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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:parasitic protozoa infectious disease
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Accession:DOID:2789 term browser browse the term
Definition:A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes. (DO)
Synonyms:exact_synonym: Histomoniasis;   Protozoan Infection;   histomoniases;   mastigophora infectious disease;   protozoan infections;   sarcomastigophora infectious disease
 primary_id: MESH:D011528
 xref: ICD10CM:B64;   NCI:C34953
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Acanthamoeba Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:cornea RGD PMID:21155840 RGD:7777095 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Amebic Liver Abscess term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL2 interleukin 2 treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:26809113 RGD:39458041 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism, haplotype: :HLA-DQB1*04, HLA-DQB1*02 RGD PMID:25938667 RGD:36049810 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Amoebic Dysentery due to Entamoeba Histolytica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL25 interleukin 25 ISO protein:decreased expression:intestine RGD PMID:28246365 RGD:39128243 NCBI chr14:4,191,888...4,195,043
Ensembl chr14:22,286,347...22,289,498 		JBrowse link
Animal Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO mRNA, protein:increased expression:blood vessel endothelial cell RGD PMID:15710456 RGD:2307183 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:19741601 RGD:8661685 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G FOXP3 forkhead box P3 ISO mRNA:decreased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:8881756 RGD:12910478 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:31231617 RGD:39939039 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352 		JBrowse link
G IL17A interleukin 17A ISO mRNA,protein:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL21 interleukin 21 ISO RGD PMID:23667536 RGD:127285360 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:15265921 RGD:39457943 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G IL2RB interleukin 2 receptor subunit beta ameliorates ISO RGD PMID:11286020 RGD:42724468 NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038 		JBrowse link
G IL6 interleukin 6 ISO mRNA:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LDLR low density lipoprotein receptor ISO RGD PMID:18316222 RGD:5490254 NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 ISO RGD PMID:25855987 RGD:11057198 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G RORC RAR related orphan receptor C ISO mRNA:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 1:127,164,725...127,190,479
Ensembl chr 1:130,808,705...130,834,490 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31416833 RGD:39128220 NCBI chr 5:134,845,689...134,852,938
Ensembl chr 5:140,967,399...140,973,846 		JBrowse link
babesiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:serum (human) RGD PMID:25539588 RGD:11541121 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
boutonneuse fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CFB complement factor B ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr 6:31,606,716...31,612,782 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14507644 RGD:5135450 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14507644 RGD:5135450 NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502 		JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891 		JBrowse link
G AQP4 aquaporin 4 disease_progression ISO protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G CAST calpastatin ISO protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650 		JBrowse link
G CD36 CD36 molecule ISO RGD PMID:17367535 RGD:6893527 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G CLEC12A C-type lectin domain family 12 member A ameliorates ISO RGD PMID:31269448 RGD:41412201 NCBI chr12:9,999,334...10,056,108
Ensembl chr12:10,248,209...10,272,070 		JBrowse link
G IL33 interleukin 33 treatment ISO protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955 RGD:40400741 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G JAK3 Janus kinase 3 ISO RGD PMID:22363534 RGD:11531103 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G LTA lymphotoxin alpha ISO RGD PMID:12021316 RGD:10449455 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G NRG1 neuregulin 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model		 RGD PMID:24433482 PMID:29636063 RGD:39456084 RGD:39456102 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:25775137 RGD:38599200 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO RGD PMID:12228317 RGD:5131158 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFKB1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20156658 RGD:40902838 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression ISO DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:22537745 RGD:39939013 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:24055715 RGD:7364866 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:28356392 RGD:39457935 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G MBL2 mannose binding lectin 2 severity ISO RGD PMID:26745156 RGD:11076757 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G PCNA proliferating cell nuclear antigen ISO protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr20:5,134,930...5,146,603
