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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms:exact_synonym: Physiological Sexual Disorder;   physiological sexual disorders;   physiological sexual dysfunction;   physiological sexual dysfunctions;   sex disorders
 narrow_synonym: antidepressant-induced sexual dysfunction
 primary_id: MESH:D012735
 xref: EFO:0004714;   EFO:0006322;   ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chr 1:76,391,112...76,417,147
Ensembl chr 1:76,391,116...76,417,301 		JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G PTGER1 prostaglandin E receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 2:64,796,944...64,800,199
Ensembl chr 2:64,797,216...64,800,458 		JBrowse link
G PTGER2 prostaglandin E receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 1:181,993,961...182,009,959
Ensembl chr 1:181,994,560...182,009,953 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr16:25,670,832...25,686,556
Ensembl chr16:25,670,862...25,686,552 		JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G AGT angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666
G BAD BCL2 associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 2:7,831,192...7,842,864
Ensembl chr 2:7,830,920...7,842,863 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:12394778 PMID:21235725 RGD:10053666 RGD:1579980 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12394778 RGD:1579980 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CCND1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CCND2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr 5:66,092,483...66,114,575
Ensembl chr 5:66,087,379...66,114,571 		JBrowse link
G CFL1 cofilin 1 treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25444982 PMID:25923835 RGD:11568706 RGD:11570410 NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chr14:40,455,954...40,458,352
Ensembl chr14:40,455,985...40,459,104 		JBrowse link
G EDN1 endothelin 1 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12002441 PMID:17420087 RGD:2292142 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G EDNRA endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17420087 PMID:18823320 RGD:2292142 NCBI chr 8:81,210,750...81,279,053
Ensembl chr 8:81,209,327...81,276,853 		JBrowse link
G FABP4 fatty acid binding protein 4 ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 1:243,263,202...243,416,739
Ensembl chr 1:243,259,495...243,415,590 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G HDAC3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 2:143,273,188...143,287,421
Ensembl chr 2:143,273,192...143,287,399 		JBrowse link
G HDAC4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:21595839 PMID:24576658 RGD:10402763 RGD:10402765 NCBI chr18:50,002,921...50,009,425
Ensembl chr18:50,003,022...50,010,690 		JBrowse link
G IL6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827 RGD:9495931 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G MCAM melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr 9:46,506,375...46,522,091
Ensembl chr 9:46,512,784...46,522,083 		JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue		 RGD PMID:23522997 PMID:23535456 PMID:23698784 RGD:7244246 RGD:7257656 RGD:7257657 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity		 RGD
CTD		 PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891 RGD:13504711 RGD:2292142 RGD:4891999 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G P2RY1 purinergic receptor P2Y1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr13:92,991,150...92,997,702
Ensembl chr13:92,991,152...92,997,700 		JBrowse link
G P2RY2 purinergic receptor P2Y2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 9:7,672,294...7,695,085
Ensembl chr 9:7,672,403...7,695,163 		JBrowse link
G PDE5A phosphodiesterase 5A ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental		 RGD PMID:15578039 PMID:15667904 PMID:15920460 RGD:2314519 RGD:2314520 RGD:2314521 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010 		JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G SHBG sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr12:52,914,711...52,919,092 JBrowse link
G SIRT1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:14995446 RGD:2306738 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G THBD thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr17:30,219,870...30,223,499
Ensembl chr17:30,217,303...30,224,099 		JBrowse link
G TNF tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr15:37,544,177...37,600,925
Ensembl chr15:37,544,707...37,599,041 		JBrowse link
G APOD apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr13:132,514,546...132,562,594
Ensembl chr13:132,514,949...132,562,599 		JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:17287493 RGD:2314469 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17412
    disease of anatomical entity 14873
      reproductive system disease 2868
        male reproductive system disease 1888
          sexual dysfunction 49
            impotence + 45
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 17412
    disease of anatomical entity 14873
      Urogenital Diseases 4677
        reproductive system disease 2868
          male reproductive system disease 1888
            sexual dysfunction 49
              impotence + 45
              premature ejaculation 0
              psychologic dyspareunia 0
              psychologic vaginismus 0
paths to the root