptor 1 severity IMP
IEP
ISO		 protein:increased expression:lung, leukocyte
protein:increased expression:respiratory tract		 RGD PMID:16511606 PMID:20802484 PMID:17544263 PMID:15940127 RGD:5130166, RGD:5129681, RGD:5129560, RGD:5129561 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Card11 caspase recruitment domain family, member 11 susceptibility IMP
ISO		 ClinVar Annotator: match by term: Asthma ClinVar
RGD		 PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 More... RGD:11100037 NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO mRNA:decreased expression:lung RGD PMID:20423833 RGD:9491823 NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919 		JBrowse link
G Casp1 caspase 1 ISO protein:increased expression:serum RGD PMID:12396474 RGD:5130192 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Cat catalase severity ISO
IDA		 DNA:polymorphism:promoter:-21A>T (human)
CTD Direct Evidence: marker/mechanism
protein:decreased activity
DNA:polymorphism:promoter:-262C>T (human)
protein:increased expression:erythrocyte		 CTD
RGD		 PMID:18048809 PMID:19373626 PMID:16622028 PMID:18048809 PMID:19475625 RGD:5130753, RGD:5130867, RGD:5130856, RGD:5130751 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:20455898 RGD:4891420 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 treatment
susceptibility
severity		 ISO
IEP
IMP		 protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :p.A23T (human)
mRNA:increased expression:lung		 OMIM
CTD
RGD		 PMID:16304252 PMID:22932891 PMID:17074272 PMID:17845580 PMID:20704746 More... RGD:5130930, RGD:7248416, RGD:4145461, RGD:4145457, RGD:4145387, RGD:4145392, RGD:4145451, RGD:4891485 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO
IMP
IEP
IDA		 mRNA:increased expression:lung
protein:increased expression:respiratory system fluid/secretion		 RGD PMID:15993846 PMID:11160256 PMID:20074456 PMID:15947487 PMID:20237293 RGD:2306304, RGD:4145603, RGD:4145487, RGD:4145513, RGD:4145486 NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO protein:increased expression:bronchus submucosa, mast cell RGD PMID:16959919 RGD:5130911 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity
treatment		 ISO
IEP
IDA		 protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (mouse)
DNA:haplotype::-2518A>G (human)
protein:increased expression:lung		 CTD
RGD		 PMID:19373627 PMID:19373627 PMID:12055264 PMID:25441643 PMID:23454776 More... RGD:4891466, RGD:11528570, RGD:11528569, RGD:8551842, RGD:2307055, RGD:4145509 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO protein:increased expression:respiratory system fluid/secretion
associated with Allergic Rhinitis;protein:increased expression:serum		 RGD PMID:18422729 PMID:22469443 RGD:7483597, RGD:7483618 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 IMP
ISO
IEP		 mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion
mRNA:increased expression:lung
protein:increased expression:respiratory system fluid/secretion		 RGD PMID:10384142 PMID:18684970 PMID:15993846 PMID:18316417 RGD:4891475, RGD:4145489, RGD:2306304, RGD:4891474 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 susceptibility ISO
IMP		 DNA:SNPs: :179T>C, 275C>T (human)
DNA:SNPs: :304C>A, 1272A>G (human)
protein:increased expression:respiratory system fluid/secretion
DNA:SNP: :1265A>G (human)
protein:increased expression:plasma		 RGD PMID:15207712 PMID:17548626 PMID:18712274 PMID:12952266 PMID:12761043 More... RGD:4891495, RGD:4891484, RGD:4891483, RGD:4891496, RGD:5130932, RGD:4891485, RGD:5130930 NCBI chr 5:135,598,789...135,601,977
Ensembl chr 5:135,598,791...135,601,903 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 treatment ISO
IDA		 protein:increased expression:plasma
DNA:SNPs: :77C>T, 2497T>G (human)
DNA:SNPs: :77C>T, 716A>G, 1579G>A (human)		 RGD PMID:16304252 PMID:25399816 PMID:25530546 PMID:15207712 PMID:18712274 RGD:5130930, RGD:11087575, RGD:11081163, RGD:4891495, RGD:4891483 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423 		JBrowse link
G Ccl27a C-C motif chemokine ligand 27A ISO RGD PMID:19541356 RGD:5130899 NCBI chr 4:41,769,467...41,774,251
Ensembl chr 4:41,769,467...41,774,247 		JBrowse link
G Ccl28 C-C motif chemokine ligand 28 IEP mRNA:increased expression:lung (mouse) RGD PMID:16290206 RGD:4892195 NCBI chr13:120,085,355...120,115,895
Ensembl chr13:120,085,355...120,115,895 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO RGD PMID:18774390 RGD:5130915 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility IEP
ISO		 protein:increased expression:lung, secretion (mouse)
CTD Direct Evidence: marker/mechanism
protein:increased expression:smooth muscle cell
DNA:transition:5' utr:-403G>A (human)		 CTD
RGD		 PMID:8534483 PMID:20092989 PMID:18208670 PMID:20430255 RGD:4891430, RGD:2307112, RGD:4891381 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO
IEP		 RGD PMID:21388664 PMID:19965981 RGD:5130983, RGD:5130979 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 severity IEP
IMP		 mRNA:increased expression:lung
associated with Respiratory Syncytial Virus Infections		 RGD PMID:15654816 PMID:15593301 RGD:5688158, RGD:5688159 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO
IEP		 DNA:SNP:cds:p.V64I (human)
DNA:haplotype:cds:p.V64I(human)
protein:increased expression:lung, dendritic cell (mouse)		 RGD PMID:17298432 PMID:23454776 PMID:19917684 RGD:4145110, RGD:8551842, RGD:8549811 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 IMP
ISO
IDA		 protein:increased expression:respiratory system fluid/secretion, neutrophil
DNA:SNP:exon:51T>C (human)		 RGD PMID:18699933 PMID:19017998 PMID:17145927 PMID:16978084 PMID:20220260 More... RGD:4145633, RGD:4145632, RGD:1601020, RGD:4145646, RGD:4145638, RGD:4145623, RGD:4145618 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 ISO mRNA:increased expression:lung RGD PMID:15993846 RGD:2306304 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 no_association IMP
ISO
IEP		 DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human)
mRNA:increased expression:lung (mouse)
protein:decreased expression:blood, lymphocyte (human)
DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)		 RGD PMID:16474097 PMID:23454776 PMID:18094012 PMID:15256090 PMID:20220260 RGD:4892093, RGD:8551842, RGD:4892088, RGD:4892108, RGD:4145638 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IEP protein:increased expression:lung, dendritic cell (mouse) RGD PMID:19917684 RGD:8549811 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 IEP protein:increased expression:lung, dendritic cell (mouse) RGD PMID:19917684 RGD:8549811 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 ISO mRNA:increased expression:lung RGD PMID:15993846 RGD:2306304 NCBI chr 9:119,921,199...119,923,972
Ensembl chr 9:119,921,180...119,923,972 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 ISO mRNA, protein:increased expression:blood, mature NK T cell RGD PMID:16210593 RGD:5130925 NCBI chr 9:123,596,276...123,612,522
Ensembl chr 9:123,507,504...123,613,395 		JBrowse link
G Cd14 CD14 antigen severity
no_association
susceptibility		 ISO DNA:polymorphism:promoter:c. -260C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:c. -159C>T (human)
DNA:SNPs: :
protein:increased expression:serum|DNA:polymorphism:promoter:c. -159C>T (human)		 CTD
RGD		 PMID:17607003 PMID:15940135 PMID:15741437 PMID:19096003 PMID:18312481 More... RGD:4144814, RGD:4144815, RGD:4144228, RGD:4144208, RGD:4144813 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd1d1 CD1d1 antigen susceptibility IMP associated with fasciolopsiasis RGD PMID:20304473 RGD:4140417 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd209a CD209a antigen ISO RGD PMID:21471959 RGD:5131188 NCBI chr 8:3,793,395...3,798,984
Ensembl chr 8:3,793,397...3,798,984 		JBrowse link
G Cd274 CD274 antigen treatment IMP associated with Chlamydia pneumonia RGD PMID:26378990 RGD:41412180 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd28 CD28 antigen ISO RGD PMID:21356099 RGD:5131612 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cd40 CD40 antigen treatment ISO
IEP		 RGD PMID:19220210 PMID:20205594 PMID:19159017 PMID:20941750 RGD:5132272, RGD:8547792, RGD:4144188, RGD:4892277 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand severity IMP RGD PMID:9502776 RGD:11352238 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cd80 CD80 antigen IEP RGD PMID:21051864 PMID:21440530 PMID:21352203 RGD:5132621, RGD:5132619, RGD:5132620 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697 		JBrowse link
G Cd86 CD86 antigen treatment IEP
IMP
ISO		 protein:increased expression:lung, alveolar macrophage (mouse)
protein:increased expression:blood, B cell (human)
protein:increased expression:lung, dendritic cell (rat)
DNA:snp:exon:p.I179V rs2681417 (human)		 RGD PMID:20941750 PMID:25344652 PMID:9449507 PMID:20668438 PMID:9551945 More... RGD:4892277, RGD:11354965, RGD:4892555, RGD:4892199, RGD:4892202, RGD:4892280 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cdh1 cadherin 1 ISO RGD PMID:21540309 RGD:5132878 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdhr3 cadherin-related family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24241537 NCBI chr12:33,083,781...33,142,900
Ensembl chr12:33,083,795...33,142,874 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator susceptibility ISO DNA:deletion: :p.F508del(human) RGD PMID:20298391 RGD:4140387 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Chat choline O-acetyltransferase ISO Protein:decreased expression:lung epithelium RGD PMID:17328924 RGD:5686690 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Chi3l1 chitinase 3 like 1 susceptibility ISO human gene in mouse model
