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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:anxiety disorder
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Accession:DOID:2030 term browser browse the term
Definition:A cognitive disorder that involves an excessive, irrational dread of everyday situations. (DO)
Synonyms:exact_synonym: ANXIETY;   Neurotic Anxiety State;   anxiety disorders;   anxiety neuroses;   anxiety state;   neurotic anxiety states
 narrow_synonym: HARM AVOIDANCE
 related_synonym: SEROTONIN TRANSPORTER ACTIVITY, INCREASED/DECREASED
 primary_id: MESH:D001008
 alt_id: OMIM:607834
 xref: ICD10CM:F41.9;   NCI:C2878
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 3:89,714,469...89,753,455
Ensembl chr 3:89,715,022...89,753,446
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 PMID:16118787 PMID:18305461 PMID:20532872 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO RGD PMID:21669254 RGD:6480479 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G App amyloid beta (A4) precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19664757 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Avpr1b arginine vasopressin receptor 1B treatment ISO
IMP
RGD PMID:24654684, PMID:21956463 RGD:14700666, RGD:14700676 NCBI chr 1:131,599,114...131,612,000
Ensembl chr 1:131,599,239...131,612,000
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890
JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12600694 NCBI chr13:99,898,483...99,910,179
Ensembl chr13:99,898,489...99,901,091
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 IMP associated with Sciatic Neuropathy; RGD PMID:24907405 RGD:8661781 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19220484 PMID:29944862 NCBI chr 9:54,980,827...55,011,420
Ensembl chr 9:54,980,880...55,007,779
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23419392 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) ISO CTD Direct Evidence: marker/mechanism CTD PMID:15081793 PMID:18690112 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:7816204 PMID:8736133 PMID:11440811 PMID:11875628 PMID:12424556 PMID:12438692 PMID:14575894 PMID:16495007 PMID:17293045 PMID:21268831 PMID:22231481 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9299637 PMID:22231481 NCBI chr11:104,130,463...104,175,523
Ensembl chr11:104,132,855...104,175,523
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10742108 NCBI chr 6:55,090,048...55,133,016
Ensembl chr 6:55,090,049...55,133,016
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO associated with Coronary Disease;
CTD Direct Evidence: marker/mechanism
CTD PMID:20194079, PMID:18603621 RGD:9491832 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctnnd2 catenin (cadherin associated protein), delta 2 susceptibility ISO DNA:polymorphism:multiple (human) RGD PMID:24256404 RGD:40902831 NCBI chr15:30,172,534...31,029,344
Ensembl chr15:30,172,593...31,029,341
JBrowse link
G Disc1 disrupted in schizophrenia 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29643356 NCBI chr 8:125,048,767...125,265,143
Ensembl chr 8:125,054,195...125,261,858
JBrowse link
G Dixdc1 DIX domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr 9:50,662,752...50,739,602
Ensembl chr 9:50,662,752...50,739,517
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23791455 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B ISO mRNA:decreased expression:hypothalamus: RGD PMID:23529784 RGD:9588317 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:snp:cds:p.H313H (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18305461 PMID:20532872, PMID:9513185 RGD:1358603 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Eomes eomesodermin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26415720 NCBI chr 9:118,478,186...118,486,132
Ensembl chr 9:118,478,212...118,486,132
JBrowse link
G Esr2 estrogen receptor 2 (beta) treatment ISO RGD PMID:24015243, PMID:24631553 RGD:7364908, RGD:10045678 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fmr1 FMRP translational regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28616095 NCBI chr  X:68,678,536...68,717,963
Ensembl chr  X:68,678,541...68,717,963
JBrowse link
G Fos FBJ osteosarcoma oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18313124 NCBI chr 5:70,958,392...71,095,849
Ensembl chr 5:70,957,597...71,095,849
JBrowse link
G Gad1 glutamate decarboxylase 1 susceptibility ISO DNA:snp(s) (human ortholog) RGD PMID:22328461 RGD:6480264 NCBI chr 2:70,561,303...70,602,014
Ensembl chr 2:70,553,072...70,602,014
JBrowse link
G Glo1 glyoxalase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr17:30,592,861...30,612,659
Ensembl chr17:30,584,936...30,626,871
JBrowse link
G Gnb1 guanine nucleotide binding protein (G protein), beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 4:155,491,300...155,559,269
Ensembl chr 4:155,491,361...155,559,269
JBrowse link
G Grm8 glutamate receptor, metabotropic 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17434465 NCBI chr 6:27,275,121...28,135,146
