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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:nose disease
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Accession:DOID:2825 term browser browse the term
Definition:Disorders of the nose, general or unspecified.
Synonyms:exact_synonym: Nasal Diseases;   Nasal Disorder;   disorder of the nose;   nasal disease;   nasal disorders;   nose diseases
 primary_id: MESH:D009668
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
allergic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 severity ISO DNA:snp:exon:c.1236C>T (human) RGD PMID:24040855 RGD:8657076 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ACE angiotensin I converting enzyme no_association ISO DNA:deletion:intron:IVS16+1464-1751del (human) RGD PMID:15112973 RGD:8142345 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO mRNA, protein:increased expression:nasal mucosa (rat) RGD PMID:15362690 RGD:11522724 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29028686 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO protein:increased expression:oronasal secretion (human) RGD PMID:23883806 RGD:7364793 NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874 		JBrowse link
G CD40 CD40 molecule ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CLDN3 claudin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 Ensembl chr 7:80,924,731...80,925,393 JBrowse link
G CLDN7 claudin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr17:7,289,766...7,292,433
Ensembl chr17:7,277,313...7,281,859 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 treatment ISO RGD PMID:10436391 RGD:11344920 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:nasal mucus RGD PMID:21711961 RGD:5147783 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr 4:149,566,563...149,712,135
Ensembl chr 4:161,380,933...161,524,376 		JBrowse link
G HRH1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23333628 NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757 		JBrowse link
G IFNG interferon gamma treatment ISO associated with Asthma RGD PMID:12787306 PMID:18510219 RGD:10755770 RGD:7829803 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:23253209 PMID:23883806 RGD:7364793 RGD:7364818 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL13 interleukin 13 susceptibility
no_association		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)		 OMIM
CTD
RGD		 PMID:12928861 RGD:8549516 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO protein:increased expression:serum RGD PMID:21462799 RGD:8549521 NCBI chr  X:104,092,993...104,146,062
Ensembl chr  X:114,597,077...114,635,253 		JBrowse link
G IL17A interleukin 17A susceptibility ISO mRNA:increased expression:peripheral blood mononuclear cell (human)
DNA:snp:promoter:c.-444A>G (human)		 RGD PMID:21535180 PMID:22507625 RGD:5147409 RGD:9068429 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 no_association
severity		 ISO DNA:SNP:promoter:-140C>G (rs360721) (human)
DNA:SNP:promoter:-137G>C (rs187238) (human)		 RGD PMID:22840759 RGD:8655914 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:nasal mucus RGD PMID:7750009 RGD:7401199 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:12592663 RGD:8662963 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662 RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL5 interleukin 5 treatment ISO RGD PMID:23934070 PMID:24620662 RGD:11354976 RGD:11522769 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G ITGB2 integrin subunit beta 2 treatment ISO RGD PMID:12046991 RGD:9698435 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO mRNA,protein:decreased expression:nasal mucosa RGD PMID:31425778 RGD:127345100 NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:22972875 RGD:7364746 NCBI chr11:1,191,223...1,234,373 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:23858718 RGD:8547523 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G OCLN occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342 		JBrowse link
G PON1 paraoxonase 1 severity ISO protein:decreased activity:plasma (human) RGD PMID:23406590 RGD:8547583 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO protein:increased expression:nasal cavity epithelium RGD PMID:24012634 RGD:7775060 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16979129 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO mRNA:decreased expression:nasal mucosa, lung RGD PMID:17882576 RGD:5144135 NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873 		JBrowse link
G SCGB3A2 secretoglobin family 3A member 2 susceptibility ISO DNA:SNP: :rs7726552 (human) RGD PMID:21410962 RGD:5144225 NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003 		JBrowse link
G SERPINE1 serpin family E member 1 ISO mRNA:increased expression:nasal mucosa (mouse) RGD PMID:21339035 RGD:8547809 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G TACR1 tachykinin receptor 1 ISO mRNA:increased expression:nasal mucosa RGD PMID:12768696 RGD:5147835 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:31368266 RGD:14995445 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TLR2 toll like receptor 2 severity ISO mRNA:decreased expression:nasal mucosa:
DNA:polymorphism:cds:p.R753Q(human)
protein:increased expression:neutrophil:		 RGD PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057 RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 susceptibility
no_association
treatment
severity		 ISO protein:increased expression:nasal lavage,leukocyte, bone marrow:
DNA:SNP: :rs1927911(human)
protein:decreased expression:nasal mucosa:
DNA:polymorphism: :4216G>C(human)
DNA:polymorphism:cds:p.D299G(human)		 RGD PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 More... RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Allergic Rhinoconjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment ISO associated with Eosinophilic Esophagitis; DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065 		JBrowse link
G IL3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human) RGD PMID:23953855 RGD:13506915 NCBI chr 5:127,483,843...127,486,388
Ensembl chr 5:133,647,667...133,650,213 		JBrowse link
Arhinia, Choanal Atresia, and Microphthalmia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO ClinVar Annotator: match by term: Arhinia, choanal atresia, and microphthalmia OMIM
ClinVar		 PMID:672092 PMID:5032329 PMID:6802865 PMID:8446727 PMID:8723126 More... NCBI chr18:11,479,742...11,627,035
Ensembl chr18:13,785,912...13,933,887 		JBrowse link
Asthma and Nasal Polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100987081 HLA class II histocompatibility antigen, DR alpha chain susceptibility ISO DNA:SNPs,haplotype:introns: RGD PMID:22391069 RGD:13506908 NCBI chr 6:32,105,421...32,110,579
Ensembl chr 6:32,982,228...32,987,417 		JBrowse link