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 7
DNA:snp:5' utr:g.-131C>G rs4950928 (human)
protein:increased secretion:serum (human)		 OMIM
ClinVar
RGD		 PMID:18403759 PMID:19414556 PMID:19568425 PMID:18003958 RGD:4892663, RGD:4892630, RGD:4892632 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919 		JBrowse link
G Chia1 chitinase, acidic 1 no_association ISO
IMP
IEP		 DNA:snps:5' utr, cds:multiple (human)
DNA:snps:multiple (human)
mRNA:increased expression:lung, epithelial cell (human)
mRNA:increased expression:lung (mouse)		 RGD PMID:16179638 PMID:20226308 PMID:19548841 PMID:15192232 PMID:14734765 RGD:4996473, RGD:5024922, RGD:5024921, RGD:4985150, RGD:4990463 NCBI chr 3:106,020,698...106,039,434
Ensembl chr 3:106,020,545...106,039,436 		JBrowse link
G Chml choroideremia-like ISO RGD PMID:18343558 RGD:5133238 NCBI chr 1:175,509,803...175,520,198
Ensembl chr 1:175,509,803...175,520,467 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS ISO RGD PMID:16931638 RGD:5133416 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac ISO DNA:SNP: :rs6962027 (human) RGD PMID:19308904 RGD:5509586 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac severity ISO
IMP		 RGD PMID:20394512 PMID:18348887 RGD:5133437, RGD:5133438 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase IMP RGD PMID:21496385 RGD:5133703 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Clca1 chloride channel accessory 1 susceptibility IMP
ISO		 DNA:SNPs (human) RGD PMID:11296262 PMID:17898169 PMID:15318163 RGD:4145661, RGD:4145653, RGD:4145656 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537 		JBrowse link
G Cldn18 claudin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27215490 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320 		JBrowse link
G Cma1 chymase 1, mast cell severity
susceptibility
no_association		 ISO protein:increased expression:lung epithelium, mast cell (human)
DNA:duplications:3' utr:g.*254-?dupTG, dupGA (human)
DNA:polymorphism:5' utr:g.-1903G>A rs1800875 (human)		 RGD PMID:20813890 PMID:15924217 PMID:15248847 RGD:5128804, RGD:1625396, RGD:1625397 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO DNA:SNP: :RS242941 (human)
DNA:SNPs: :rs1876828, rs242939, rs242941 (human)		 RGD PMID:19663668 PMID:16113459 RGD:5147485, RGD:5147488 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO DNA:SNPs: :multiple (human) RGD PMID:18408560 RGD:5130938 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum RGD PMID:21140796 RGD:5131288 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) severity IEP
IMP
ISO		 protein:increased expression:lung
protein:increased expression:sputum		 RGD PMID:20405019 PMID:9717963 PMID:19213775 RGD:5131473, RGD:10449521, RGD:5131476 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) ISO RGD PMID:17145927 RGD:1601020 NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047 		JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) ISO RGD PMID:17145927 RGD:1601020 NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) IEP
ISO		 protein:increased expression:lung RGD PMID:20405019 PMID:21396376 RGD:5131473, RGD:5133731 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 severity
treatment
no_association		 ISO
IDA
IMP
IEP		 protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
DNA:SNP: :rs3087243 (human)
DNA:polymorphism:promoter:-318C>T (human)
DNA:SNPs:promoter, exon:-1147C>T, -318C>T, 49A>G (human)
DNA:polymorphisms:promoter, exon:-318C>T 49A>G (human)		 CTD
RGD		 PMID:28807506 PMID:15871446 PMID:11726402 PMID:15316504 PMID:19895365 More... RGD:4891529, RGD:11344922, RGD:4891519, RGD:4891526, RGD:4891510, RGD:4891521, RGD:4891522, RGD:4891514, RGD:4891528, RGD:4891517, RGD:4891516, RGD:4891527 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Ctnna3 catenin alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19187332 NCBI chr10:63,265,877...64,841,174
Ensembl chr10:63,265,877...64,839,446 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:plasma RGD PMID:14657873 RGD:4891906 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 no_association IMP
ISO		 DNA:SNPs: :p.V249I, rs2669849 (human)
DNA:polymorphisms: :p.V249I, p.T280M (human)		 RGD PMID:21037587 PMID:17082760 PMID:17505143 RGD:4891882, RGD:4891895, RGD:4891904 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 severity ISO RGD PMID:20371397 RGD:5134983 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO
IMP		 protein:decreased expression:plasma RGD PMID:17302903 PMID:16602032 PMID:11994485 RGD:5135439, RGD:5135457, RGD:5135452 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21150878 NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP mRNA:increased expression:lung RGD PMID:20045013 RGD:5129686 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 severity ISO RGD PMID:20371397 RGD:5134983 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 ISO
IEP		 mRNA:increased expression:bronchus epithelium RGD PMID:17234659 PMID:9620668 RGD:5135243, RGD:5135265 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 IMP RGD PMID:15210824 RGD:5135447 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 susceptibility
severity		 IEP
ISO		 DNA:SNP:intron:IVS1+234G>A (human)
protein:decreased expression:respiratory system fluid/secretion, T cell		 RGD PMID:18094012 PMID:16043121 PMID:16548899 PMID:17641057 RGD:4892088, RGD:5143934, RGD:5143932, RGD:5135484 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide susceptibility ISO DNA:polymorphism: :-930A>G (human)
DNA:SNPs: :-930A>G, 242C>T, 640A>G (human)		 RGD PMID:19459419 PMID:18716406 RGD:4311041, RGD:4772770 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA, protein:increased expression, decreased activity:lung RGD PMID:12415424 RGD:4892074 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO DNA:polymorphism: :1934G>A (human) RGD PMID:19575027 RGD:5143944 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP		 mRNA:decreased expression:leukocyte
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28807506 PMID:20514434 PMID:17081494 RGD:4892076, RGD:4892220 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 no_association
severity		 ISO
IMP		 DNA:SNPs:promoter, exon:multiple (human)
DNA:SNPs:promoter:-634C>T, -475A>C, -336A>G (human)
DNA:SNP: :927T>C (human)
mRNA, protein:increased expression:respiratory system mucosa 		RGD PMID:16771777 PMID:16630147 PMID:16776674 PMID:8087328 PMID:11591188 More... RGD:4889116, RGD:4784257, RGD:4782072, RGD:4888514, RGD:4848936, RGD:4781742, RGD:4781449, RGD:4843543, RGD:4847129 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO DNA:polymorphism: :601A>G (human)
DNA:polymorphism: :-1220A>C (human)		 RGD PMID:15475736 PMID:15454733 RGD:5144002, RGD:5144003 NCBI chr14:73,263,043...73,286,554
Ensembl chr14:73,263,043...73,286,554 		JBrowse link
G Dcn decorin ISO RGD PMID:16387756 RGD:2311423 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005 		JBrowse link
G Defb1 defensin beta 1 susceptibility ISO DNA:SNP: :-1816 T>C (human)
DNA:SNPs:5' utr:g.-52G>A, g.-44C>G, g.-20G>A (human)		 RGD PMID:15696078 PMID:16435024 RGD:4892263, RGD:4892254 NCBI chr 8:22,266,571...22,285,201
Ensembl chr 8:22,266,615...22,285,201 		JBrowse link
G Dnah5 dynein, axonemal, heavy chain 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21912604 NCBI chr15:28,155,000...28,472,191
Ensembl chr15:28,203,898...28,472,198 		JBrowse link
G Dnmt1 DNA methyltransferase 1 IEP
ISO		 DNA,mRNA:hypermethylation,decreased expression:promoter,respiratory tract:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:23423710 PMID:23196709 RGD:9588646 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Dpp10 dipeptidylpeptidase 10 ISO DNA:SNPs (human)
DNA:SNP:exon (human)
protein:increased expression:bronchus
DNA:SNP: :rs10208402 (human)		 RGD
GAD		 PMID:21103062 PMID:15118671 PMID:14566338 PMID:17967935 PMID:19672052 RGD:4889866, RGD:1331525, RGD:4892276, RGD:4892278, RGD:4892275 NCBI chr 1:123,259,871...124,773,774
Ensembl chr 1:123,249,200...124,773,776 		JBrowse link
G Ear1 eosinophil-associated, ribonuclease A family, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8874658 PMID:12153692 PMID:12587966 NCBI chr14:44,056,222...44,057,096
Ensembl chr14:44,056,222...44,112,974 		JBrowse link
G Ebi3 Epstein-Barr virus induced gene 3 IMP RGD PMID:21255010 RGD:5128488 NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022 		JBrowse link
G Edn1 endothelin 1 ISO DNA:transition:intron:g.4124T>C (human)
CTD Direct Evidence: marker/mechanism
Severe Persistent Allergic Asthma; protein:increased secretion:lung (human)		 CTD
RGD		 PMID:16981460 PMID:11668616 PMID:20588001 RGD:4144869, RGD:4144895 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:18632188 PMID:17448648 RGD:4892288, RGD:4892322 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093 		JBrowse link
G Ednrb endothelin receptor type B IMP
ISO		 DNA:polymorphism (human)
mRNA:increased expression:bronchus, smooth muscle cell		 RGD PMID:18632188 PMID:17470272 PMID:15245576 RGD:4892288, RGD:4892321, RGD:4892324 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Egfr epidermal growth factor receptor severity IMP
ISO
IEP		 protein:increased expression:bronchial epithelium (human)
protein:increased expression:lung epithelium (mouse)
protein:increased expression:lung epithelium (rat)		 RGD PMID:21224214 PMID:12580917 PMID:21072743 PMID:19954006 RGD:5131633, RGD:5131468, RGD:5131642, RGD:5131870 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egr1 early growth response 1 IMP
ISO		 mRNA:increased expression:bronchoalveolar lavage cell (human)
