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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:anxiety disorder
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Accession:DOID:2030 term browser browse the term
Definition:A cognitive disorder that involves an excessive, irrational dread of everyday situations. (DO)
Synonyms:exact_synonym: ANXIETY;   Neurotic Anxiety State;   anxiety disorders;   anxiety neuroses;   anxiety state;   neurotic anxiety states
 narrow_synonym: HARM AVOIDANCE
 related_synonym: SEROTONIN TRANSPORTER ACTIVITY, INCREASED/DECREASED
 primary_id: MESH:D001008
 alt_id: OMIM:607834
 xref: ICD10CM:F41.9;   NCI:C2878
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 PMID:16118787 PMID:18305461 PMID:20532872 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:21669254 RGD:6480479 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G App amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19664757 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Avpr1b arginine vasopressin receptor 1B treatment IMP
ISO
RGD PMID:24654684, PMID:21956463 RGD:14700666, RGD:14700676 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12600694 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO associated with Sciatic Neuropathy; RGD PMID:24907405 RGD:8661781
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19220484 PMID:29944862 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:23419392 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15081793 PMID:18690112 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:7816204 PMID:8736133 PMID:11440811 PMID:11875628 PMID:12424556 PMID:12438692 PMID:14575894 PMID:16495007 PMID:17293045 PMID:21268831 PMID:22231481 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9299637 PMID:22231481 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10742108 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Crp C-reactive protein ISO associated with Coronary Disease;
CTD Direct Evidence: marker/mechanism
CTD PMID:20194079, PMID:18603621 RGD:9491832 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctnnd2 catenin delta 2 susceptibility ISO DNA:polymorphism:multiple (human) RGD PMID:24256404 RGD:40902831 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 IMP protein:altered activity::treatment RGD PMID:17376576 RGD:5685599 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Disc1 DISC1 scaffold protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:29643356 NCBI chr19:57,818,838...58,069,992
Ensembl chr19:57,820,260...58,066,152
JBrowse link
G Dixdc1 DIX domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr 8:55,091,232...55,164,636
Ensembl chr 8:55,091,235...55,162,421
JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23791455 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta IEP mRNA:decreased expression:hypothalamus: RGD PMID:23529784 RGD:9588317 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:snp:cds:p.H313H (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18305461 PMID:20532872, PMID:9513185 RGD:1358603 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eomes eomesodermin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26415720 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Esr2 estrogen receptor 2 treatment IDA RGD PMID:24015243, PMID:24631553 RGD:7364908, RGD:10045678 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fmr1 FMRP translational regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28616095 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18313124 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gad1 glutamate decarboxylase 1 susceptibility ISO DNA:snp(s) (human ortholog) RGD PMID:22328461 RGD:6480264 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Glo1 glyoxalase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gnb1 G protein subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986
JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17434465 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IMP RGD PMID:22884333 RGD:9686419 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:23485013 RGD:9590265 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hmbs hydroxymethylbilane synthase ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO
ISS
OMIM:607834 MouseDO PMID:21512427 RGD:5683629 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IDA RGD PMID:12040062 RGD:625756 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IDA RGD PMID:17074317 RGD:1625000 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:21859099, PMID:16828124, PMID:16828124 RGD:6482189, RGD:6482189 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Kdm3b lysine demethylase 3B IDA RGD PMID:24397026 RGD:9590119 NCBI chr18:27,593,823...27,631,129
Ensembl chr18:27,576,129...27,631,088
JBrowse link