Ensembl chr20:4,927,731...4,939,440 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma disease_progression ISO mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)		 RGD PMID:29666415 RGD:38599151 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
Chagas disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:16844401 RGD:2307145 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:20452453 RGD:4889906 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 ISO RGD PMID:9148906 RGD:5509585 NCBI chr 7:128,827,089...128,978,496
Ensembl chr 7:141,466,396...141,467,796 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:blood plasma (human) RGD PMID:20699256 PMID:21866301 RGD:40818435 RGD:5147778 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 ISO RGD PMID:21801456 RGD:6218957 NCBI chr 5:128,463,186...128,517,563
Ensembl chr 5:134,619,076...134,673,658 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:10684988 RGD:10755744 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL23A interleukin 23 subunit alpha susceptibility ISO RGD PMID:23182712 RGD:39457956 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G PRG2 proteoglycan 2, pro eosinophil major basic protein ISO mRNA:increased expression:plancenta (human) RGD PMID:29545200 RGD:40902989 NCBI chr11:52,628,289...52,631,634
Ensembl chr 3:160,118,111...160,122,002 		JBrowse link
G SOAT1 sterol O-acyltransferase 1 ameliorates ISO DNA:SNP:exon: rs1044925 (human) RGD PMID:31236660 RGD:126925205 NCBI chr 1:154,776,305...154,840,594
Ensembl chr 1:158,464,886...158,524,909 		JBrowse link
G VIM vimentin severity ISO protein:increased expression:plasma RGD PMID:22199233 RGD:6480538 NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642 		JBrowse link
coccidiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL2RB interleukin 2 receptor subunit beta exacerbates ISO RGD PMID:20460838 RGD:42724464 NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038 		JBrowse link
cryptosporidiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:polymorphisms, haplotype:promoter,exon: RGD PMID:19827946 RGD:12910843 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
cutaneous leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase ISO protein:decreased activity:erythrocyte: RGD PMID:9892499 RGD:9479188 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:12874303 RGD:5688168 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:foot, lymph node RGD PMID:12874303 RGD:5688168 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association ISO DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD PMID:17214851 PMID:23632983 RGD:8549764 RGD:8549765 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD163 CD163 molecule ISO mRNA, protein:increased expression:skin of body, blood plasma, CD14-positive monocyte (human) RGD PMID:32023254 RGD:127345130 NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023 		JBrowse link
G CD274 CD274 molecule ISO RGD PMID:16358363 RGD:41410801 NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402 		JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO DNA:SNPs: :rs1061237, rs2586488 (human) RGD PMID:25562121 RGD:11041176 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G FOXP3 forkhead box P3 ISO mRNA:increased expression:Peripheral blood mononuclear cell: RGD PMID:29205403 RGD:38455981 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IFNG interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:8154019 PMID:9234779 PMID:20102417 PMID:27999013 RGD:40890273 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:Peripheral blood mononuclear cell:		 CTD
RGD		 PMID:20102417 PMID:29205403 RGD:38455981 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL13 interleukin 13 treatment ISO RGD PMID:12739821 PMID:18924210 RGD:8549536 RGD:8549561 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL17A interleukin 17A ISO mRNA:increased expression:Peripheral blood mononuclear cell: RGD PMID:29205403 RGD:38455981 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:29078003 RGD:39457938 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G IL32 interleukin 32 susceptibility
ameliorates		 ISO DNA:SNPs:enhancers: (rs4786370, rs4349147) (human) RGD PMID:28709468 PMID:32023240 RGD:150340717 RGD:150340742 NCBI chr16:2,007,018...2,023,757
