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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:bronchiolitis obliterans
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Accession:DOID:2799 term browser browse the term
Definition:Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Synonyms:exact_synonym: Bronchiolitis exudativa;   Bronchiolitis fibrosa obliterans;   Constrictive Bronchiolitides;   Constrictive Bronchiolitis;   Exudative Bronchiolitides;   Exudative Bronchiolitis;   Obliterative Bronchiolitis;   Proliferative Bronchiolitides;   Proliferative Bronchiolitis
 primary_id: MESH:D001989
 alt_id: RDO:0005069
 xref: GARD:9551;   NCI:C62580
For additional species annotation, visit the Alliance of Genome Resources.


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bronchiolitis obliterans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP RGD PMID:17097496 RGD:4140933 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adora2a adenosine A2a receptor ISO RGD PMID:19766783 RGD:4890362 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO RGD PMID:18785972 RGD:4145604 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14611812 RGD:2307195 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO RGD PMID:20628341 RGD:4891471 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP
IMP
mRNA:increased expression:lung (rat) RGD PMID:19840961, PMID:14611812 RGD:4889978, RGD:2307195 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 IEP protein:increased expression:bronchoalveolar Lavage fluid RGD PMID:22215510 RGD:6483763 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:trachea: RGD PMID:11518728 RGD:4145124
G Cd86 CD86 molecule IMP RGD PMID:11266944 RGD:2307206 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Csf2 colony stimulating factor 2 IEP associated with Respiratory Aspiration;protein:increased expression:serum RGD PMID:18557728 RGD:2317286 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:16709871, PMID:12097412, PMID:12097412 RGD:5135441, RGD:5135451, RGD:5135451 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412, PMID:12097412 RGD:5135451, RGD:5135451 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:16709871, PMID:12097412, PMID:12097412 RGD:5135441, RGD:5135451, RGD:5135451 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:16709871, PMID:12097412 RGD:5135441, RGD:5135451 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Edn1 endothelin 1 ISO human gene in a rat model RGD PMID:9595474 RGD:8662402 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Foxp3 forkhead box P3 IEP mRNA:increased expression:lung RGD PMID:19840961 RGD:4889978 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gzmb granzyme B ISO RGD PMID:19737140 RGD:5135518 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:12973103 RGD:4145412 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:16137903 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17182591 RGD:4146242 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO RGD PMID:17182591 RGD:4146242 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17182591 RGD:4146242 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061
JBrowse link
G Il17a interleukin 17A ISO mRNA:increased expression:trachea RGD PMID:20393404 RGD:4143277 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:lung RGD PMID:11889437 RGD:4143176 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:serum RGD PMID:18557728 RGD:2317286 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20393404 RGD:4143277 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mbl2 mannose binding lectin 2 resistance ISO DNA:transversion:5' utr:-290C>G rs7096206 (human) RGD PMID:19104434 RGD:4889456 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:20417130 RGD:5130759 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:16969297 RGD:5131273 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:18158963 RGD:5131450 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with lung transplantation; protein:increased expression:lung RGD PMID:11112135 RGD:4892082 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 IEP protein:increased expression:lung RGD PMID:15136885 RGD:4892068 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage RGD PMID:11981419 RGD:5147386 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Sftpd surfactant protein D ISO RGD PMID:18347569 RGD:4143500 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Tlr9 toll-like receptor 9 ISO DNA:SNPs:promoter, 3' utr:g.-1485C>T (rs187084), rs352162 (human) RGD PMID:20227302 RGD:5130722 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
cryptogenic organizing pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:lung, macrophage (human) RGD PMID:21144722 RGD:5131112 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:lung, lymphocyte (human) RGD PMID:21144722 RGD:5131112 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      Skin and Connective Tissue Diseases 4954
        connective tissue disease 3626
          interstitial lung disease 354
            bronchiolitis obliterans 37
              cryptogenic organizing pneumonia 2
Path 2
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      respiratory system disease 2708
        lower respiratory tract disease 1646
          lung disease 1602
            obstructive lung disease 435
              bronchitis 89
                bronchiolitis 76
                  bronchiolitis obliterans 37
                    cryptogenic organizing pneumonia 2
paths to the root