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)		 RGD PMID:11254538 PMID:18774390 PMID:18507785 RGD:5131985, RGD:5130915, RGD:5131993 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Elp1 elongator complex protein 1 no_association ISO RGD PMID:11281413 PMID:12774215 RGD:5129157, RGD:5129158 NCBI chr 4:56,746,547...56,802,565
Ensembl chr 4:56,749,680...56,802,331 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal susceptibility ISO DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human) RGD PMID:17711870 RGD:4889407 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Epx eosinophil peroxidase severity
disease_progression		 ISO protein:increased activity:sputum,nasal,pharyngeal mucosa RGD PMID:26645423 PMID:12199967 PMID:20813885 RGD:11574908, RGD:13506892, RGD:13506891 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362 		JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO mRNA:decreased expression:lung (rat) RGD PMID:18375789 RGD:8694127 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F2 coagulation factor II ISO protein:increased expression:plasma
associated with Rhinosinusitis, associated with Nasal Polyps;protein:increased expression:nasal mucus		 RGD PMID:21658190 PMID:21711961 RGD:5147753, RGD:5147783 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO RGD PMID:19864598 RGD:4892589 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G F7 coagulation factor VII treatment ISO RGD PMID:24523826 RGD:11040539 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:eosinophil RGD PMID:16337971 RGD:1600350 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide severity ISO Asthma symptoms persistent despite steroids in humans
Fatal asthma subjects		 RGD PMID:20937062 PMID:21388666 RGD:5128717, RGD:5128711 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb IMP RGD PMID:20179765 RGD:11344929 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G Fcgr4 Fc receptor, IgG, low affinity IV susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human) RGD PMID:18199088 RGD:5508449 NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330 		JBrowse link
G Fga fibrinogen alpha chain treatment ISO RGD PMID:24523826 RGD:11040539 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Fkbp5 FK506 binding protein 5 ISO ClinVar Annotator: match by term: Asthma ClinVar NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Foxp3 forkhead box P3 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27965764 PMID:29317916 PMID:28944907 PMID:27633092 RGD:38549365, RGD:38548920 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gata3 GATA binding protein 3 ISO RGD PMID:9949310 PMID:18186587 RGD:5128802, RGD:5128803 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gc vitamin D binding protein IMP
ISO		 protein, mRNA:increased expression:bronchoalveolar lavage fluid: RGD PMID:21169467 PMID:21169467 RGD:5509920, RGD:5509920 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) susceptibility ISO DNA:polymorphism:promoter: -69C>T (human) RGD PMID:20374258 RGD:5490988 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 resistance
susceptibility		 ISO DNA:deletion: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16870661 PMID:18988661 PMID:17651144 PMID:21051083 PMID:11075422 RGD:4142509, RGD:5490962, RGD:4140921 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm3 glutathione S-transferase, mu 3 ISO DNA:polymorphism RGD PMID:11470996 PMID:17550934 RGD:5135039, RGD:5135038 NCBI chr 3:107,871,019...107,876,484
Ensembl chr 3:107,871,012...107,876,599 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 ISO DNA:polymorphism RGD PMID:11470996 PMID:17550934 RGD:5135038 RGD:5135039 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 susceptibility ISO DNA:polymorphism:exon:p. N142D (human) RGD PMID:20374258 RGD:5490988 NCBI chr19:47,853,879...47,874,747
Ensembl chr19:47,853,973...47,874,763 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 severity
susceptibility
disease_progression
no_association		 ISO
IAGP		 DNA:polymorphism:exon:p.I105V (rs1695) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human)
DNA:SNPs:intron,exon:(rs749174), (rs1138272)(human)
DNA:SNPs: :p.I105V, p.A114V (human)
DNA:polymorphism:exon:p.I105V (human)
DNA:SNP: :p.A114V (human)		 CTD
RGD		 PMID:11994713 PMID:16870661 PMID:18988661 PMID:24117884 PMID:29411558 More... RGD:4142526, RGD:5490999, RGD:5490991, RGD:5490985, RGD:4140951, RGD:4142519, RGD:4140947, RGD:4140946 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 susceptibility ISO DNA:deletion: : RGD PMID:15300848 PMID:21051083 PMID:11075422 RGD:4142539, RGD:5490962, RGD:4140921 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphisms (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human) 		CTD
RGD		 PMID:10792356 PMID:12890388 PMID:10051703 PMID:11802952 PMID:19052351 RGD:5147799, RGD:1331670, RGD:5147831, RGD:5147617 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility
disease_progression
no_association		 ISO Alternaria sensitive asthma
DNA:polymorphisms: :
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms (human)		 CTD
RGD		 PMID:10792356 PMID:20298583 PMID:20159242 PMID:20214848 PMID:23331206 More... RGD:4144113, RGD:13506913, RGD:4144181, RGD:13506906, RGD:5147831, RGD:5147799, RGD:5147617 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha susceptibility ISO DNA:polymorphisms: : RGD PMID:20159242 RGD:13506913 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility
no_association
severity		 ISO DNA:polymorphisms: :
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human) 		CTD
RGD		 PMID:16792590 PMID:19528258 PMID:20159242 PMID:23331206 PMID:10051703 More... RGD:4144196, RGD:13506913, RGD:13506906, RGD:1331670, RGD:5147663, RGD:5147607, RGD:4144181 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 susceptibility ISO DNA:polymorphism: RGD PMID:28380482 RGD:13506910 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 susceptibility ISO CTD Direct Evidence: marker/mechanism CTD
OMIM
RGD		 PMID:15611928 RGD:5144118 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G H2-Pa histocompatibility 2, P region alpha locus susceptibility ISO DNA:polymorphism: : RGD PMID:21814517 RGD:13506911 NCBI chr17:34,303,587...34,304,826
Ensembl chr17:34,303,575...34,304,797 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO RGD PMID:20628202 RGD:5128851 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 IMP RGD PMID:17517968 RGD:5135525 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Hc hemolytic complement severity IEP
ISO
IAGP		 mRNA:decreased expression:lung RGD PMID:10973279 PMID:15278436 PMID:20143644 PMID:11591795 PMID:20802484 RGD:5130158, RGD:5129512, RGD:5129706, RGD:1600651, RGD:5129681 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450 		JBrowse link
G Hdac2 histone deacetylase 2 ISO mRNA:decreased expression:macrophage: RGD PMID:20538962 RGD:9590321 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdc histidine decarboxylase ISO associated with Rhinitis;DNA:SNP: :p.E644D (rs2073440) (human) RGD PMID:20608921 RGD:5128884 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment IEP RGD PMID:18160846 RGD:10402541 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase ISO RGD PMID:20084838 RGD:5508450 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 severity IDA
ISO		 CTD Direct Evidence: marker/mechanism
mRNA;protein:increased expression:Leukocytes, Mononuclear		 CTD
RGD		 PMID:18048809 PMID:20596599 PMID:16196283 RGD:4145403, RGD:4145408 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnmt histamine N-methyltransferase no_association
susceptibility		 ISO ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD
RGD		 PMID:10752634 PMID:10803682 PMID:16205835 PMID:17651147 PMID:25741868 More... RGD:5128888, RGD:5128883, RGD:5128885, RGD:5128881, RGD:5128887 NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406 		JBrowse link
G Hp haptoglobin ISO RGD PMID:21471098 PMID:21169467 RGD:5144151, RGD:5509920 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11932298 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25322896 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO
IEP		 protein:increased expression:lung, serum (rat)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:aorta (mouse)
protein:increased secretion:lung (human)		 CTD
RGD		 PMID:17014439 PMID:25003170 PMID:20953388 PMID:20400685 PMID:20205697 RGD:4145331, RGD:4145444, RGD:4145509 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma treatment
resistance		 IDA
IMP
ISO		 protein:increased expression:sputum RGD
GAD		 PMID:19542437 PMID:12396623 PMID:15118671 PMID:20953328 PMID:20817868 RGD:5128479, RGD:10755706, RGD:1331525, RGD:4145525, RGD:4145651 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IAGP
ISO		 DNA: SNP: Leu467Pro RGD PMID:21737883 PMID:12851715 RGD:6480255, RGD:6480431 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Ifnl2 interferon lambda 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22295096 NCBI chr 7:28,208,209...28,209,957
Ensembl chr 7:28,208,261...28,209,880 		JBrowse link
G Ikzf3 IKAROS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25256354 NCBI chr11:98,355,436...98,437,157
Ensembl chr11:98,355,728...98,436,857 		JBrowse link
G Il10 interleukin 10 treatment
susceptibility		 ISO
IMP
IEP		 CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :-627C>A (human)
protein:decreased expression:plasma		 CTD
RGD		 PMID:29317916 PMID:20560982 PMID:21998459 PMID:20237464 PMID:20644177 More... RGD:5131623, RGD:11046261, RGD:4140471, RGD:4140459, RGD:4143221, RGD:4140451, RGD:4140421 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12a interleukin 12a IMP RGD PMID:17056578 PMID:17548618 RGD:4438438, RGD:4373570 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b severity