Ensembl chr16:3,179,637...3,203,929 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G LTA lymphotoxin alpha no_association ISO DNA:SNP:intron:252A>G (human) RGD PMID:16950634 RGD:8548800 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G LTB lymphotoxin beta ISO RGD PMID:17911622 RGD:8548820 NCBI chr 6:31,241,643...31,244,454
Ensembl chr 6:32,131,760...32,133,467 		JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:21091666 RGD:8657030 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G PDCD1LG2 programmed cell death 1 ligand 2 ISO RGD PMID:16358363 RGD:41410801 NCBI chr 9:5,313,071...5,391,676
Ensembl chr 9:5,514,449...5,575,688 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO RGD PMID:27999013 RGD:40890273 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO DNA:insertion/deletion (human) RGD PMID:20089160 RGD:5684930 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941 		JBrowse link
G SOD1 superoxide dismutase 1 ISO protein:increased activity:erythrocyte: RGD PMID:9892499 RGD:9479188 NCBI chr21:18,029,831...18,037,526 JBrowse link
G STAT4 signal transducer and activator of transcription 4 ISO RGD PMID:10458767 RGD:8661703 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011 		JBrowse link
G TLR2 toll like receptor 2 ISO protein:decreased expression:skin: RGD PMID:20493664 RGD:7794748 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO protein:decreased expression:skin: RGD PMID:20493664 RGD:7794748 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor no_association ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:-308G>A (rs1800629) (human)		 CTD
RGD		 PMID:16950634 PMID:20102417 RGD:8548800 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Entamoebiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16374615 PMID:29255076 RGD:14975099 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL5 interleukin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20086086 RGD:40902842 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:15910421 RGD:7241086 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO protein:increased expression:brain RGD PMID:25014011 RGD:8695986 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G ARG1 arginase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21232540 NCBI chr 6:129,372,747...129,383,880
Ensembl chr 6:133,479,966...133,491,162 		JBrowse link
G BTK Bruton tyrosine kinase susceptibility ISO RGD PMID:28783468 RGD:124715477 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187 		JBrowse link
G C3 complement C3 ISO RGD PMID:15378355 RGD:7401274 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:10899907 RGD:8661227 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 disease_progression ISO associated with HIV Infections;protein:increased expression:blood, T cell RGD PMID:10553079 PMID:17457607 RGD:8551832 RGD:8551841 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17218153 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G DUSP1 dual specificity phosphatase 1 treatment ISO RGD PMID:21471446 RGD:7771536 NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960 		JBrowse link
G DUSP6 dual specificity phosphatase 6 treatment ISO RGD PMID:21471446 RGD:7771536 NCBI chr12:86,875,289...86,879,731
Ensembl chr12:90,195,482...90,200,321 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:2145107 PMID:16540374 PMID:17218153 RGD:7829781 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16540374 PMID:20404924 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL18 interleukin 18 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:10768930 PMID:16879623 RGD:8655909 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:6224858 RGD:8693326 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL21 interleukin 21 exacerbates ISO protein:increased expression:popliteal lymph node (mouse) RGD PMID:22429963 RGD:127285547 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL27 interleukin 27 exacerbates ISO RGD PMID:25466588 RGD:126790552
G IL4 interleukin 4 treatment ISO protein:increased expression:serum RGD PMID:2145107 PMID:2521244 RGD:7829781 RGD:7829820 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16540374 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGB2 integrin subunit beta 2 ameliorates ISO RGD PMID:14502280 RGD:127285813 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670606 NCBI chr 1:125,918,760...125,923,952
Ensembl chr 1:129,566,827...129,572,086 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO lupoid leishmaniasis;protein:increased expression:skin of body (human) RGD PMID:23989888 RGD:36947873 NCBI chr17:26,546,177...26,572,301
Ensembl chr17:27,050,900...27,092,882 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16540374 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20139272
