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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:transitional cell carcinoma
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Accession:DOID:2671 term browser browse the term
Definition:A carcinoma that derives_from transitional epithelial cells. (DO)
Synonyms:exact_synonym: TCC;   transitional carcinoma;   transitional cell carcinomas;   transitional cell tumor;   urothelial carcinoma;   urothelial cell carcinoma
 narrow_synonym: invasive transitional cell carcinoma;   transitional cell carcinoma of the bladder
 related_synonym: transitional cell neoplasm
 primary_id: MESH:D002295
 alt_id: OMIA:001512
 xref: EFO:0008528;   EFO:1000601;   GARD:7794;   ICDO:8120/3;   NCI:C128126;   NCI:C2930;   NCI:C6783
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
transitional cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: therapeutic CTD PMID:14644129 NCBI chrNW_004624760:21,047,576...21,064,698
Ensembl chrNW_004624760:21,047,303...21,068,076 		JBrowse link
G Angpt1 angiopoietin 1 disease_progression ISO RGD PMID:15517881 RGD:2293863 NCBI chrNW_004624763:22,645,807...22,818,592
Ensembl chrNW_004624763:22,646,231...22,718,294 		JBrowse link
G Angpt2 angiopoietin 2 disease_progression ISO RGD PMID:15705099 RGD:2293853 NCBI chrNW_004624861:4,457,519...4,510,035
Ensembl chrNW_004624861:4,457,158...4,509,623 		JBrowse link
G Anxa1 annexin A1 severity ISO mRNA, protein:increased expression:urinary bladder RGD PMID:17994624 RGD:2306889 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133271 NCBI chrNW_004624750:8,835,521...8,940,957
Ensembl chrNW_004624750:8,837,037...8,938,009 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO DNA:methylation: : RGD PMID:21599969 RGD:7242057 NCBI chrNW_004624743:30,517,034...30,635,740
Ensembl chrNW_004624743:30,546,323...30,635,737 		JBrowse link
G Apoa1 apolipoprotein A1 severity ISO protein:increased expression:urine
mRNA:decreased expression:urinary bladder 		RGD PMID:19399409 PMID:21496341 RGD:2325183 RGD:7241214 NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136 		JBrowse link
G Areg amphiregulin ISO mRNA:increased expression:urinary bladder RGD PMID:16469638 RGD:2289980 NCBI chrNW_004624730:1,290,692...1,299,365
Ensembl chrNW_004624730:1,290,655...1,299,410 		JBrowse link
G Arid1a AT-rich interaction domain 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO RGD PMID:18047955 RGD:1643477 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344 		JBrowse link
G Bcl2l1 BCL2 like 1 ISO RGD PMID:18047955 RGD:1643477 NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507 		JBrowse link
G Birc5 baculoviral IAP repeat containing 5 disease_progression ISO protein:increased expression:urinary bladder
mRNA:increased expression:urine 		RGD PMID:17559031 PMID:17828507 PMID:18172282 RGD:2293093 RGD:2293099 RGD:2298937 NCBI chrNW_004624801:7,727,084...7,735,946
Ensembl chrNW_004624801:7,727,093...7,735,940 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO Transitional cell carcinoma OMIA PMID:998613 PMID:2593174 PMID:15112777 PMID:24936033 PMID:25747698 More... NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Brd4 bromodomain containing 4 disease_progression ISO mRNA,protein:increased expression:bladder: RGD PMID:25120803 RGD:9586352 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Bsg basigin (Ok blood group) disease_progression ISO RGD PMID:17671123 RGD:2289051 NCBI chrNW_004624828:7,913,297...7,920,891
Ensembl chrNW_004624828:7,913,099...7,920,804 		JBrowse link
G Ca9 carbonic anhydrase 9 disease_progression ISO RGD PMID:15069539 RGD:2298947 NCBI chrNW_004624868:5,110,602...5,131,167
Ensembl chrNW_004624868:5,109,846...5,116,949 		JBrowse link
G Cav1 caveolin 1 disease_progression ISO protein:increased expression:urinary bladder RGD PMID:16328005 RGD:2289103 NCBI chrNW_004624827:2,844,855...2,878,367
