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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:anxiety disorder
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Accession:DOID:2030 term browser browse the term
Definition:A cognitive disorder that involves an excessive, irrational dread of everyday situations. (DO)
Synonyms:exact_synonym: ANXIETY;   Neurotic Anxiety State;   anxiety disorders;   anxiety neuroses;   anxiety state;   neurotic anxiety states
 narrow_synonym: HARM AVOIDANCE
 related_synonym: SEROTONIN TRANSPORTER ACTIVITY, INCREASED/DECREASED
 primary_id: MESH:D001008
 alt_id: OMIM:607834
 xref: ICD10CM:F41.9;   NCI:C2878
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013
JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:12825092 PMID:16118787 PMID:18305461 PMID:20532872 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:21669254 RGD:6480479 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G APP amyloid beta precursor protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:19664757 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AVPR1B arginine vasopressin receptor 1B treatment ISO RGD PMID:24654684, PMID:21956463 RGD:14700666, RGD:14700676 NCBI chr 1:206,106,936...206,117,388
Ensembl chr 1:206,106,936...206,117,699
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C EXP CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,772...2,697,950
JBrowse link
G CARTPT CART prepropeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:12600694 NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Sciatic Neuropathy; RGD PMID:24907405 RGD:8661781 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19220484 PMID:29944862 NCBI chr15:78,565,520...78,595,269
Ensembl chr15:78,565,520...78,595,269
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:23419392 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CNR1 cannabinoid receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15081793 PMID:18690112 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G CRH corticotropin releasing hormone EXP CTD Direct Evidence: marker/mechanism CTD PMID:7816204 PMID:8736133 PMID:11440811 PMID:11875628 PMID:12424556 PMID:12438692 PMID:14575894 PMID:16495007 PMID:17293045 PMID:21268831 PMID:22231481 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:9299637 PMID:22231481 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,280...45,835,828
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:10742108 NCBI chr 7:30,649,406...30,700,103
Ensembl chr 7:30,651,942...30,700,129
JBrowse link
G CRP C-reactive protein IEP
EXP
associated with Coronary Disease;
CTD Direct Evidence: marker/mechanism
CTD PMID:20194079, PMID:18603621 RGD:9491832 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CTNND2 catenin delta 2 susceptibility IAGP DNA:polymorphism:multiple (human) RGD PMID:24256404 RGD:40902831 NCBI chr 5:10,971,836...11,904,446
Ensembl chr 5:10,971,836...11,904,446
JBrowse link
G DISC1 DISC1 scaffold protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:29643356 NCBI chr 1:231,626,790...232,041,272
Ensembl chr 1:231,626,790...232,041,272
JBrowse link
G DIXDC1 DIX domain containing 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr11:111,927,169...112,022,653
Ensembl chr11:111,927,144...112,022,653
JBrowse link
G DNMT1 DNA methyltransferase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23791455 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:decreased expression:hypothalamus: RGD PMID:23529784 RGD:9588317 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DRD2 dopamine receptor D2 IAGP
EXP
DNA:snp:cds:p.H313H (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18305461 PMID:20532872, PMID:9513185 RGD:1358603 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G EOMES eomesodermin EXP CTD Direct Evidence: marker/mechanism CTD PMID:26415720 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711
JBrowse link
G ESR2 estrogen receptor 2 treatment ISO RGD PMID:24015243, PMID:24631553 RGD:7364908, RGD:10045678 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FMR1 FMRP translational regulator 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28616095 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18313124 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230
JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility IAGP DNA:snp(s) RGD PMID:22328461 RGD:6480264 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GLO1 glyoxalase I EXP CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G GNB1 G protein subunit beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr 1:1,785,286...1,891,087
Ensembl chr 1:1,785,285...1,891,117
JBrowse link
G GRM8 glutamate metabotropic receptor 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17434465 NCBI chr 7:126,438,598...127,252,941
Ensembl chr 7:126,438,598...127,253,093
JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22884333 RGD:9686419 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
JBrowse link
G HDAC2 histone deacetylase 2 ISO RGD PMID:23485013 RGD:9590265 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HMBS hydroxymethylbilane synthase IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr11:119,084,864...119,093,549
Ensembl chr11:119,084,866...119,093,549