G L1cam L1 cell adhesion molecule IEP protein:increased expression: brain, multiple (rat) RGD PMID:19746433 RGD:6483075 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25653350 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Mapt microtubule-associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:29860433 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdk midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:19217924 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22231481 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20177408 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir34a microRNA 34a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27424985 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IMP RGD PMID:20051490 RGD:5688287 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nps neuropeptide S ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:19339610 PMID:21466221 NCBI chr 1:207,508,414...207,512,195
Ensembl chr 1:207,508,414...207,512,195
JBrowse link
G Npy neuropeptide Y susceptibility ISO DNA:SNPs, haplotypes
CTD Direct Evidence: therapeutic
CTD PMID:11440811, PMID:22328461 RGD:6480264 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy1r neuropeptide Y receptor Y1 treatment IDA
ISO
CTD Direct Evidence: therapeutic CTD PMID:11440811, PMID:21803058 RGD:10448284 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:19228979 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815072 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Rai1 retinoic acid induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18285828 NCBI chr10:46,511,271...46,571,591
Ensembl chr10:46,511,271...46,571,583
JBrowse link
G Serpina1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18272690 NCBI chr 1:100,297,137...100,344,377
Ensembl chr 1:100,297,152...100,344,377
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19120712 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP
ISO
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:18686203 PMID:19531786, PMID:18295409 RGD:4889509 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc6a4m1Hubr solute carrier family 6 member 4; ZFN induced mutant1, Hubr IMP RGD PMID:18295409 RGD:4889509
G Tafa2 TAFA chemokine like family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29339520 NCBI chr 7:66,017,066...66,496,690
Ensembl chr 7:66,017,086...66,172,360
JBrowse link
G Tg thyroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:30373627 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20194079 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucn urocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Ush2a usherin ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:9624053 PMID:10090909 PMID:10729113 PMID:10909849 PMID:11402400 PMID:12112664 PMID:12525556 PMID:14970843 PMID:15025721 PMID:15325563 PMID:15326663 PMID:17405132 PMID:18641288 PMID:19881469 PMID:20145675 PMID:20301515 PMID:20507924 PMID:22581970 PMID:24033266 PMID:24088041 PMID:24160897 PMID:24607488 PMID:24944099 PMID:25097241 PMID:25404053 PMID:25649381 PMID:25741868 PMID:26633545 PMID:26872967 PMID:28041643 PMID:28492532 PMID:29953849 PMID:30718709 NCBI chr13:106,750,738...107,434,195
Ensembl chr13:106,751,625...107,427,329
JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase IEP RGD PMID:20645790 RGD:5509849 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Crp C-reactive protein ISO RGD PMID:19628221 RGD:9585647 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO ClinVar Annotator: match by term: Orthostatic hypotension 1
ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency
ClinVar Annotator: match by OMIM:223360
OMIM
ClinVar
PMID:11857564 PMID:14598346 PMID:15060114 PMID:16199547 PMID:21209083 PMID:21471955 PMID:22028891 PMID:24033266 PMID:25450229 PMID:25741868 PMID:26762739 PMID:27778639 PMID:28492532 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:21209083 RGD:5685690 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
generalized anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 severity ISO protein:increased expression:serum (human) RGD PMID:27512921 RGD:39938860 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Slc6a4 solute carrier family 6 member 4 treatment ISO DNA:repeats, haplotype:promoter: RGD PMID:22907732 RGD:36947386 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Zfp462 zinc finger protein 462 ISS MouseDO NCBI chr 5:71,679,841...71,824,077
Ensembl chr 5:71,742,911...71,823,139
JBrowse link
neurocirculatory asthenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 member 2 ISO orthostatic intolerance,OMIM:604715;DNA:point mutation:exon:A457P RGD PMID:10684912 RGD:1624278 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
obsessive-compulsive disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:12836135 RGD:734644 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8878350 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:11840516 RGD:1300383 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Hoxb8 homeo box B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11779477 NCBI chr10:84,131,484...84,133,874
Ensembl chr10:84,131,495...84,133,246
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:10621951 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:19644229 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:17267119 RGD:6482188 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO OCD1,OMIM:164230;DNA:polymorphism:I425V
ClinVar Annotator: match by term: Obsessive-compulsive disorder
ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869649 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593431 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:15995945 PMID:16642437 PMID:17101915 PMID:18197083 PMID:19531786 PMID:25741868, PMID:14593431 RGD:1624295 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slitrk5 SLIT and NTRK-like family, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20418887 NCBI chr15:96,817,907...96,826,760
Ensembl chr15:96,821,832...96,826,653
JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Gnas GNAS complex locus sussceptibility ISO DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnb3 G protein subunit beta 3 susceptibility ISO DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 ISO RGD PMID:10449650 RGD:1581056 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Oprd1 opioid receptor, delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb561 cytochrome b-561 ISO ClinVar Annotator: match by term: ORTHOSTATIC HYPOTENSION 2 ClinVar
OMIM
NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
JBrowse link
Orthostatic Intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 member 2 ISO ClinVar Annotator: match by OMIM:604715
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:10684912 PMID:11458707 PMID:11875370 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
panic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor ISO GAD PMID:15118671 RGD:1331525 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:14656453 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8878350, PMID:15354400 RGD:1358454 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Comt catechol-O-methyltransferase ISO ClinVar Annotator: match by term: CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM OMIM
ClinVar
PMID:7304673 PMID:7585135 PMID:8886163 PMID:10459407 PMID:11381111 PMID:11502905 PMID:11925305 PMID:12611827 PMID:12716966 PMID:15457404 PMID:15645182 PMID:15652872 PMID:15821730 PMID:15824744 PMID:16043133 PMID:16395295 PMID:16513880 PMID:16542388 PMID:17156920 PMID:17548664 PMID:18192898 PMID:19094200 PMID:19514130 PMID:21398039 PMID:22695756 PMID:22992668 PMID:23210659 PMID:23302985 PMID:23459442 PMID:23686330 PMID:23773341 PMID:24533707 PMID:25155931 PMID:25185591 PMID:25741868 PMID:26555332 PMID:26902643 PMID:27027462 PMID:28006928 PMID:28346387 PMID:28745577 PMID:29259946 PMID:29474345 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:14675801 RGD:1358525 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IMP
ISO
RGD PMID:21421022, PMID:20817074 RGD:5683630, RGD:5683631 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12073167 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Maoa monoamine oxidase A ISO RGD PMID:15670397 RGD:1600723 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism: : RGD PMID:24856568 RGD:12910826 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Tph2 tryptophan hydroxylase 2 susceptibility ISO DNA:SNP:intron: (rs1386494) (human) RGD PMID:17123728 RGD:5686356 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
phobic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309392 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Med12 mediator complex subunit 12 ISO DNA:mutation:multiple RGD PMID:12216017 RGD:1358728 NCBI chr  X:71,174,653...71,197,812
Ensembl chr  X:71,174,699...71,197,812
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2554359 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor susceptibility ISO DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 RGD:10059367 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp12 caspase 12 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp9 caspase 9 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21714072 RGD:5147887 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Mdm2 MDM2 proto-oncogene IDA RGD PMID:23174211 RGD:10412309 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein treatment IEP RGD PMID:17968352 RGD:8694407 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
postural orthostatic tachycardia syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 member 2 ISS OMIM:604715 MouseDO NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
separation anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20731709 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
social phobia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntnap2 contactin associated protein 2 susceptibility ISO DNA:SNP: :rs2710102(human) RGD PMID:21193173 RGD:13450911 NCBI chr 4:74,700,539...77,025,463 JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppb natriuretic peptide B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17129
    disease of anatomical entity 16476
      nervous system disease 12074
        central nervous system disease 10353
          brain disease 9712
            disease of mental health 7022
              cognitive disorder 1949
                anxiety disorder 166
                  Neuroticism 0
                  acute stress disorder + 18
                  generalized anxiety disorder 3
                  neurocirculatory asthenia + 11
                  neurotic disorder 0
                  obsessive-compulsive disorder + 10
                  panic disorder + 11
                  phobic disorder + 5
                  post-traumatic stress disorder 12
                  separation anxiety disorder 1
paths to the root