brain ischemia - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	brain ischemia	go back to main search page
Accession:	DOID:2316	browse the term
Definition:	An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand. (DO)
Synonyms:	exact_synonym:	Cerebral Hypoperfusion; Cerebral Ischemias; Ischaemic encephalopathy; brain ischemias; cerebral ischemia; ischemic encephalopathies; ischemic encephalopathy
	primary_id:	MESH:D002545
	xref:	EFO:0003883; MONDO:0005299
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (641) Mouse (635) Human (1154) Chinchilla (571) Bonobo (602) Dog (619) Squirrel (577) Pig (614) Green Monkey (591) Naked Mole-rat (566) All
Genes (635)

brain ischemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

RGD

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

angiotensin I converting enzyme

CTD Direct Evidence: marker/mechanism

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

mRNA:increased expression:brain

RGD

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

adducin 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:53,128,874...53,235,518
Ensembl chr19:53,128,874...53,235,830

G

adenosine kinase

RGD

PMID:21427729 PMID:17457365

RGD:6482652, RGD:6482655

NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637

G

advanced glycosylation end product-specific receptor

mRNA:increased expression:pyramidal cell, hippocampus

RGD

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

allograft inflammatory factor 1

protein:increased expression:cerebral cortex (rat)

RGD

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

A kinase anchor protein 1

protein:altered expression:parietal cortex, hippocampus (rat)

RGD

NCBI chr11:88,721,618...88,755,426
Ensembl chr11:88,721,618...88,755,412

G

A kinase anchor protein 12

RGD

NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470

G

thymoma viral proto-oncogene 1

protein:decreased serine phosphorylation:cerebral cortex

RGD

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

CTD Direct Evidence: therapeutic

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

arachidonate 15-lipoxygenase

mRNA, protein:increased expression:brain

RGD

NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857

G

arachidonate 5-lipoxygenase

RGD

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

angiopoietin 1

RGD

NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373

G

angiopoietin 2

RGD

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

annexin A1

treatment

RGD

PMID:1830327 PMID:1830327

RGD:7421662, RGD:7421662

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

apoptotic peptidase activating factor 1

protein:increased expression:striatum

RGD

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

apurinic/apyrimidinic endonuclease 1

protein:decreased expression:hippocampus CA1, neuron

RGD

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

aquaporin 3

RGD

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

aquaporin 4

RGD

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

aquaporin 5

RGD

NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710

G

aquaporin 8

RGD

NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227

G

acid-sensing ion channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:99,568,090...99,599,011
Ensembl chr15:99,568,249...99,599,011

G

BCL2-associated agonist of cell death

protein:decreased serine phosphorylation:brain

RGD

PMID:18078455 PMID:22843461

RGD:2292681, RGD:10053716

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2 binding component 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130

G

B cell leukemia/lymphoma 2

treatment

RGD

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

protein:increased expression:cerebral cortex

RGD

PMID:17706879 PMID:22843461

RGD:1643491, RGD:10053716

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

brain derived neurotrophic factor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

protein:increased expression:hippocampus, frontal cortex

RGD

PMID:19574998 PMID:17936001

RGD:6483094, RGD:6483313

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

bone morphogenetic protein 6

RGD

NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278

G

BTG anti-proliferation factor 2

mRNA:increased expression:forebrain (rat)

RGD

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

complement component 3

protein:increased expression:brain

RGD

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 12

mRNA, protein:increased expresssion:brain

RGD

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

CTD Direct Evidence: marker/mechanism

PMID:11756504 PMID:17901229

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 6

mRNA:increased expression:cerebral cortex

RGD

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 9

CTD Direct Evidence: marker/mechanism

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calpastatin

RGD

NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929

G

catalase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17564305 PMID:21213399

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

RGD

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

C-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781

G

C-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15829914 PMID:17394460 PMID:19260320

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 20

mRNA:increased expression:cerebral cortex

RGD

NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888

G

C-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

PMID:15829914 PMID:17394460

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509

G

C-C motif chemokine ligand 9

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984

G

C-C motif chemokine receptor 5

mRNA:increased expression:brain (rat)

RGD

NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736

G

CD36 molecule

RGD

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

cyclin dependent kinase 5

RGD

NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528

G

CCAAT/enhancer binding protein beta

CTD Direct Evidence: marker/mechanism

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

cholinergic receptor, muscarinic 1, CNS

CTD Direct Evidence: marker/mechanism

NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

RGD

NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422

G

clusterin

RGD

NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996

G

ceruloplasmin

mRNA, protein:decreased expression:cerebral cortex, hippocampus

RGD

NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309

G

cAMP responsive element binding protein 1

treatment

mRNA,protein:decreased expression,decreased phosphorylation:brain:

RGD

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

corticotropin releasing hormone

mRNA:increased expression:cerebral cortex (rat)

RGD

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

mRNA:increased expression:brain

RGD

NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047

G

colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

mRNA:increased expression:brain

NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921

G

colony stimulating factor 3 (granulocyte)

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

chondroitin sulfate proteoglycan 4

RGD

NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154

G

cystatin C

protein:decreased expression:cerebrospinal fluid

RGD

NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612

G

cathepsin B

protein:increased activity:cerebrum (rat)

RGD

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin C

mRNA:increased expression:cerebral cortex

RGD

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

cathepsin L

protein:increased activity:cerebrum (rat)

RGD

NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704

G

C-X-C motif chemokine ligand 10

mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15829914 PMID:17549754

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 12

mRNA, protein:increased expression:brain

RGD

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

cytochrome c, somatic

CTD Direct Evidence: marker/mechanism

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

dopamine beta hydroxylase

protein:decreased expression:forebrain (rat)

RGD

NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212

G

DNA-damage inducible transcript 3

Protein:increased expression:brain

RGD

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

diablo, IAP-binding mitochondrial protein

CTD Direct Evidence: marker/mechanism

NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239

G

dihydropyrimidinase-like 2

mRNA:increased expression:brain

RGD

NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410

G

dopamine receptor D2

RGD

NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477

G

dual specificity phosphatase 6

mRNA:increased expression:brain

RGD

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

dynein light chain LC8-type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058

G

endothelin 1

protein:increased expression:cerebral cortex (rat)

RGD

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early growth response 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

endonuclease G

RGD

NCBI chr 2:30,061,525...30,064,057
Ensembl chr 2:30,061,505...30,064,081

G

erythropoietin receptor

protein:increased expression:brain:

RGD

NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802

G

estrogen receptor 2 (beta)

mRNA:decreased expression:cerebral cortex, ipsilateral side (rat)

RGD

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

coagulation factor II

CTD Direct Evidence: marker/mechanism

PMID:14753426 PMID:15534175

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor II thrombin receptor

RGD

NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995

G

coagulation factor V

CTD Direct Evidence: marker/mechanism

NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846

G

Fas cell surface death receptor

protein:increased expression:brain

RGD

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

protein:increased expression:brain

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fibrinogen alpha chain

treatment

RGD

NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934

G

fibroblast growth factor 1

Rat model using human FGF1

RGD

PMID:19497570 PMID:16635575

RGD:5509879, RGD:5509881

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

galanin and GMAP prepropeptide

RGD

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

vitamin D binding protein

protein:increased expression:urine

RGD

NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757

G

glial cell line derived neurotrophic factor family receptor alpha 1

protein:increased expression:cerebral cortex

RGD

NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341

G

gap junction protein, alpha 1

protein:increased expression:cerebral cortex

RGD

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

glutamate dehydrogenase 1

protein:decreased activity:brain

RGD

NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222

G

glycoprotein 1b, alpha polypeptide

exacerbates

associated with Pneumococcal Infections

RGD

NCBI chr11:70,529,928...70,534,812
Ensembl chr11:70,529,948...70,532,862

G

glutathione peroxidase 1

CTD Direct Evidence: therapeutic

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 3

protein:increased expression:plasma

RGD

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

hypoxia inducible factor 1, alpha subunit

treatment

protein:increased expression:brain
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:cerebral cortex (rat)

CTD
RGD

PMID:19429140 PMID:17554006 PMID:18369388 PMID:17101276

RGD:1626331, RGD:9068895, RGD:9068892

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

RGD

PMID:16464361 PMID:21276833

RGD:1582709, RGD:10755576

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heat shock protein 1B

associated with advanced age and Diabetes Mellitus, Type 2 (MeSH:D003924)