G TBX21 T-box transcription factor 21 ISO ClinVar Annotator: match by term: Asthma and nasal polyps ClinVar PMID:15806396 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
asthma, nasal polyps, and aspirin intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:17959182 PMID:21558275 PMID:30643255 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
G PTGER2 prostaglandin E receptor 2 ISO OMIM NCBI chr14:32,910,755...32,926,138
Ensembl chr14:51,195,381...51,209,686 		JBrowse link
G TBX21 T-box transcription factor 21 ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance OMIM
ClinVar		 PMID:25741868 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
Bifid Nose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FREM1 FRAS1 related extracellular matrix 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23221805 NCBI chr 9:14,567,781...14,748,474
Ensembl chr 9:15,081,208...15,253,399 		JBrowse link
Burn-McKeown syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADNP2 ADNP homeobox 2 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,757,926...73,789,771
Ensembl chr18:77,080,441...77,103,098 		JBrowse link
G ATP9B ATPase phospholipid transporting 9B (putative) ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:72,468,421...72,847,314
Ensembl chr18:75,686,430...75,988,106 		JBrowse link
G CTDP1 CTD phosphatase subunit 1 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,279,510...73,357,718
Ensembl chr18:76,646,641...76,722,573 		JBrowse link
G GALR1 galanin receptor 1 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:70,643,718...70,664,068
Ensembl chr18:73,899,995...73,917,752 		JBrowse link
G HSBP1L1 heat shock factor binding protein 1 like 1 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,608,483...73,615,823 JBrowse link
G KCNG2 potassium voltage-gated channel modifier subfamily G member 2 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,431,735...73,546,602 JBrowse link
G MBP myelin basic protein ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:70,369,882...70,526,693
Ensembl chr18:73,629,522...73,755,351 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:72,948,067...73,083,180
Ensembl chr18:76,017,454...76,094,453 		JBrowse link
G PARD6G par-6 family cell polarity regulator gamma ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,806,710...73,904,494
Ensembl chr18:77,122,483...77,167,659 		JBrowse link
G RBFA ribosome binding factor A ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,679,972...73,696,321
Ensembl chr18:76,997,888...77,013,864 		JBrowse link
G SALL3 spalt like transcription factor 3 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:72,381,249...72,403,789 JBrowse link
G SLC66A2 solute carrier family 66 member 2 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:73,549,273...73,596,658 JBrowse link
G TXNL4A thioredoxin like 4A ISO ClinVar Annotator: match by term: Bilateral choanal atresia, cardiac defects, deafness, and dysmorphic appearance | ClinVar Annotator: match by term: Burn-McKeown syndrome OMIM
ClinVar		 PMID:1342861 PMID:14564154 PMID:16523509 PMID:25434003 PMID:25741868 More... NCBI chr18:73,618,302...73,679,603
Ensembl chr18:76,937,460...76,952,428 		JBrowse link
G ZNF236 zinc finger protein 236 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:70,213,383...70,361,741
Ensembl chr18:73,496,761...73,617,956 		JBrowse link
G ZNF516 zinc finger protein 516 ISO ClinVar Annotator: match by term: Burn-McKeown syndrome ClinVar PMID:25434003 NCBI chr18:69,748,472...69,891,026
Ensembl chr18:73,026,076...73,103,609 		JBrowse link
choanal atresia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KMT2D lysine methyltransferase 2D ISO ClinVar Annotator: match by term: Choanal atresia ClinVar PMID:25741868 PMID:31395954 NCBI chr12:39,689,463...39,731,904
Ensembl chr12:40,575,083...40,608,661 		JBrowse link
Choanal Atresia and Lymphedema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN14 protein tyrosine phosphatase non-receptor type 14 ISO ClinVar Annotator: match by term: Choanal atresia and lymphedema OMIM
ClinVar		 PMID:20826270 PMID:25741868 NCBI chr 1:189,925,706...190,120,232
Ensembl chr 1:194,780,068...194,887,798 		JBrowse link
chronic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human) RGD PMID:8845175 RGD:8661738 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
Chronic Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD8A CD8 subunit alpha ameliorates ISO protein:decreased expression:blood, T cell (human) RGD PMID:24639246 RGD:124715444 NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635 		JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:uncinate process, nasal mucosa (human) RGD PMID:23613503 RGD:8696039 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein susceptibility ISO DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human) RGD PMID:16549749 RGD:8549791 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G MBL2 mannose binding lectin 2 ISO protein:decreased activity:serum: RGD PMID:23144819 RGD:8693716 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G PRG2 proteoglycan 2, pro eosinophil major basic protein disease_progression ISO associated with Nasal Polyps; RGD PMID:24450586 RGD:13506943 NCBI chr11:52,628,289...52,631,634
Ensembl chr 3:160,118,111...160,122,002 		JBrowse link
Epistaxis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Epistaxis ClinVar PMID:11484689 PMID:15687131 PMID:16540754 PMID:17786384 PMID:18159113 More... NCBI chr12:36,839,869...36,856,351
Ensembl chr12:37,615,888...37,631,691 		JBrowse link
G ENG endoglin ISO ClinVar Annotator: match by term: Spontaneous, recurrent epistaxis ClinVar PMID:15879500 PMID:16542389 PMID:28492532 PMID:30251589 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641 		JBrowse link
maxillary sinus squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN1A cyclin dependent kinase inhibitor 1A ISO RGD PMID:15040115 RGD:8662355 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
nasal cavity adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLU clusterin ISO RGD PMID:19903339 RGD:9014708 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
nasal cavity cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX2 SRY-box transcription factor 2 ISO DNA:amplification RGD PMID:23544055 RGD:8661654 NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662 		JBrowse link
G TP53 tumor protein p53 ISO RGD PMID:19950227 RGD:8547762 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
Nasal Obstruction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPY neuropeptide Y ISO CTD Direct Evidence: therapeutic CTD PMID:9288221 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