G TNFSF4 TNF superfamily member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10637281 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 severity ISO RGD PMID:24453980 RGD:126925972 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091 		JBrowse link
G VDR vitamin D receptor ISO RGD PMID:17551101 RGD:8158083 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
Lyme disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 ISO protein:increased expression:synovial fluid RGD PMID:23371320 RGD:7488895 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 severity ISO RGD PMID:12847259 RGD:7257681 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:21387014 RGD:5508754 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO mRNA:increased expression:skin RGD PMID:19461880 RGD:6483813 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561 		JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:serum (human) RGD PMID:16358960 RGD:11528571 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 treatment
susceptibility		 ISO DNA:haplotype: :1236C>T, 2677G>T,3435C>T (human)
DNA:hypermethylation:promoter
DNA:SNP: :c3435C>T(human)
DNA:SNPs,haplotype: :rs2032582, rs1128503 (human)		 RGD PMID:17015054 PMID:19331170 PMID:28422980 PMID:28934955 RGD:39456120 RGD:39456123 RGD:39457679 RGD:39457680 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ACE angiotensin I converting enzyme severity ISO RGD PMID:31234939 RGD:39939120 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ACKR1 atypical chemokine receptor 1 (Duffy blood group) susceptibility ISO ClinVar Annotator: match by term: Plasmodium vivax, resistance to OMIM
ClinVar		 PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More... NCBI chr 1:134,554,406...134,557,386
Ensembl chr 1:138,352,086...138,354,733 		JBrowse link
G AICDA activation induced cytidine deaminase ISO protein:increased expression: B cell RGD PMID:27980783 RGD:30310233 NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917 		JBrowse link
G ANK1 ankyrin 1 ISO OMIM:609148 | OMIM:611162 MouseDO NCBI chr 8:40,897,879...41,140,290
Ensembl chr 8:38,346,503...38,588,549 		JBrowse link
G APOE apolipoprotein E ISO DNA:missense mutations:cds:p.C112R, p.C158R (human) RGD PMID:24116184 RGD:11039486 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G AQP4 aquaporin 4 ISO OMIM:609148 | OMIM:611162 MouseDO NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G CBS cystathionine beta-synthase susceptibility ISO DNA:insertion:cds: (844ins68) (human) RGD PMID:27198213 RGD:40903062 NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932 		JBrowse link
G CD163 CD163 molecule exacerbates
severity		 ISO protein:increased expression:blood plasma (human)
protein:altered expression:blood plasma (human)		 RGD PMID:18632918 PMID:22290142 RGD:127285797 RGD:149735529 NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023 		JBrowse link
G CD1D CD1d molecule exacerbates
ameliorates		 ISO RGD PMID:12938235 PMID:24703850 RGD:127345117 RGD:127345121 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173 		JBrowse link
G CD36 CD36 molecule susceptibility ISO ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:10890433 PMID:18305138 PMID:19403559 PMID:25741868 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G CD40 CD40 molecule severity ISO RGD PMID:11485931 RGD:11352239 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand severity ISO RGD PMID:11485931 RGD:11352239 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CISH cytokine inducible SH2 containing protein susceptibility ISO ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:20484391 NCBI chr 3:50,531,870...50,537,319
Ensembl chr 3:51,769,194...51,774,548 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) susceptibility ISO ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:10528197 PMID:14694201 PMID:20855594 PMID:25741868 NCBI chr 1:183,094,601...183,246,957 JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:8730300 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 disease_progression
treatment		 ISO RGD PMID:28892065 RGD:38455986 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G EPHB2 EPH receptor B2 ISO mRNA:increased expression:liver RGD PMID:25784101 RGD:127285023 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118 		JBrowse link
G EPHB3 EPH receptor B3 ISO RGD PMID:25784101 RGD:127285023 NCBI chr 3:181,604,188...181,624,744
Ensembl chr 3:190,089,522...190,104,905 		JBrowse link
G EPHB6 EPH receptor B6 ISO RGD PMID:25784101 RGD:127285023 NCBI chr 7:134,845,936...134,862,114
Ensembl chr 7:147,337,558...147,353,575 		JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa susceptibility ISO ClinVar Annotator: match by term: Malaria, severe, susceptibility to OMIM
ClinVar		 PMID:8636449 PMID:9843982 PMID:10675363 PMID:15367919 PMID:19915573 More... NCBI chr 1:136,892,311...136,906,450 JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb susceptibility ISO ClinVar Annotator: match by term: Malaria, resistance to OMIM