susceptibility		 ISO DNA:polymorphisms:introns:
ClinVar Annotator: match by term: Asthma, susceptibility to
DNA:polymorphisms:promoter, 3'utr:
DNA:polymorphism:promoter		 ClinVar
RGD		 PMID:15322986 PMID:15322986 PMID:16210052 PMID:12241719 RGD:1600043, RGD:4145438, RGD:4145428 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il13 interleukin 13 susceptibility
severity
no_association		 IMP
ISO
IDA
IEP		 ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism
associated with Dermatitis, Atopic;DNA, protein:SNP, increased expression:promoter, serum:-1112C>T (human)
DNA:polymorphism: :-1512A>C, -1112C>T, 2044G>A (human)
mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid
protein:increased expression:serum
DNA:polymorphism:cds:p.R130Q (human)
DNA:polymorphisms:promoters,exon4: rs1881457, rs1800925, rs20541 (human)
DNA:polymorphism: :p. R110Q (human)
DNA:SNP: :c. -646A>G (human)
protein:increased expression:sputum
DNA:polymorphism: :c. 1923C>T (human)
DNA:polymorphism:promoter:c. -1055C>T (human)
DNA:polymorphisms: :rs20541, rs1295685(human)
DNA:polymorphism:3'utr:c.4738G>A (human)
DNA:polymorphism: :c.-1055C>T (human)
DNA:polymorphism: :c. 2044G>A (human)		 ClinVar
OMIM
CTD
RGD		 PMID:10699178 PMID:11588017 PMID:11709756 PMID:12847555 PMID:12928861 More... RGD:4206706, RGD:8549509, RGD:4892639, RGD:2301686, RGD:4145664, RGD:4145453, RGD:4145508, RGD:2307110, RGD:4763153, RGD:4763761, RGD:4145601, RGD:4145639, RGD:4321828, RGD:4146241, RGD:4145777, RGD:4145775, RGD:4220633, RGD:4145534, RGD:4765128, RGD:4145593, RGD:4145776 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 no_association IDA
ISO
IMP
IEP		 DNA:polymorphism: :1398A>G (human)
DNA:polymorphisms:promoter, 3' utr:-281T>G, 1365A>G (human)
DNA:polymorphism: :1050C>T (human)
mRNA:increased expression:bronchus		 RGD PMID:11714828 PMID:17006604 PMID:17392323 PMID:10686479 PMID:18480254 More... RGD:4892654, RGD:4892639, RGD:4892650, RGD:4892655, RGD:4892647, RGD:4892646 NCBI chr  X:35,375,761...35,434,915
Ensembl chr  X:35,375,763...35,434,912 		JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 IMP
ISO
IEP		 protein:increased expression:serum
mRNA:increased expression:bronchus		 RGD PMID:17885690 PMID:21462799 PMID:20383033 RGD:4892649, RGD:8549521, RGD:4892646 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188 		JBrowse link
G Il15 interleukin 15 no_association IMP
ISO		 DNA:SNPs: :multiple (human) RGD PMID:15843549 PMID:16629787 PMID:11160248 PMID:15131572 PMID:19133918 RGD:5000757, RGD:4984421, RGD:4990462, RGD:5000758, RGD:5000760 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il16 interleukin 16 no_association
severity		 IMP
ISO		 DNA:SNP:promoter:-295T>C (human)
protein:increased expression:serum
associated with Rhinitis;protein:increased expression:respiratory system fluid/secretion		 RGD PMID:10585533 PMID:15784111 PMID:16387589 PMID:12872394 PMID:16734115 RGD:5024937, RGD:5024935, RGD:5024934, RGD:5024930, RGD:5024928 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Il17a interleukin 17A susceptibility ISO
IMP		 mRNA,protein:increased expression:Leukocytes, Mononuclear, lung, serum
protein:increased expression:sputum
protein:increased expression:alveolar macrophage
DNA:SNP:promoter:rs2275913 (human)		 RGD PMID:18060619 PMID:20351038 PMID:15730730 PMID:18941201 PMID:20437253 RGD:4839043, RGD:4888527, RGD:4889114, RGD:4889152, RGD:4889139 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il17rb interleukin 17 receptor B IMP associated with Picornaviridae Infections RGD PMID:25273095 RGD:39128256 NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853 		JBrowse link
G Il18 interleukin 18 severity
susceptibility
disease_progression		 ISO
IMP		 DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human)
DNA:SNP:promoter:c.and -137G>C (rs187238)(human)
protein:increased expression:serum
DNA:SNP:promoter: c.-380C>G (rs5744247)(human)
DNA:polymorphism: :c. -105A>C (human)		 RGD PMID:17767553 PMID:20497957 PMID:16433859 PMID:18826499 PMID:11174201 More... RGD:4889585, RGD:4889898, RGD:4889923, RGD:4889908, RGD:4889863, RGD:4889898, RGD:4889900, RGD:4889910 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il18r1 interleukin 18 receptor 1 ISO
IEP		 DNA:SNP: :rs3771166 (human)
DNA:SNPs: :multiple (human)		 RGD PMID:19910030 PMID:20860503 PMID:18382474 PMID:11972614 PMID:18774397 RGD:5024945, RGD:5024942, RGD:5024947, RGD:5024948, RGD:5024946 NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014 		JBrowse link
G Il19 interleukin 19 IEP mRNA, protein:increased expression:lung, serum RGD PMID:15557163 RGD:5037236 NCBI chr 1:130,860,393...130,873,194
Ensembl chr 1:130,860,393...130,867,852 		JBrowse link
G Il1a interleukin 1 alpha ISO DNA:polymorphisms: : RGD PMID:18763028 RGD:4142802 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta susceptibility IDA
ISO		 CTD Direct Evidence: marker/mechanism
protein:decreased expression:neutrophil
DNA:polymorphism: :-511C>T (human)		 CTD
RGD		 PMID:9176529 PMID:19684087 PMID:19842845 PMID:18926055 RGD:4142836, RGD:4142830, RGD:4142864 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 susceptibility
severity		 IEP
ISO
IMP		 protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs1420101 (human)
DNA:SNPs:intron:rs1420089, rs1861245,rs1946131 (human)
DNA:SNP: :rs10197862 (human)
DNA:SNP: :rs1041973 (human)		 CTD
RGD		 PMID:19198610 PMID:21150878 PMID:21804549 PMID:24241537 PMID:27472835 More... RGD:5144235, RGD:5144245, RGD:5144244, RGD:5144243, RGD:5144242, RGD:5144240, RGD:5144239, RGD:5144237 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility
severity		 ISO DNA:SNP: :rs2234678 (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
DNA:SNPs: :rs447713, rs3087271 (human)
protein:increased expression:plasma
DNA, protein:repeat, decreased expression (human)
DNA:polymorphism:intron (human)		 CTD
RGD		 PMID:9176529 PMID:17107994 PMID:15020290 PMID:16409203 PMID:16724092 More... RGD:4143208, RGD:4143216, RGD:4143163, RGD:4143209, RGD:4143225, RGD:4143224, RGD:4142864, RGD:4142802 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il2 interleukin 2 susceptibility ISO DNA:SNP:promoter:rs2069762(human) RGD PMID:20926789 PMID:16333313 RGD:4889118, RGD:8663473 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il21 interleukin 21 ISO DNA:SNP:exon:5250C>T (human) RGD PMID:18802358 RGD:5147396 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il22 interleukin 22 treatment
severity		 IMP
ISO		 mRNA:increased expression:blood, mononuclear cell
protein:increased expression:serum		 RGD PMID:21789181 PMID:21998459 PMID:21535180 PMID:21297073 RGD:5147401, RGD:11046261, RGD:5147409, RGD:5147403 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952 		JBrowse link
G Il22b interleukin 22B severity ISO protein:increased expression:serum
mRNA:increased expression:blood, mononuclear cell		 RGD PMID:21297073 PMID:21535180 RGD:5147403 RGD:5147409 NCBI chr10:118,125,534...118,130,943
Ensembl chr10:118,125,534...118,130,943 		JBrowse link
G Il23r interleukin 23 receptor IMP RGD PMID:19935773 RGD:5037240 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839 		JBrowse link
G Il25 interleukin 25 IEP mRNA, protein:increased expression:lung RGD PMID:25273095 RGD:39128256 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294 		JBrowse link
G Il27 interleukin 27 treatment
susceptibility		 IDA
IMP
ISO		 protein:increased expression:sputum
DNA:SNP: :g.-964A>G (human)		 RGD PMID:17878337 PMID:26595888 PMID:20817868 PMID:17318299 PMID:19542437 RGD:5128491, RGD:11076728, RGD:4145651, RGD:5128485, RGD:5128479 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Il27ra interleukin 27 receptor, alpha IMP RGD PMID:16081811 RGD:5128496 NCBI chr 8:84,756,915...84,769,250
Ensembl chr 8:84,756,923...84,769,218 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain IMP RGD PMID:21377197 PMID:20525707 RGD:5147437, RGD:5147445 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain ISO
IMP		 DNA:SNP: :rs2284033 (human) RGD PMID:20860503 PMID:18641329 RGD:5024942, RGD:5147447 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human)
DNA:polymorphism:cds:+79T>C(S27P)(human)		 RGD PMID:24684517 PMID:15372320 RGD:13506914, RGD:13506916 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il33 interleukin 33 treatment
severity		 ISO
IMP		 CTD Direct Evidence: marker/mechanism
associated with viral pneumonia;
associated with fungal infectious disease		 CTD
RGD		 PMID:19198610 PMID:21804549 PMID:24241537 PMID:27472835 PMID:29067999 More... RGD:39939002, RGD:39938968 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Il4 interleukin 4 treatment
no_association		 IMP
ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA, protein:increase expression:leukocyte, serum
protein:increased expression:lung
DNA:SNP: :589C>T (human)
DNA:polymorphism (human)
mRNA:increased expression:lung, spleen
protein:increased expression:respiratory system fluid/secretion		 CTD
RGD		 PMID:18357729 PMID:21375458 PMID:24946644 PMID:24450480 PMID:18211752 More... RGD:5128557, RGD:10402799, RGD:10402791, RGD:2317290, RGD:5128560, RGD:4889866, RGD:5128500, RGD:5128502 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il4ra interleukin 4 receptor, alpha susceptibility
severity
disease_progression		 ISO
IAGP
IMP		 DNA:polymorphism:cds:p.Q551R (human)
OMIM:600807
DNA:polymorphism:cds:p.I50V (human)
DNA:polymorphism::-1902G/A (human)
DNA:SNPs: :multiple
DNA:SNPs:cds:p. I75V, Q576R (human)