Ensembl chrNW_004624827:2,844,115...2,879,179 		JBrowse link
G Cbx7 chromobox 7 severity ISO mRNA:decreased expression:urinary bladder: RGD PMID:18984978 RGD:9587361 NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA, protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:12151359 PMID:16896691 RGD:2289144 NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191 		JBrowse link
G Ccnd2 cyclin D2 ISO DNA:hypermethylation:urinary bladder, urine RGD PMID:17017434 RGD:2289150 NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107 		JBrowse link
G Cd44 CD44 molecule (IN blood group) ISO mRNA:splice variants:kidney pelvis, ureter RGD PMID:10022688 RGD:2289363 NCBI chrNW_004624767:11,938,452...12,024,970
Ensembl chrNW_004624767:11,938,028...12,025,069 		JBrowse link
G Cd82 CD82 molecule ISO RGD PMID:17393117 RGD:2289390 NCBI chrNW_004624767:3,556,128...3,589,956 JBrowse link
G Cd9 CD9 molecule disease_progression ISO protein:decreased expression:urinary bladder RGD PMID:17393117 RGD:2289390 NCBI chrNW_004624860:3,027,126...3,055,974
Ensembl chrNW_004624860:3,027,029...3,056,798 		JBrowse link
G Cdk1 cyclin dependent kinase 1 severity ISO RGD PMID:18245534 RGD:2701900 NCBI chrNW_004624791:2,891,239...2,915,001 JBrowse link
G Cdk4 cyclin dependent kinase 4 disease_progression ISO RGD PMID:15161057 RGD:2293580 NCBI chrNW_004624802:10,191,679...10,194,585
Ensembl chrNW_004624802:10,191,014...10,194,275 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359 PMID:18640142 NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B disease_progression ISO RGD PMID:10886076 RGD:2293608 NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B ISO associated with Bladder Neoplasms;DNA, mRNA:deletion, decreased expression:urinary bladder urothelium RGD PMID:11720438 RGD:2289697 NCBI chrNW_004624736:25,929,314...25,933,318
Ensembl chrNW_004624736:25,926,668...25,933,440 		JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624790:12,610,418...12,858,062
Ensembl chrNW_004624790:12,610,254...12,858,368 		JBrowse link
G Crebbp CREB binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624824:1,516,481...1,655,364
Ensembl chrNW_004624824:1,517,966...1,655,329 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:7525883 PMID:7543010 NCBI chrNW_004624795:3,162,999...3,167,248
Ensembl chrNW_004624795:3,163,009...3,166,594 		JBrowse link
G Ctnna1 catenin alpha 1 ISO RGD PMID:16426728 RGD:2298486 NCBI chrNW_004624743:31,512,481...31,700,340 JBrowse link
G Ctnnb1 catenin beta 1 disease_progression ISO RGD PMID:16426728 PMID:17363521 RGD:2289818 RGD:2298486 NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234 		JBrowse link
G Ctsb cathepsin B ISO protein:increased expression:urinary bladder RGD PMID:15183956 RGD:2315615 NCBI chrNW_004624758:25,366,120...25,384,554
Ensembl chrNW_004624758:25,366,840...25,373,954 		JBrowse link
G Ctsh cathepsin H ISO protein:increased expression:urinary bladder RGD PMID:15183956 RGD:2315615 NCBI chrNW_004624941:82,209...98,156
Ensembl chrNW_004624941:82,209...98,182 		JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133271 NCBI chrNW_004624809:9,585,426...9,794,582
Ensembl chrNW_004624809:9,586,225...9,793,208 		JBrowse link
G Daxx death domain associated protein ISO RGD PMID:23819605 RGD:9587843 NCBI chrNW_004624754:23,504,465...23,509,034
Ensembl chrNW_004624754:23,505,386...23,509,241 		JBrowse link
G Egfr epidermal growth factor receptor ISO mRNA:decreased expression:urinary bladder RGD PMID:3499520 PMID:16469638 RGD:10395259 RGD:2289980 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 severity ISO protein:increased expression:urinary bladder
mRNA:increased expression:urinary bladder 		RGD PMID:14614020 PMID:17987577 RGD:2289927 RGD:2298506 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO mRNA:increased expression:urinary bladder RGD PMID:14614020 PMID:16469638 RGD:2289980 RGD:2298506 NCBI chrNW_004624802:11,906,279...11,925,530
