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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:Physiological disturbances in normal sexual performance in either the male or the female.
Synonyms:exact_synonym: Physiological Sexual Disorder;   Physiological Sexual Dysfunctions;   Sex Disorders;   physiological sexual disorders;   physiological sexual dysfunction
 primary_id: MESH:D012735
 xref: ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.


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sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chrNW_004936564:6,280,890...6,299,838 JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chrNW_004936552:7,204,298...7,212,632 JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chrNW_004936659:3,014,633...3,018,617 JBrowse link
G Ptger2 prostaglandin E receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chrNW_004936697:2,440,943...2,453,897 JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chrNW_004936518:1,903,636...1,916,746 JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Agt angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12394778 PMID:21235725 RGD:10053666 RGD:1579980 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bcl2l1 BCL2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12394778 RGD:1579980 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Casp3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408
G Ccnd2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chrNW_004936606:4,474,801...4,496,158 JBrowse link
G Cfl1 cofilin 1 treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25444982 PMID:25923835 RGD:11568706 RGD:11570410 NCBI chrNW_004936599:3,678,724...3,682,314 JBrowse link
G Cnr1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chrNW_004936510:3,779,930...3,806,615 JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chrNW_004936668:451,846...484,841 JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD
RGD
PMID:12002441 PMID:17420087 RGD:2292142 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Ednra endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17420087 PMID:18823320 RGD:2292142 NCBI chrNW_004936535:1,950,117...2,005,786 JBrowse link
G Fabp4 fatty acid binding protein 4 ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chrNW_004936656:2,722,970...2,727,383 JBrowse link
G Gja1 gap junction protein alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chrNW_004936658:3,920,043...3,932,987 JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chrNW_004936524:9,720,777...9,884,984 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chrNW_004936504:12,530,546...12,546,556 JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chrNW_004936745:1,730,743...1,942,071 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:21595839 PMID:24576658 RGD:10402763 RGD:10402765 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Il6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827 RGD:9495931 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G LOC101977899 vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chrNW_004936489:5,425,778...5,434,483 JBrowse link
G Mcam melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chrNW_004936542:4,235,914...4,244,981 JBrowse link
G Nos1 nitric oxide synthase 1 treatment ISO associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD PMID:23522997 PMID:23535456 PMID:23698784 RGD:7244246 RGD:7257656 RGD:7257657 NCBI chrNW_004936558:5,162,471...5,302,488 JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Cocaine-Related Disorders;protein:decreased expression:penis
RGD
CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891 RGD:13504711 RGD:2292142 RGD:4891999 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G P2ry1 purinergic receptor P2Y1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chrNW_004936519:865,756...872,466 JBrowse link
G P2ry2 purinergic receptor P2Y2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chrNW_004936498:2,432,436...2,444,495 JBrowse link
G Pde5a phosphodiesterase 5A ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15578039 PMID:15667904 PMID:15920460 RGD:2314519 RGD:2314520 RGD:2314521 NCBI chrNW_004936869:24,265...117,120 JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chrNW_004936787:330,390...1,491,994 JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chrNW_004936552:7,204,298...7,212,632 JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chrNW_004936595:894,048...897,249 JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:14995446 RGD:2306738 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chrNW_004936706:752,571...783,746 JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chrNW_004936615:4,472,261...4,524,537 JBrowse link
G Apod apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chrNW_004936833:260,798...277,060 JBrowse link
G Pde5a phosphodiesterase 5A ISO RGD PMID:17287493 RGD:2314469 NCBI chrNW_004936869:24,265...117,120 JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chrNW_004936473:21,324,669...21,409,430 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13020
    disease of anatomical entity 12701
      reproductive system disease 2563
        female reproductive system disease 1626
          sexual dysfunction 48
            impotence + 44
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 13020
    disease of anatomical entity 12701
      nervous system disease 10555
        central nervous system disease 9242
          brain disease 8678
            disease of mental health 6319
              sexual health disorder 53
                sexual dysfunction 48
                  impotence + 44
                  premature ejaculation 0
                  psychologic dyspareunia 0
                  psychologic vaginismus 0
paths to the root