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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:anxiety disorder
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Accession:DOID:2030 term browser browse the term
Definition:A cognitive disorder that involves an excessive, irrational dread of everyday situations. (DO)
Synonyms:exact_synonym: ANXIETY;   Neurotic Anxiety State;   anxiety disorders;   anxiety neuroses;   anxiety state;   neurotic anxiety states
 narrow_synonym: HARM AVOIDANCE
 related_synonym: SEROTONIN TRANSPORTER ACTIVITY, INCREASED/DECREASED
 primary_id: MESH:D001008
 alt_id: OMIM:607834
 xref: EFO:0005230;   EFO:0006788;   ICD10CM:F41.9;   NCI:C2878
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26767952 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ADAR adenosine deaminase RNA specific IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013 		JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:12825092 PMID:16118787 PMID:18305461 PMID:20532872 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:21669254 RGD:6480479 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G APOE apolipoprotein E EXP CTD Direct Evidence: marker/mechanism CTD PMID:32057829 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:19664757 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ARC activity regulated cytoskeleton associated protein ameliorates ISO associated with alcohol use disorder
associated with alcohol dependence		 RGD PMID:18322102 PMID:24103311 PMID:25814047 PMID:21182574 RGD:401938616, RGD:401938663, RGD:401938652, RGD:401938648 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G AVPR1B arginine vasopressin receptor 1B treatment ISO RGD PMID:24654684 PMID:21956463 RGD:14700666, RGD:14700676 NCBI chr 1:206,106,936...206,117,388
Ensembl chr 1:206,106,936...206,117,699 		JBrowse link
G BDNF brain derived neurotrophic factor treatment
ameliorates		 ISO associated with alcohol dependence
associated with alcohol use disorder		 RGD PMID:25283985 PMID:24103311 PMID:25814047 PMID:18322102 RGD:151356735, RGD:401938663, RGD:401938652, RGD:401938616 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C EXP CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CARTPT CART prepropeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:12600694 NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Sciatic Neuropathy; RGD PMID:24907405 RGD:8661781 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CHD8 chromodomain helicase DNA binding protein 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:35365720 NCBI chr14:21,385,199...21,456,123
Ensembl chr14:21,385,194...21,456,126 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19220484 PMID:29944862 NCBI chr15:78,565,520...78,595,269
Ensembl chr15:78,565,520...78,595,269 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:23419392 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013 		JBrowse link
G CNR1 cannabinoid receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15081793 PMID:18690112 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO associated with alcohol use disorder RGD PMID:18322102 PMID:32014377 RGD:401938616, RGD:401827932 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CRH corticotropin releasing hormone EXP CTD Direct Evidence: marker/mechanism CTD PMID:7816204 PMID:8736133 PMID:11440811 PMID:11875628 PMID:12424556 More... NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:9299637 PMID:22231481 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:10742108 NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129 		JBrowse link
G CRP C-reactive protein IEP
EXP		 associated with Coronary Disease;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20194079 PMID:18603621 RGD:9491832 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CTNND2 catenin delta 2 susceptibility IAGP DNA:polymorphism:multiple (human) RGD PMID:24256404 RGD:40902831 NCBI chr 5:10,971,836...11,904,446
Ensembl chr 5:10,971,836...11,904,446 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO protein:altered activity::treatment RGD PMID:17376576 RGD:5685599 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DISC1 DISC1 scaffold protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:29643356 NCBI chr 1:231,626,790...232,041,272
Ensembl chr 1:231,626,790...232,041,272 		JBrowse link
G DIXDC1 DIX domain containing 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr11:111,927,315...112,022,653
Ensembl chr11:111,927,144...112,022,653 		JBrowse link
G DNMT1 DNA methyltransferase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23791455 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:decreased expression:hypothalamus: RGD PMID:23529784 RGD:9588317 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G DRD2 dopamine receptor D2 IAGP
EXP		 DNA:snp:cds:p.H313H (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18305461 PMID:20532872 PMID:9513185 RGD:1358603 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G ELK1 ETS transcription factor ELK1 ameliorates ISO associated with alcohol use disorder RGD PMID:18322102 RGD:401938616 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604 		JBrowse link
G EOMES eomesodermin EXP CTD Direct Evidence: marker/mechanism CTD PMID:26415720 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711 		JBrowse link
G ESR2 estrogen receptor 2 treatment ISO RGD PMID:24015243 PMID:24631553 RGD:7364908, RGD:10045678 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28616095 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G FNTB farnesyltransferase, CAAX box, subunit beta IAGP DNA:SNP:CDS:multiple (human) RGD PMID:35642741 RGD:401854249 NCBI chr14:64,986,895...65,062,650