Ensembl chr 6:27,275,119...28,135,178
JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22884333 RGD:9686419 NCBI chr13:117,602,320...117,981,028
Ensembl chr13:117,602,320...117,987,418
JBrowse link
G Hdac2 histone deacetylase 2 ISO RGD PMID:23485013 RGD:9590265 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889
JBrowse link
G Hmbs hydroxymethylbilane synthase ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 9:44,336,348...44,344,228
Ensembl chr 9:44,336,339...44,344,228
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO
IEA
OMIM:607834 MouseDO PMID:21512427 RGD:5683629 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B ISO RGD PMID:12040062 RGD:625756 NCBI chr 9:81,628,291...81,633,832
Ensembl chr 9:81,628,291...81,633,828
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C ISO RGD PMID:17074317 RGD:1625000 NCBI chr  X:146,962,464...147,197,277
Ensembl chr  X:146,962,513...147,197,277
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO
IMP
CTD Direct Evidence: marker/mechanism CTD PMID:21859099, PMID:16828124, PMID:16828124 RGD:6482189, RGD:6482189 NCBI chr19:35,958,415...36,058,133
Ensembl chr19:35,958,734...36,057,507
JBrowse link
G Kdm3b KDM3B lysine (K)-specific demethylase 3B ISO RGD PMID:24397026 RGD:9590119 NCBI chr18:34,777,008...34,839,370
Ensembl chr18:34,777,047...34,838,660
JBrowse link
G L1cam L1 cell adhesion molecule ISO protein:increased expression: brain, multiple (rat) RGD PMID:19746433 RGD:6483075 NCBI chr  X:73,853,778...73,880,838
Ensembl chr  X:73,853,778...73,896,105
JBrowse link
G LOC110991260 solute carrier family 6 member 4 gene promoter ISO ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:19531786 NCBI chr11:76,996,162...76,998,647 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25653350 NCBI chr 5:19,219,387...20,704,792
Ensembl chr 5:19,227,036...20,704,792
JBrowse link
G Mapt microtubule-associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:29860433 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mdk midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:19217924 NCBI chr 2:91,929,805...91,932,297
Ensembl chr 2:91,929,805...91,932,297
JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22231481 NCBI chr  X:74,026,592...74,085,690
Ensembl chr  X:74,026,592...74,135,363
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20177408 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mir34a microRNA 34a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27424985 NCBI chr 4:150,068,454...150,068,555
Ensembl chr 4:150,068,454...150,068,555
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:20051490 RGD:5688287 NCBI chr11:62,315,663...62,457,414
Ensembl chr11:62,316,426...62,458,541
JBrowse link
G Nps neuropeptide S ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:19339610 PMID:21466221 NCBI chr 7:135,268,619...135,272,942
Ensembl chr 7:135,258,703...135,272,942
JBrowse link
G Npy neuropeptide Y susceptibility ISO DNA:SNPs, haplotypes
CTD Direct Evidence: therapeutic
CTD PMID:11440811, PMID:22328461 RGD:6480264 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Npy1r neuropeptide Y receptor Y1 treatment ISO CTD Direct Evidence: therapeutic CTD PMID:11440811, PMID:21803058 RGD:10448284 NCBI chr 8:66,697,149...66,706,800
Ensembl chr 8:66,697,192...66,706,792
JBrowse link
G Oxt oxytocin ISO CTD Direct Evidence: therapeutic CTD PMID:19228979 NCBI chr 2:130,574,519...130,577,054
Ensembl chr 2:130,576,173...130,577,054
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815072 NCBI chr 1:97,821,091...98,095,853
Ensembl chr 1:97,795,114...98,095,646
JBrowse link
G Rai1 retinoic acid induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18285828 NCBI chr11:60,104,917...60,199,197
Ensembl chr11:60,105,013...60,199,197
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18272690 NCBI chr 7:44,308,916...44,360,094
Ensembl chr 7:44,310,253...44,360,572
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19120712 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ISO ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:18686203 PMID:19531786, PMID:18295409 RGD:4889509 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Tafa2 TAFA chemokine like family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29339520 NCBI chr10:123,264,024...123,741,204
Ensembl chr10:123,263,996...123,741,204
JBrowse link
G Tg thyroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:30373627 NCBI chr15:66,670,754...66,850,721
Ensembl chr15:66,670,753...66,850,721
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20194079 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Ucn urocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr 5:31,137,989...31,138,895
Ensembl chr 5:31,138,063...31,138,829
JBrowse link
