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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Wernicke encephalopathy
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Accession:DOID:2384 term browser browse the term
Definition:An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
Synonyms:exact_synonym: Cerebral Beriberi;   Encephalopathy, Wernickes;   Gayet Wernicke Encephalopathy;   Wernicke Disease;   Wernicke Encephalopathies;   Wernicke Superior Hemorrhagic Polioencephalitis;   Wernicke Syndrome;   Wernicke's Disease;   Wernicke's Encephalopathy;   Wernicke's Superior Hemorrhagic Polioencephalitis;   Wernicke's Syndrome
 primary_id: MESH:D014899;   RDO:0006822
 xref: ICD10CM:E51.2
For additional species annotation, visit the Alliance of Genome Resources.



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Wernicke encephalopathy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP mRNA, protein:increased expression:medial thalamic group, inferior colliculus, neuron RGD PMID:18481165 RGD:2300278 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tkt transketolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:3762968 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    Chemically-Induced Disorders 1218
      substance-related disorder 616
        Alcohol-Related Disorders 289
          Wernicke encephalopathy 2
Path 2
Term Annotations click to browse term
  disease 17289
    Nutritional and Metabolic Diseases 5565
      disease of metabolism 5565
        acquired metabolic disease 2898
          nutrition disease 920
            Malnutrition 225
              nutritional deficiency disease 216
                Avitaminosis 121
                  Vitamin B Deficiency 69
                    thiamine deficiency disease 4
                      Wernicke encephalopathy 2
paths to the root