Ensembl chrNW_004624802:11,905,271...11,925,707 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO mRNA:decreased expression:urinary bladder
mRNA:increased expression:urinary bladder 		RGD PMID:14614020 PMID:16469638 RGD:2289980 RGD:2298506 NCBI chrNW_004624765:3,612,781...4,742,219
Ensembl chrNW_004624765:3,613,379...4,734,585 		JBrowse link
G Espl1 extra spindle pole bodies like 1, separase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chrNW_004624904:1,305,040...1,330,505
Ensembl chrNW_004624904:1,305,000...1,330,761 		JBrowse link
G Esr2 estrogen receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16700038 NCBI chrNW_004624734:36,742,913...36,862,993
Ensembl chrNW_004624734:36,759,104...36,825,295 		JBrowse link
G Fas Fas cell surface death receptor disease_progression ISO protein:increased expression:urine
protein:decreased expression 		RGD PMID:12470426 PMID:16091761 PMID:16541433 RGD:2290058 RGD:2290075 RGD:2290077 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848 		JBrowse link
G Faslg Fas ligand disease_progression ISO RGD PMID:12470426 PMID:12651606 RGD:2290076 RGD:2290077 NCBI chrNW_004624771:9,031,978...9,038,760
Ensembl chrNW_004624771:9,032,016...9,038,825 		JBrowse link
G Fgf1 fibroblast growth factor 1 disease_progression ISO protein:increased expression:urine, urinary bladder RGD PMID:7690426 RGD:2298518 NCBI chrNW_004624774:1,779,168...1,867,321
Ensembl chrNW_004624774:1,779,170...1,867,300 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO protein:decreased expression:urinary bladder RGD PMID:7549793 RGD:2298517 NCBI chrNW_004624777:3,268,674...3,321,424
Ensembl chrNW_004624777:3,268,953...3,321,145 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO mRNA, protein:decreased expression:urinary bladder RGD PMID:9018118 RGD:2301194 NCBI chrNW_004624737:25,052,698...25,158,346
Ensembl chrNW_004624737:25,052,606...25,158,529 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO DNA:missense mutations:CDS:somatic mutations in 26/63 tumors (41%) and 4/18 cell lines (22%) with most identical to activating germline mutations which cause thanatophoric dysplasia
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:11314002 PMID:24121792 RGD:2289866 NCBI chrNW_004624755:25,633,690...25,647,361
Ensembl chrNW_004624755:25,635,165...25,646,932 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815704 NCBI chrNW_004624744:28,752,785...28,786,293
Ensembl chrNW_004624744:28,752,909...28,785,661 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15247771 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism
DNA, mRNA:mutation, increased expression:urinary bladder 		CTD
RGD		 PMID:3433577 PMID:19303097 RGD:2314836 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Hrh2 histamine receptor H2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6224980 NCBI chrNW_004624733:14,261,799...14,308,320
Ensembl chrNW_004624733:14,260,720...14,308,217 		JBrowse link
G Ifnb1 interferon beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:2297754 NCBI chrNW_004624736:25,099,061...25,099,746 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 disease_progression ISO CTD Direct Evidence: marker/mechanism
DNA:hypermethylation 		CTD
RGD		 PMID:17541304 PMID:21347663 RGD:2301466 NCBI chrNW_004624740:6,878,818...6,886,512
Ensembl chrNW_004624740:6,877,348...6,886,512 		JBrowse link
G Kdm6a lysine demethylase 6A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624887:1,065,173...1,279,660
Ensembl chrNW_004624887:1,065,883...1,279,186 		JBrowse link
G Kdr kinase insert domain receptor disease_progression ISO transitional cell cancer of the bladder; protein:increased expression:tumor:correlated with stage (p=0.05) and invasion into muscle (p<0.01) RGD PMID:16515971 PMID:18645275 RGD:2291934 RGD:2301755 NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051 		JBrowse link