ClinVar		 PMID:12115230 PMID:15459183 PMID:16115811 PMID:16170323 PMID:17435165 More... NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637 		JBrowse link
G FOXP3 forkhead box P3 disease_progression ISO RGD PMID:16169501 PMID:19338000 RGD:38455985 RGD:38455992 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase susceptibility
severity		 ISO ClinVar Annotator: match by term: Malaria, susceptibility to | ClinVar Annotator: match by term: Plasmodium vivax, resistance to
DNA:point mutation:cds:c.968T>C (human)		 OMIM
ClinVar
RGD		 PMID:5448 PMID:16832 PMID:1303173 PMID:1459579 PMID:1551674 More... RGD:10449115 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674 		JBrowse link
G GYPA glycophorin A (MNS blood group) susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD		 NCBI chr 4:136,455,397...136,486,858
Ensembl chr 4:147,987,750...148,019,005
Ensembl chr 4:147,987,750...148,019,005 		JBrowse link
G GYPB glycophorin B (MNS blood group) susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD		 NCBI chr 4:136,335,881...136,359,518 JBrowse link
G GYPC glycophorin C (Gerbich blood group) susceptibility ISO ClinVar Annotator: match by term: Malaria, resistance to OMIM
ClinVar		 PMID:1991173 PMID:5011657 PMID:8157284 PMID:11719395 PMID:12469115 More... NCBI chr2B:33,578,851...33,619,869 JBrowse link
G HMOX1 heme oxygenase 1 ISO OMIM:609148 | OMIM:611162 MouseDO NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 susceptibility ISO ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:9259284 PMID:9861406 PMID:10417733 PMID:10699175 PMID:23609612 More... NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNG interferon gamma ISO OMIM:609148 | OMIM:611162 MouseDO NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:1945893 PMID:3198117 PMID:7803800 PMID:8244337 PMID:8471773 More... NCBI chr  X:143,988,720...144,010,078
Ensembl chr  X:153,854,493...153,876,092 		JBrowse link
G IL21 interleukin 21 exacerbates ISO RGD PMID:25763578 RGD:127285358 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL27 interleukin 27 ameliorates ISO RGD PMID:24522137 PMID:26968425 RGD:11530371 RGD:126790512
G IL33 interleukin 33 ISO protein:increased expression:serum: RGD PMID:28359899 RGD:39938859 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G LTBR lymphotoxin beta receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15788153 NCBI chr12:6,514,432...6,521,966
Ensembl chr12:6,422,470...6,438,510 		JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:20484391 NCBI chr 3:50,542,547...50,574,817
Ensembl chr 3:51,779,912...51,812,124 		JBrowse link
G MKI67 marker of proliferation Ki-67 ISO associated with Lung Neoplasms RGD PMID:21931708 RGD:6483517 NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555 		JBrowse link
G NCR3 natural cytotoxicity triggering receptor 3 susceptibility ISO ClinVar Annotator: match by term: Malaria, severe, susceptibility to OMIM
ClinVar		 PMID:17208487 NCBI chr 6:31,249,947...31,281,613
Ensembl chr 6:32,139,981...32,171,525 		JBrowse link
G NOS2 nitric oxide synthase 2 susceptibility ISO ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:9457101 PMID:12433515 PMID:31995689 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G PKLR pyruvate kinase L/R susceptibility ISO DNA:missense mutation:cds:p.I90N (mouse)
OMIM:609148 | OMIM:611162
DNA:mutations, haplotype:multiple (human)		 RGD
MouseDO		 PMID:14595440 PMID:20377593 RGD:11535999 RGD:11537407 NCBI chr 1:130,634,111...130,646,644
Ensembl chr 1:134,239,565...134,251,351 		JBrowse link
G PRF1 perforin 1 ISO RGD PMID:21525386 RGD:6482803 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070 		JBrowse link
G PROCR protein C receptor disease_progression ISO RGD PMID:27671831 RGD:126848795 NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO DNA:SNP::g.80G>A (human) RGD PMID:27198213 RGD:40903062 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC4A1 solute carrier family 4 member 1 (Diego blood group) susceptibility ISO ClinVar Annotator: match by term: Malaria, cerebral, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to OMIM
ClinVar		 PMID:1378323 PMID:1722314 PMID:1737855 PMID:2146504 PMID:6338046 More... NCBI chr17:13,131,851...13,150,872
Ensembl chr17:13,302,796...13,317,312 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:16552072 RGD:1581333 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935 		JBrowse link
G TBX21 T-box transcription factor 21 ISO RGD PMID:19338000 RGD:38455985 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G TIRAP TIR domain containing adaptor protein susceptibility ISO ClinVar Annotator: match by term: Malaria, resistance to OMIM
ClinVar		 PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868 NCBI chr11:121,100,558...121,112,844