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A IAGP
ISS
OMIM:607834 MouseDO PMID:21512427 RGD:5683629 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:12040062 RGD:625756 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:17074317 RGD:1625000 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061
JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:21859099, PMID:16828124, PMID:16828124 RGD:6482189, RGD:6482189 NCBI chr10:90,738,693...90,858,039
Ensembl chr10:90,740,823...90,858,039
JBrowse link
G IFNA2 interferon alpha 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12297606 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398
JBrowse link
G KDM3B lysine demethylase 3B ISO RGD PMID:24397026 RGD:9590119 NCBI chr 5:138,352,685...138,437,027
Ensembl chr 5:138,352,685...138,437,028
JBrowse link
G L1CAM L1 cell adhesion molecule ISO protein:increased expression: brain, multiple (rat) RGD PMID:19746433 RGD:6483075 NCBI chr  X:153,861,514...153,886,173
Ensembl chr  X:153,861,514...153,886,173
JBrowse link
G LOC110806262 solute carrier family 6 member 4 gene promoter IAGP ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:19531786 NCBI chr17:30,235,481...30,237,521 JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25653350 NCBI chr 7:78,017,055...79,453,667
Ensembl chr 7:78,017,055...79,453,667
JBrowse link
G MAPT microtubule associated protein tau EXP CTD Direct Evidence: marker/mechanism CTD PMID:29860433 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MDK midkine EXP CTD Direct Evidence: marker/mechanism CTD PMID:19217924 NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837
JBrowse link
G MECP2 methyl-CpG binding protein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22231481 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103
JBrowse link
G MIF macrophage migration inhibitory factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20177408 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MIR34A microRNA 34a EXP CTD Direct Evidence: marker/mechanism CTD PMID:27424985 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:20051490 RGD:5688287 NCBI chr17:16,029,157...16,216,475
Ensembl chr17:16,029,157...16,218,185
JBrowse link
G NPS neuropeptide S EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:19339610 PMID:21466221 NCBI chr10:127,549,309...127,553,540
Ensembl chr10:127,549,309...127,553,540
JBrowse link
G NPY neuropeptide Y susceptibility IAGP
EXP
DNA:SNPs, haplotypes
CTD Direct Evidence: therapeutic
CTD PMID:11440811, PMID:22328461 RGD:6480264 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NPY1R neuropeptide Y receptor Y1 treatment ISO
EXP
CTD Direct Evidence: therapeutic CTD PMID:11440811, PMID:21803058 RGD:10448284 NCBI chr 4:163,323,962...163,344,832
Ensembl chr 4:163,323,962...163,344,832
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide EXP CTD Direct Evidence: therapeutic CTD PMID:19228979 NCBI chr20:3,068,871...3,072,517
Ensembl chr20:3,071,620...3,072,517
JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19815072 NCBI chr 5:102,754,783...103,031,105
Ensembl chr 5:102,753,981...103,029,730
JBrowse link
G RAI1 retinoic acid induced 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18285828 NCBI chr17:17,681,376...17,811,453
Ensembl chr17:17,681,458...17,811,453
JBrowse link
G SERPINA1 serpin family A member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr14:94,376,747...94,390,654
Ensembl chr14:94,376,747...94,390,693
JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18272690 NCBI chr19:50,659,255...50,719,802
Ensembl chr19:50,659,255...50,719,802
JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19120712 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO
IAGP
EXP
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:18686203 PMID:19531786, PMID:18295409 RGD:4889509 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G TAFA2 TAFA chemokine like family member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29339520 NCBI chr12:61,708,273...62,260,104
Ensembl chr12:61,708,273...62,279,150
JBrowse link
G TG thyroglobulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:30373627 NCBI chr 8:132,866,943...133,134,902
Ensembl chr 8:132,866,958...133,134,903
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20194079 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G UCN urocortin EXP CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445
JBrowse link
G USH2A usherin IAGP ClinVar Annotator: match by term: Anxiety ClinVar PMID:9624053 PMID:10090909 PMID:10729113 PMID:10909849 PMID:11402400 PMID:12112664 PMID:12525556 PMID:14970843 PMID:15025721 PMID:15325563 PMID:15326663 PMID:17405132 PMID:18641288 PMID:19881469 PMID:20145675 PMID:20301515 PMID:20507924 PMID:22581970 PMID:24033266 PMID:24088041 PMID:24160897 PMID:24607488 PMID:24944099 PMID:25097241 PMID:25404053 PMID:25649381 PMID:25741868 PMID:26633545 PMID:26872967 PMID:28041643 PMID:28492532 PMID:29953849 PMID:30718709 NCBI chr 1:215,622,891...216,423,448
Ensembl chr 1:215,622,891...216,423,448
JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) ISO RGD PMID:20645790 RGD:5509849 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C EXP CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,772...2,697,950
JBrowse link