protein:increased secretion:plasma|DNA:polymorphism:promoter:c.-3223C>T (human)
DNA:SNPs:cds:p.E375A, Q551R (human)
DNA:polymorphism:cds:p.Q576R (human)
DNA:polymorphism:cds:p. S478P (human)
DNA:mutation:cds:p.Q576R (mouse)		 MouseDO
RGD		 PMID:17586032 PMID:18425216 PMID:20868478 PMID:17823973 PMID:11398072 More... RGD:4890348, RGD:4890346, RGD:4890387, RGD:4890347, RGD:4890406, RGD:4890404, RGD:4890351, RGD:4890349, RGD:4890402, RGD:4890024, RGD:5128514, RGD:5128553, RGD:4890003, RGD:4890352 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Il5 interleukin 5 treatment
disease_progression		 IEP
ISO
IMP		 protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism
protein:increased expression:lungs, respiratory system fluid/secretion
protein: increased levels: sputum
DNA:polymorphism:promoter:-703C>T (human)		 CTD
RGD		 PMID:7540862 PMID:23266719 PMID:15626484 PMID:25008888 PMID:11159041 More... RGD:4890947, RGD:11354973, RGD:5687189, RGD:5687144, RGD:5687140, RGD:4890948, RGD:4890963, RGD:4145461, RGD:4890962, RGD:4890940, RGD:4890938 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il5ra interleukin 5 receptor, alpha IMP
ISO		 DNA:SNP: :c.25091G>A (human)
DNA:SNPs (human)		 RGD PMID:10848907 PMID:20592918 PMID:17276963 PMID:10224351 PMID:16217591 More... RGD:5128627, RGD:5128614, RGD:5128617, RGD:5128623, RGD:5128626, RGD:5128625 NCBI chr 6:106,687,336...106,725,998
Ensembl chr 6:106,687,318...106,725,998 		JBrowse link
G Il6 interleukin 6 IDA
ISO		 CTD Direct Evidence: marker/mechanism
associated with Hypersensitivity;protein:increased expression:sputum
protein:increased expression:lung		 CTD
RGD		 PMID:29902480 PMID:21115736 PMID:20840469 PMID:20816188 PMID:20658762 RGD:5128630, RGD:4143265, RGD:4143266, RGD:4143271 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha IMP
ISO
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29902480 PMID:17496315 PMID:21115736 RGD:5128662, RGD:5128630 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Il9 interleukin 9 ISO
IMP
IEP		 protein:increased expression:respiratory system fluid/secretion
protein:increased expression:sputum, macrophage, cytoplasm		 RGD PMID:21356110 PMID:17446528 PMID:15531759 PMID:15303135 PMID:12153980 RGD:5128707, RGD:5128686, RGD:5128690, RGD:5128691, RGD:5128700 NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059 		JBrowse link
G Il9r interleukin 9 receptor ISO RGD PMID:10629460 RGD:5128704 NCBI chr11:32,137,544...32,155,283
Ensembl chr11:32,137,541...32,150,279 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 susceptibility ISO ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 5 ClinVar
OMIM		 PMID:17503328 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Irf1 interferon regulatory factor 1 no_association
susceptibility		 ISO DNA:polymorphisms:promoter, cds:-300G>T, 4396A>G, 6355G>A (human)
DNA:repeat:intron (human)
protein:increased expression:respiratory tract epithelium		 RGD PMID:11069564 PMID:16961714 PMID:10225979 RGD:5128726, RGD:5128724, RGD:5128723 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Irf3 interferon regulatory factor 3 IMP RGD PMID:20673978 RGD:5128793 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Itgb3 integrin beta 3 ISO DNA:SNPs: : RGD PMID:17556058 RGD:5037230 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Itgb6 integrin beta 6 IAGP OMIM:600807 MouseDO NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 ISO RGD PMID:21777465 RGD:5147661 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Kdr kinase insert domain protein receptor IMP
ISO		 associated with Rhinitis,Allergic,Seasonal;protein:increased expression:nasal cavity of mucosa: RGD PMID:20921519 PMID:17651148 RGD:5684385, RGD:8551771 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Kif3a kinesin family member 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21912604 NCBI chr11:53,456,531...53,495,075
Ensembl chr11:53,458,206...53,492,794 		JBrowse link
G Krt19 keratin 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15478392 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491 		JBrowse link
G Lep leptin ISO protein:increased expression:plasma RGD PMID:19705789 RGD:5128781 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 treatment ISO RGD PMID:16424226 RGD:9685213 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Lta lymphotoxin A susceptibility
no_association		 ISO DNA:polymorphisms:promoter
DNA:polymorphism:intron		 RGD PMID:15969671 PMID:18947013 PMID:17536219 PMID:12530118 RGD:4143373, RGD:4143370, RGD:4143371, RGD:4143254 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO mRNA:increased expression:lung, cerebral cortex (rat) RGD PMID:15715933 RGD:2316607 NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility ISO associated with Bronchiolitis;DNA:polymorphism:exon:
DNA:SNP:cds:p.G54D(human)		 RGD PMID:22512728 PMID:22674410 RGD:8693709, RGD:12910828 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mefv Mediterranean fever susceptibility ISO DNA:mutations:exons RGD PMID:18219832 RGD:5129186 NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) severity ISO
IMP		 protein:increased expression:bronchoalveolar lavage fluid
DNA:SNP:promoter:rs755622(human)
DNA:repeats:promoter		 RGD PMID:9637721 PMID:19317738 PMID:17373669 PMID:16186482 PMID:16455830 RGD:4891043, RGD:4891059, RGD:4891035, RGD:4891052, RGD:1641985 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Mmp10 matrix metallopeptidase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16926187 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) ISO CTD Direct Evidence: marker/mechanism CTD PMID:24469321 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
DNA:SNP: : rs2664538(human)
mRNA, protein:increased expression:lung		 CTD
RGD		 PMID:11742282 PMID:15131573 PMID:21439806 PMID:19361849 PMID:20181264 More... RGD:5129204, RGD:5129687, RGD:5130859, RGD:2325953, RGD:5129522 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase susceptibility ISO DNA:polymorphism: :−463G > A (human)
protein:increased expression:serum		 RGD PMID:19544176 PMID:10731862 RGD:5130989, RGD:5130994 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 susceptibility ISO DNA:SNPs:multiple:, rs573790, rs2583476, rs569108
DNA:SNPs: : rs556917, rs502581, rs502419 (human)
DNA:SNP: : -109C>T (human)
Atopy and bronchial hyperresponsiveness, OMIM:147050		 RGD PMID:19218813 PMID:21320344 PMID:19862939 PMID:8817330 RGD:5131151, RGD:5131149, RGD:5131092, RGD:1599903 NCBI chr19:11,592,881...11,601,154
Ensembl chr19:11,592,887...11,601,083 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:transition:cds:g.677C>T (human) RGD PMID:20456312 RGD:4891145 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Muc1 mucin 1, transmembrane ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Muc2 mucin 2 ISO
IEP		 associated with hypersensitivity RGD PMID:11062147 PMID:14594655 RGD:5131178, RGD:7349354 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric treatment ISO
IDA
IEP		 protein:increased expression:lung
mRNA, protein:increased expression:lung
mRNA,protein:increased expression:lung		 RGD PMID:17698377 PMID:21549818 PMID:21780541 PMID:14594655 PMID:17590487 RGD:5131204, RGD:7364729, RGD:7349407, RGD:7349354, RGD:2324962 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Muc5b mucin 5, subtype B, tracheobronchial ISO
IEP		 protein:altered expression:sputum RGD PMID:11802783 PMID:11587997 RGD:5131252, RGD:7364763 NCBI chr 7:141,392,796...141,426,826
Ensembl chr 7:141,392,807...141,426,821 		JBrowse link
G Myb myeloblastosis oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19198610 NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 ameliorates IMP RGD PMID:26882889 RGD:11531666 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Mylk myosin, light polypeptide kinase ISO RGD PMID:17472811 RGD:4891492 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) susceptibility ISO DNA:polymorphisms: :
Asthma, Aspirin-Induced; DNA:polymorphism: :		 RGD PMID:16924569 PMID:20602614 RGD:5131606, RGD:5131600 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 severity ISO mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human) RGD PMID:21514635 RGD:6893376 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngf nerve growth factor severity ISO
IEP		 protein:increased expression:blood, eosinophil
protein:increased expression:lung, serum		 RGD PMID:12752594 PMID:17164945 PMID:11737043 PMID:17497413 RGD:4891122, RGD:4891108, RGD:4891123, RGD:4891068 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) IMP RGD PMID:16603479 PMID:12540484 RGD:5144070, RGD:5144072 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 susceptibility ISO DNA:SNP: :rs2075817 (human)
DNA:insertion:cds:		 RGD PMID:16918516 PMID:15718249 RGD:5131519, RGD:5131518 NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO
IDA		 DNA:polymorphisms:intron, exon/3'UTR (rs1077861, rs3135500) (human) RGD PMID:16008671 PMID:21051079 RGD:5131477, RGD:5508757 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal susceptibility ISO DNA:repeats:exon
DNA:repeats:intron
DNA:repeats: :		 RGD PMID:10833424 PMID:14767694 PMID:10673365 PMID:20609134 RGD:5132860, RGD:5132615, RGD:5132869, RGD:5132863 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible severity
disease_progression
no_association		 IMP
ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression, increased activity:lung (rat)
DNA:repeats:promoter
protein:increased expression:lung, bronchoalveolar lavage fluid
associated with Rhinitis, Allergic, Seasonal; protein:increased expression:nasal mucosa
DNA:repeats:promoter, introns (human)