G Kiss1 KiSS-1 metastasis suppressor ISO urinary bladder TCC; mRNA:increased expression:tumor:versus normal bladder, no difference between low- and high-grade tumors RGD PMID:17164231 RGD:2292127 NCBI chrNW_004624807:6,800,144...6,805,555
Ensembl chrNW_004624807:6,803,265...6,805,433 		JBrowse link
G Kiss1r KISS1 receptor severity ISO urinary bladder TCC; mRNA:increased expression:tumor:versus normal bladder, with significantly higher expression in high-grade vs low-grade tumors (p=0.03) RGD PMID:17164231 RGD:2292127 NCBI chrNW_004624828:7,677,467...7,680,508
Ensembl chrNW_004624828:7,677,395...7,680,355 		JBrowse link
G Kmt2a lysine methyltransferase 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624784:13,824,507...13,912,672
Ensembl chrNW_004624784:13,824,541...13,908,077 		JBrowse link
G Kmt2c lysine methyltransferase 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624800:4,510,669...4,785,909
Ensembl chrNW_004624800:4,511,549...4,784,053 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO mRNA:increased expression:urinary bladder RGD PMID:19303097 RGD:2314836 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:9751409 RGD:2314950 NCBI chrNW_004624820:9,667,371...9,677,488
Ensembl chrNW_004624820:9,667,262...9,677,774 		JBrowse link
G Mmp15 matrix metallopeptidase 15 ISO RGD PMID:9751409 RGD:2314950 NCBI chrNW_004624746:28,128,687...28,147,964
Ensembl chrNW_004624746:28,130,128...28,147,381 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chrNW_004624757:1,450,680...1,479,160
Ensembl chrNW_004624757:1,448,698...1,479,255 		JBrowse link
G Msh2 mutS homolog 2 ISO associated with Lynch syndrome RGD PMID:22883484 RGD:126790557 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:transversion:cds:g.1298A>C (human) RGD PMID:21046286 RGD:6893477 NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168 		JBrowse link
G Ncor1 nuclear receptor corepressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chrNW_004624877:4,203,125...4,379,891
Ensembl chrNW_004624877:4,233,282...4,377,211 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO mRNA:increased expression:urinary bladder RGD PMID:19303097 RGD:2314836 NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase severity ISO DNA:missense mutation:exon:p.S326C (rs1052133) (human) RGD PMID:22110223 RGD:8657372 NCBI chrNW_004624731:4,383,000...4,388,486
Ensembl chrNW_004624731:4,383,434...4,388,196 		JBrowse link
G Pabpc1 poly(A) binding protein cytoplasmic 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25783786 NCBI chrNW_004624763:7,552,541...7,568,047
Ensembl chrNW_004624763:7,550,307...7,567,918 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 severity ISO protein:increased expression:urinary bladder RGD PMID:18167251 RGD:2299157 NCBI chrNW_004624863:442,465...609,159
Ensembl chrNW_004624863:439,541...525,918 		JBrowse link
G Phb1 prohibitin 1 disease_progression ISO protein:increased expression:urinary bladder RGD PMID:17465217 RGD:2292396 NCBI chrNW_004624795:5,556,728...5,565,969
Ensembl chrNW_004624795:5,556,450...5,565,988 		JBrowse link
G Pla2g4a phospholipase A2 group IVA ISO mRNA:increased expression:bladder RGD PMID:16621493 RGD:1642457 NCBI chrNW_004624814:6,597,248...6,744,294
Ensembl chrNW_004624814:6,597,005...6,744,286 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:urinary tract, tumor (human) 		CTD
RGD		 PMID:14644129 PMID:15191676 RGD:7241280 NCBI chrNW_004624754:7,405,637...7,415,870
Ensembl chrNW_004624754:7,408,983...7,416,559 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO mRNA, protein:increased expression:urinary bladder RGD PMID:17205510 RGD:2292435 NCBI chrNW_004624754:24,758,055...24,764,723 JBrowse link
G Prom1 prominin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32673656 NCBI chrNW_004624755:15,765,162...15,886,023
