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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:neuritis
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Accession:DOID:1803 term browser browse the term
Definition:A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
Synonyms:exact_synonym: Peripheral Neuritides;   Peripheral Neuritis;   Polyneuritides;   Polyneuritis;   Sensory Neuritides;   neuritides;   sensory neuritis
 primary_id: MESH:D009443
 alt_id: RDO:0006205
 xref: NCI:C116381
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
brachial plexus neuritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEPTIN9 septin 9 ISO ClinVar Annotator: match by term: Amyotrophic neuralgia | ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic | ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA) OMIM
ClinVar		 PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr17:71,361,002...71,580,995
Ensembl chr17:76,920,236...77,139,586 		JBrowse link
carpal tunnel syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TTR transthyretin ISO ClinVar Annotator: match by term: Carpal tunnel syndrome | ClinVar Annotator: match by term: Carpal tunnel syndrome, familial ClinVar PMID:192115 PMID:1335038 PMID:1351039 PMID:1353008 PMID:1358785 More... NCBI chr18:24,809,707...24,816,713
Ensembl chr18:28,407,893...28,414,960 		JBrowse link
carpal tunnel syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TTR transthyretin ISO ClinVar Annotator: match by term: Carpal tunnel syndrome 1 OMIM
ClinVar		 PMID:192115 PMID:1335038 PMID:1351039 PMID:1353008 PMID:1358785 More... NCBI chr18:24,809,707...24,816,713
Ensembl chr18:28,407,893...28,414,960 		JBrowse link
carpal tunnel syndrome 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMP cartilage oligomeric matrix protein ISO ClinVar Annotator: match by term: Carpal tunnel syndrome 2 OMIM
ClinVar		 PMID:12483304 PMID:14684695 PMID:21834907 PMID:21965141 PMID:24595329 More... NCBI chr19:18,222,270...18,230,936
Ensembl chr19:19,229,562...19,238,008 		JBrowse link
Experimental Autoimmune Neuritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 ISO RGD PMID:9670863 RGD:2325244 Ensembl chr10:134,172,724...134,186,227 JBrowse link
G AIF1 allograft inflammatory factor 1 ISO protein:increased expression:spinal cord (rat) RGD PMID:15710454 RGD:2313042 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G ANXA1 annexin A1 ISO protein:increased expression:sciatic nerve RGD PMID:10603033 RGD:2306914 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G APP amyloid beta precursor protein treatment ISO RGD PMID:28446186 RGD:13782060 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G CAV1 caveolin 1 ISO protein:increased phosphorylation:sciatic nerve RGD PMID:17234162 RGD:2289125 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO protein:increased expression:sciatic nerve, macrophage, T cell RGD PMID:20500551 RGD:5688140 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755 		JBrowse link
G CD14 CD14 molecule severity ISO RGD PMID:19162137 RGD:2312712 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966 		JBrowse link
G CD28 CD28 molecule ISO RGD PMID:12864982 RGD:2307204 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:17188497 RGD:5491181 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:17188497 RGD:5491181 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) ISO protein:increased expression:Schwann cell (rat) RGD PMID:10450801 RGD:1600494 NCBI chr11:33,680,580...33,708,479
Ensembl chr11:33,552,164...33,590,157 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:18448252 RGD:4891968 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:18448252 RGD:4891968 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G DCC DCC netrin 1 receptor ISO RGD PMID:16337279 RGD:2314374 NCBI chr18:45,717,924...46,913,998
Ensembl chr18:49,268,812...50,255,155 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) treatment ISO RGD PMID:11522581 RGD:11040446 NCBI chr16:52,977,879...52,994,496
Ensembl chr16:71,854,238...71,870,673 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:23603807 RGD:10395381 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
G EPO erythropoietin ISO RGD PMID:20361946 RGD:10400894 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G FOXP3 forkhead box P3 ISO protein:decreased expression:sciatic nerve RGD PMID:30464413 RGD:38549576 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 disease_progression ISO mRNA,protein:increased expression:sciatic nerve: RGD PMID:21784136 RGD:9686114 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO RGD PMID:23603807 RGD:10395381 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase disease_progression ISO RGD PMID:17286627 RGD:5508466 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G IFNB1 interferon beta 1 ameliorates ISO RGD PMID:10494101 RGD:401854240 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IL17A interleukin 17A ISO mRNA, protein:increased expression:sciatic nerve, inguinal lymph node RGD PMID:10785455 PMID:19207263 RGD:4831923 RGD:4888513 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL1B interleukin 1 beta treatment ISO RGD PMID:18400050 RGD:7401218 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL5 interleukin 5 treatment ISO RGD PMID:22310911 RGD:11522768 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G MMP7 matrix metallopeptidase 7 ISO RGD PMID:9546322 RGD:9685357 NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:9546322 RGD:9685357 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:nerve root, leukocyte, Schwann cell (rat) RGD PMID:15144861 RGD:1580265 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression: RGD PMID:12916703 RGD:5688236 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression: RGD PMID:12916703 RGD:5688236 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G RHOA ras homolog family member A ISO protein:increased expression:spinal ganglion, macrophage, T cell RGD PMID:17367505 RGD:1642966 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:15531104 RGD:1581323 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935 		JBrowse link