Nasal Polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO associated with Chronic Rhinosinusitis;protein:increased expression:nasal sinus (human) RGD PMID:22223515 RGD:8657074 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ADRB2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:p.R16G(human) RGD PMID:17621827 RGD:8548469 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO mRNA:decreased expression:nasal cavity epithelium RGD PMID:20554417 RGD:5509597 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:nasal cavity epithelium		 CTD
RGD		 PMID:20554417 PMID:30643255 RGD:5509597 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
G ANG angiogenin ISO RGD PMID:21711968 RGD:6892710 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393 		JBrowse link
G ANXA1 annexin A1 ISO RGD PMID:20549082 RGD:7421567 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G BDNF brain derived neurotrophic factor ISO associated with Sinusitis;protein:decreased expression:respiratory system mucosa RGD PMID:19958603 RGD:4891064 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CAT catalase ISO protein:increased activity:nasal concha: RGD PMID:16287205 RGD:9479048 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO associated with Sinusitis RGD PMID:20598643 RGD:4891418 NCBI chr17:22,425,022...22,430,243
Ensembl chr17:22,719,425...22,722,341 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:10415058 RGD:4145448 NCBI chr17:22,495,737...22,515,144
Ensembl chr17:22,806,076...22,808,345
Ensembl chr17:22,806,076...22,808,345 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:sinus: RGD PMID:22287435 RGD:7483612 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO associated with Rhinosinusitis
associated with Allergic Rhinitis		 RGD PMID:19027509 PMID:22287435 RGD:7483586 RGD:7483612 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:10415058 RGD:4145448 NCBI chr 7:68,206,688...68,210,343
Ensembl chr 7:82,263,310...82,265,480 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:21303604 RGD:5130929 NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:22287435 RGD:7483612 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO associated with Rhinosinusitis RGD PMID:22287435 RGD:7483612 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779 		JBrowse link
G CHIA chitinase acidic ISO associated with Sinusitis; mRNA:increased expression:mucosa of ethmoidal sinus (human) RGD PMID:16871939 RGD:5024927 NCBI chr 1:113,935,888...113,965,541
Ensembl chr 1:126,381,724...126,391,909 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO associated with Sinusitis;mRNA:increased expression:respiratory system mucosa RGD PMID:19178793 RGD:5134986 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO protein:increased expression:nasal cavity epithelium
associated with Asthma
associated with Rhinitis;mRNA:increased expression:nasal cavity epithelium		 RGD PMID:11591188 PMID:16689996 PMID:16739673 RGD:4783198 RGD:4848936 RGD:4889117 NCBI chr  X:67,412,410...67,469,366
Ensembl chr  X:77,524,455...77,525,468 		JBrowse link
G EGR1 early growth response 1 ISO mRNA:increased expression:nasal polyp (human) RGD PMID:19158123 RGD:4890001 NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260 		JBrowse link
G FAS Fas cell surface death receptor ISO protein:decreased expression:nasal polyp (human) RGD PMID:15283292 RGD:8662435 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FGF1 fibroblast growth factor 1 ISO RGD PMID:16720444 RGD:8655569 NCBI chr 5:137,949,100...138,054,553
Ensembl chr 5:144,056,387...144,078,001 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO RGD PMID:16720444 RGD:8655569 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO associated with GSTT1 null genotype:DNA:deletion: : RGD PMID:16550944 RGD:4142528 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HGF hepatocyte growth factor ISO mRNA,protein:increased expression:nasal cavity mucosa: RGD PMID:16982975 RGD:8548613 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:nasal cavity epithelium RGD PMID:11593541 RGD:8547687 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:nasal mucosa, tissue: RGD PMID:9149164 RGD:8158035 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:increased expression:nasal cavity mucosa: RGD PMID:18202785 RGD:8548875 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IL10 interleukin 10 ISO RGD PMID:22462754 RGD:7364835 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL13 interleukin 13 ISO associated with Rhinosinusitis;protein:increased expression:serum RGD PMID:23969075 RGD:8549540 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL16 interleukin 16 ISO associated with Sinusitis RGD PMID:17431659 RGD:5024933 NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861 		JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:nose, serum
associated with rhinitis; protein:increased expression:nasal mucosa		 RGD PMID:20506642 PMID:21091665 RGD:4889132 RGD:4889137 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL1A interleukin 1 alpha susceptibility ISO associated with asthma; DNA:polymorphism:exon:
DNA:SNPs:exon:		 RGD PMID:12752325 PMID:17638785 RGD:4142804 RGD:4142855 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL5RA interleukin 5 receptor subunit alpha ISO protein:increased expression:nasal mucus, serum RGD PMID:12752323 RGD:5128621 NCBI chr 3:3,009,780...3,051,604
Ensembl chr 3:3,112,355...3,156,282 		JBrowse link
G IL9 interleukin 9 ISO associated with Bronchial Hyperreactivity RGD PMID:15007348 RGD:5128694 NCBI chr 5:131,283,170...131,289,777
Ensembl chr 5:137,425,367...137,428,945 		JBrowse link
G ITGAL integrin subunit alpha L ISO protein:increased expression:nasal cavity epithelium RGD PMID:11593541 RGD:8547687 NCBI chr16:24,445,966...24,496,037
Ensembl chr16:30,843,747...30,892,597 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA:decreased expression:nasal cavity epithelium RGD PMID:19158123 RGD:4890001 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:inferior nasal concha: RGD PMID:12515274 RGD:8551781 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G KITLG KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:15813808 NCBI chr12:86,036,501...86,124,274
Ensembl chr12:89,341,921...89,436,758 		JBrowse link
G LEPR leptin receptor ISO mRNA:increased expression:nose RGD PMID:20422702 RGD:5129163 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:haplotype: : HLA-DQB1*0201;
associated with intrinsic asthma;DNA:polymorphism, haplotype:cds:HLA-DQB1*0202 (human)		 RGD PMID:10718431 PMID:16890076 RGD:5147813 RGD:8547658 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G LOC100977568 tenascin ISO protein:increased expression:nasal cavity epithelium RGD PMID:12916355 RGD:4889591 NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299 		JBrowse link
G LOC100982859 patr class I histocompatibility antigen, B-2 alpha chain susceptibility ISO DNA:polymorphisms:cds:HLA-B*07, HLA-B*57 (human, Turkish) RGD PMID:18922348 RGD:7364876 NCBI chr 6:31,106,562...31,109,933