Ensembl chr14:64,986,895...65,062,652 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18313124 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility IAGP DNA:snp(s) RGD PMID:22328461 RGD:6480264 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151 		JBrowse link
G GLO1 glyoxalase I EXP CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GNB1 G protein subunit beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 1:1,785,286...1,891,087
Ensembl chr 1:1,785,285...1,892,292 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17434465 NCBI chr 7:126,438,598...127,252,941
Ensembl chr 7:126,438,598...127,253,093 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22884333 RGD:9686419 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498 		JBrowse link
G HDAC2 histone deacetylase 2 ISO associated with alcohol use disorder ;mRNA,protein:increased expression:amygdala (rat) RGD PMID:23485013 PMID:25814047 RGD:9590265, RGD:401938652 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308 		JBrowse link
G HMBS hydroxymethylbilane synthase IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A IAGP
ISS		 OMIM:607834 MouseDO
RGD		 PMID:21512427 RGD:5683629 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:12040062 RGD:625756 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:17074317 RGD:1625000 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21859099 PMID:16828124 PMID:16828124 RGD:6482189, RGD:6482189 NCBI chr10:90,740,823...90,858,039
Ensembl chr10:90,740,823...90,858,039 		JBrowse link
G IFNA2 interferon alpha 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12297606 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398 		JBrowse link
G KDM3B lysine demethylase 3B ISO RGD PMID:24397026 RGD:9590119 NCBI chr 5:138,352,685...138,437,027
Ensembl chr 5:138,352,685...138,437,028 		JBrowse link
G L1CAM L1 cell adhesion molecule ISO protein:increased expression: brain, multiple (rat) RGD PMID:19746433 RGD:6483075 NCBI chr  X:153,861,514...153,886,173
Ensembl chr  X:153,861,514...153,886,173 		JBrowse link
G LOC110806262 solute carrier family 6 member 4 gene promoter IAGP ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... NCBI chr17:30,235,481...30,237,521 JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25653350 NCBI chr 7:78,017,055...79,453,667
Ensembl chr 7:78,017,055...79,453,667 		JBrowse link
G MANEA mannosidase endo-alpha susceptibility IAGP DNA:SNP:3'utr: (rs1133503) (Human) RGD PMID:24473444 RGD:401851911 NCBI chr 6:95,577,535...95,609,452
Ensembl chr 6:95,577,485...95,609,470 		JBrowse link
G MAPT microtubule associated protein tau EXP CTD Direct Evidence: marker/mechanism CTD PMID:29860433 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G MDK midkine EXP CTD Direct Evidence: marker/mechanism CTD PMID:19217924 NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837 		JBrowse link
G MECP2 methyl-CpG binding protein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22231481 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G MIF macrophage migration inhibitory factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20177408 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227 		JBrowse link
G MIR34A microRNA 34a EXP CTD Direct Evidence: marker/mechanism CTD PMID:27424985 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:20051490 RGD:5688287 NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185 		JBrowse link
G NPS neuropeptide S EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:19339610 PMID:21466221 NCBI chr10:127,549,309...127,553,540
Ensembl chr10:127,549,309...127,553,540 		JBrowse link
G NPY neuropeptide Y susceptibility IAGP
EXP		 DNA:SNPs, haplotypes
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:11440811 PMID:22328461 RGD:6480264 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 treatment ISO
EXP		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:11440811 PMID:21803058 RGD:10448284 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ameliorates ISO associated with alcohol use disorder RGD PMID:18322102 RGD:401938616 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G OPRM1 opioid receptor mu 1 treatment ISO RGD PMID:32014377 RGD:401827932 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide EXP CTD Direct Evidence: therapeutic CTD PMID:19228979 NCBI chr20:3,071,620...3,072,517
Ensembl chr20:3,071,620...3,072,517 		JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19815072 NCBI chr 5:102,754,783...103,031,105
Ensembl chr 5:102,753,981...103,029,730 		JBrowse link
G RAI1 retinoic acid induced 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18285828 NCBI chr17:17,681,458...17,811,453
Ensembl chr17:17,681,458...17,811,453 		JBrowse link
G SERPINA1 serpin family A member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr14:94,376,747...94,390,635
Ensembl chr14:94,376,747...94,390,693 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18272690 NCBI chr19:50,659,255...50,719,802
Ensembl chr19:50,659,255...50,719,802 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19120712 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO
IAGP
EXP		 ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM
RGD		 PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... RGD:4889509 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G TAFA2 TAFA chemokine like family member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29339520 NCBI chr12:61,708,273...62,260,034
Ensembl chr12:61,708,273...62,279,150 		JBrowse link
G TG thyroglobulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:30373627 NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903 		JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20194079 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UCN urocortin EXP CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445 		JBrowse link