G TLR2 toll like receptor 2 severity ISO RGD PMID:19162137 RGD:2312712 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:multiple tissues RGD PMID:18434754 RGD:2312677 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:18400050 RGD:7401218 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 ameliorates ISO mRNA:increased expression:sciatic nerve,peripheral blood mononuclar cell RGD PMID:28260057 RGD:127284841 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091 		JBrowse link
lesion of sciatic nerve term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG1 BAG cochaperone 1 ISO RGD PMID:23108487 RGD:13506903 NCBI chr 9:33,033,267...33,043,013
Ensembl chr 9:33,841,449...33,851,167 		JBrowse link
G RGS3 regulator of G protein signaling 3 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chr 9:84,561,302...84,696,534
Ensembl chr 9:112,927,407...113,065,746 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225 		JBrowse link
median neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO RGD PMID:18845940 RGD:126790486 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19296522 RGD:10449020 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:18845940 PMID:19296522 RGD:10449020 RGD:126790486 NCBI chr12:32,811,533...32,834,958
Ensembl chr12:33,063,434...33,084,994 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:18845940 PMID:19296522 RGD:10449020 RGD:126790486 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G LOC100986475 metallothionein-2 ISO mRNA:decreased expression:left median nerve (rat) RGD PMID:22253198 RGD:6483815 NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G MT3 metallothionein 3 treatment ISO RGD PMID:22253198 RGD:6483815 NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G NPY neuropeptide Y ISO RGD PMID:19456245 RGD:10448955 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
G NRG1 neuregulin 1 ISO RGD PMID:19296522 RGD:10449020 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G SH3TC2 SH3 domain and tetratricopeptide repeats 2 ISO ClinVar Annotator: match by term: Mononeuropathy of the Median Nerve ClinVar PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr 5:144,412,449...144,490,183
Ensembl chr 5:150,438,976...150,498,354 		JBrowse link
sciatic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496 		JBrowse link
G ADRB2 adrenoceptor beta 2 treatment ISO RGD PMID:19912227 RGD:8548489 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:20886512 RGD:5129198 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:spinal cord: RGD PMID:19937403 RGD:14348968 NCBI chr 6:149,058,350...149,176,710
Ensembl chr 6:153,757,081...153,873,925 		JBrowse link
G AMIGO3 adhesion molecule with Ig like domain 3 ISO protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 3:49,648,967...49,652,285
Ensembl chr 3:50,885,925...50,887,439 		JBrowse link
G APOA1 apolipoprotein A1 ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G APOE apolipoprotein E ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G ASL argininosuccinate lyase ISO RGD PMID:12895509 RGD:727768 NCBI chr 7:59,908,648...59,948,822
Ensembl chr 7:73,142,842...73,157,472
Ensembl chr 7:73,142,842...73,157,472
Ensembl chr 7:73,142,842...73,157,472 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:18182225 RGD:5129227 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:18182225 RGD:5129227 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO protein:increased expression:dorsal root ganglion: RGD PMID:22309829 PMID:24388817 RGD:10059363 RGD:8657100 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G C3 complement C3 ISO protein:increased expression:sciatic nerve RGD PMID:18052971 RGD:5129535 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO mRNA:decreased expression:spinal cord dorsal horn RGD PMID:16026470 RGD:6906922 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr22:20,463,511...20,595,253
Ensembl chr22:38,296,436...38,414,963 		JBrowse link
G CALCA calcitonin related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:19852068 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CAPN1 calpain 1 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr11:60,545,837...60,576,631
Ensembl chr11:63,886,015...63,916,021 		JBrowse link
G CAPN2 calpain 2 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr 1:199,335,582...199,399,267
Ensembl chr 1:204,335,573...204,409,150 		JBrowse link
G CASP3 caspase 3 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP7 caspase 7 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626 		JBrowse link
G CASP8 caspase 8 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CAT catalase ISO protein:decreased activity:sciatic nerve, spinal cord, dorsal root ganglion: RGD PMID:19675389 RGD:9479064 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CAV1 caveolin 1 ISO protein:decreased expression:spinal cord, blood vessel RGD PMID:21795534 RGD:6784526 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:spinal cord dorsal horn, axon terminal (rat)