Ensembl chr 6:31,997,381...32,000,067 		JBrowse link
G MBL2 mannose binding lectin 2 ISO associated with Sinusitis; protein:increased secretion:serum (human) RGD PMID:19593977 RGD:4889484 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO mRNA,protein:increased expression:nasal cavity mucosa: RGD PMID:16982975 RGD:8548613 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159 		JBrowse link
G MMP1 matrix metallopeptidase 1 ISO associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa RGD PMID:23064462 RGD:8549735 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104 		JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa RGD PMID:21305560 PMID:23064462 RGD:8549735 RGD:8656001 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP9 matrix metallopeptidase 9 susceptibility
disease_progression		 ISO associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa
associated with Asthma, Aspirin-Induced; DNA:polymorphism:promoter: -1562C>T (human)		 RGD PMID:19958602 PMID:23064462 PMID:23987197 RGD:5130861 RGD:8549735 RGD:8657056 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:15715404 RGD:7364740 NCBI chr11:1,191,223...1,234,373 JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA:increased expression:nasal mucosa
DNA:repeats:promoter		 RGD PMID:18714530 PMID:20554417 RGD:4891508 RGD:5509597 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO protein:increased expression:nasal mucosa (human) RGD PMID:15942806 RGD:7771559 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO associated with Sinusitis RGD PMID:21711960 RGD:6483796 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561 		JBrowse link
G PON1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:23238704 RGD:8547666 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493 		JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO associated with Chronic Rhinosinusitis;mRNA:increased expression:mucosa of paranasal sinus (human) RGD PMID:18391768 RGD:9999402 NCBI chr17:44,224,007...44,240,906
Ensembl chr17:49,098,089...49,126,932 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO associated with Cystic Fibrosis; protein:increased expression:nasal mucosa: RGD PMID:16517580 RGD:5143924 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO associated with Cystic Fibrosis; protein:increased expression:nasal mucosa: RGD PMID:16517580 RGD:5143924 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G SOD1 superoxide dismutase 1 ISO associated with Rhinosinusitis;protein:decreased expression:nasal mucosa:
mRNA, protein:increased expression:middle nasal turbinate, lamella (human)		 RGD PMID:16540901 PMID:23921602 RGD:1581230 RGD:8547534 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO associated with Rhinosinusitis;mRNA,protein:decreased expression:nasal mucosa: RGD PMID:23921602 RGD:8547534 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G SOD3 superoxide dismutase 3 ISO mRNA, protein:increased expression:middle nasal turbinate, lamella (human) RGD PMID:16540901 RGD:1581230 NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:22959364 RGD:8694314 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA:decreased expression:nasal cavity epithelium
associated with Rhinitis		 RGD PMID:12761968 PMID:18423831 PMID:23406597 RGD:4145277 RGD:7394830 RGD:7394852 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TLR2 toll like receptor 2 ISO associated with Cystic Fibrosis;mRNA:increased expression:inferior nasal concha: RGD PMID:15836755 RGD:8552992 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO associated with Rhinosinusitis;mRNA,protein:increased expression: RGD PMID:23157229 RGD:7800741 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TLR7 toll like receptor 7 ISO associated with Rhinosinusitis;mRNA,protein:increased expression: RGD PMID:23157229 RGD:7800741 NCBI chr  X:5,479,247...5,504,810
Ensembl chr  X:12,767,981...12,790,517 		JBrowse link
G TNF tumor necrosis factor ISO DNA:SNPs:promoter: RGD PMID:17638785 RGD:4142855 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO mRNA:decreased expression:nasal polyp (human) RGD PMID:19095579 RGD:5131442 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO mRNA:decreased expression:nasal polyp (human) RGD PMID:19095579 RGD:5131442 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:Turbinates: RGD PMID:12761968 RGD:7394830 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
nasal type extranodal NK/T-cell lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 severity ISO Nasal Type;protein:increased expression:nasal cavity (human) RGD PMID:18756548 RGD:8657087 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G CD274 CD274 molecule disease_progression ISO associated with Epstein-Barr Virus Infections RGD PMID:27595782 RGD:41412182 NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:15924153 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045 		JBrowse link
G FAS Fas cell surface death receptor ISO DNA:insertion, deletions:cds:multiple (human) RGD PMID:12466128 RGD:8662407 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G GPX3 glutathione peroxidase 3 treatment ISO associated with ethmoid sinus cancer and Neoplasm Metastasis RGD PMID:29496492 RGD:151708712 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G JAK3 Janus kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22705984 PMID:23689514 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29200404 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G PRDM1 PR/SET domain 1 disease_progression ISO RGD PMID:24438193 RGD:150530467 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:increased expression:nasal cavity (human) RGD PMID:17225522 RGD:153298933 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
Nose Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMBT1 deleted in malignant brain tumors 1 ISO mRNA, Protein:increased expression RGD PMID:12419858 RGD:1599782 NCBI chr10:119,129,440...119,200,232
Ensembl chr10:122,540,855...123,474,497 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16178123 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
paranasal sinus benign neoplasm term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:20970165 RGD:7421559 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G ANXA2 annexin A2 disease_progression ISO RGD PMID:20970165 RGD:7421559 NCBI chr15:39,322,303...39,371,565
Ensembl chr15:57,625,425...57,674,250 		JBrowse link
G TP53 tumor protein p53 treatment ISO DNA:mutations:cds: RGD PMID:22575263 PMID:23369851 RGD:8547763 RGD:8547764 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