DNA:SNP:exon:p.S608L (human)
mRNA:increased expression:monocyte
DNA:repeat:promoter		 CTD
RGD		 PMID:19800904 PMID:20841959 PMID:21847581 PMID:18714530 PMID:17161822 More... RGD:4891480, RGD:5509073, RGD:4891508, RGD:4891927, RGD:4891910, RGD:4891924, RGD:4891925, RGD:4891419, RGD:4891957, RGD:4891953 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell susceptibility ISO DNA:snps, repeat, haplotype:promoter, introns, exons:multiple (human)
DNA:polymorphisms:promoter:c. -786C>T, -691C>T (human)
DNA:repeats:intron		 RGD PMID:18486767 PMID:16837812 PMID:16081038 RGD:4892053, RGD:4892058, RGD:4892062 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Npsr1 neuropeptide S receptor 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2		 OMIM
CTD
ClinVar
RGD		 PMID:15073379 PMID:15710598 PMID:15764725 PMID:16926187 PMID:15073379 More... RGD:4891921, RGD:4891922, RGD:4891923 NCBI chr 9:24,009,212...24,229,151
Ensembl chr 9:24,009,292...24,227,694 		JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:9731035 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 susceptibility ISO DNA:SNP:exon:c. 609C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:exon:c.609C>T (human)		 CTD
RGD		 PMID:20049212 PMID:19027876 PMID:19591959 RGD:5135006, RGD:5135005 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment
susceptibility
severity		 ISO DNA:polymorphism:intron
protein:increased expression, decreased activity:leukocyte, mononuclear		 RGD PMID:18396779 PMID:28297812 PMID:20727335 PMID:21113676 PMID:18799869 More... RGD:4892328, RGD:408364991, RGD:7174728, RGD:4892568, RGD:4892594, RGD:4892609 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Ntf3 neurotrophin 3 IEP
ISO		 protein:increased expression:lung, serum RGD PMID:17497413 PMID:11737043 RGD:4891068, RGD:4891123 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntf5 neurotrophin 5 IEP protein:increased expression:lung, serum RGD PMID:17497413 RGD:4891068 NCBI chr 7:45,063,119...45,066,603
Ensembl chr 7:45,063,119...45,066,603 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 IMP
ISO		 mRNA:increased expression:lung: RGD PMID:20934630 PMID:16708804 RGD:5684766, RGD:5684772 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Ormdl3 ORM1-like 3 (S. cerevisiae) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21150878 PMID:25256354 NCBI chr11:98,472,120...98,478,071
Ensembl chr11:98,472,082...98,478,194 		JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 ISO
IMP		 RGD PMID:22010907 PMID:19822647 RGD:6480532, RGD:6480533 NCBI chr 3:59,123,692...59,170,408
Ensembl chr 3:59,123,693...59,170,292 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 treatment IMP
ISO		 CTD Direct Evidence: marker/mechanism
protein:increased activation:lung, blood, mononuclear cell		 CTD
RGD		 PMID:18261157 PMID:12594058 PMID:26205779 PMID:26205779 RGD:5683910, RGD:11073727, RGD:11073727 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdcd1 programmed cell death 1 treatment IMP associated with Chlamydia pneumonia RGD PMID:26378990 RGD:41412180 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:21912604 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:19426955 PMID:21611147 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide IEP
ISO		 protein: increased expression RGD PMID:21216974 PMID:21216974 RGD:6483071, RGD:6483071 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pgf placental growth factor IMP RGD PMID:22268141 RGD:6483605 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP RGD PMID:18754810 RGD:6482695 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:18188456 RGD:8693422 NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO RGD PMID:15557087 RGD:1642462 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:10733466 PMID:10733466 RGD:1581025 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21912604 PMID:18519237 RGD:4892037 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO CTD Direct Evidence: marker/mechanism CTD PMID:22205926 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Prf1 perforin 1 (pore forming protein) IMP
ISO		 RGD PMID:22250087 PMID:21426642 RGD:6482815, RGD:6482818 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
G Prg2 proteoglycan 2, bone marrow severity
disease_progression
no_association		 ISO
IMP		 mRNA:increased expression:eosinophil:
associated with cough;protein:increased expression:sputum:
associated with viral infection;mRNA:increased expression:sputum:		 RGD PMID:16982448 PMID:22022864 PMID:24450586 PMID:11067904 RGD:13506941, RGD:13506944, RGD:13506943, RGD:13506942 NCBI chr 2:84,810,805...84,813,977
Ensembl chr 2:84,810,805...84,813,976 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 ISO mRNA:increased expression:lung RGD PMID:20423833 RGD:9491823 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992 		JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 ISO mRNA:increased expression:lung, spleen RGD PMID:20423833 RGD:9491823 NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699 		JBrowse link
G Prmt3 protein arginine N-methyltransferase 3 ISO mRNA:increased expression:lung RGD PMID:20423833 RGD:9491823 NCBI chr 7:49,428,067...49,508,016
Ensembl chr 7:49,428,094...49,508,013 		JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 ISO mRNA:increased expression:lung, spleen RGD PMID:20423833 RGD:9491823 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982 		JBrowse link
G Proc protein C treatment ISO RGD PMID:26381519 RGD:11099992 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Prol1 proline rich, lacrimal 1 ISO ClinVar Annotator: match by term: Asthma, protection against
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:11378823 PMID:16759176 PMID:28492532 NCBI chr 5:88,465,171...88,476,676
Ensembl chr 5:88,465,171...88,476,673 		JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: therapeutic CTD PMID:17982072 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgdr prostaglandin D receptor susceptibility ISO OMIM NCBI chr14:45,088,692...45,096,832
Ensembl chr14:45,088,692...45,096,832 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 ISO
IMP		 Aspirin exacerbated asthma
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27103662 PMID:19796209 PMID:19392992 PMID:18757520 RGD:5135020, RGD:5135019, RGD:5135018 NCBI chr19:10,901,883...10,919,875
Ensembl chr19:10,914,524...10,919,875 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) treatment ISO RGD PMID:23221044 RGD:10043366 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 susceptibility
severity		 ISO
IEP
IMP		 mRNA:increased expression:lung
DNA:SNP: :8473T>C (human)
mRNA, protein:increased expression:lung:
DNA:SNP: :rs689465 (human)		 RGD PMID:19862936 PMID:19878559 PMID:15316498 PMID:17573729 PMID:18097056 More... RGD:5135515, RGD:5135514, RGD:5143931, RGD:5143923, RGD:5135534, RGD:5135526, RGD:5135522 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rad50 RAD50 double strand break repair protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24241537 NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:18391481 RGD:2298885 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Runx1 runt related transcription factor 1 ISO DNA:SNPs: :multiple RGD PMID:21803869 RGD:6482835 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx3 runt related transcription factor 3 IAGP OMIM:600807 MouseDO NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 susceptibility ISO mRNA,protein:decreased expression:bronchial alveolar lavage fluid, lung:
ClinVar Annotator: match by term: Asthma, susceptibility to
associated with allergic rhinitis; DNA:SNP:exon:38G>A (human)
protein:decreased expression:serum		 ClinVar
RGD		 PMID:9550363 PMID:9643286 PMID:12100044 PMID:12921604 PMID:21255142 More... RGD:5144052, RGD:5144226, RGD:5144148 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Scgb3a2 secretoglobin, family 3A, member 2 susceptibility
severity
no_association		 ISO
IEP
IDA		 DNA:SNP:promoter:-112G>A (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Asthma, susceptibility to
mRNA,protein:decreased expression:;lung
protein:increased expression:sputum		 CTD
OMIM
ClinVar
RGD		 PMID:11813133 PMID:11813133 PMID:15531759 PMID:16456148 PMID:17218572 More... RGD:5144229, RGD:5128690, RGD:5144233, RGD:5144232, RGD:5144231, RGD:5144230 NCBI chr18:43,897,346...43,900,464
Ensembl chr18:43,897,354...43,900,464 		JBrowse link
G Sell selectin, lymphocyte IMP RGD PMID:21437035 PMID:21515793 RGD:5685685, RGD:5685696 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 severity
susceptibility
no_association		 ISO protein:increased expression:plasma
DNA:polymorphism:promoter:rs1799768 (human)
protein:increased activity, increased expression:plasma, lung		 RGD PMID:19703828 PMID:19063817 PMID:19604112 PMID:18594148 RGD:4144831, RGD:4144832, RGD:4144833, RGD:4144836 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sftpa1 surfactant associated protein A1 ISO
IEP		 protein:decreased expression:lung, Clara cell, pneumocyte
mRNA, protein:increased expression:lung		 RGD PMID:15816355 PMID:16629790 PMID:18926058 PMID:18802356 RGD:4143398, RGD:4143462, RGD:4143289, RGD:4143516 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B ISO
IEP		 protein:increased expression:lung
mRNA, protein:decreased expression:lung
protein:decreased expression:lung, Clara cell		 RGD PMID:16629790 PMID:11472974 PMID:15816355 PMID:18926058 RGD:4143462, RGD:4143465, RGD:4143398, RGD:4143289 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Sftpc surfactant associated protein C susceptibility ISO
IEP		 DNA:polymorphism: :p.A53T (human)