G Ush2a usherin ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:9624053 PMID:10090909 PMID:10729113 PMID:10909849 PMID:11402400 PMID:12112664 PMID:14970843 PMID:15025721 PMID:15325563 PMID:15326663 PMID:17405132 PMID:18641288 PMID:19881469 PMID:20145675 PMID:20301515 PMID:22581970 PMID:24033266 PMID:24088041 PMID:24160897 PMID:24607488 PMID:25097241 PMID:25404053 PMID:25649381 PMID:25741868 PMID:26633545 PMID:26872967 PMID:28041643 PMID:28492532 PMID:29953849 PMID:30718709 NCBI chr 1:188,262,838...188,965,497
Ensembl chr 1:188,262,023...188,965,041
JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:20645790 RGD:5509849 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO RGD PMID:19628221 RGD:9585647 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta hydroxylase ISO
IEA
ClinVar Annotator: match by term: Orthostatic hypotension 1
OMIM:223360
ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency
ClinVar Annotator: match by OMIM:223360
OMIM
ClinVar
MouseDO
PMID:11857564 PMID:14598346 PMID:15060114 PMID:21209083 PMID:21471955 PMID:22028891 PMID:24033266 PMID:25450229 PMID:25741868 PMID:26762739 PMID:27778639 PMID:28492532 NCBI chr 2:27,165,507...27,183,204
Ensembl chr 2:27,165,233...27,183,200
JBrowse link
G Hspa5 heat shock protein 5 ISO RGD PMID:21209083 RGD:5685690 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
generalized anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 severity ISO protein:increased expression:serum (human) RGD PMID:27512921 RGD:39938860 NCBI chr 5:139,423,150...139,427,800
Ensembl chr 5:139,423,151...139,427,800
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 treatment ISO DNA:repeats, haplotype:promoter: RGD PMID:22907732 RGD:36947386 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Zfp462 zinc finger protein 462 IEA MouseDO NCBI chr 4:54,944,491...55,083,563
Ensembl chr 4:54,945,048...55,083,563
JBrowse link
neurocirculatory asthenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ISO orthostatic intolerance,OMIM:604715;DNA:point mutation:exon:A457P RGD PMID:10684912 RGD:1624278 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
obsessive-compulsive disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor ISO RGD PMID:12836135 RGD:734644 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8878350 NCBI chr 7:105,425,676...105,436,339
Ensembl chr 7:105,425,731...105,470,898
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:11840516 RGD:1300383 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Hoxb8 homeobox B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11779477 NCBI chr11:96,279,401...96,285,325
Ensembl chr11:96,281,905...96,285,315
JBrowse link
G Hras Harvey rat sarcoma virus oncogene ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Htr1d 5-hydroxytryptamine (serotonin) receptor 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:10621951 NCBI chr 4:136,423,522...136,444,405
Ensembl chr 4:136,423,524...136,444,398
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:19644229 NCBI chr14:74,640,874...74,706,859
Ensembl chr14:74,640,840...74,709,494
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 IMP RGD PMID:17267119 RGD:6482188 NCBI chr19:35,958,415...36,058,133
Ensembl chr19:35,958,734...36,057,507
JBrowse link
G LOC110991260 solute carrier family 6 member 4 gene promoter ISO ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:19531786 NCBI chr11:76,996,162...76,998,647 JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ISO OCD1,OMIM:164230;DNA:polymorphism:I425V
ClinVar Annotator: match by term: Obsessive-compulsive disorder
ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869649 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593431 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:15995945 PMID:16642437 PMID:17101915 PMID:18197083 PMID:19531786 PMID:25741868, PMID:14593431 RGD:1624295 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Slitrk5 SLIT and NTRK-like family, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20418887 NCBI chr14:111,675,115...111,683,144
Ensembl chr14:111,675,097...111,683,141
JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus sussceptibility ISO DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr 2:174,284,320...174,346,744
Ensembl chr 2:174,284,320...174,346,744
JBrowse link
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 susceptibility ISO DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr 6:124,834,240...124,840,275
Ensembl chr 6:124,834,240...124,840,275
JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial ISO RGD PMID:10449650 RGD:1581056 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
JBrowse link
G Oprd1 opioid receptor, delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 4:132,110,188...132,144,486
Ensembl chr 4:132,110,726...132,144,486
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb561 cytochrome b-561 ISO ClinVar Annotator: match by term: ORTHOSTATIC HYPOTENSION 2 ClinVar
OMIM
NCBI chr11:105,933,702...105,945,019
Ensembl chr11:105,933,702...105,953,336
JBrowse link
Orthostatic Intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ISO ClinVar Annotator: match by OMIM:604715