Perennial Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:serum RGD PMID:19725899 RGD:5686851 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19389874 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein ISO protein:increased expression:nasal turbinate RGD PMID:19364335 RGD:5147461 NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607 		JBrowse link
G CAT catalase ISO protein:decreased expression:plasma RGD PMID:20493834 RGD:5130771 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:nasal turbinate, mucosa (human) RGD PMID:9865755 RGD:8548839 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:Nasal Mucosa RGD PMID:17982926 RGD:4145109 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:17982926 RGD:4145109 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:20226305 RGD:5132269 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD86 CD86 molecule ISO protein:increased expression:nasal mucosa, dendritic cell (human) RGD PMID:17088138 RGD:4892343 NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339 		JBrowse link
G CHIA chitinase acidic ISO mRNA, protein:increased expression:turbinate, mucosa (human) RGD PMID:20422678 RGD:5037226 NCBI chr 1:113,935,888...113,965,541
Ensembl chr 1:126,381,724...126,391,909 		JBrowse link
G EGR1 early growth response 1 ISO DNA:snp:5' utr:g.-4071A>G rs7729723 (human) RGD PMID:19833116 RGD:5131984 NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISO RGD PMID:17727088 RGD:4892590 NCBI chr 5:38,462,521...38,478,882
Ensembl chr 5:39,006,331...39,024,265 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD PMID:17181111 RGD:4142523 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G HMOX1 heme oxygenase 1 ISO mRNA, protein:increased expression: nasal mucosa RGD PMID:16540907 RGD:4145406 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx (human)
protein:increased expression:lung, endothelium (mouse)		 RGD PMID:19047814 PMID:19968652 RGD:4145464 RGD:4145520 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNGR1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053 		JBrowse link
G IL13 interleukin 13 ISO mRNA, protein:increased expression:nasal mucosa RGD PMID:8520776 RGD:4782826 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL17A interleukin 17A severity ISO protein:increased expression:serum RGD PMID:19226302 RGD:4889151 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 susceptibility ISO DNA:SNP:promoter:c. -607A>C (rs1946518) (human) RGD PMID:16406079 RGD:4889924 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1A interleukin 1 alpha ISO DNA:polymorphism:exon:c.4845G>T (human) RGD PMID:14533660 RGD:4142859 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:18637763 RGD:5037238 Ensembl chr2A:103,193,131...103,230,005 JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17608155 RGD:8662959 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 treatment ISO protein:increased expression:serum RGD PMID:9237816 PMID:15329007 PMID:21171297 RGD:5128559 RGD:7829804 RGD:7829817 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL5 interleukin 5 ISO protein: increased levels: sputum RGD PMID:22186238 RGD:5687140 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:14587983 RGD:4892078 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO DNA:snp:promoter:g.-786T>C (human) RGD PMID:18086269 RGD:4892054 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO protein:altered expression:nasal mucosa RGD PMID:20185258 RGD:4892593 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO mRNA, protein:increased expression:nasal mucosa (human) RGD PMID:17116814 RGD:8552811 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G TBXA2R thromboxane A2 receptor treatment ISO RGD PMID:15247523 RGD:11059532 NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924 		JBrowse link
rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNPs: :multiple (human) RGD PMID:15298558 PMID:18778489 RGD:4145378 RGD:4145383 NCBI chr20:3,750,158...3,764,262
Ensembl chr20:3,508,620...3,521,628 		JBrowse link
G ANG angiogenin ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:12165532 RGD:5129220 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:1890650 PMID:11149999 RGD:4891033 RGD:4891044 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G BDNF brain derived neurotrophic factor susceptibility ISO DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
mRNA:increased expression:nasal cavity epithelium		 RGD PMID:20464992 PMID:21723144 RGD:4891116 RGD:8655967 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G C3 complement C3 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:17345707 PMID:20109314 RGD:5129524 RGD:5129539 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G C3AR1 complement C3a receptor 1 severity ISO protein:increased expression:nasal cavity RGD PMID:18538384 RGD:5129559 NCBI chr12:8,178,064...8,186,206
Ensembl chr12:8,220,933...8,222,381 		JBrowse link
G C5AR1 complement C5a receptor 1 ISO RGD PMID:18538384 RGD:5129559 NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146 		JBrowse link
G CASP1 caspase 1 ISO protein:increased expression:serum RGD PMID:12396474 PMID:20974310 RGD:5130187 RGD:5130192 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CAT catalase treatment ISO protein:increased activity:blood,nasal cavity mucosa: RGD PMID:21541033 RGD:9479054 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:17982926 RGD:4145109 NCBI chr17:22,425,022...22,430,243
Ensembl chr17:22,719,425...22,722,341 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 severity ISO protein:increased expression:nasal mucus
associated with Sinusitis;protein:increased expression:paranasal sinus		 RGD PMID:16120080 PMID:17999785 RGD:4145411 RGD:4145455 NCBI chr17:22,495,737...22,515,144
Ensembl chr17:22,806,076...22,808,345
Ensembl chr17:22,806,076...22,808,345 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr16:37,678,518...37,689,350
Ensembl chr16:56,819,949...56,822,131 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 ISO RGD PMID:17947663 RGD:5130909 NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 ISO mRNA:increased expression:nasal cavity epithelium
DNA:SNPs: :179T>C, 275C>T (human)		 RGD PMID:15580493 PMID:17982926 RGD:4145109 RGD:4891493 NCBI chr 7:68,206,688...68,210,343
Ensembl chr 7:82,263,310...82,265,480 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO DNA:polymorphism: :2497T>G (human)
associated with Eosinophilia;protein:increased expression:oronasal secretion (human)		 RGD PMID:15580493 PMID:24989688 RGD:11531119 RGD:4891493 NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874 		JBrowse link
G CCL8 C-C motif chemokine ligand 8 ISO RGD PMID:20625511 RGD:5131089 NCBI chr17:22,468,080...22,470,443
Ensembl chr17:22,761,064...22,763,933 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 susceptibility ISO Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human) RGD PMID:17135764 RGD:4145111 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO DNA:SNP:exon:51T>C (human)