G CRP C-reactive protein IEP RGD PMID:19628221 RGD:9585647 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase IAGP ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency
ClinVar Annotator: match by term: Orthostatic hypotension 1
ClinVar
OMIM
PMID:11857564 PMID:14598346 PMID:15060114 PMID:16199547 PMID:21209083 PMID:21471955 PMID:22028891 PMID:24033266 PMID:25450229 PMID:25741868 PMID:26762739 PMID:27778639 PMID:28492532 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329
JBrowse link
G DBH-AS1 DBH antisense RNA 1 IAGP ClinVar Annotator: match by term: Dopamine beta hydroxylase deficiency
ClinVar Annotator: match by term: Orthostatic hypotension 1
ClinVar PMID:22028891 PMID:25450229 PMID:28492532 NCBI chr 9:133,654,587...133,657,408
Ensembl chr 9:133,654,586...133,657,313
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 IAGP RGD PMID:21209083 RGD:5685690 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
generalized anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 severity IEP protein:increased expression:serum (human) RGD PMID:27512921 RGD:39938860 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G SLC6A4 solute carrier family 6 member 4 treatment IAGP DNA:repeats, haplotype:promoter: RGD PMID:22907732 RGD:36947386 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G ZNF462 zinc finger protein 462 ISS MouseDO NCBI chr 9:106,860,154...107,013,634
Ensembl chr 9:106,863,166...107,013,634
JBrowse link
neurocirculatory asthenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 IAGP orthostatic intolerance,OMIM:604715;DNA:point mutation:exon:A457P RGD PMID:10684912 RGD:1624278 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,988...55,707,645
JBrowse link
obsessive-compulsive disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor IAGP RGD PMID:12836135 RGD:734644 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CCKBR cholecystokinin B receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:8878350 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127
JBrowse link
G COMT catechol-O-methyltransferase IAGP RGD PMID:11840516 RGD:1300383 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G HOXB8 homeobox B8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11779477 NCBI chr17:48,612,346...48,619,531
Ensembl chr17:48,611,377...48,615,292
JBrowse link
G HRAS HRas proto-oncogene, GTPase IAGP DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G HTR1D 5-hydroxytryptamine receptor 1D EXP CTD Direct Evidence: marker/mechanism CTD PMID:10621951 NCBI chr 1:23,191,895...23,217,502
Ensembl chr 1:23,191,895...23,217,502
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A IAGP
EXP
CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:19644229 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:17267119 RGD:6482188 NCBI chr10:90,738,693...90,858,039
Ensembl chr10:90,740,823...90,858,039
JBrowse link
G LOC110806262 solute carrier family 6 member 4 gene promoter IAGP ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased ClinVar PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:16642437 PMID:17101915 PMID:19531786 NCBI chr17:30,235,481...30,237,521 JBrowse link
G SLC6A4 solute carrier family 6 member 4 IAGP
EXP
OCD1,OMIM:164230;DNA:polymorphism:I425V
ClinVar Annotator: match by term: Obsessive-compulsive disorder
ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to
ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 PMID:11602621 PMID:11772685 PMID:12130784 PMID:12476327 PMID:12599191 PMID:12869649 PMID:12869766 PMID:12915525 PMID:12966525 PMID:14530202 PMID:14593431 PMID:14593433 PMID:14735161 PMID:15037864 PMID:15108187 PMID:15263905 PMID:15520364 PMID:15578606 PMID:15592465 PMID:15635638 PMID:15642926 PMID:15691525 PMID:15729746 PMID:15824745 PMID:15867107 PMID:15880108 PMID:15995945 PMID:16642437 PMID:17101915 PMID:18197083 PMID:19531786 PMID:25741868, PMID:14593431 RGD:1624295 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G SLITRK5 SLIT and NTRK like family member 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20418887 NCBI chr13:87,671,371...87,679,616
Ensembl chr13:87,671,371...87,696,272
JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G GNAS GNAS complex locus sussceptibility IAGP DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr20:58,839,681...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G GNB3 G protein subunit beta 3 susceptibility IAGP DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr12:6,840,922...6,847,393
Ensembl chr12:6,839,954...6,847,393
JBrowse link
G MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 IAGP RGD PMID:10449650 RGD:1581056 NCBI chr MT:4,470...5,511
Ensembl chr MT:4,470...5,511
JBrowse link
G OPRD1 opioid receptor delta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,142...28,871,267
JBrowse link
G OPRM1 opioid receptor mu 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB561 cytochrome b561 IAGP ClinVar Annotator: match by term: ORTHOSTATIC HYPOTENSION 2 ClinVar
OMIM
NCBI chr17:63,432,304...63,446,639
Ensembl chr17:63,432,304...63,446,354
JBrowse link
Orthostatic Intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 IAGP
EXP
ClinVar Annotator: match by term: Orthostatic intolerance
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: SLC6A2-related disorder
ClinVar
CTD
OMIM