protein:increased expression:lung
mRNA, protein:decreased expression:lung		 RGD PMID:19910179 PMID:16629790 PMID:11472974 RGD:4144063, RGD:4143462, RGD:4143465 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521 		JBrowse link
G Sftpd surfactant associated protein D ISO
IEP		 mRNA, protein:increased expression:lung
associated with Bronchitis;protein:increased expression:lung		 RGD PMID:18802356 PMID:11472974 PMID:18266831 PMID:16839409 PMID:16629790 RGD:4143516, RGD:4143465, RGD:4143517, RGD:4143508, RGD:4143462 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106 		JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 IAGP RGD PMID:12847242 RGD:5684966 NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221 		JBrowse link
G Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 ISO RGD PMID:17328924 RGD:5686690 NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 ISO RGD PMID:17328924 RGD:5686690 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc5a7 solute carrier family 5 (choline transporter), member 7 ISO mRNA:decreased expression:lung RGD PMID:17328924 RGD:5686690 NCBI chr17:54,580,618...54,606,071
Ensembl chr17:54,580,618...54,606,062 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 susceptibility ISO DNA:repeat:intron (human) RGD PMID:19806585 RGD:4889460 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO CTD Direct Evidence: marker/mechanism CTD PMID:22867017 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO RGD PMID:15743779 RGD:1581231 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sprr2b small proline-rich protein 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:21912604 NCBI chr 3:92,224,012...92,225,448
Ensembl chr 3:92,223,927...92,225,392 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:28807506 PMID:18211752 RGD:2317290 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 treatment ISO RGD PMID:19087723 PMID:16083555 RGD:7244151, RGD:7244153 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Tac1 tachykinin 1 ISO protein:increased expression:lung RGD PMID:11031342 RGD:5147836 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO protein:increased expression:lung
mRNA:increased expression:lung
mRNA,protein:increased expression:lung		 RGD PMID:17392578 PMID:8240667 PMID:16409782 RGD:2304339, RGD:5147645, RGD:5147475 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tacr2 tachykinin receptor 2 ISO DNA:SNP:cds:p.G231E (human) RGD PMID:20175803 PMID:19880429 RGD:5147640, RGD:5147641 NCBI chr10:62,088,217...62,101,769
Ensembl chr10:62,088,217...62,101,769 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO DNA:polymorphism: : RGD PMID:12640628 RGD:5147845 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tbx21 T-box 21 ISO
IAGP		 CTD Direct Evidence: marker/mechanism
OMIM:600807		 CTD
MouseDO		 PMID:15806396 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tbxa2r thromboxane A2 receptor susceptibility
severity		 ISO ClinVar Annotator: match by term: Asthma
DNA:polymorphism:cds:924T>C(human)		 ClinVar
RGD		 PMID:2955539 PMID:7929844 PMID:8428006 PMID:8613548 PMID:15118671 More... RGD:1331525, RGD:11059535, RGD:11059534 NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 no_association
onset		 ISO
IMP
IEP		 DNA:polymorphism: :-509C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter, exon:multiple (human)
mRNA:increased expression:lung
protein:increased expression:serum
DNA:SNP:cds:915G>C (human)
DNA:polymorphisms: :multiple (human)
DNA:SNP: :-509C>T (human)		 CTD
RGD		 PMID:16365456 PMID:19138248 PMID:19222424 PMID:19620629 PMID:19096005 More... RGD:4145299, RGD:4145132, RGD:4145143, RGD:4145113, RGD:4145139, RGD:4145142, RGD:4145144, RGD:4145280, RGD:4145295, RGD:4143443, RGD:4145297 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin ISO RGD PMID:20709825 RGD:5684984 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16926187 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370 		JBrowse link
G Tlr1 toll-like receptor 1 susceptibility ISO DNA:SNP (human) RGD PMID:18547625 RGD:4889528 NCBI chr 5:65,082,023...65,090,945
Ensembl chr 5:65,082,022...65,090,906 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility
severity		 ISO
IEP
IMP		 DNA:SNP: :596T>C (human)
DNA:polymorphism:cds:p.R753Q(human)
DNA:SNP: :rs3804100 (human)
DNA:SNP: :rs4696480 (human)
DNA:SNP: :rs7656411 (human)		 RGD PMID:19096003 PMID:22402138 PMID:19148143 PMID:20685742 PMID:20815312 More... RGD:4144228, RGD:7800732, RGD:2312679, RGD:4144171, RGD:4145352, RGD:4145343, RGD:4145334 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr3 toll-like receptor 3 no_association ISO
IMP		 Asthma, Virus-Induced; mRNA:increased expression:sputum (human)
DNA:snp:cds:p.L412F (human)		 RGD PMID:21129050 PMID:14987294 PMID:21364926 PMID:17434873 PMID:17610940 RGD:5129226, RGD:5129493, RGD:5128500, RGD:5129478, RGD:5129475 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility
no_association
severity		 ISO
IDA
IMP		 DNA:Polymorphism:cds:p.D299G (human)
DNA:SNPs: :rs10983755, rs1927914 (human)
DNA:SNPs::
protein:decreased expression:leukocytes, mononuclear
DNA:polymorphisms:cds:c.896A>G, 1196C>T (human)		 RGD PMID:15356557 PMID:19159017 PMID:20628601 PMID:19330007 PMID:20685742 More... RGD:4144817, RGD:4144188, RGD:4144176, RGD:4144141, RGD:4144171, RGD:4144190, RGD:4144198 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr6 toll-like receptor 6 susceptibility ISO DNA:SNP (human)
DNA:SNP: :p.S249P (human)		 RGD PMID:18547625 PMID:15266299 RGD:4889528, RGD:4889538 NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440 		JBrowse link
G Tlr9 toll-like receptor 9 no_association
susceptibility
severity		 ISO
IMP		 DNA:snp:promoter:g.-1237T>C rs5743836 (human)
protein:increased expression:peripheral blood mononuclear cell (human)		 RGD PMID:21324137 PMID:18312481 PMID:20016192 PMID:20072849 RGD:5130712, RGD:4144208, RGD:5129104, RGD:4889523 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnc tenascin C ISO
IMP		 DNA:SNP:exon:p.L1677I (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
protein:increased expression:bronchus basement membrane		 CTD
RGD		 PMID:16115819 PMID:16115819 PMID:18305139 PMID:17125141 PMID:9310019 RGD:4889569, RGD:4889589, RGD:4889565, RGD:4889572 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252 		JBrowse link
G Tnf tumor necrosis factor susceptibility
no_association		 ISO
IMP		 DNA:polymorphism:promoter: c. -308A>G (human)
ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism
associated with obesity; DNA:polymorphism:promoter
DNA:polymorphisms:: rs1799964, rs1799724 (human)
DNA:polymorphisms: :
associated with nasal polys; protein:increased expression:nose
DNA:polymorphism:promoter:c.-863C > A (human)		 OMIM
ClinVar
CTD
RGD		 PMID:8056188 PMID:9818939 PMID:10450718 PMID:11261930 PMID:11506397 More... RGD:4143443, RGD:4143238, RGD:4145508, RGD:4143240, RGD:4143254, RGD:4142802, RGD:4143369, RGD:4143372 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IEP protein:increased expression:lung (mouse) RGD PMID:20484920 RGD:5131201 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24453940 NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 severity ISO CTD Direct Evidence: marker/mechanism
ovalbumin sensitization		 CTD
RGD		 PMID:19458046 PMID:31969645 RGD:127285811 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21804549 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
G Ucn urocortin ISO associated with Hypersensitivity;mRNA, protein:increased expression:lung RGD PMID:16427607 RGD:1642781 NCBI chr 5:31,295,333...31,296,239
Ensembl chr 5:31,295,407...31,296,173 		JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:17045018 RGD:2306832 NCBI chr 4:151,081,554...151,086,267
Ensembl chr 4:151,081,554...151,086,267 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor no_association ISO DNA:SNP: :rs7975232 (human)
DNA:SNPs (human)
DNA:SNP (human)
DNA:SNPs: :multiple (human)		 RGD PMID:19622139 PMID:20124605 PMID:21103062 PMID:15282200 RGD:4889868, RGD:4889867, RGD:4889866, RGD:4889854 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:sputum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11907124 PMID:15201500 PMID:19263519 PMID:19178538 RGD:6892723 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vip vasoactive intestinal polypeptide ISO
IDA		 RGD PMID:21419198 PMID:16782752 RGD:5685381, RGD:5685620 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
G Wdr36 WD repeat domain 36 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19198610 NCBI chr18:32,970,241...33,000,008
Ensembl chr18:32,970,278...33,000,647 		JBrowse link
acute asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 treatment ISO RGD PMID:30059697 RGD:39939057 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
allergic asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl26 C-C motif chemokine ligand 26 treatment IDA RGD PMID:25530546 RGD:11081163 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 treatment IMP RGD PMID:23933317 RGD:40903070 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285 		JBrowse link
G Epx eosinophil peroxidase ISO protein:increased expression:urine: RGD PMID:11846868 RGD:13506893 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO RGD PMID:22397267 RGD:13506905 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 susceptibility ISO DNA:polymorphism: RGD PMID:28380482 RGD:13506910 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-Pa histocompatibility 2, P region alpha locus susceptibility ISO DNA:polymorphism: RGD PMID:28380482 RGD:13506910 NCBI chr17:34,303,587...34,304,826
Ensembl chr17:34,303,575...34,304,797 		JBrowse link