mRNA:increased expression:nose
protein:increased expression:blood, T cell		 RGD PMID:17135764 PMID:17156343 PMID:20696593 RGD:4145111 RGD:4145454 RGD:4145645 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630 		JBrowse link
G CD14 CD14 molecule resistance
susceptibility		 ISO DNA:polymorphism:promoter:c. -159c>T (human) RGD PMID:16950285 PMID:20109306 RGD:4144795 RGD:4144810 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966 		JBrowse link
G CD28 CD28 molecule ISO RGD PMID:21356099 RGD:5131612 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213 		JBrowse link
G CD80 CD80 molecule ISO RGD PMID:21108691 RGD:5132622 NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870 		JBrowse link
G CDC42 cell division cycle 42 ISO mRNA:increased expression:nasal turbinate RGD PMID:19432938 RGD:5688273 NCBI chr 1:21,245,970...21,286,210 JBrowse link
G CFTR CF transmembrane conductance regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:16083808 NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO protein:increased expression:T cell RGD PMID:17625281 RGD:4891512 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:plasma RGD PMID:14657873 RGD:4891906 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO protein:increased expression:nasal mucus RGD PMID:20659080 RGD:4892030 NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:15379985 PMID:16689996 PMID:17627772 PMID:18946234 RGD:4781451 RGD:4783198 RGD:4847512 RGD:4888516 NCBI chr  X:67,412,410...67,469,366
Ensembl chr  X:77,524,455...77,525,468 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:16689996 RGD:4783198 NCBI chr13:29,796,598...29,853,676
Ensembl chr13:48,551,757...48,552,797 		JBrowse link
G FCER1A Fc fragment of IgE receptor Ia ISO RGD PMID:20650300 RGD:5128714 NCBI chr 1:134,655,230...134,660,961
Ensembl chr 1:138,439,921...138,458,258 		JBrowse link
G FIS1 fission, mitochondrial 1 ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683 		JBrowse link
G HDC histidine decarboxylase ISO DNA:SNP: :p.E644D (rs2073440) (human) RGD PMID:15054596 PMID:20608921 RGD:5128884 RGD:5143921 NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577 		JBrowse link
G HNMT histamine N-methyltransferase no_association ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17651147 RGD:5128885 NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315 		JBrowse link
G HRH1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757 		JBrowse link
G IL13 interleukin 13 susceptibility
disease_progression		 ISO DNA:polymorphism: :rs1800925 (human)
mRNA:increased expression:nose
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human)		 RGD PMID:16120094 PMID:17088137 PMID:20358028 PMID:20484924 PMID:20696593 RGD:4145454 RGD:4145534 RGD:4145767 RGD:4159171 RGD:4206706 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17088137 RGD:4159171 NCBI chr  X:104,092,993...104,146,062
Ensembl chr  X:114,597,077...114,635,253 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:16750998 RGD:5000756 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622 		JBrowse link
G IL16 interleukin 16 ISO protein:increased expression:nasal cavity epithelium, serum
protein:increased expression:serum		 RGD PMID:18254318 PMID:19295235 RGD:5024931 RGD:5024932 NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861 		JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:nasal mucosa RGD PMID:19927541 PMID:20506642 RGD:4889137 RGD:4889144 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 disease_progression ISO protein:increased expression:serum
protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid
rhinitis allergic, seasonal; protein:increased expression:plasma		 RGD PMID:15934281 PMID:17305282 PMID:17323858 RGD:4889916 RGD:4889917 RGD:4889927 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta susceptibility ISO associated with Hypersensitivity;protein:increased expression:nasal mucus
associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human)
mRNA:increased expression:nasal cavity epithelium		 RGD PMID:10224452 PMID:14533660 PMID:20490816 RGD:4142821 RGD:4142859 RGD:4143227 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL2 interleukin 2 susceptibility ISO DNA:SNP:promoter:rs2069762(human) RGD PMID:16333313 RGD:8663473 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL21 interleukin 21 ISO RGD PMID:17982108 RGD:5147397 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL22 interleukin 22 severity ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:21535180 RGD:5147409 NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421 		JBrowse link
G IL23R interleukin 23 receptor susceptibility ISO DNA:SNP,haplotype: :rs7517847(human) RGD PMID:23696856 RGD:8549605 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha ISO RGD PMID:19354069 RGD:5128480 Ensembl chr19:14,323,618...14,343,627 JBrowse link
G IL4 interleukin 4 ISO mRNA:increased expression:nasal cavity epithelium
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18826099 PMID:19672097 PMID:21208219 RGD:2317285 RGD:5128558 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL4R interleukin 4 receptor ISO DNA:polymorphism: :c.1432T>C (human) RGD PMID:15564773 RGD:4890394 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL5 interleukin 5 ISO RGD PMID:11884474 RGD:5128622 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G IL9 interleukin 9 ISO RGD PMID:20525149 RGD:5128687 NCBI chr 5:131,283,170...131,289,777
Ensembl chr 5:137,425,367...137,428,945 		JBrowse link
G LEP leptin ISO RGD PMID:19860581 RGD:5128850 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0602 (human) RGD PMID:14990915 RGD:5147798 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein susceptibility ISO associated with Hypersensitivity
associated with Hypersensitivity;DNA:repeat:intron (human)		 RGD PMID:10224452 PMID:14533660 PMID:15178892 RGD:4142859 RGD:4143215 RGD:4143227 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism: : RGD PMID:18831943 RGD:8693717 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G MFN1 mitofusin 1 ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763 		JBrowse link
G MIF macrophage migration inhibitory factor severity ISO protein:increased expression:serum, nasal mucosa RGD PMID:15053202 PMID:15922619 RGD:4891045 RGD:4891056 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO RGD PMID:15480314 RGD:5131152 NCBI chr11:55,318,843...55,326,779
Ensembl chr11:58,764,911...58,772,567 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:nose RGD PMID:15715404 PMID:20696593 RGD:4145454 RGD:7364740 NCBI chr11:1,191,223...1,234,373 JBrowse link
G NGF nerve growth factor ISO protein:increased expression:respiratory system fluid/secretion