G USH2A usherin IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:9624053 PMID:10090909 PMID:10729113 PMID:10909849 PMID:11402400 More... NCBI chr 1:215,622,891...216,423,448
Ensembl chr 1:215,622,891...216,423,448 		JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) ISO RGD PMID:20645790 RGD:5509849 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C EXP CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CRP C-reactive protein IEP RGD PMID:19628221 RGD:9585647 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
Acute Stress Disorders, Traumatic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2A 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:15507224 RGD:401900762 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase IAGP
ISS
EXP		 ClinVar Annotator: match by term: Orthostatic hypotension 1
OMIM:223360
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
MouseDO
CTD		 PMID:7715704 PMID:9536098 PMID:11170900 PMID:11857564 PMID:14598346 More... NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DBH-AS1 DBH antisense RNA 1 IAGP ClinVar Annotator: match by term: Orthostatic hypotension 1 ClinVar PMID:7715704 PMID:9536098 PMID:15060114 PMID:17576681 PMID:22028891 More... NCBI chr 9:133,654,587...133,657,408
Ensembl chr 9:133,654,586...133,657,313 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 IAGP RGD PMID:21209083 RGD:5685690 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
generalized anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 severity IEP protein:increased expression:serum (human) RGD PMID:27512921 RGD:39938860 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 treatment IAGP DNA:repeats, haplotype:promoter: RGD PMID:22907732 RGD:36947386 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G ZNF462 zinc finger protein 462 ISS MouseDO NCBI chr 9:106,860,158...107,013,634
Ensembl chr 9:106,863,166...107,013,634 		JBrowse link
neurocirculatory asthenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 IAGP orthostatic intolerance,OMIM:604715;DNA:point mutation:exon:A457P
ClinVar Annotator: match by term: Neurocirculatory asthenia		 ClinVar
RGD		 PMID:10684912 PMID:11875370 PMID:10684912 RGD:1624278 NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645 		JBrowse link
obsessive-compulsive disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor IAGP
ISO		 associated with morphine withdrawal disorder;mRNA:decreased expression:nucleus accumbens RGD PMID:12836135 PMID:31693870 RGD:734644, RGD:401959588 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CCKBR cholecystokinin B receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:8878350 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G COMT catechol-O-methyltransferase IAGP RGD PMID:11840516 RGD:1300383 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO associated with morphine withdrawal disorder;protein:increased phosphorylation:nucleus accumbens RGD PMID:31693870 RGD:401959588 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G HOXB8 homeobox B8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11779477 NCBI chr17:48,612,346...48,615,292
Ensembl chr17:48,611,377...48,615,292 		JBrowse link
G HRAS HRas proto-oncogene, GTPase IAGP DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HTR1D 5-hydroxytryptamine receptor 1D EXP CTD Direct Evidence: marker/mechanism CTD PMID:10621951 NCBI chr 1:23,191,895...23,217,502
Ensembl chr 1:23,191,895...23,217,502 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A susceptibility EXP
IAGP		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to		 CTD
OMIM
ClinVar		 PMID:9635956 PMID:12476319 PMID:15364038 PMID:19644229 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:17267119 RGD:6482188 NCBI chr10:90,740,823...90,858,039
Ensembl chr10:90,740,823...90,858,039 		JBrowse link
G LOC110806262 solute carrier family 6 member 4 gene promoter IAGP ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... NCBI chr17:30,235,481...30,237,521 JBrowse link
G SLC6A4 solute carrier family 6 member 4 IAGP
EXP		 OCD1,OMIM:164230;DNA:polymorphism:I425V
ClinVar Annotator: match by term: Obsessive-compulsive disorder
ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM
RGD		 PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... RGD:1624295 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SLITRK5 SLIT and NTRK like family member 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20418887 NCBI chr13:87,671,371...87,679,616
Ensembl chr13:87,671,371...87,696,272 		JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G COL1A2 collagen type I alpha 2 chain IAGP ClinVar Annotator: match by term: Orthostatic hypotension ClinVar NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G GNAS GNAS complex locus susceptibility IAGP DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192 		JBrowse link
G GNB3 G protein subunit beta 3 susceptibility IAGP DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr12:6,840,925...6,847,393
Ensembl chr12:6,839,954...6,847,393 		JBrowse link
G MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 IAGP RGD PMID:10449650 RGD:1581056 NCBI chr MT:4,470...5,511
Ensembl chr MT:4,470...5,511 		JBrowse link
G OPRD1 opioid receptor delta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRM1 opioid receptor mu 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB561 cytochrome b561 IAGP ClinVar Annotator: match by term: Orthostatic hypotension 2 OMIM
ClinVar		 NCBI chr17:63,432,304...63,446,639
Ensembl chr17:63,432,304...63,446,354 		JBrowse link
G LOC112533658 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61513919-61514833 IAGP ClinVar Annotator: match by term: Orthostatic hypotension 2 ClinVar NCBI chr17:63,436,558...63,437,472 JBrowse link
Orthostatic Intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 IAGP