Ensembl chrNW_004624755:15,771,286...15,886,348 		JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:urinary bladder
mRNA:increased expression:urinary bladder 		RGD PMID:14499677 PMID:16621493 RGD:1642457 RGD:2300088 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 disease_progression ISO protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:10582676 PMID:10873095 PMID:12151359 PMID:12664575 PMID:18449376 RGD:2300124 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Rad50 RAD50 double strand break repair protein ISO upper urinary tract urothelial cell carcinoma; DNA:mutation:tumor:associated with microsatellite instability RGD PMID:16288216 RGD:2293511 NCBI chrNW_004624733:39,445,083...39,544,415
Ensembl chrNW_004624733:39,447,461...39,544,409 		JBrowse link
G Rassf1 Ras association domain family member 1 ISO DNA, protein:hypermethylation, decreased expression:promoter, urinary bladder RGD PMID:18480993 RGD:2299862 NCBI chrNW_004624730:4,181,207...4,190,603
Ensembl chrNW_004624730:4,181,462...4,190,431 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO Urinary bladder TCC; protein, mRNA:altered localization, increased expression:tumor:increased expression (p<0.01) and increased nuclear localization (p<0.01) vs adjacent non-cancerous bladder mucosa RGD PMID:12452071 RGD:2300270 NCBI chrNW_004624833:1,016,330...1,053,514
Ensembl chrNW_004624833:1,022,656...1,053,342 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO mRNA, protein:increased expression:urinary bladder mucosa, nucleus RGD PMID:12452071 RGD:2300270 NCBI chrNW_004624907:1,806,784...1,829,686
Ensembl chrNW_004624907:1,806,874...1,829,417 		JBrowse link
G Sfn stratifin disease_progression ISO DNA:hypermethylation:promoter RGD PMID:16964403 RGD:2299929 NCBI chrNW_004624764:10,859,556...10,860,876
Ensembl chrNW_004624764:10,859,667...10,860,413 		JBrowse link
G Skp2 S-phase kinase associated protein 2 disease_progression ISO protein:increased expression:kidney RGD PMID:15351619 RGD:2315044 NCBI chrNW_004624759:18,796,055...18,858,692
Ensembl chrNW_004624759:18,830,323...18,858,712 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 ISO protein:increased expression:bladder RGD PMID:28339760 RGD:151361118 NCBI chrNW_004624926:1,301,866...1,314,598
Ensembl chrNW_004624926:1,301,584...1,315,707 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO protein:increased expression:bladder RGD PMID:28339760 RGD:151361118 NCBI chrNW_004624746:1,325,368...1,349,616 JBrowse link
G Smad4 SMAD family member 4 ISO protein:decreased expression:urinary bladder RGD PMID:16859125 RGD:2299980 NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325 		JBrowse link
G Sox2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:22899292 RGD:8661672 NCBI chrNW_004624730:59,570,879...59,573,001
Ensembl chrNW_004624730:59,570,915...59,571,871 		JBrowse link
G Spink1 serine peptidase inhibitor Kazal type 1 disease_progression ISO protein:increased expression:urine RGD PMID:15963628 RGD:2300385 NCBI chrNW_004624774:7,281,298...7,287,735
Ensembl chrNW_004624774:7,281,227...7,287,791 		JBrowse link
G Stag2 STAG2 cohesin complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chrNW_004624797:2,659,785...2,794,168
Ensembl chrNW_004624797:2,719,508...2,794,379 		JBrowse link
G Tacc3 transforming acidic coiled-coil containing protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chrNW_004624755:25,683,314...25,695,102
Ensembl chrNW_004624755:25,683,137...25,692,504 		JBrowse link
G Tert telomerase reverse transcriptase disease_progression ISO mRNA:increased expression:urine, urothelial cell RGD PMID:17961306 RGD:2291982 NCBI chrNW_004624751:624,569...647,198 JBrowse link
G Tfrc transferrin receptor disease_progression ISO RGD PMID:9373912 RGD:2292023 NCBI chrNW_004624730:61,282,650...61,313,487
Ensembl chrNW_004624730:61,285,334...61,313,550 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO protein:decreased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chrNW_004624978:120,723...125,006
