RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
Synonyms:
exact_synonym:
Generalized Histiocytosis; Hand Schueller Christian Disease; Hand Schueller Christian Syndrome; Hand Schüller Christian Disease; Hand Schüller Christian Syndrome; Hashimoto-Pritzger Disease; Histiocytosis X; Langerhan's cell histiocytosis; Langerhans Cell Granulomatoses; Langerhans Cell Granulomatosis; Langerhans Cell Histiocytoses; Letterer Siwe Disease; Letterer-Siwe disease involving intra-abdominal lymph nodes; Letterer-Siwe disease involving intrapelvic lymph nodes; Letterer-Siwe disease involving intrathoracic lymph nodes; Letterer-Siwe disease involving lymph nodes of axilla and upper limb; Letterer-Siwe disease involving lymph nodes of head, face, and neck; Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb; Letterer-Siwe disease involving lymph nodes of multiple sites; Letterer-Siwe disease involving spleen; Letterer-Siwe disease of intra-abdominal lymph nodes; Letterer-Siwe disease of intrapelvic lymph nodes; Letterer-Siwe disease of intrathoracic lymph nodes; Letterer-Siwe disease of lymph nodes of axilla and upper limb; Letterer-Siwe disease of lymph nodes of axilla and/or upper limb; Letterer-Siwe disease of lymph nodes of head, face and neck; Letterer-Siwe disease of lymph nodes of head, face and/or neck; Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb; Letterer-Siwe disease of lymph nodes of inguinal region and lower limb; Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb; Letterer-Siwe disease of lymph nodes of multiple sites; Letterer-Siwe disease of spleen; Non Lipid Reticuloendotheliosis; Non-Lipid Reticuloendothelioses; Pulmonary Histiocytosis X; Pulmonary Langerhans Cell Granulomatosis; Schueller Christian Disease; Systemic Aleukemic Reticuloendothelioses; Systemic Aleukemic Reticuloendotheliosis; Type 2 Histiocytoses; generalized histiocytoses; type 2 histiocytosis