RGD

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 8

RGD

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

heat shock protein 9

mRNA:increased expression:brain

RGD

NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410

G

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism

PMID:17394460 PMID:19417757

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

insulin-like growth factor 1

RGD

PMID:16882007 PMID:19332057

RGD:1598411, RGD:2306694

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

interleukin 10 receptor, beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:91,203,166...91,222,718
Ensembl chr16:91,203,052...91,222,722

G

interleukin 12 receptor, beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:71,261,005...71,276,186
Ensembl chr 8:71,261,093...71,274,068

G

interleukin 17A

protein, mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15829914 PMID:16305645

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 17 receptor A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:120,440,143...120,460,692
Ensembl chr 6:120,440,208...120,464,520

G

interleukin 18

mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15829914 PMID:11807395

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

PMID:9236716 PMID:15737438 PMID:15756928 PMID:17394460

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor antagonist

CTD Direct Evidence: therapeutic

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 6

CTD Direct Evidence: marker/mechanism

PMID:15829914 PMID:17394460

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 signal transducer

mRNA:increased expression:brain, astrocyte

RGD

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

interleukin-1 receptor-associated kinase 1

mRNA, protein:increased expression:cerebral cortex

RGD

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

G

interleukin-1 receptor-associated kinase 4

mRNA, protein:increased expression:cerebral cortex

RGD

NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696

G

integrin alpha M

associated with Hypotension;protein:increased expression:pyramidal layer of CA1 (rat)

RGD

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

jun proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium channel, subfamily K, member 10

mRNA, protein:increased expression:cerebral cortex, hippocampus (rat)

RGD

NCBI chr12:98,395,691...98,544,472
Ensembl chr12:98,395,696...98,544,569

G

potassium channel, subfamily K, member 2

mRNA:increased expression:hippocampus (rat)

RGD

NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470

G

kinase insert domain protein receptor

RGD

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

lectin, galactose binding, soluble 3

RGD

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

leukemia inhibitory factor

mRNA:increased expression:brain

RGD

NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514

G

lon peptidase 1, mitochondrial

RGD

NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887

G

microtubule-associated protein 2

protein:increased expression:serum

RGD

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase kinase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17901229 PMID:10536014

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

mitogen-activated protein kinase kinase kinase 7

treatment

RGD

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

G

mitogen-activated protein kinase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17901229 PMID:15669185

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

RGD

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

microtubule-associated protein tau

protein:increased phosphorylation

RGD

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

malate dehydrogenase 2, NAD (mitochondrial)

RGD

NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252

G

midkine

RGD

NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642

G

microRNA 223

treatment

RGD

NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532

G

matrix metallopeptidase 13

RGD

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

matrix metallopeptidase 14 (membrane-inserted)

RGD

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 2

RGD

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15060315 PMID:16846501

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

CTD Direct Evidence: marker/mechanism

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

musashi RNA-binding protein 1

RGD

NCBI chr 5:115,567,734...115,593,757
Ensembl chr 5:115,567,658...115,593,757

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

NLR family, apoptosis inhibitory protein 2

protein:increased expression:thalamus (rat)

RGD

NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600

G

nestin

protein:increased expression:hippocampus

RGD

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

CTD Direct Evidence: therapeutic

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 1, neuronal

protein:decreased expression:hippocampus

RGD

PMID:17451676 PMID:21718970

RGD:1642142, RGD:6480433

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

CTD Direct Evidence: marker/mechanism

PMID:9778187 PMID:17394460

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

RGD

PMID:21212863 PMID:17600658

RGD:4891961, RGD:2292134

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NADPH oxidase 4

mRNA, protein:increased expression:cerebral cortex (human)

RGD

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

natriuretic peptide precursor type A

no_association

RGD

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

neuronal pentraxin receptor

mRNA:decreased expression:neocortex

RGD

NCBI chr15:79,670,552...79,688,910
Ensembl chr15:79,670,552...79,688,967

G

nuclear receptor subfamily 3, group C, member 1

protein:decreased expression:brain cortex

RGD

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

ornithine decarboxylase antizyme 1

mRNA:altered expression:cerebral cortex (rat)

RGD

NCBI chr10:80,662,490...80,665,124
Ensembl chr10:80,662,516...80,665,124

G

opioid receptor, mu 1

RGD

NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198

G

p21 (RAC1) activated kinase 1

protein:increased expression:brain

RGD

NCBI chr 7:97,437,748...97,561,588
Ensembl chr 7:97,437,748...97,561,588

G

poly (ADP-ribose) polymerase family, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

proliferating cell nuclear antigen

protein:increased expression:brain

RGD

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

placental growth factor

RGD

NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564

G

phospholipase A2, group IVA (cytosolic, calcium-dependent)

mRNA:increased expression:hippocampus

RGD

NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041

G

plasminogen activator, tissue

no_association

DNA:polymorphism:-7351C>T (human)
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:7477192 PMID:9259745 PMID:9400355 PMID:9479658 PMID:9566367 More...

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:9731615 PMID:10472989 PMID:10512912 PMID:17927297

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

pro-platelet basic protein

RGD

NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922

G

peptidylprolyl isomerase D (cyclophilin D)

RGD

NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957

G

protein phosphatase 1, regulatory (inhibitor) subunit 15A

protein:increased expression:cerebral cortex, caudate nucleus (rat)

RGD

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein kinase, cAMP dependent, catalytic, alpha

protein:decreased expression:hippocampus, cerebral cortex, nucleus

RGD

NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072

G

protein kinase, cAMP dependent, catalytic, beta

protein:decreased expression:hippocampus, cerebral cortex, cytosol, nucleus

RGD

NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745

G

protein kinase C, alpha

associated with Subarachnoid Hemorrhage;protein:increased phosphorylation:cerebral artery

RGD

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, delta

RGD

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

protein Z, vitamin K-dependent plasma glycoprotein

RGD

NCBI chr 8:13,110,583...13,126,026
Ensembl chr 8:13,110,914...13,126,026

G

prostaglandin I2 (prostacyclin) synthase

RGD

NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524

G

prostaglandin-endoperoxide synthase 1

protein:increased expression:microglia, macrophage

RGD

PMID:11740205 PMID:10867793

RGD:5688240, RGD:5688247

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

protein:increased expression:hippocampus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15737438 PMID:17394460 PMID:17564305 PMID:19417757 PMID:21718970 More...

RGD:6480433, RGD:5688292, RGD:1581286

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

PTK2 protein tyrosine kinase 2 beta

protein:increased tyrosine phosphorylation:cerebral cortex

RGD

NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

CTD Direct Evidence: therapeutic

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ret proto-oncogene

protein:increased expression:cerebral cortex

RGD

NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679

G

S100 protein, beta polypeptide, neural

protein:increased expression:serum

RGD

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

sodium channel, voltage-gated, type V, alpha

RGD

NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082

G

selectin, endothelial cell

associated with Hypertension
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17394460 PMID:19107136

NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

treatment

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

protein:increased expression:brain

RGD

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 29 (nucleoside transporters), member 1

RGD

NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532

G

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

RGD

NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493

G

solute carrier family 8 (sodium/calcium exchanger), member 1

protein:increased expression:brain
mRNA:decreased expression:cerebral cortex (rat)

RGD

PMID:17662498 PMID:22036625 PMID:12377375

RGD:1642717, RGD:6771236, RGD:727449

NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806

G

solute carrier family 8 (sodium/calcium exchanger), member 2

RGD

NCBI chr 7:15,861,540...15,894,988
Ensembl chr 7:15,863,751...15,894,988

G

solute carrier family 8 (sodium/calcium exchanger), member 3

RGD

NCBI chr12:81,244,686...81,380,506
Ensembl chr12:81,244,689...81,379,954

G

superoxide dismutase 1, soluble

CTD Direct Evidence: therapeutic

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15060315 PMID:17901229 PMID:19429140 PMID:10212301

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

RGD

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

SOS Ras/Rac guanine nucleotide exchange factor 1

RGD

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

G

Rous sarcoma oncogene

RGD

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

TEK receptor tyrosine kinase

RGD

NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213

G

transforming growth factor, beta 1

mRNA:increased expression:brain

RGD

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tyrosine hydroxylase

protein:decreased expression:solitary tract nucleus, medulla oblongata, locus coeruleus (rat)

RGD

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

tight junction protein 1

protein:decreased expression:brain

RGD

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

toll-like receptor 4

no_association

DNA:polymorphisms: :p.N299G, p.T399I (human)

RGD

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 1a

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15829914 PMID:16442237

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

CTD Direct Evidence: marker/mechanism

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

transformation related protein 53

CTD Direct Evidence: marker/mechanism

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transthyretin

RGD

NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378

G

uncoupling protein 2 (mitochondrial, proton carrier)