Ensembl chr11:125,018,064...125,022,309 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to OMIM
ClinVar		 PMID:8056188 PMID:9818939 PMID:10369255 PMID:10450718 PMID:11261930 More... NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 severity ISO RGD PMID:27671831 RGD:126848795 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO mRNA:altered expression:multiple (mouse) RGD PMID:28955823 RGD:38596344 NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130 		JBrowse link
Malarial Anemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A1 solute carrier family 4 member 1 (Diego blood group) severity ISO DNA:snp:promoter:g.-5699T>C (human) RGD PMID:16960783 RGD:10450507 NCBI chr17:13,131,851...13,150,872
Ensembl chr17:13,302,796...13,317,312 		JBrowse link
mucocutaneous leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:7854095 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G LTA lymphotoxin alpha ISO DNA:polymorphism:intron RGD PMID:7595196 RGD:8548799 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G TNF tumor necrosis factor ISO DNA:SNP:promoter:-308G>A (human) RGD PMID:7595196 RGD:8548799 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Ocular Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:22740770 RGD:7421536 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G IL10 interleukin 10 ISO RGD PMID:19026704 RGD:7365028 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL17A interleukin 17A treatment ISO protein:increased expression:aqueous humor (human) RGD PMID:22927448 RGD:8698652 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL27 interleukin 27 disease_progression ISO mRNA:increased expression:eye, cervical lymph node (mouse) RGD PMID:29779048 RGD:126790500
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:snp:3' utr:g.*397A>C (rs3135499)(human) RGD PMID:23100559 RGD:8547527 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr 9:104,541,051...104,582,574
Ensembl chr 9:133,156,761...133,193,707 		JBrowse link
G CAST calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650 		JBrowse link
G CLEC11A C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr19:47,682,806...47,690,389
Ensembl chr19:56,586,183...56,588,580 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:9230440 PMID:11724985 NCBI chr 1:183,094,601...183,246,957 JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment ISO DNA:polymorphisms:: RGD PMID:10471063 RGD:124713538 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065 		JBrowse link
G FAS Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G G6PD glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G TNF tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Plasmodium vivax malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACKR1 atypical chemokine receptor 1 (Duffy blood group) ISO ClinVar Annotator: match by term: Resistance to Plasmodium vivax infection OMIM
ClinVar		 PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More... NCBI chr 1:134,554,406...134,557,386
Ensembl chr 1:138,352,086...138,354,733 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
sleeping sickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS2 nitric oxide synthase 2 ISO protein:altered activity:brain, peritoneal macrophage RGD PMID:20169057 RGD:4891375 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G TSLP thymic stromal lymphopoietin susceptibility ISO protein:increased expression:serum (mouse) RGD PMID:28769924 RGD:38549587 NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130 		JBrowse link
Tick-Borne Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24218580 NCBI chr12:40,974,756...40,999,471
Ensembl chr12:41,848,785...41,873,252 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:24812878 RGD:10054127 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G IL27 interleukin 27 susceptibility ISO RGD PMID:22981537 PMID:31548322 RGD:126790501 RGD:126790522
G NFKBIA NFKB inhibitor alpha exacerbates ISO human gene in a mouse model RGD PMID:12626571 RGD:126925984 NCBI chr14:16,155,331...16,158,588 JBrowse link
G UCP2 uncoupling protein 2 susceptibility ISO RGD PMID:11101840 RGD:737759 NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185 		JBrowse link
trypanosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO RGD PMID:20809996 RGD:5128861 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868 		JBrowse link
G BCHE butyrylcholinesterase ISO protein:decreased expression:plasma RGD PMID:20138875 RGD:5687328 NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481 		JBrowse link
G CD1D CD1d molecule exacerbates ISO RGD PMID:15731095 RGD:127345115 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:25375156 RGD:150521552 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:24731531 RGD:10402804 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G PRF1 perforin 1 ISO RGD PMID:19651871 RGD:6482814 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070 		JBrowse link