Ensembl chrNW_004624978:121,803...124,912 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO protein:decreased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chrNW_004624801:8,228,618...8,270,606
Ensembl chrNW_004624801:8,228,357...8,270,982 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:3361654 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:bladder 		CTD
RGD		 PMID:18270948 PMID:22929185 RGD:2290532 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:18955789 RGD:2315431 NCBI chrNW_004624730:67,283,444...67,489,808
Ensembl chrNW_004624730:67,286,160...67,489,670 		JBrowse link
G Tp73 tumor protein p73 disease_progression ISO mRNA:increased expression:kidney RGD PMID:15492852 RGD:2290588 NCBI chrNW_004624818:6,775,588...6,817,187
Ensembl chrNW_004624818:6,775,599...6,809,289 		JBrowse link
G Tymp thymidine phosphorylase ISO RGD PMID:15841086 RGD:2293720 NCBI chrNW_004624752:251,670...256,243
Ensembl chrNW_004624752:252,937...256,244 		JBrowse link
G Vdr vitamin D receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16080513 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
G Xpo5 exportin 5 severity ISO mRNA:increased expression:urothelium (human) RGD PMID:22766726 RGD:11041723 NCBI chrNW_004624754:16,083,356...16,124,682
Ensembl chrNW_004624754:16,083,407...16,123,407 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP: :p.R194W RGD PMID:18199464 RGD:2293824 NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266 		JBrowse link
bladder urothelial carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl7a actin like 7A ISO RGD PMID:29058301 RGD:13831338 NCBI chrNW_004624758:2,650,235...2,651,843
Ensembl chrNW_004624758:2,650,360...2,651,682 		JBrowse link
G Birc5 baculoviral IAP repeat containing 5 disease_progression ISO mRNA:increased expression:urinary bladder (human) RGD PMID:31964418 RGD:153344516 NCBI chrNW_004624801:7,727,084...7,735,946
Ensembl chrNW_004624801:7,727,093...7,735,940 		JBrowse link
G Birc7 baculoviral IAP repeat containing 7 disease_progression ISO mRNA:increased expression:urinary bladder (human) RGD PMID:31964418 RGD:153344516 NCBI chrNW_004624741:28,937,836...28,944,000 JBrowse link
G Ca2 carbonic anhydrase 2 severity ISO protein:increased expression:bladder epithelial cell RGD PMID:28004470 RGD:408426005 NCBI chrNW_004624744:6,168,030...6,183,407
Ensembl chrNW_004624744:6,167,606...6,183,538 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 severity ISO protein:increased expression:urothelial cells (human) RGD PMID:28507621 RGD:38500205 NCBI chrNW_004624755:25,633,690...25,647,361
Ensembl chrNW_004624755:25,635,165...25,646,932 		JBrowse link
G Kdm6a lysine demethylase 6A susceptibility ISO associated with upper tract urothelial carcinoma; DNA:mutations:multiple: (human) RGD PMID:30352907 RGD:150429735 NCBI chrNW_004624887:1,065,173...1,279,660
Ensembl chrNW_004624887:1,065,883...1,279,186 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14234
    disease of cellular proliferation 6854
      cancer 5027
        cell type cancer 3325
          carcinoma 2855
            transitional cell carcinoma 107
              Bartholin's gland transitional cell carcinoma 0
              bladder urothelial carcinoma + 6
              endometrial transitional cell carcinoma 0
              fallopian tube transitional cell carcinoma 0
              ovary transitional cell carcinoma 0
              papillary transitional carcinoma 0
              prostate transitional cell carcinoma 0
              renal pelvis transitional cell carcinoma + 0
              sarcomatoid transitional cell carcinoma + 0
              upper tract urothelial carcinoma + 0
              ureter transitional cell carcinoma + 0
              urethra transitional cell carcinoma 0
paths to the root