G Il25 interleukin 25 treatment IMP RGD PMID:17889290 RGD:40902975 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 exacerbates IEP
IDA		 RGD PMID:21592044 PMID:21592044 RGD:126928124, RGD:126928124 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952 		JBrowse link
aspirin-induced respiratory disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacng6 calcium channel, voltage-dependent, gamma subunit 6 susceptibility ISO DNA:SNP,haplotype:rs192808(human) RGD PMID:20860846 RGD:13524562 NCBI chr 7:3,472,017...3,484,183
Ensembl chr 7:3,472,711...3,484,183 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20485159 PMID:20022477 RGD:4145619 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 PMID:17641958 PMID:20485159 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16502481 PMID:20485159 PMID:15970796 RGD:5144000 NCBI chr14:73,263,043...73,286,554
Ensembl chr14:73,263,043...73,286,554 		JBrowse link
G Fancc Fanconi anemia, complementation group C ISO DNA:haplotype::rs4647416(human) RGD PMID:21670957 RGD:11045795 NCBI chr13:63,452,519...63,645,126
Ensembl chr13:63,432,857...63,645,092 		JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO RGD PMID:25975240 RGD:11074090 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO RGD PMID:25975240 RGD:11074090 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO RGD PMID:25975240 RGD:11074090 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Il4 interleukin 4 susceptibility ISO DNA:SNPs:promoter,5'UTR,intron:multiple RGD PMID:20921925 RGD:11528633 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443 		JBrowse link
G Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 NCBI chr19:11,592,881...11,601,154
Ensembl chr19:11,592,887...11,601,083 		JBrowse link
G Postn periostin, osteoblast specific factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr19:10,901,883...10,919,875
Ensembl chr19:10,914,524...10,919,875 		JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) ISO ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD		 PMID:15496426 PMID:16502481 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277 		JBrowse link
G Ptgir prostaglandin I receptor (IP) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr 7:16,640,442...16,644,828
Ensembl chr 7:16,640,415...16,644,830 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:mast cell
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16502481 PMID:20485159 PMID:9487340 RGD:5143936 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) ISO RGD PMID:21796142 RGD:5147839 NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295 		JBrowse link
G Tbx21 T-box 21 ISO ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD		 PMID:15806396 PMID:16502481 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tbxa2r thromboxane A2 receptor susceptibility ISO DNA:polymorphism: :795T>C (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16502481 PMID:20485159 PMID:15898979 RGD:11059537 NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006 		JBrowse link
Asthma and Nasal Polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-Ea histocompatibility 2, class II antigen E alpha susceptibility ISO DNA:SNPs,haplotype:introns: RGD PMID:22391069 RGD:13506908 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618 		JBrowse link
G Tbx21 T-box 21 ISO ClinVar Annotator: match by term: Asthma and nasal polyps ClinVar PMID:15806396 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
asthma, nasal polyps, and aspirin intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:25741868 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443 		JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD		 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277 		JBrowse link
G Tbx21 T-box 21 susceptibility ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:25741868 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
childhood-onset asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha exacerbates ISO associated with respiratory syncytial virus infectious disease;DNA:SNPs:protomer: (rs2233409) (human) RGD PMID:23487427 RGD:40902982 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
chronic asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngf nerve growth factor treatment ISO RGD PMID:30681402 RGD:405100716 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
Eosinophilic Asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl26 C-C motif chemokine ligand 26 severity ISO protein:increased expression:sputum (human) RGD PMID:25936567 RGD:11531115 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423 		JBrowse link
G Epx eosinophil peroxidase treatment ISO RGD PMID:28751233 RGD:13506890 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362 		JBrowse link
exercise-induced bronchoconstriction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:10984370 RGD:4890423 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (human) RGD PMID:19996575 RGD:4892021 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:8630576 RGD:5147837 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
Experimental Allergic Asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl3 acyl-CoA synthetase long-chain family member 3 IEP RGD PMID:23526225 RGD:13831300 NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:29713367 RGD:13792581 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Cd86 CD86 antigen treatment IMP RGD PMID:25344652 RGD:11354965 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO RGD PMID:29713367 RGD:13792581 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand treatment ISO RGD PMID:29713367 RGD:13792581 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 IMP RGD PMID:19935773 PMID:26344076 RGD:5037240, RGD:11251537 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
occupational asthma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:33075463 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Cdh17 cadherin 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25918132 NCBI chr 4:11,758,157...11,817,905
Ensembl chr 4:11,758,147...11,817,895 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 susceptibility ISO DNA:SNP: :rs1811197(human) RGD PMID:24709764 RGD:13506912 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-Oa histocompatibility 2, O region alpha locus treatment ISO DNA:SNP: :rs3128935(human) RGD PMID:24709764 RGD:13506912 NCBI chr17:34,311,353...34,314,286
Ensembl chr17:34,311,314...34,314,208 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 susceptibility ISO DNA:SNP: :rs1573294(human) RGD PMID:24709764 RGD:13506912 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25918132 NCBI chr 7:55,699,872...55,884,373
Ensembl chr 7:55,699,944...55,881,548 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO CTD Direct Evidence: marker/mechanism CTD PMID:27504716 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Prkca protein kinase C, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27504716 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkd1 protein kinase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27504716 NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25721048 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25721048 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tenm3 teneurin transmembrane protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25918132 NCBI chr 8:48,678,700...51,370,255
Ensembl chr 8:48,680,717...49,296,986 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25721048 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25721048 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Platelet-Activating Factor Acetylhydrolase Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO ClinVar Annotator: match by term: Platelet-activating factor acetylhydrolase deficiency
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:8675689 PMID:9412624 PMID:10194471 PMID:10733466 PMID:16787988 More... NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
status asthmaticus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma resistance IDA RGD PMID:20817868 RGD:4145651 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:lung RGD PMID:9927362 RGD:4143184 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il5 interleukin 5 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:10934091 RGD:4890960 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased expression:serum RGD PMID:10731862 RGD:5130994 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16225
    disease of anatomical entity 15844
      respiratory system disease 5127
        respiratory allergy 389
          asthma 349
            Asthma and Nasal Polyps 2
            Asthma, Short Stature, and Elevated IgA 0
            Eosinophilic Asthma 2
            Platelet-Activating Factor Acetylhydrolase Deficiency 1
            acute asthma + 5
            atopic dermatitis 3 0
            chronic asthma + 49
Path 2
Term Annotations click to browse term
  disease 16225
    disease of anatomical entity 15844
      Immune & Inflammatory Diseases 5365
        immune system disease 4732
          allergic disease 612
            Immediate Hypersensitivity 465
              respiratory allergy 389
                asthma 349
                  Asthma and Nasal Polyps 2
                  Asthma, Short Stature, and Elevated IgA 0
                  Eosinophilic Asthma 2
                  Platelet-Activating Factor Acetylhydrolase Deficiency 1
                  acute asthma + 5
                  atopic dermatitis 3 0
                  chronic asthma + 49
paths to the root