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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:Physiological disturbances in normal sexual performance in either the male or the female.
Synonyms:exact_synonym: Physiological Sexual Disorder;   Physiological Sexual Disorders;   Physiological Sexual Dysfunctions;   Sex Disorders;   Sexual Dysfunction, Physiological
 primary_id: MESH:D012735;   RDO:0005414
 xref: ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptger2 prostaglandin E receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen treatment IDA RGD PMID:17616753 RGD:8548892 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
CTD PMID:12394778, PMID:12394778, PMID:21235725 RGD:1579980, RGD:10053666 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:12394778, PMID:12394778 RGD:1579980 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 IEP mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cfl1 cofilin 1 treatment IEP protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25923835, PMID:25444982 RGD:11568706, RGD:11570410 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment IMP RGD PMID:17433082 RGD:13207433 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Edn1 endothelin 1 IEP
ISO
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:12002441, PMID:17420087 RGD:2292142 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:18823320, PMID:17420087 RGD:2292142 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Fabp4 fatty acid binding protein 4 IEP associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Hdac3 histone deacetylase 3 IEP protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment IMP
IEP
mRNA, protein:increased expression:penis RGD PMID:24576658, PMID:21595839 RGD:10402763, RGD:10402765 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il6 interleukin 6 treatment IMP
IEP
associated with Diabetes Mellitus, Type 2 RGD PMID:21492407, PMID:24467772 RGD:10402827, RGD:9495931 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:16422887 RGD:5684417 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mcam melanoma cell adhesion molecule IEP protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA
IEP
associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD PMID:23698784, PMID:23522997, PMID:23535456 RGD:7244246, RGD:7257657, RGD:7257656 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
ISO
associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD PMID:12002441 PMID:17071732, PMID:17420087, PMID:29260891, PMID:20807325 RGD:2292142, RGD:13504711, RGD:4891999 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G P2ry1 purinergic receptor P2Y1 IDA associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Pde5a phosphodiesterase 5A IMP associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15920460, PMID:15578039, PMID:15667904 RGD:2314519, RGD:2314521, RGD:2314520 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IEP associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Sirt1 sirtuin 1 treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311, PMID:27051243 RGD:2306738, RGD:14995446 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Tnf tumor necrosis factor treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 IEP associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Apod apolipoprotein D IEP mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:17287493 RGD:2314469 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17126
    disease of anatomical entity 16474
      reproductive system disease 2724
        female reproductive system disease 1723
          sexual dysfunction 48
            impotence + 45
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 17126
    disease of anatomical entity 16474
      nervous system disease 12073
        central nervous system disease 10352
          brain disease 9711
            disease of mental health 7018
              sexual disorder 53
                sexual dysfunction 48
                  impotence + 45
                  premature ejaculation 0
                  psychologic dyspareunia 0
                  psychologic vaginismus 0
paths to the root