associated with Sinusitis;protein:increased expression:respiratory system mucosa		 RGD PMID:10224365 PMID:19958603 RGD:4891064 RGD:4891115 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor ISO protein:increased expression:blood, eosinophil RGD PMID:18647313 RGD:5144116 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO mRNA:decreased expression:nose RGD PMID:20384614 RGD:5131446 NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:cds:2104C>T,2722G>C (human) RGD PMID:12704363 RGD:5131484 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:18254476 RGD:4891910 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NPY neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
G PLAU plasminogen activator, urokinase ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:21339035 RGD:8547809 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PTGDR2 prostaglandin D2 receptor 2 ISO RGD PMID:19230460 PMID:19608418 RGD:5135017 RGD:5135021 NCBI chr11:56,114,166...56,153,820
Ensembl chr11:59,556,460...59,557,647 		JBrowse link
G SCGB3A2 secretoglobin family 3A member 2 ISO protein:increased expression:sputum
mRNA,protein:decreased expression:nasal mucosa		 RGD PMID:17218572 PMID:21385388 RGD:5144232 RGD:5147389 NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003 		JBrowse link
G SERPINE1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter:rs1799768 (human) RGD PMID:19063817 RGD:4144832 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SFTPD surfactant protein D susceptibility ISO associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human) RGD PMID:19493231 RGD:4143494 NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member susceptibility
no_association		 ISO DNA:SNPs: : RGD PMID:12018331 PMID:17982230 RGD:6482262 RGD:6482274 NCBI chr 6:32,414,665...32,423,488
Ensembl chr 6:33,530,171...33,538,978 		JBrowse link
G TBXA2R thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO associated with Sinusitis RGD PMID:18423831 RGD:4145277 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TLR2 toll like receptor 2 no_association
susceptibility		 ISO associated with Sinusitis;DNA:SNPs: :multiple (human)
DNA:SNPs: :597T>C, 1350T>C (human)
mRNA:decreased expression:nasal mucosa:		 RGD PMID:18219831 PMID:19128592 PMID:19763595 RGD:4145354 RGD:4145356 RGD:7800742 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR6 toll like receptor 6 ISO associated with Asthma;DNA:SNP: :rs2381289 (human) RGD PMID:20815312 RGD:4145352 NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490 		JBrowse link
G TNF tumor necrosis factor ISO mRNA:increased expression:nose RGD PMID:15120189 PMID:20696593 RGD:4143470 RGD:4145454 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 PMID:14680090 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
rhinoscleroma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:haplotype: : RGD PMID:17321882 RGD:8547664 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO associated with Nasal Polyps RGD PMID:22279949 RGD:7421555 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G C3 complement C3 ISO protein:increased expression:serum RGD PMID:19593977 RGD:4889484 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:16702571 RGD:7483585 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G HGF hepatocyte growth factor susceptibility ISO DNA:haplotype::rs38850,rs38855,rs38857(human) RGD PMID:20416453 RGD:8548615 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:increased expression:nose: RGD PMID:20713758 RGD:8548883 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IL10 interleukin 10 ISO protein:decreased expression:blood, mononuclear cell RGD PMID:23168151 RGD:7364820 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL17A interleukin 17A ISO associated with Asthma;mRNA, protein:increased expression:nasal polyps (human) RGD PMID:19672092 RGD:4889146 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 RGD:7401169 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL22RA1 interleukin 22 receptor subunit alpha 1 susceptibility ISO DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human) RGD PMID:19393422 RGD:5147411 NCBI chr 1:23,322,057...23,345,557
Ensembl chr 1:24,300,902...24,324,391 		JBrowse link
G IL4 interleukin 4 treatment ISO associated with Asthma RGD PMID:12787306 RGD:7829803 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:23401274 RGD:8547880 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming treatment ISO RGD PMID:19389874 PMID:23131200 RGD:7349403 RGD:7364734 NCBI chr11:1,191,223...1,234,373 JBrowse link
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 severity ISO associated with Nasal Polyps RGD PMID:22961479 RGD:7777146 NCBI chr2B:65,689,029...65,708,493
Ensembl chr2B:183,393,819...183,413,174 		JBrowse link
G SERPINE1 serpin family E member 1 ISO protein:increased expression:nasal mucosa (human) RGD PMID:21711960 RGD:6483796 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO DNA:polymorphisms:: rs3804099,rs3804100(human)
mRNA,protein:increased expression:paranasal sinus		 RGD PMID:21493395 PMID:22182736 RGD:7800733 RGD:8552975 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:paranasal sinus RGD PMID:22182736 RGD:7800733 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 PMID:20147558 RGD:7401169 RGD:7401236 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Rhinosinusitis, Allergic Fungal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0301, HLA-DQB1*0302 (human) RGD PMID:15577839 RGD:5147654 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
Seasonal Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:16677242 RGD:5147463 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G APOA4 apolipoprotein A4 resistance ISO protein:increased expression:blood serum (human) RGD PMID:20810159 RGD:5685642 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382 		JBrowse link
G BDNF brain derived neurotrophic factor severity ISO protein:increased expression:blood, nasal cavity epithelium RGD PMID:18266897 RGD:5144117 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:inferior turbinate, epithelium (human) RGD PMID:20459697 RGD:4891379 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CMA1 chymase 1 ISO protein:increased expression:nasal mucosa, mast cell (human) RGD PMID:11549546 RGD:5128839 NCBI chr14:5,277,269...5,280,335
Ensembl chr14:23,400,345...23,403,548 		JBrowse link
G FGA fibrinogen alpha chain ISO RGD PMID:21887273 RGD:5688767 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO protein:decreased expression;T lymphocyte: RGD PMID:21410266 RGD:5491008 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx, secretion (human) RGD PMID:20128420 RGD:4145459 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNGR1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:19505388 RGD:7365025 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL18 interleukin 18 susceptibility