visceral leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase ISO RGD PMID:31001826 RGD:32716386 NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:24818662 RGD:8661728 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO protein:increased expression:blood, T cell RGD PMID:15379987 RGD:6893393 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 treatment ISO RGD PMID:24617012 RGD:14401738 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD163 CD163 molecule exacerbates ISO protein:increased expression:blood serum (human) RGD PMID:28355218 RGD:127345133 NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:14573667 RGD:8547750 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:14573667 RGD:8547750 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:10467834 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8035028 PMID:17404324 RGD:10449527 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO mRNA:increased expression:liver RGD PMID:16239557 RGD:27095947 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:g.-251A>T (human)		 CTD
RGD		 PMID:22461696 PMID:25821028 PMID:32984951 RGD:150523789 RGD:150523791 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22461696 PMID:23729024 RGD:42724459 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G IFNG interferon gamma treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:1901333 PMID:3104456 PMID:7854095 PMID:27999013 RGD:40890273 RGD:8158041 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15716043 PMID:17404324 PMID:22461696 PMID:29745990 RGD:14975172 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL10RA interleukin 10 receptor subunit alpha ISO CTD Direct Evidence: therapeutic CTD PMID:15716043 NCBI chr11:112,820,445...112,835,603
Ensembl chr11:116,752,619...116,767,771 		JBrowse link
G IL18 interleukin 18 susceptibility ISO RGD PMID:16879623 RGD:8655922 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17404324 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL27 interleukin 27 ISO mRNA, protein:increased expression:spleen, liver (mouse) RGD PMID:27245409 RGD:126790520
G IL2RB interleukin 2 receptor subunit beta susceptibility ISO DNA:polymorphisms:exon:8777, 8838(human) RGD PMID:17108990 RGD:42724466 NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038 		JBrowse link
G IL32 interleukin 32 ameliorates ISO human gene in a mouse model RGD PMID:29483288 RGD:150340719 NCBI chr16:2,007,018...2,023,757
Ensembl chr16:3,179,637...3,203,929 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554475 PMID:17404324 PMID:22461696 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRF5 interferon regulatory factor 5 ISO protein:increased expression:CD4 T cell, nucleus RGD PMID:30067973 PMID:32038622 RGD:40924560 RGD:40924629 NCBI chr 7:120,889,752...120,902,096
Ensembl chr 7:133,415,170...133,426,356 		JBrowse link
G LTA lymphotoxin alpha severity ISO DNA:polymorphisms RGD PMID:12438370 PMID:15579454 RGD:8548784 RGD:8548789 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G LTB lymphotoxin beta ISO RGD PMID:12115620 RGD:8548822 NCBI chr 6:31,241,643...31,244,454
Ensembl chr 6:32,131,760...32,133,467 		JBrowse link
G MBL2 mannose binding lectin 2 disease_progression
susceptibility		 ISO DNA:polymorphism:promoter:
DNA:SNPs,haplotype:promoter,exon:
protein:increased expression:serum:		 RGD PMID:17357060 PMID:22995279 PMID:26297290 RGD:11522692 RGD:8693721 RGD:8693726 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:23729024 RGD:42724459 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO RGD PMID:27999013 RGD:40890273 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16597321 PMID:17067929 RGD:5684944 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 ISO RGD PMID:24242758 RGD:8661696 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011 		JBrowse link
G TLR2 toll like receptor 2 disease_progression ISO RGD PMID:23589575 RGD:15090808 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TNF tumor necrosis factor severity ISO DNA:polymorphisms
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:1901333 PMID:12438370 PMID:15579454 PMID:22461696 RGD:8548784 RGD:8548789 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17632
    disease by infectious agent 2125
      parasitic infectious disease 319
        parasitic protozoa infectious disease 144
          Central Nervous System Protozoal Infections + 13
          Ciliophora Infections + 0
          Euglenozoa Infections + 75
          Protozoan Infections, Animal + 16
          Tick-Borne Diseases + 15
          amebiasis + 12
          coccidiosis + 23
          dientamoebiasis 0
          giardiasis 0
          leishmaniasis + 60
          malaria + 69
          parasitic Ichthyosporea infectious disease + 0
          trichomoniasis + 0
          trypanosomiasis + 22
paths to the root