CTD Direct Evidence: marker/mechanism

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

vasoactive intestinal polypeptide

RGD

NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

protein:increased expression:cerebrospinal fluid

RGD

NCBI chr 2:163,837,082...163,860,508
Ensembl chr 2:163,836,880...163,860,508

Brain Hypoxia-Ischemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin receptor IIB

severity

mRNA, protein:increased expression:umbilical cord blood (human)

RGD

NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061

G

adenosine deaminase

protein:increased activity:brain:

RGD

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

adenosine kinase

protein:decreased expression:brain:

RGD

NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637

G

activity-dependent neuroprotective protein

RGD

NCBI chr 2:168,022,885...168,049,032
Ensembl chr 2:168,022,906...168,049,032

G

adenosine A1 receptor

protein:decreased expression:brain:

RGD

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

angiotensin II receptor, type 2

RGD

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

allograft inflammatory factor 1

protein:increased expression:right cerebral hemisphere (rat)

RGD

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

apoptosis-inducing factor, mitochondrion-associated 1

protein:increased expression:nucleus:

RGD

PMID:12871572 PMID:28108258

RGD:10053564, RGD:13524865

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

BCL2-associated X protein

treatment

RGD

PMID:21189961 PMID:24089674 PMID:29635023

RGD:10054502, RGD:155882465, RGD:13782292

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

brevican

RGD

NCBI chr 3:87,894,839...87,908,458
Ensembl chr 3:87,894,838...87,907,537

G

B cell leukemia/lymphoma 2

treatment

RGD

PMID:21189961 PMID:24089674 PMID:29635023

RGD:10054502, RGD:155882465, RGD:13782292

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

RGD

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

beclin 1, autophagy related

protein:increased expression:cerebral cortex
protein:increased expression:brain

RGD

PMID:22449108 PMID:25919564

RGD:6483050, RGD:11558017

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

basic helix-loop-helix ARNT like 1

protein:increased expression:pineal gland

RGD

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

bone morphogenetic protein 4

mRNA,protein:decreased expression:brain:

RGD

NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126

G

caspase 1

RGD

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 12

protein:increased activity:cerebral cortex, hippocampus

RGD

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

treatment

protein:increased activity:cerebral cortex, hippocampus

RGD

PMID:18603371 PMID:24089674 PMID:23046993 PMID:29635023 PMID:27216999 More...

RGD:2311455, RGD:155882465, RGD:13782359, RGD:13782292, RGD:13782279, RGD:10054502

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

treatment

RGD

PMID:29635023 PMID:23046993

RGD:13782292, RGD:13782359

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

treatment

RGD

PMID:23046993 PMID:24089674

RGD:13782359, RGD:155882465

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calpastatin

RGD

NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929

G

catalase

treatment

RGD

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

protein:increased expression:forebrain (rat)

RGD

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine receptor 2

mRNA, protein:increased expression:brain

RGD

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

C-C motif chemokine receptor 5

mRNA:increased expression:cerebral hemisphere (rat)

RGD

NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736

G

cyclin dependent kinase 5, regulatory subunit 1

treatment

RGD

NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010

G

clock circadian regulator

protein:increased expression:pineal gland

RGD

NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639

G

2',3'-cyclic nucleotide 3' phosphodiesterase

RGD

NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555

G

C-reactive protein, pentraxin-related

RGD

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

citrate synthase

treatment

RGD

PMID:15132986 PMID:15569775

RGD:243048479, RGD:243048481

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

colony stimulating factor 1 receptor

exacerbates

protein:increased expression:right cerebral hemisphere, astrocyte, neuron (rat)

RGD

PMID:32522286 PMID:33101590

RGD:151665765, RGD:151665766

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

C-X-C motif chemokine receptor 3

mRNA:increased expression:brain

RGD

NCBI chr X:100,775,141...100,777,753
Ensembl chr X:100,775,141...100,777,875

G

Fas death domain-associated protein

RGD

NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564

G

DNA methyltransferase 3A

protein:decreased expression:brain:

RGD

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

early growth response 1

mRNA:increased expression:forebrain (rat)

RGD

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

eukaryotic translation initiation factor 2, subunit 1 alpha

RGD

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

Eph receptor A4

protein:increased expression:brain

RGD

NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725

G

erythropoietin

treatment

RGD

PMID:24034924 PMID:22156696

RGD:10400911, RGD:10401072

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

endoplasmic reticulum oxidoreductase 1 alpha

mRNA:increased expression:hippocampus

RGD

NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228

G

Fas associated via death domain

treatment

RGD

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

Fas cell surface death receptor

RGD

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

FBJ osteosarcoma oncogene

protein:decreased expression:hippocampus

RGD

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

forkhead box O3

protein:increased expression:cerebral cortex,nucleus:

RGD

NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751

G

follistatin

mRNA:decreased expression:brain (rat)

RGD

NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487

G

growth hormone receptor

protein:increased expression:brain

RGD

NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

mRNA:decreased expression:hippocampus (rat)

RGD

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

mRNA:decreased expression:hippocampus (rat)

RGD

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

glutamate receptor, ionotropic, NMDA2B (epsilon 2)

mRNA:decreased expression:hippocampus (rat)

RGD

NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509

G

gelsolin

severity

protein:decreased expression:blood plasma (human)

RGD

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

mRNA:decreased expression:hippocampus,cortex:

RGD

NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954

G

histone deacetylase 3

protein:decreased expression:brain:

RGD

NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069

G

hypoxia inducible factor 1, alpha subunit

treatment

protein:increased expression:brain (rat)
mRNA, protein:increased expression:brain,kidney (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23694759 PMID:18210138 PMID:31784544 PMID:19595151

RGD:9068873, RGD:155882534, RGD:9068901

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

treatment

RGD

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heat shock protein 1A

RGD

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

insulin-like growth factor 1

treatment

RGD

PMID:11672597 PMID:23694759 PMID:19766709

RGD:8549456, RGD:12904932, RGD:10046049

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor 2

disease_progression

RGD

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor binding protein 3

RGD

NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923

G

interleukin 1 beta

protein:increased expression:brain (rat)

RGD

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

severity

DNA:polymorphism: :174G>C(human)

RGD

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

inhibin beta-A

severity
treatment

mRNA:increased expression:brain (rat)
mRNA, protein:increased expression:umbilical cord blood (human)
human construct in rat model

RGD

PMID:10415398 PMID:27957679 PMID:10415398

RGD:329322882, RGD:329849106, RGD:329322882

NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206

G

interleukin-1 receptor-associated kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

G

interleukin-1 receptor-associated kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696

G

iron responsive element binding protein 2

mRNA:increased expression:brain (rat)

RGD

NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814

G

kinase insert domain protein receptor

RGD

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

microtubule-associated protein 1 light chain 3 alpha

RGD

NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993

G

microtubule-associated protein 2

RGD

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase kinase kinase 5

RGD

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase kinase kinase 7

ameliorates

protein:increased expression:brain (rat)

RGD

PMID:29138854 PMID:32734729

RGD:155804273, RGD:155804275

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

G

microtubule-associated protein tau

treatment

RGD

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

methyl-CpG binding domain protein 2

protein:increased expression:brain:

RGD

NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202

G

myelin basic protein

protein:decreased expression:white matter:

RGD

NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762

G

microRNA 140

severity

miRNA:decreased expression:blood serum (human)

RGD

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

G

microRNA 17

RGD

NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186

G

microRNA 210

treatment
disease_progression

miRNA:decreased expression:blood serum (human)
associated with Brain Injuries;miRNA:increased expression:brain, cerebral hemisphere (human)

RGD

PMID:26875527 PMID:24089674 PMID:29568675 PMID:33402183

RGD:11572290, RGD:155882465, RGD:155598592, RGD:155582222

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

G

matrix metallopeptidase 3

treatment

RGD

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

myeloperoxidase

protein:increased activity:brain:

RGD

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)

protein:increased activity:brain:

RGD

NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498

G

nitric oxide synthase 2, inducible

CTD Direct Evidence: marker/mechanism

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nuclear respiratory factor 1

mRNA, protein:increase expression:cerebral cortex

RGD

NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457

G

neurotrophic tyrosine kinase, receptor, type 1

mRNA:increased expression:brain

RGD

NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469

G

platelet derived growth factor, B polypeptide

RGD

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

plasminogen activator, tissue

onset

RGD

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

mRNA, protein:increased expression, increased activity:hippocampus

RGD

PMID:19587273 PMID:18467699

RGD:2316117, RGD:6483831

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

protein phosphatase 1, regulatory inhibitor subunit 1B

RGD

NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622

G

protein kinase, DNA activated, catalytic polypeptide

treatment

RGD

NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099

G

protein tyrosine phosphatase, non-receptor type 5

STEP33;protein:increased expression:forebrain (rat)