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:10684912 PMID:11458707 PMID:11875370 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
panic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor ISO GAD PMID:15118671 RGD:1331525 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO CTD Direct Evidence: marker/mechanism CTD PMID:14656453 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8878350, PMID:15354400 RGD:1358454 NCBI chr 7:105,425,676...105,436,339
Ensembl chr 7:105,425,731...105,470,898
JBrowse link
G Comt catechol-O-methyltransferase ISO ClinVar Annotator: match by term: CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM OMIM
ClinVar
PMID:7304673 PMID:7585135 PMID:8886163 PMID:10459407 PMID:11381111 PMID:11502905 PMID:11925305 PMID:12611827 PMID:12716966 PMID:15457404 PMID:15645182 PMID:15652872 PMID:15821730 PMID:15824744 PMID:16043133 PMID:16395295 PMID:16513880 PMID:16542388 PMID:17156920 PMID:17548664 PMID:18192898 PMID:19094200 PMID:19514130 PMID:21398039 PMID:22695756 PMID:22992668 PMID:23210659 PMID:23302985 PMID:23459442 PMID:23686330 PMID:23773341 PMID:24533707 PMID:25155931 PMID:25185591 PMID:25741868 PMID:26555332 PMID:26902643 PMID:27027462 PMID:28006928 PMID:28346387 PMID:28745577 PMID:29259946 PMID:29474345 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:14675801 RGD:1358525 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO RGD PMID:21421022, PMID:20817074 RGD:5683630, RGD:5683631 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:12073167 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Maoa monoamine oxidase A ISO RGD PMID:15670397 RGD:1600723 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility ISO DNA:polymorphism: : RGD PMID:24856568 RGD:12910826 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Tph2 tryptophan hydroxylase 2 susceptibility ISO DNA:SNP:intron: (rs1386494) (human) RGD PMID:17123728 RGD:5686356 NCBI chr10:115,078,641...115,185,022
Ensembl chr10:115,078,641...115,185,022
JBrowse link
phobic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309392 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Hras Harvey rat sarcoma virus oncogene ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Med12 mediator complex subunit 12 ISO DNA:mutation:multiple RGD PMID:12216017 RGD:1358728 NCBI chr  X:101,274,091...101,298,934
Ensembl chr  X:101,274,030...101,297,465
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2554359 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205
JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein ISO RGD PMID:23381833 RGD:10054113 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO RGD PMID:23381833 RGD:10054113 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bdnf brain derived neurotrophic factor susceptibility ISO DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 RGD:10059367 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Casp12 caspase 12 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp9 caspase 9 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Hspa5 heat shock protein 5 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21714072 RGD:5147887 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO RGD PMID:23174211 RGD:10412309 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 ISO protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 2:121,413,902...121,438,687
Ensembl chr 2:121,413,775...121,438,687
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:17968352 RGD:8694407 NCBI chr 5:36,966,104...36,988,982
Ensembl chr 5:36,966,104...36,989,205
JBrowse link
postural orthostatic tachycardia syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ISS OMIM:604715 MouseDO NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
separation anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20731709 NCBI chr 7:141,291,974...141,296,464
Ensembl chr 7:141,292,006...141,296,464
JBrowse link
social phobia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntnap2 contactin associated protein-like 2 susceptibility ISO DNA:SNP: :rs2710102(human) RGD PMID:21193173 RGD:13450911 NCBI chr 6:45,060,061...47,301,393
Ensembl chr 6:45,059,357...47,304,213
JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppb natriuretic peptide type B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14322
    disease of anatomical entity 13921
      nervous system disease 11462
        central nervous system disease 9999
          brain disease 9387
            disease of mental health 6883
              cognitive disorder 1840
                anxiety disorder 103
                  Neuroticism 0
                  acute stress disorder + 15
                  generalized anxiety disorder 3
                  neurocirculatory asthenia + 11
                  neurotic disorder 0
                  obsessive-compulsive disorder + 11
                  panic disorder + 11
                  phobic disorder + 5
                  post-traumatic stress disorder 12
                  separation anxiety disorder 1
paths to the root