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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:laryngeal carcinoma
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Accession:DOID:2600 term browser browse the term
Definition:A larynx cancer that has_material_basis_in epithelial cells. (DO)
Synonyms:exact_synonym: carcinoma of larynx
 broad_synonym: cancer of larynx
 primary_id: RDO:9003912
 xref: NCI:C4855
For additional species annotation, visit the Alliance of Genome Resources.


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laryngeal squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:15646812 RGD:8662837 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Egfr epidermal growth factor receptor disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr10:83,411,197...83,435,078 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr 7:994,549...1,015,876 JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:22549618 RGD:126790474 NCBI chr 9:69,523,733...70,596,743 JBrowse link
G Mlh1 mutL homolog 1 disease_progression ISO mRNA:decreased expression:larynx RGD PMID:23787767 RGD:126848783 NCBI chr 8:111,196,468...111,233,721 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:17786346 RGD:5130203 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Msh2 mutS homolog 2 disease_progression ISO mRNA:decreased expression:larynx RGD PMID:23787767 RGD:126848783 NCBI chr 6:6,813,793...6,872,960 JBrowse link
G Nat2 N-acetyltransferase 2 susceptibility ISO DNA:polymorphisms: : RGD PMID:19922706, PMID:16155914 RGD:5131602, RGD:5131856 NCBI chr16:22,207,362...22,238,513 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17160
    disease of cellular proliferation 6949
      cancer 4897
        cell type cancer 3396
          carcinoma 2914
            laryngeal carcinoma 9
              laryngeal adenoid cystic carcinoma 0
              laryngeal mucoepidermoid carcinoma 0
              laryngeal small cell carcinoma 0
              laryngeal squamous cell carcinoma + 9
Path 2
Term Annotations click to browse term
  disease 17160
    disease of anatomical entity 16500
      respiratory system disease 2874
        thoracic disease 1808
          Thoracic Neoplasms 1265
            Respiratory Tract Neoplasms 822
              Laryngeal Neoplasms 24
                larynx cancer 15
                  laryngeal carcinoma 9
                    laryngeal adenoid cystic carcinoma 0
                    laryngeal mucoepidermoid carcinoma 0
                    laryngeal small cell carcinoma 0
                    laryngeal squamous cell carcinoma + 9
paths to the root