EXP		 ClinVar Annotator: match by term: SLC6A2-related disorder
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:11458707 NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645 		JBrowse link
panic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor IEA GAD PMID:15118671 RGD:1331525 NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405 		JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:12825092 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357 		JBrowse link
G ADRA2A adrenoceptor alpha 2A EXP CTD Direct Evidence: marker/mechanism CTD PMID:14656453 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G CCKBR cholecystokinin B receptor IAGP
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8878350 PMID:15354400 RGD:1358454 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G COMT catechol-O-methyltransferase IAGP
EXP		 ClinVar Annotator: match by term: CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD		 PMID:7304673 PMID:7585135 PMID:8807664 PMID:8886163 PMID:8941353 More... NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CRH corticotropin releasing hormone IAGP RGD PMID:14675801 RGD:1358525 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO
IAGP		 RGD PMID:21421022 PMID:20817074 RGD:5683630, RGD:5683631 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G INS insulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:12073167 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G MANEA mannosidase endo-alpha susceptibility IAGP associated with substance dependence; DNA:SNP:3'utr: (rs1133503) (Human) RGD PMID:24473444 RGD:401851911 NCBI chr 6:95,577,535...95,609,452
Ensembl chr 6:95,577,485...95,609,470 		JBrowse link
G MAOA monoamine oxidase A IAGP RGD PMID:15670397 RGD:1600723 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility IAGP DNA:polymorphism: : RGD PMID:24856568 RGD:12910826 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G TPH2 tryptophan hydroxylase 2 susceptibility IAGP DNA:SNP:intron: (rs1386494) (human) RGD PMID:17123728 RGD:5686356 NCBI chr12:71,938,845...72,032,440
Ensembl chr12:71,938,845...72,186,618 		JBrowse link
phobic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:15309392 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G HRAS HRas proto-oncogene, GTPase IAGP DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G MED12 mediator complex subunit 12 IAGP DNA:mutation:multiple RGD PMID:12216017 RGD:1358728 NCBI chr  X:71,118,596...71,142,450
Ensembl chr  X:71,118,543...71,144,103 		JBrowse link
G PRL prolactin EXP CTD Direct Evidence: marker/mechanism CTD PMID:2554359 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor susceptibility
treatment		 IAGP
ISO		 DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 PMID:28791385 RGD:10059367, RGD:401940159 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C IAGP ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:32332995 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) ISO RGD PMID:25331812 RGD:13782181 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP9 caspase 9 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CNR1 cannabinoid receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CNR2 cannabinoid receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 IAGP ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:18349090 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:27421892 RGD:405255654 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A treatment ISO RGD PMID:28791385 RGD:401940159 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IL2 interleukin 2 IEP RGD PMID:21714072 RGD:5147887 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G MDM2 MDM2 proto-oncogene ISO RGD PMID:23174211 RGD:10412309 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G OPRM1 opioid receptor mu 1 severity IAGP DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) RGD PMID:22143634 RGD:401827931 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 ISO RGD PMID:25331812 RGD:13782181 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279 		JBrowse link
G SIGMAR1 sigma non-opioid intracellular receptor 1 treatment ISO RGD PMID:28791385 RGD:401940159 NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,844 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:17968352 RGD:8694407 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265 		JBrowse link
separation anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD4 dopamine receptor D4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20731709 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G NGF nerve growth factor ISO protein:decreased expression:hippocampus RGD PMID:24407463 RGD:401976437 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
social phobia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNTNAP2 contactin associated protein 2 susceptibility IAGP DNA:SNP: :rs2710102(human) RGD PMID:21193173 RGD:13450911 NCBI chr 7:146,116,801...148,420,998
Ensembl chr 7:146,116,002...148,420,998 		JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPB natriuretic peptide B IEP associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      nervous system disease 26233
        central nervous system disease 23468
          brain disease 21902
            disease of mental health 17210
              cognitive disorder 5504
                anxiety disorder 122
                  Neuroticism 0
                  acute stress disorder + 23
                  generalized anxiety disorder 3
                  neurocirculatory asthenia + 14
                  neurotic disorder 0
                  obsessive-compulsive disorder + 12
                  panic disorder + 12
                  phobic disorder + 5
                  post-traumatic stress disorder 20
                  separation anxiety disorder 2
paths to the root