RGD

NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432

G

protein tyrosine phosphatase receptor type Z, polypeptide 1

RGD

NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915

G

ring finger protein 146

RGD

NCBI chr10:29,220,172...29,238,438
Ensembl chr10:29,220,172...29,238,438

G

roundabout guidance receptor 1

exacerbates

RGD

NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983

G

S100 protein, beta polypeptide, neural

severity

associated with Asphyxia Neonatorum;protein:increased expression:urine
protein:increased expression:blood serum (human)

RGD

PMID:14707571 PMID:29568675

RGD:5508819, RGD:155598592

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

solute carrier family 9 (sodium/hydrogen exchanger), member 1

RGD

NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013

G

slit guidance ligand 2

treatment

RGD

NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075

G

Spi-1 proto-oncogene

protein:increased expression:CA1 field of hippocampus

RGD

NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101

G

SLIT-ROBO Rho GTPase activating protein 1

exacerbates

RGD

NCBI chr10:121,616,896...121,883,740
Ensembl chr10:121,616,896...121,883,220

G

telomerase reverse transcriptase

treatment

RGD

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

G

transcription factor A, mitochondrial

mRNA:increased expression:cerebral cortex

RGD

NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110

G

toll-like receptor 2

RGD

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

transferrin

treatment

RGD

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

transient receptor potential cation channel, subfamily C, member 6

mRNA:increased expression:glomerular podocytes (rat)

RGD

NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

zinc finger E-box binding homeobox 2

mRNA:increased expression:glomerular podocytes (rat)

RGD

PMID:31784544 PMID:34852714

RGD:155882534, RGD:155882542

NCBI chr 2:44,873,523...45,007,378
Ensembl chr 2:44,873,644...45,007,407

brain infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

RGD

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adenosine kinase

RGD

PMID:16685255 PMID:9731623

RGD:6482657, RGD:6482667

NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637

G

adrenomedullin

treatment

RGD

NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027

G

activity-dependent neuroprotective protein

RGD

NCBI chr 2:168,022,885...168,049,032
Ensembl chr 2:168,022,906...168,049,032

G

allograft inflammatory factor 1

protein:increased expression:brain subventricular zone (rat)
protein:increased expression:brain white matter (human)

RGD

PMID:19053043 PMID:10683518

RGD:2313025, RGD:2313026

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

aldehyde dehydrogenase 2, mitochondrial

susceptibility

RGD

NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887

G

arachidonate 5-lipoxygenase activating protein

associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human)

RGD

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

arrestin, beta 2

protein:increased expression:spleen

RGD

NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654

G

ATPase, Ca++ transporting, plasma membrane 2

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 6:113,720,803...114,019,574
Ensembl chr 6:113,720,792...114,019,574

G

beclin 1, autophagy related

protein:increased expression:brain

RGD

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

calcium channel, voltage-dependent, alpha2/delta subunit 1

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502

G

calcitonin receptor-like

mRNA:increased expression:brain (rat)

RGD

NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755

G

CD8 subunit alpha

mRNA:increased expression:brain (rat)

RGD

NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157

G

complement component factor h

treatment

RGD

NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502

G

cortistatin

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 4:149,209,491...149,211,132
Ensembl chr 4:149,209,491...149,211,220

G

cathepsin B

protein:increased expression:cerebral cortical segment, cytoplasm (rat)

RGD

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

C-X-C motif chemokine ligand 10

protein:increased expression:brain (rat)

RGD

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

cytochrome b-245, beta polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

cytochrome P450, family 2, subfamily r, polypeptide 1

DNA:variants:CDS:multiple (human)

RGD

NCBI chr 7:114,149,358...114,162,283
Ensembl chr 7:114,148,917...114,162,207

G

doublecortin

protein:altered expression:brain (rat)

RGD

NCBI chr X:142,638,838...142,716,392
Ensembl chr X:142,638,838...142,716,307

G

endothelin converting enzyme 1

RGD

NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540

G

fibroblast growth factor 2

CTD Direct Evidence: therapeutic

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

glycoprotein (transmembrane) nmb

mRNA:increased expression:brain (rat)

RGD

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

G protein-coupled receptor 17

CTD Direct Evidence: therapeutic

NCBI chr18:32,076,052...32,082,925
Ensembl chr18:32,076,050...32,082,689

G

granzyme B

protein:increased expression:brain (rat)

RGD

NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717

G

histocompatibility 2, class II antigen A, alpha

DNA:polymorphisms (human)

RGD

NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797

G

hepatocyte growth factor

treatment

RGD

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

hypoxia inducible factor 1, alpha subunit

exacerbates

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

high mobility group box 1

RGD

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

histamine N-methyltransferase

severity

RGD

PMID:21131122 PMID:16330002

RGD:5509772, RGD:5509773

NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406

G

5-hydroxytryptamine (serotonin) receptor 2B

mRNA:increased expression:brain (rat)

RGD

NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692

G

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

insulin-like growth factor 2

mRNA, protein:increased expression:brain

RGD

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

interleukin 15

associated with Hypertension;protein:increased expression:serum

RGD

NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851

G

interleukin 1 beta

protein:increased expression:cerebral cortex (rat)

RGD

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

protein:increased expression:brain (rat)

RGD

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

potassium inwardly-rectifying channel, subfamily K, member 6

mRNA:increased expression:brain (rat)

RGD

NCBI chr 7:28,921,353...28,931,947
Ensembl chr 7:28,921,351...28,931,940

G

midkine

RGD

NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642

G

Meis homeobox 2

protein:altered expression:brain (rat)

RGD

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

matrix Gla protein

mRNA:increased expression:brain (rat)

RGD

NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821

G

microRNA 223

RNA:increased expression:brain,blood

RGD

NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532

G

matrix metallopeptidase 14 (membrane-inserted)

mRNA:increased expression:brain (rat)

RGD

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 8

mRNA:increased expression:brain (rat)

RGD

NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486

G

matrix metallopeptidase 9

RGD

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

musashi RNA-binding protein 1

RGD

NCBI chr 5:115,567,734...115,593,757
Ensembl chr 5:115,567,658...115,593,757

G

nestin

associated with Hypertension

RGD

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

poly (ADP-ribose) glycohydrolase

associated with Reperfusion Injury

RGD

NCBI chr14:31,923,900...32,020,671
Ensembl chr14:31,923,906...32,019,507

G

pre B cell leukemia homeobox 1

protein:altered expression:brain (rat)

RGD

NCBI chr 1:167,946,933...168,259,898
Ensembl chr 1:167,946,933...168,259,839

G

platelet derived growth factor, B polypeptide

RGD

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

plasminogen activator, tissue

CTD Direct Evidence: therapeutic

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

protein phosphatase 1, regulatory inhibitor subunit 1B

protein:altered expression:brain (rat)

RGD

NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622

G

prolylcarboxypeptidase (angiotensinase C)

mRNA:increased expression:brain (rat)

RGD

NCBI chr 7:92,524,461...92,583,789
Ensembl chr 7:92,523,678...92,583,791

G

RNA binding protein, fox-1 homolog (C. elegans) 3

protein:altered expression:brain (rat)

RGD

NCBI chr11:118,380,586...118,802,423
Ensembl chr11:118,380,588...118,802,423

G

sodium channel, voltage-gated, type VII, alpha

mRNA:increased expression:brain (rat)

RGD

NCBI chr 2:66,503,770...66,615,254
Ensembl chr 2:66,503,769...66,615,258

G

sirtuin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

thromboxane A synthase 1, platelet

RGD

NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519

G

tumor necrosis factor

protein:increased expression:brain (rat)

RGD

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

two pore segment channel 2

mRNA:increased expression:brain (rat)

RGD

NCBI chr 7:144,735,370...144,837,743
Ensembl chr 7:144,740,261...144,837,748

G

vimentin

RGD

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HtrA serine peptidase 1

ClinVar Annotator: match by term: CARASIL | ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease

PMID:11889251 PMID:18316707 PMID:19387015 PMID:20437615 PMID:21115960 More...

NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390

G

purine rich element binding protein A

ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease

PMID:24500651 PMID:27148565

NCBI chr18:36,413,614...36,434,575
Ensembl chr18:36,414,150...36,425,588

cerebral infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

disease_progression

RGD

NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186

G

angiotensin I converting enzyme

DNA:deletion:intron:IVS16+1464-1751del (human)
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

adenosine A1 receptor

RGD

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

advanced glycosylation end product-specific receptor

protein:increased expression:plasma

RGD

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

alanine-glyoxylate aminotransferase 2

onset

DNA:missense mutation:cds:V498L (rs16899974) (human)

RGD

NCBI chr15:10,358,602...10,410,244
Ensembl chr15:10,358,618...10,410,239

G

alpha hemoglobin stabilizing protein

mRNA:increased expression:venous blood (human)

RGD

NCBI chr 7:127,902,016...127,902,926
Ensembl chr 7:127,901,969...127,902,930

G

arachidonate 5-lipoxygenase activating protein

susceptibility

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

angiogenin, ribonuclease, RNase A family, 5

severity

protein:increased expression:serum

RGD

NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466

G

annexin A1

treatment

associated with Ischemic Attack, Transient

RGD

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

apolipoprotein A-V

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human)

RGD

NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217

G

apolipoprotein B

protein:increased expression:serum

RGD

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein E

susceptibility

DNA:polymorphism: :3932T>C (human)

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

betaine-homocysteine methyltransferase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469

G

bone morphogenetic protein/retinoic acid inducible neural specific 3

associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell:

RGD

NCBI chr 1:146,371,367...146,778,210
Ensembl chr 1:146,370,498...146,778,210

G

cystathionine beta-synthase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212

G

C-C motif chemokine ligand 2

treatment

RGD

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 3

treatment

RGD

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine receptor 5

RGD

NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736

G

CD36 molecule

associated with Hyperlipidemias

RGD

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

epoxide hydrolase 2, cytoplasmic

RGD

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

coagulation factor II

susceptibility

ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:8696333 More...

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor V

ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More...

NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846

G

coagulation factor VII

treatment

protein:increased expression, increased activity:plasma (human)
human protein in a mouse model

RGD

PMID:14733777 PMID:21998055

RGD:11049518, RGD:11049520

NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809

G

fibrillin 1

ClinVar Annotator: match by term: Ischemic stroke

PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 More...

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

folate hydrolase 1

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151

G

GTP cyclohydrolase 1

exacerbates
treatment

DNA:SNP:3' UTR:+243C>T (human)
DNA:SNP, haplotype:rs841 (human)

RGD

PMID:21181356 PMID:16282548 PMID:21963893

RGD:329961322, RGD:329961574, RGD:329961572

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

glycoprotein 6 (platelet)

ameliorates

RGD

NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743

G

glutathione peroxidase 3

susceptibility

DNA, protein:SNP,decreased expression:promoter,plasma:-861A>T (human)
DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human)
DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human)

RGD

PMID:25126700 PMID:20946167 PMID:17122425

RGD:401827128, RGD:401827165, RGD:401827163

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

severity

RGD

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

granulin

ClinVar Annotator: match by term: Ischemic stroke

PMID:18723524 PMID:28492532

NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874

G

gelsolin

severity

protein:decreased expression:blood plasma (human)

RGD

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

H19, imprinted maternally expressed transcript

disease_progression
susceptibility
ameliorates

RNA:increased expression:blood plasma, plasma exosome (human)
DNA:SNP::(rs217727) (human)
DNA:SNPs,haplotypes: (rs217727,rs4929984) (human)
associated with atherosclerosis

RGD

PMID:36453417 PMID:33541284 PMID:28203482 PMID:30778327 PMID:36453417

RGD:155882574, RGD:156430336, RGD:155900760, RGD:155900761, RGD:155882574

NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917

G

histocompatibility 2, class II antigen E beta

susceptibility

DNA:polymorphism,haplotype::HLA-B37:01 (human)

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

histocompatibility 2, M region locus 2

susceptibility

DNA:polymorphism::HLA-B37:01 (human)

NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443

G

histocompatibility 2, Q region locus 1

susceptibility

DNA:polymorphism::HLA-A31:01 (human)

NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075

G

hemoglobin alpha, adult chain 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465

G

hypoxia inducible factor 1, alpha subunit

severity

protein:increased expression:blood serum (human)

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

high mobility group box 1

protein:increased expression:plasma

RGD

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

heme oxygenase 1

RGD

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

HNF1 homeobox A

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153

G

intercellular adhesion molecule 1

mRNA, protein:increased expression:cerebral cortex

RGD

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

interferon beta 1, fibroblast

susceptibility
no_association

DNA:SNP,haplotype: rs9333358(human)

RGD

PMID:31810024 PMID:16514094

RGD:401851921, RGD:401854228

NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011

G

interleukin 10

treatment

RGD

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 18

treatment

RGD

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

treatment

RGD

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

treatment

RGD

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interferon regulatory factor 8

exacerbates

RGD

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

integrin alpha 9

susceptibility

DNA:SNPs,haplotype:rs189897,rs2212020(human)

RGD

NCBI chr 9:118,435,777...118,730,071
Ensembl chr 9:118,435,758...118,730,071

G

integrin alpha M

protein:increased expression:neutrophil (human)

RGD

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

kalirin, RhoGEF kinase

susceptibility
sexual_dimorphism

DNA:SNP:intron: (rs6438833) (human)
DNA:SNPs, haplotypes:intron,cds: (rs7620580, rs1708303) (human)

RGD

PMID:25917671 PMID:28706949

RGD:11085239, RGD:329956420

NCBI chr16:33,789,443...34,393,647
Ensembl chr16:33,789,443...34,393,902

G

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

ameliorates

RGD

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

G

lipase, endothelial

susceptibility

DNA:polymorphism: :584C>T (human)

RGD

NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334

G

lymphotoxin A

RGD

NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327

G

microtubule-associated protein 2

RGD

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase kinase kinase 5

treatment

RGD

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

microRNA 145a

ameliorates

miRNA:increased expression:blood (human)

RGD

PMID:22370881 PMID:26722607

RGD:155260291, RGD:155260295

NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965

G

microRNA 210

severity
treatment

miRNA:decreased expression:blood (human)
miRNA:decreased expression:blood serum (human)

RGD

PMID:21622133 PMID:29111308 PMID:34708885

RGD:155260318, RGD:155260331, RGD:155260326

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

G

microRNA 21a

RNA:increased expression:brain

RGD

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

microRNA 223

treatment

RGD

NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532

G

microRNA 30a

treatment

RGD

NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420

G

microRNA 383

treatment

RGD

NCBI chr 8:38,719,287...38,719,356
Ensembl chr 8:38,719,287...38,719,356

G

microRNA 494

disease_progression

RGD

NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

cytochrome c oxidase II, mitochondrial

ClinVar Annotator: match by term: Ischemic stroke

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

cytochrome b, mitochondrial

ClinVar Annotator: match by term: Ischemic stroke

NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288

G

methylenetetrahydrofolate reductase

DNA:transition:cds:g.677C>T (human)

RGD

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999

G

myelin regulatory factor

DNA:SNP:exon:rs174535(human)

RGD

NCBI chr19:10,185,635...10,218,134
Ensembl chr19:10,185,636...10,218,112

G

NADH:ubiquinone oxidoreductase subunit A13

protein:increased expression:brain, neuron, astrocyte:

RGD

NCBI chr 8:70,346,813...70,355,208
Ensembl chr 8:70,346,830...70,355,208

G

nitric oxide synthase 3, endothelial cell

ClinVar Annotator: match by term: Ischemic stroke

PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More...

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 3

ClinVar Annotator: match by term: Ischemic stroke

PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 More...

NCBI chr17:32,339,794...32,385,869
Ensembl chr17:32,339,794...32,385,826

G

neuropeptide Y

protein:increased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11821007 PMID:17123484

NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487

G

nuclear receptor subfamily 1, group H, member 3

susceptibility

DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)

RGD

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

Parkinson disease (autosomal recessive, early onset) 7

treatment

RGD

PMID:18003894 PMID:18003894

RGD:13462069, RGD:13462069

NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894

G

pancreatic and duodenal homeobox 1

associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human)

RGD

NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658

G

phosphatase and actin regulator 1

DNA:SNP:intron: (rs12526453) (human)

RGD

NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002

G

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

RGD

NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092

G

plasminogen activator, tissue

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 More...