no_association		 ISO DNA:SNPs:promoters, exon:multiple
DNA:SNPs:promoters:multiple		 RGD PMID:12532106 RGD:8655871 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL4 interleukin 4 ISO protein:increased expression:serum
mRNA:increased expression:nose:		 RGD PMID:7551298 PMID:9237816 RGD:7829817 RGD:8662960 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:nasal cavity of mucosa: RGD PMID:17651148 RGD:8551771 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*05 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)		 RGD PMID:9641569 PMID:22032123 RGD:7421561 RGD:7421576 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human) RGD PMID:22237587 RGD:8547819 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 susceptibility ISO DNA:SNP: :rs2075817 (human) RGD PMID:16918516 RGD:5131519 NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human) RGD PMID:16008671 RGD:5131477 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO mRNA, protein:decreased expression:nasal lavage fluid RGD PMID:15836756 RGD:5144234 NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873 		JBrowse link
G TLR3 toll like receptor 3 ISO protein:decreased expression:bone marrow, blood, eosinophil (human) RGD PMID:19752565 RGD:5129130 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728 		JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18517079 RGD:4144192 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid: RGD PMID:12633568 RGD:7483595 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
sinonasal undifferentiated carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAML3 mastermind like transcriptional coactivator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24859338 NCBI chr 4:132,082,120...132,518,928
Ensembl chr 4:143,391,606...143,562,699 		JBrowse link
G PAX3 paired box 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24859338 NCBI chr2B:109,441,938...109,541,449
Ensembl chr2B:228,022,453...228,121,874 		JBrowse link
G SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 ISO RGD PMID:30120966 RGD:127285653 NCBI chr22:4,542,764...4,589,461
Ensembl chr22:22,627,982...22,673,921 		JBrowse link
sinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFB complement factor B ISO protein:decreased expression:serum RGD PMID:14510109 RGD:7411729 NCBI chr 6:31,606,716...31,612,782 JBrowse link
G CFTR CF transmembrane conductance regulator susceptibility ISO DNA:mutations: :
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11773581 PMID:16083808 RGD:4140477 NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864 		JBrowse link
G CHIA chitinase acidic severity ISO mRNA:decreased expression:sinus, epithelial cell (human) RGD PMID:19379605 RGD:5037227 NCBI chr 1:113,935,888...113,965,541
Ensembl chr 1:126,381,724...126,391,909 		JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 ISO associated with Rhinitis;mRNA:increased expression:paranasal sinus RGD PMID:19153309 RGD:5135257 NCBI chr 4:50,192,665...50,195,642
Ensembl chr 4:56,024,848...56,027,989 		JBrowse link
G IL13 interleukin 13 susceptibility ISO CTD Direct Evidence: marker/mechanism
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human)		 CTD
RGD		 PMID:20358028 RGD:4145767 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL1B interleukin 1 beta ISO associated with Hypersensitivity RGD PMID:16358839 RGD:4143214 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:11758471 RGD:8662964 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G LOC100980965 zinc-alpha-2-glycoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr 7:91,999,717...92,009,066
Ensembl chr 7:105,432,782...105,442,219 		JBrowse link
G LTA lymphotoxin alpha susceptibility ISO DNA:polymorphism: : RGD PMID:11037831 RGD:4143260 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression: : RGD PMID:20392482 RGD:5130763 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:18396779 RGD:4892328 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO protein: increased expression: nasal cavity epithelium RGD PMID:21255638 RGD:6483060 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883 		JBrowse link
G PIP prolactin induced protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr 7:135,127,479...135,135,117 JBrowse link
G PLAU plasminogen activator, urokinase ISO RGD PMID:21711960 RGD:6483796 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:21711960 RGD:6483796 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561 		JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr17:44,224,007...44,240,906
Ensembl chr17:49,098,089...49,126,932 		JBrowse link
G SCGB3A2 secretoglobin family 3A member 2 ISO mRNA,protein:decreased expression:nasal mucosa RGD PMID:21385388 RGD:5147389 NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003 		JBrowse link
G SFTPA1 surfactant protein A1 ISO associated with Cystic Fibrosis;mRNA:increased expression:respiratory system mucosa RGD PMID:17599561 RGD:4143506 NCBI chr10:76,571,312...76,575,820 JBrowse link
G SFTPD surfactant protein D ISO associated with Cystic Fibrosis;mRNA:increased expression:respiratory system mucosa RGD PMID:17599561 RGD:4143506 NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181 		JBrowse link
G TLR2 toll like receptor 2 ISO mRNA:increased expression:nasal cavity epithelium: RGD PMID:14743629 RGD:8552991 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO associated with Pneumococal Infections;
mRNA:increased expression:nasal cavity epithelium:		 RGD PMID:14743629 PMID:16301373 RGD:7800729 RGD:8552991 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17632
    sensory system disease 6729
      Otorhinolaryngologic Diseases 1746
        nose disease 215
          Bifid Nose 1
          Epistaxis + 2
          Nasal Alar Collapse, Bilateral 0
          Nasal Obstruction 1
          Nasal Polyps + 71
          Nasal Septal Perforation 0
          Nose Deformities, Acquired + 0
          Nose Neoplasms + 20
          lethal midline granuloma 0
          nasal cavity disease + 174
          paranasal sinus disease + 57
          rhinoscleroma 1
Path 2
Term Annotations click to browse term
  disease 17632
    disease of anatomical entity 15049
      nervous system disease 13178
        Neurologic Manifestations 9597
          sensory system disease 6729
            Otorhinolaryngologic Diseases 1746
              nose disease 215
                Bifid Nose 1
                Epistaxis + 2
                Nasal Alar Collapse, Bilateral 0
                Nasal Obstruction 1
                Nasal Polyps + 71
                Nasal Septal Perforation 0
                Nose Deformities, Acquired + 0
                Nose Neoplasms + 20
                lethal midline granuloma 0
                nasal cavity disease + 174
                paranasal sinus disease + 57
                rhinoscleroma 1
paths to the root