PMID:10684912 PMID:11458707 PMID:11875370 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,988...55,707,645
JBrowse link
panic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor IEA GAD PMID:15118671 RGD:1331525 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:12825092 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G ADRA2A adrenoceptor alpha 2A EXP CTD Direct Evidence: marker/mechanism CTD PMID:14656453 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G CCKBR cholecystokinin B receptor IAGP
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:8878350, PMID:15354400 RGD:1358454 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127
JBrowse link
G COMT catechol-O-methyltransferase IAGP ClinVar Annotator: match by term: CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM OMIM
ClinVar
PMID:7304673 PMID:7585135 PMID:8886163 PMID:10459407 PMID:11381111 PMID:11502905 PMID:11925305 PMID:12611827 PMID:12716966 PMID:15457404 PMID:15645182 PMID:15652872 PMID:15821730 PMID:15824744 PMID:16043133 PMID:16395295 PMID:16513880 PMID:16542388 PMID:17156920 PMID:17548664 PMID:18192898 PMID:19094200 PMID:19514130 PMID:21398039 PMID:22695756 PMID:22992668 PMID:23210659 PMID:23302985 PMID:23459442 PMID:23686330 PMID:23773341 PMID:24533707 PMID:25155931 PMID:25185591 PMID:25741868 PMID:26555332 PMID:26902643 PMID:27027462 PMID:28006928 PMID:28346387 PMID:28745577 PMID:29259946 PMID:29474345 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CRH corticotropin releasing hormone IAGP RGD PMID:14675801 RGD:1358525 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO
IAGP
RGD PMID:21421022, PMID:20817074 RGD:5683630, RGD:5683631 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
JBrowse link
G INS insulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:12073167 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G MAOA monoamine oxidase A IAGP RGD PMID:15670397 RGD:1600723 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MBL2 mannose binding lectin 2 susceptibility IAGP DNA:polymorphism: : RGD PMID:24856568 RGD:12910826 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G TPH2 tryptophan hydroxylase 2 susceptibility IAGP DNA:SNP:intron: (rs1386494) (human) RGD PMID:17123728 RGD:5686356 NCBI chr12:71,938,845...72,032,440
Ensembl chr12:71,938,845...72,186,618
JBrowse link
phobic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:15309392 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G HRAS HRas proto-oncogene, GTPase IAGP DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G MED12 mediator complex subunit 12 IAGP DNA:mutation:multiple RGD PMID:12216017 RGD:1358728 NCBI chr  X:71,118,596...71,142,450
Ensembl chr  X:71,118,556...71,142,454
JBrowse link
G PRL prolactin EXP CTD Direct Evidence: marker/mechanism CTD PMID:2554359 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BDNF brain derived neurotrophic factor susceptibility IAGP DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 RGD:10059367 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) ISO RGD PMID:25331812 RGD:13782181 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP9 caspase 9 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:25331812 RGD:13782181 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G IL2 interleukin 2 IEP RGD PMID:21714072 RGD:5147887 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G MDM2 MDM2 proto-oncogene ISO RGD PMID:23174211 RGD:10412309 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,054
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 ISO RGD PMID:25331812 RGD:13782181 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,410...43,773,278
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:17968352 RGD:8694407 NCBI chr 4:6,260,368...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
postural orthostatic tachycardia syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 IEA OMIM:604715 MouseDO NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,988...55,707,645
JBrowse link
separation anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD4 dopamine receptor D4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20731709 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706
JBrowse link
social phobia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNTNAP2 contactin associated protein 2 susceptibility IAGP DNA:SNP: :rs2710102(human) RGD PMID:21193173 RGD:13450911 NCBI chr 7:146,116,207...148,420,998
Ensembl chr 7:146,116,002...148,420,998
JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPB natriuretic peptide B IEP associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20158
    disease of anatomical entity 18756
      nervous system disease 14794
        central nervous system disease 12970
          brain disease 12188
            disease of mental health 9313
              cognitive disorder 2734
                anxiety disorder 106
                  Neuroticism 0
                  acute stress disorder + 15
                  generalized anxiety disorder 3
                  neurocirculatory asthenia + 12
                  neurotic disorder 0
                  obsessive-compulsive disorder + 11
                  panic disorder + 11
                  phobic disorder + 5
                  post-traumatic stress disorder 12
                  separation anxiety disorder 1
paths to the root