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:12133459 PMID:16773802

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

plasminogen activator, urokinase receptor

RGD

NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393

G

paraoxonase 1

susceptibility

DNA:missense mutation:cds:p.Q192R (human)

RGD

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

paraoxonase 2

susceptibility

DNA:SNPs,haplotypes: (rs11545941, rs6954345) (human)

RGD

NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455

G

protein kinase C, eta

susceptibility

ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke

PMID:12958323 PMID:17206144 PMID:25741868

NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959

G

protein C

CTD Direct Evidence: marker/mechanism

NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623

G

protein S (alpha)

DNA:missense mutation:exon:p.R355C (1063C>T) (human)

RGD

NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709

G

prostaglandin I2 (prostacyclin) synthase

exacerbates
treatment

DNA:SNP, haplotype:3' utr: (rs5602) (human)
DNA:SNPs:exon, 3' utr: (rs5629, rs5602) (human)
DNA:repeat:promoter:g.-6(CCGCCAGCC)3-7 (human)

RGD

PMID:28478978 PMID:28108096 PMID:11130769 PMID:11997284

RGD:401901149, RGD:401959400, RGD:401901269, RGD:401901194

NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524

G

retinol binding protein 4, plasma

exacerbates
severity

protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)
associated with diabetes mellitus; protein:increased expression:blood serum (human)

RGD

PMID:19846170 PMID:30030781 PMID:30038059

RGD:329845582, RGD:329853305, RGD:329845588

NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

treatment

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade G, member 1

treatment

associated with Venous Thrombosis

RGD

NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788

G

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

mRNA:increased expression:cerebral cortex, neuron

RGD

NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493

G

SOS Ras/Rac guanine nucleotide exchange factor 1

mRNA:increased expression:blood (human)

RGD

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

G

thromboxane A synthase 1, platelet

susceptibility

DNA:polymorphisms: :

RGD

NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519

G

thrombomodulin

susceptibility

DNA:missense mutation:cds:p.A455V (human)

RGD

NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108

G

tumor necrosis factor

treatment

RGD

PMID:16173529 PMID:29111308

RGD:1580315, RGD:155260331

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

disease_progression

RGD

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

translocase of outer mitochondrial membrane 40 homolog (yeast)

DNA:SNP: :rs2075650 (human)

RGD

NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363

G

thymidylate synthase

susceptibility

DNA:SNPs,haplotypes: (rs502396,rs16430,rs8423)

NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615

G

vimentin

RGD

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

Chronic Cerebral Hypoperfusion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

protein:decreased expression:hippocampus

RGD

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

apolipoprotein E

protein:increased expression:cerebral cortex, synapse

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

amyloid beta precursor protein

protein:increased expression:cerebral white matter:

RGD

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

beta-site APP cleaving enzyme 1

protein:increased expression:hippocampus

RGD

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2/adenovirus E1B interacting protein 3-like

mRNA:increased expression:hippocampus

RGD

NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326

G

dystroglycan 1

RGD

NCBI chr 9:108,082,060...108,141,176
Ensembl chr 9:108,081,833...108,141,157

G

ferritin heavy polypeptide 1

protein:increased expression:hippocampus

RGD

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

glutathione S-transferase, pi 1

treatment

RGD

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

RGD

NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954

G

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

RGD

NCBI chr10:79,552,468...79,571,942
Ensembl chr10:79,552,468...79,571,942

G

hypoxia inducible factor 1, alpha subunit

protein:increased expression:hippocampus

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

mitogen-activated protein kinase kinase kinase 5

protein:hyperphosphorylation:brain:

RGD

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase 14

protein:hyperphosphorylation:corpus callosum, endothelial cell, astrocyte:

RGD

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

minichromosome maintenance complex component 2

protein:increased expression:dentate gyrus

RGD

NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762

G

nitric oxide synthase 3, endothelial cell

RGD

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NADPH oxidase 1

ameliorates

RGD

NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705

G

transferrin receptor

protein:increased expression:hippocampus

RGD

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

lateral medullary syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

follicle stimulating hormone beta

CTD Direct Evidence: marker/mechanism

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

middle cerebral artery infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family C member 8

treatment

RGD

PMID:23149556 PMID:24602692

RGD:12790979, RGD:12791996

NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457

G

angiotensin I converting enzyme

treatment

RGD

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

mRNA, protein:increased expression:brain

RGD

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

activin A receptor, type 1

RGD

NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169

G

activin receptor IIB

mRNA:increased expression:brain (mouse)

RGD

NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061

G

adenosine A1 receptor

CTD Direct Evidence: therapeutic

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

advanced glycosylation end product-specific receptor

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25446913 PMID:24211797

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

angiotensinogen

protein:increased expression:brain, serum

RGD

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

apoptosis-inducing factor, mitochondrion-associated 1

protein:altered localization: :

RGD

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

adenylate kinase 1

protein:decreased expression:cerebral cortex (rat)

RGD

NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070

G

albumin

treatment

RGD

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

adaptor-related protein complex 2, beta 1 subunit

protein:increased degradation:brain

RGD

NCBI chr11:83,189,545...83,295,861
Ensembl chr11:83,189,850...83,295,861

G

apoptotic peptidase activating factor 1

treatment

RGD

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

apolipoprotein E

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

amyloid beta precursor protein

treatment

RGD

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

aquaporin 4

treatment

RGD

PMID:20815926 PMID:33127515

RGD:8695955, RGD:155646130

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

activity regulated cytoskeletal-associated protein

RGD

NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419

G

activating transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

BCL2-associated agonist of cell death

treatment

RGD

PMID:22200499 PMID:21891976

RGD:10053665, RGD:10053704

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

treatment

RGD

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

brevican

RGD

NCBI chr 3:87,894,839...87,908,458
Ensembl chr 3:87,894,838...87,907,537

G

B cell leukemia/lymphoma 2

treatment

RGD

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

brain derived neurotrophic factor

treatment

RGD

PMID:20417695 PMID:28202057 PMID:35218623

RGD:4891138, RGD:405878057, RGD:401960864

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

treatment

RGD

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

BCL2/adenovirus E1B interacting protein 3

protein:increased expression:brain

RGD

NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248

G

BCL2/adenovirus E1B interacting protein 3-like

RGD

PMID:15902200 PMID:21029239

RGD:2314138, RGD:9068917

NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326

G

C1q and tumor necrosis factor related protein 6

ameliorates

RGD

NCBI chr15:78,407,546...78,416,370
Ensembl chr15:78,407,546...78,415,616

G

complement component 3

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23199288 PMID:22103620

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

calcitonin/calcitonin-related polypeptide, alpha

treatment

RGD

NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592

G

calcium/calmodulin-dependent protein kinase II alpha

RGD

NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224

G

caspase 3

treatment

RGD

PMID:21891976 PMID:26868427 PMID:23143152

RGD:10053704, RGD:13782346, RGD:10054501

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 6

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 9

treatment

RGD

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:12374626 PMID:23043544 PMID:25257527

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 7

CTD Direct Evidence: marker/mechanism

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

CD36 molecule

treatment

RGD

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD86 antigen

protein:increased expression:brain subventricular zone, microglial cell (rat)

RGD

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cyclin dependent kinase 5

RGD

NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528

G

claudin 5

treatment

RGD

NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012

G

cAMP responsive element binding protein 1

treatment

RGD

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

corticotropin releasing hormone

protein:decreased expression:median eminence of hypothalamus (rat)

RGD

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

C-reactive protein, pentraxin-related

RGD

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

CREB regulated transcription coactivator 1

treatment

RGD

NCBI chr 8:70,835,002...70,892,720
Ensembl chr 8:70,835,005...70,892,229

G

colony stimulating factor 3 (granulocyte)

treatment

mRNA, protein:increased expression:brain:

RGD

PMID:19298757 PMID:15530654

RGD:11039420, RGD:11039425

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

C-X-C motif chemokine ligand 10

RGD

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

C-X-C motif chemokine receptor 3

mRNA:increased expression:cerebral cortex

RGD

NCBI chr X:100,775,141...100,777,753
Ensembl chr X:100,775,141...100,777,875

G

cytochrome P450, family 2, subfamily e, polypeptide 1

RGD

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

dicer 1, ribonuclease type III

mRNA:decreased expression:brain:

RGD

NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211

G

DNA methyltransferase 1

RGD

NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184

G

DNA methyltransferase 3A

RGD

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

dynein light chain LC8-type 1

RGD

NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058

G

endothelin 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early growth response 1

