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Term:Landau-Kleffner syndrome
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Accession:DOID:2538 term browser browse the term
Definition:A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495)
Synonyms:exact_synonym: Acquired Aphasia with Convulsive Disorder;   Acquired Aphasia with Epilepsy;   Acquired Childhoood Aphasia with Convulsive Disorder;   Acquired Epileptic Aphasia;   Acquired Epileptic Aphasias;   Acquired Epileptiform Aphasia;   Acquired Epileptiform Aphasias;   LKS;   Landau Kleffner Acquired Epileptiform Aphasia
 primary_id: MESH:D018887;   RDO:0007242
 xref: GARD:6855;   ICD10CM:G40.8;   NCI:C84806;   ORDO:98818
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Landau-Kleffner syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:11554173

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  disease 15602
    syndrome 5231
      Landau-Kleffner syndrome 1
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  disease 15602
    disease of anatomical entity 14933
      nervous system disease 10260
        central nervous system disease 8136
          brain disease 7608
            epilepsy 1093
              electroclinical syndrome 338
                absence epilepsy 100
                  childhood electroclinical syndrome 74
                    Landau-Kleffner syndrome 1
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