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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:impotence
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Accession:DOID:1875 term browser browse the term
Definition:The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Synonyms:exact_synonym: Male Impotence;   erectile dysfunction;   male sexual impotence;   sexual impotence
 primary_id: MESH:D007172
 alt_id: RDO:0005882
For additional species annotation, visit the Alliance of Genome Resources.

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impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936 		JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899 		JBrowse link
G Bax BCL2-associated X protein treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD PMID:12394778, PMID:12394778, PMID:21235725 RGD:1579980, RGD:10053666 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bcl2l1 BCL2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12394778, PMID:12394778 RGD:1579980 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728 		JBrowse link
G Casp3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccnd2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193 		JBrowse link
G Cfl1 cofilin 1, non-muscle treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25923835, PMID:25444982 RGD:11568706, RGD:11570410 NCBI chr19:5,490,455...5,494,031
Ensembl chr19:5,490,455...5,495,201 		JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chr 5:115,297,110...115,300,990
Ensembl chr 5:115,297,110...115,300,999 		JBrowse link
G Edn1 endothelin 1 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD PMID:12002441, PMID:17420087 RGD:2292142 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990 		JBrowse link
G Ednra endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD PMID:18823320, PMID:17420087 RGD:2292142 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513 		JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222 		JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr18:37,936,971...37,955,015
Ensembl chr18:37,935,844...37,955,016 		JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 1:91,928,779...92,195,702
Ensembl chr 1:91,928,779...92,195,699 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:24576658, PMID:21595839 RGD:10402763, RGD:10402765 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923 		JBrowse link
G Il6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407, PMID:24467772 RGD:10402827, RGD:9495931 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Kdr kinase insert domain protein receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458 		JBrowse link
G Mcam melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr 9:44,134,658...44,142,727
Ensembl chr 9:44,134,469...44,142,727 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal treatment ISO associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue		 RGD PMID:23698784, PMID:23522997, PMID:23535456 RGD:7244246, RGD:7257657, RGD:7257656 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity		 CTD PMID:12002441 PMID:17071732, PMID:17420087, PMID:29260891, PMID:20807325 RGD:2292142, RGD:13504711, RGD:4891999 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474 		JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 3:61,002,785...61,008,982
Ensembl chr 3:61,002,795...61,008,982 		JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 7:100,996,568...101,012,053
Ensembl chr 7:100,996,568...101,012,866 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental		 RGD PMID:15667904, PMID:15920460, PMID:15578039 RGD:2314520, RGD:2314519, RGD:2314521 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr19:30,564,487...31,765,268
Ensembl chr19:30,564,489...31,765,033 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205 		JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr11:69,610,282...69,618,026
Ensembl chr11:69,614,804...69,617,905 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311, PMID:27051243 RGD:2306738, RGD:14995446 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr 2:148,404,471...148,408,188
Ensembl chr 2:148,404,466...148,408,188 		JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
G Vip vasoactive intestinal polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr10:5,639,193...5,647,617
Ensembl chr10:5,639,218...5,647,617 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr 7:24,546,699...24,573,438
Ensembl chr 7:24,546,289...24,573,440 		JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr 8:18,690,263...18,741,562
Ensembl chr 8:18,690,263...18,741,562 		JBrowse link
G Apod apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr16:31,296,192...31,314,808
Ensembl chr16:31,296,192...31,314,808 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific ISO RGD PMID:17287493 RGD:2314469 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 9:116,087,695...116,175,363
Ensembl chr 9:116,084,293...116,175,360 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13481
    disease of anatomical entity 12962
      reproductive system disease 2572
        male reproductive system disease 1750
          sexual dysfunction 48
            impotence 45
              vasculogenic impotence 4
Path 2
Term Annotations click to browse term
  disease 13481
    disease of anatomical entity 12962
      nervous system disease 10499
        central nervous system disease 8839
          brain disease 8161
            disease of mental health 5912
              sexual disorder 53
                sexual dysfunction 48
                  impotence 45
                    vasculogenic impotence 4
paths to the root