RGD

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

early growth response 2

RGD

NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018

G

early growth response 4

RGD

NCBI chr 6:85,488,103...85,490,571
Ensembl chr 6:85,488,103...85,490,571

G

eukaryotic translation initiation factor 2, subunit 1 alpha

treatment

RGD

PMID:23669639 PMID:19763736

RGD:10395346, RGD:10755569

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

elastase, neutrophil expressed

treatment

RGD

NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049

G

endoglin

RGD

NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681

G

epithelial cell adhesion molecule

RGD

NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557

G

Eph receptor B2

treatment

mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone

RGD

PMID:16321245 PMID:16321245

RGD:1642069, RGD:1642069

NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299

G

epsin 1

protein:increased degradation:brain

RGD

NCBI chr 7:5,083,207...5,101,178
Ensembl chr 7:5,083,234...5,101,177

G

erythropoietin

treatment

RGD

PMID:20833153 PMID:20547143

RGD:10400898, RGD:10401066

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

excision repair cross-complementing rodent repair deficiency, complementation group 6

RGD

NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947

G

coagulation factor XI

RGD

NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068

G

coagulation factor XII (Hageman factor)

treatment

RGD

PMID:16533887 PMID:16533887

RGD:11041786, RGD:11041786

NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606

G

coagulation factor II

CTD Direct Evidence: marker/mechanism

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

Fas associated via death domain

treatment

RGD

PMID:18950622 PMID:23378241

RGD:11341807, RGD:11344885

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

fibroblast growth factor 2

treatment

RGD

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 21

CTD Direct Evidence: marker/mechanism

NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914

G

FBJ osteosarcoma oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

gamma-aminobutyric acid type A receptor subunit alpha 6

CTD Direct Evidence: marker/mechanism

NCBI chr11:42,197,264...42,211,977
Ensembl chr11:42,197,264...42,211,899

G

growth associated protein 43

treatment

RGD

NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014

G

glyceraldehyde-3-phosphate dehydrogenase

RGD

NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430

G

GTP cyclohydrolase 1

treatment

RGD

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

glial cell line derived neurotrophic factor

treatment

RGD

PMID:29497380 PMID:28202057 PMID:20468049 PMID:21347705

RGD:40925919, RGD:405878057, RGD:405866363, RGD:405866359

NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056

G

ghrelin

treatment

RGD

NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841

G

growth hormone secretagogue receptor

RGD

NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159

G

glutamate-ammonia ligase

treatment

protein:increased expression:eye
protein:increased expression:cerebrum, astrocyte

RGD

PMID:24518488 PMID:23595285 PMID:26024074 PMID:26093193

RGD:401794420, RGD:401794586, RGD:401794592, RGD:401794587

NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

treatment

RGD

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

granulin

treatment

RGD

NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874

G

GrpE-like 1, mitochondrial

mRNA:increased expression:cerebral cortex

RGD

NCBI chr 5:36,622,529...36,631,421
Ensembl chr 5:36,622,342...36,631,424

G

glycogen synthase kinase 3 beta

treatment

RGD

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

gelsolin

ameliorates

RGD

PMID:18234195 PMID:9927495

RGD:329333031, RGD:329333033

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

H19, imprinted maternally expressed transcript

ameliorates

RNA:increased expression:brain (rat)
RNA:increased expression:brain (mouse)

RGD

PMID:28203482 PMID:28630232 PMID:35322553 PMID:31170091 PMID:32335212

RGD:155900760, RGD:242905192, RGD:242905190, RGD:242905188, RGD:156451661

NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917

G

hepcidin antimicrobial peptide

mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum

RGD

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

hyaluronan synthase 2

mRNA:increased expression:brain

RGD

NCBI chr15:56,529,023...56,557,942
Ensembl chr15:56,529,023...56,557,935

G

histone deacetylase 2

exacerbates

RGD

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 4

treatment

mRNA,protein:decreased expression:brain:

RGD

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

histone deacetylase 5

treatment

mRNA,protein:decreased expression:brain:

RGD

NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992

G

histone deacetylase 9

mRNA:increased expression:brain:

RGD

NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094

G

hypoxia inducible factor 1, alpha subunit

treatment

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

high mobility group box 1

treatment

RGD

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

heme oxygenase 1

treatment

RGD

PMID:24252362 PMID:23870531 PMID:20888632

RGD:10755587, RGD:10755755, RGD:10755588

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

haptoglobin

RGD

NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804

G

heat shock protein 4

rat gene in mouse model

RGD

PMID:17473852 PMID:21709150

RGD:5688754, RGD:6218961

NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284

G

heat shock protein 1 (chaperonin)

CTD Direct Evidence: marker/mechanism

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

HtrA serine peptidase 2

protein:increased expression:brain, cytosol (rat)
protein:increased expression:brain, cytosol (mouse)

RGD

PMID:16978742 PMID:15306124

RGD:2314385, RGD:5688372

NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254

G

hydrogen voltage-gated channel 1

RGD

NCBI chr 5:122,344,872...122,380,360
Ensembl chr 5:122,344,867...122,380,360

G

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

insulin-like growth factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

inhibitor of kappaB kinase beta

treatment

RGD

NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605

G

interleukin 10

ameliorates

RGD

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858

G

interleukin 13

protein:increased expression:cerebral cortex

RGD

NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529

G

interleukin 1 beta

ameliorates
treatment

protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25257527 PMID:23028794 PMID:35322553 PMID:29498696 PMID:24916922

RGD:7204480, RGD:242905190, RGD:13792833, RGD:10450594

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor antagonist

treatment

human gene in a rat model

RGD

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 22B

CTD Direct Evidence: marker/mechanism

NCBI chr10:118,125,534...118,130,943
Ensembl chr10:118,125,534...118,130,943

G

interleukin 4

protein:increased expression:cerebral cortex

RGD

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 5

RGD

NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933

G

interleukin 6

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 receptor, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503

G

interleukin 6 signal transducer

CTD Direct Evidence: marker/mechanism

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

interleukin 7 receptor

protein:increased expression:brain:

RGD

NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262

G

internexin neuronal intermediate filament protein, alpha

RGD

NCBI chr19:47,003,120...47,013,766
Ensembl chr19:47,003,137...47,013,766

G

inhibin beta-A

RGD

NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206

G

interferon regulatory factor 4

RGD

NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959

G

jun B proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347

G

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

ameliorates

RGD

PMID:26661208 PMID:25477223 PMID:21750563

RGD:329955572, RGD:401700383, RGD:329955444

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

G

myelin-associated glycoprotein

treatment

RGD

NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298

G

mitogen-activated protein kinase 1

treatment

RGD

PMID:27152455 PMID:35218623

RGD:13800881, RGD:401960864

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

treatment

RGD

PMID:27152455 PMID:35218623

RGD:13800881, RGD:401960864

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

microtubule-associated protein tau

treatment

RGD

PMID:28886009 PMID:25903928 PMID:28886009

RGD:13800886, RGD:13800913, RGD:13800886

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

microRNA 107

RNA:increased expression:brain

RGD

NCBI chr19:34,798,087...34,798,173
Ensembl chr19:34,798,087...34,798,173

G

microRNA 132

treatment

mRNA:decreased expression:brain (mouse)

RGD

PMID:33763412 PMID:33763412

RGD:329849104, RGD:329849104

NCBI chr11:75,064,508...75,064,573
Ensembl chr11:75,064,508...75,064,573

G

microRNA 140

ameliorates

miRNA:decreased expression:cerebral cortex (rat)

RGD

PMID:33246036 PMID:27035554

RGD:329337375, RGD:329337377

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

G

microRNA 19a

RNA:decreased expression:brain (mouse)

RGD

NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513

G

microRNA 210

treatment

RGD

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

G

microRNA 29b-1

exacerbates

RGD

NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028

G

microRNA 494

ameliorates

RGD

PMID:32239566 PMID:31465536

RGD:155883173, RGD:156430320

NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836

G

matrix metallopeptidase 9

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19309543 PMID:24842554

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

metallothionein 3

protein:decreased expression:brain

RGD

NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774

G

mechanistic target of rapamycin kinase

treatment

RGD

PMID:24583056 PMID:21185267 PMID:23777415

RGD:10040971, RGD:10041016, RGD:10040974

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

NEDD8 activating enzyme E1 subunit 1

RGD

NCBI chr 8:105,237,660...105,261,269
Ensembl chr 8:105,237,660...105,261,269

G

nicotinamide phosphoribosyltransferase

treatment

RGD

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

neural cell adhesion molecule 1

treatment

RGD

PMID:32962079 PMID:29497380

RGD:40924633, RGD:40925919

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

neurofilament, heavy polypeptide

RGD

NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064

G

neurofilament, light polypeptide

protein:increased expression:brain

RGD

NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544

G

neurofilament, medium polypeptide

protein:altered expression:brain

RGD

NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295

G

nuclear factor, erythroid derived 2, like 2

treatment

RGD

PMID:23880501 PMID:24466583

RGD:10412696, RGD:10412714

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

treatment

RGD

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nerve growth factor

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:10408807 PMID:29409115

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nerve growth factor receptor (TNFR superfamily, member 16)

treatment

RGD

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

nucleotide-binding oligomerization domain containing 2

treatment

RGD

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

G

nitric oxide synthase 2, inducible

protein:increased expression:brain (rat)
mRNA:increased expression:brain (mouse)

RGD

PMID:21959178 PMID:22020035

RGD:5508751, RGD:5509037

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NADPH oxidase 1

treatment

RGD

NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705

G

NAD(P)H dehydrogenase, quinone 1

treatment

protein:increased expression:brain

RGD

PMID:21120604 PMID:25069640

RGD:5133239, RGD:11035212

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

neuregulin 1

treatment
ameliorates

RGD

PMID:20691195 PMID:30206770

RGD:10449015, RGD:405650589

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

8-oxoguanine DNA-glycosylase 1

treatment

associated with Hypertension

RGD

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

Parkinson disease (autosomal recessive, early onset) 7

treatment

RGD

NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894

G

poly (ADP-ribose) polymerase family, member 1

treatment

RGD

PMID:21311064 PMID:25882840 PMID:23143152 PMID:23801245

RGD:5683909, RGD:13792686, RGD:10054501, RGD:11073732

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

PRKC, apoptosis, WT1, regulator

treatment

protein:increased expression:brain:

RGD

PMID:16403464 PMID:19352052 PMID:11323519

RGD:9835380, RGD:9850083, RGD:9835381

NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101

G

platelet derived growth factor receptor, alpha polypeptide

treatment

RGD

NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876

G

platelet derived growth factor receptor, beta polypeptide

treatment

RGD

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

plasminogen activator, tissue

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:12297567 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 More...

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:11677890 PMID:15181847 PMID:17702958

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

phospholipase D1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511

G

protein kinase C, gamma

RGD

NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615

G

protein C

treatment

RGD

NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623

G

protein tyrosine phosphatase receptor type Z, polypeptide 1

mRNA:increased expression:cerebral cortex

RGD

NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915

G

RNA binding protein, fox-1 homolog (C. elegans) 3

treatment

RGD

NCBI chr11:118,380,586...118,802,423
Ensembl chr11:118,380,588...118,802,423

G

reelin

severity

RGD

NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700

G

repulsive guidance molecule family member A

treatment

RGD

PMID:21840379 PMID:23275173

RGD:9850121, RGD:9850122

NCBI chr 7:73,025,268...73,069,647
Ensembl chr 7:73,025,257...73,069,647

G

ribosomal protein L28

RGD

NCBI chr 7:4,795,964...4,797,546
Ensembl chr 7:4,795,873...4,798,065

G

runt related transcription factor 1

mRNA:increased expression:brain

RGD

NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037

G

S100 calcium binding protein A5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:90,513,787...90,519,091
Ensembl chr 3:90,515,830...90,519,087

G

S100 protein, beta polypeptide, neural

protein:increased expression:cerebrum, astrocyte

RGD

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade F, member 1

treatment

RGD

NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

sonic hedgehog

treatment

RGD

NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254

G

sirtuin 1

treatment

RGD

PMID:23600725 PMID:23600725

RGD:9585664, RGD:9585664

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

solute carrier family 12, member 2

treatment

protein:increased expression:brain:

RGD

PMID:12535773 PMID:27798271

RGD:1580583, RGD:14398833

NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893

G

solute carrier family 1 (glial high affinity glutamate transporter), member 2

treatment

RGD

NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129

G

solute carrier family 2 (facilitated glucose transporter), member 1

treatment

RGD

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 9 (sodium/hydrogen exchanger), member 1

treatment

RGD

NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013

G

secretory leukocyte peptidase inhibitor

treatment

RGD

NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015

G

smoothened, frizzled class receptor

treatment

RGD

PMID:23696546 PMID:23499832

RGD:12832759, RGD:12879404

NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364

G

spermine oxidase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:131,333,624...131,367,103
Ensembl chr 2:131,333,416...131,367,842

G

synaptosomal-associated protein 91

protein:increased degradation:brain

RGD

NCBI chr 9:86,647,976...86,762,766
Ensembl chr 9:86,647,976...86,762,707

G

superoxide dismutase 1, soluble

treatment

mRNA, protein:increased expression:cerebral cortex (rat)

RGD

PMID:22001340 PMID:22133807

RGD:8657021, RGD:8657023

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sphingosine kinase 2

CTD Direct Evidence: therapeutic

NCBI chr 7:45,358,887...45,367,426
Ensembl chr 7:45,358,891...45,367,426

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

transforming growth factor, beta 1

ameliorates

RGD

PMID:31409163 PMID:28630232

RGD:14995477, RGD:242905192

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tyrosine hydroxylase

protein:decreased expression:substantia nigra pars compacta, neuron (rat)

RGD

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

tumor necrosis factor

treatment
ameliorates

RGD

PMID:24916922 PMID:28630232 PMID:35322553 PMID:15647744 PMID:29498696

RGD:10450594, RGD:242905192, RGD:242905190, RGD:13825261, RGD:13792833

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor alpha induced protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698

G

tumor necrosis factor receptor superfamily, member 1a

RGD

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

triggering receptor expressed on myeloid cells 1

ameliorates

RGD

NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952

G

uridine phosphorylase 1

mRNA, protein:increased expression:brain (rat)

RGD

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

vascular endothelial growth factor A

treatment

mRNA,protein:increased expression:cerebral cortex (rat)

RGD

PMID:29497380 PMID:30531687 PMID:27035554

RGD:40925919, RGD:329849008, RGD:329337377

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

xanthine dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

Multi-Infarct Dementia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

protein:decreased expression:cerebrospinal fluid:

RGD

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

BCL2-associated X protein

treatment

RGD

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

treatment

RGD

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

glucose-6-phosphate dehydrogenase X-linked

treatment

RGD

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

interleukin 2

severity

protein:increased secretion:mononuclear cell:

RGD

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

pyridoxamine 5'-phosphate oxidase deficiency

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

pyridoxine 5'-phosphate oxidase

ClinVar Annotator: match by term: Pyridoxal phosphate-responsive seizures
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:9536098 PMID:15182361 PMID:15772097 PMID:16199547 PMID:17216302 More...

NCBI chr11:96,828,642...96,834,845
Ensembl chr11:96,828,651...96,834,812

transient cerebral ischemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor, type II-like 1

RGD

NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

mRNA, protein:increased expression:brain

RGD

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4

RGD

NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206

G

adenosine deaminase, RNA-specific, B1

RGD

NCBI chr10:77,126,561...77,254,125
Ensembl chr10:77,126,560...77,254,104

G

adenosine A1 receptor

CTD Direct Evidence: therapeutic

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

advanced glycosylation end product-specific receptor

protein:altered expression:cerebral cortex, striatum (rat)
protein:increased expression:brain, plasma

RGD

PMID:22528836 PMID:23288172

RGD:7245542, RGD:8696004

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

angiotensinogen

RGD

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

aryl-hydrocarbon receptor

treatment

RGD

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

apoptosis-inducing factor, mitochondrion-associated 1

mRNA:decreased expression, altered localization:CA1 pyramidal layer, nucleus:
protein:increased expression:nucleus:

RGD

PMID:14526224 PMID:15087715

RGD:10047409, RGD:10053562

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

angiogenin, ribonuclease, RNase A family, 5

treatment

RGD

NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466

G

ankyrin 1, erythroid

RGD

NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513

G

ankyrin 2, brain

RGD

NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999

G

apolipoprotein E

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

aquaporin 4

treatment

RGD

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

activating transcription factor 2

RGD

PMID:10077326 PMID:9813301

RGD:10047405, RGD:10047413

NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983

G

ATP synthase F1 subunit beta

protein:increased expression:cerebrum (rat)

RGD

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

axin 2

treatment

RGD

NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609

G

beta-site APP cleaving enzyme 1

protein:increased activity,increased expression:brain cortex

RGD

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated agonist of cell death

CTD Direct Evidence: marker/mechanism

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

treatment

RGD

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCL2 binding component 3

protein:increased expression:hippocampus CA1, pyramidal cell

RGD

NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130

G