protein:increased expression:lumbar dorsal root ganglion (mouse)		 RGD PMID:19059387 PMID:22564672 RGD:2307005 RGD:8549487 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:19152028 RGD:4890004 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:24907405 RGD:8661781 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541 		JBrowse link
G CERS2 ceramide synthase 2 ISO mRNA,protein:decreased expression:sciatic nerve: RGD PMID:22393241 RGD:11041067 NCBI chr 1:126,314,483...126,324,312
Ensembl chr 1:129,962,022...129,972,722 		JBrowse link
G CNR2 cannabinoid receptor 2 treatment ISO RGD PMID:19345493 RGD:2316195 NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO protein:increased phosphorylation:nucleus RGD PMID:19918364 PMID:33596416 RGD:10059430 RGD:401960870 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130 		JBrowse link
G CRH corticotropin releasing hormone ISO mRNA:increased expression:central nucleus of amygdala, bed nucleus of stria terminalis (rat) RGD PMID:21684787 RGD:5490542 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 treatment ISO RGD PMID:15341587 PMID:20524966 PMID:20921832 RGD:1358720 RGD:9354422 RGD:9491396 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 ISO protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:16632873 RGD:4889134 NCBI chr15:53,280,110...53,310,868
Ensembl chr15:72,901,286...72,931,164 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO mRNA:decreased expression:spinal cord (rat) RGD PMID:17720801 RGD:4889112 NCBI chr10:99,431,762...99,439,619
Ensembl chr10:102,896,376...102,901,514 		JBrowse link
G DBN1 drebrin 1 ISO protein:increased expression:neuron: RGD PMID:11578820 RGD:10398813 NCBI chr 5:172,758,316...172,774,974
Ensembl chr 5:179,820,791...179,836,872 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO protein:increased expression:brain: RGD PMID:22031875 RGD:9589072 NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605 		JBrowse link
G ELAVL4 ELAV like RNA binding protein 4 ISO RGD PMID:12957493 RGD:1579851 NCBI chr 1:49,288,364...49,444,457
Ensembl chr 1:50,853,276...50,951,058 		JBrowse link
G FAS Fas cell surface death receptor ISO RGD PMID:29970988 RGD:13792563 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO mRNA:increased expression:neuron: RGD PMID:8971765 RGD:10402092 NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904 		JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase ISO RGD PMID:33829413 PMID:36545239 RGD:329951012 RGD:329951014 NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231 		JBrowse link
G FUBP1 far upstream element binding protein 1 ISO RGD PMID:23939805 RGD:13673880 NCBI chr 1:77,162,675...77,198,486 JBrowse link
G GC GC vitamin D binding protein ISO protein:increased expression:nerve RGD PMID:15509515 RGD:2316214 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073 		JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO protein:increased expression:dorsal horn of spinal cord RGD PMID:23515624 RGD:401700393 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362 		JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO protein:increased expression:spinal cord dorsal horn RGD PMID:20533358 RGD:6218963 NCBI chr10:112,645,574...112,862,413
Ensembl chr10:116,079,063...116,295,164 		JBrowse link
G GFRA3 GDNF family receptor alpha 3 ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr 5:133,630,274...133,652,525
Ensembl chr 5:139,762,690...139,784,942 		JBrowse link
G GPX3 glutathione peroxidase 3 treatment ISO RGD PMID:28508406 RGD:401827908 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:26656067 RGD:13792690 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:26656067 RGD:13792690 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:27125978 RGD:13792740 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:18941443 RGD:8548631 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO RGD PMID:23991202 RGD:10402062 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:23224421 RGD:10755722 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:17350523 RGD:1626418 NCBI chr20:58,581,228...58,586,585
Ensembl chr20:59,901,327...59,909,901 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO RGD PMID:20546684 RGD:8547739 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IL10 interleukin 10 treatment ISO associated with Constriction, Pathologic RGD PMID:22173123 PMID:22889616 RGD:7364826 RGD:7364836 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL1B interleukin 1 beta treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:12574433 RGD:7175064 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089 		JBrowse link
G JAK1 Janus kinase 1 ISO mRNA:increased expression:spinal cord RGD PMID:32012267 RGD:150527842 NCBI chr 1:64,083,562...64,315,909
Ensembl chr 1:65,973,904...66,024,991 		JBrowse link
G JAM3 junctional adhesion molecule 3 ISO RGD PMID:22950044 RGD:7488944 NCBI chr11:128,916,024...129,006,497
Ensembl chr11:132,783,580...132,864,657 		JBrowse link
G KARS1 lysyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr16:56,196,867...56,216,909
Ensembl chr16:75,545,002...75,565,043 		JBrowse link
G KCNC4 potassium voltage-gated channel subfamily C member 4 ISO RGD PMID:17855600 RGD:10411908 NCBI chr 1:112,860,887...112,884,687
Ensembl chr 1:127,458,968...127,480,182 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:17108688 RGD:7297043 NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 treatment ISO RGD PMID:30015858 RGD:13703060 NCBI chr  X:109,700,185...109,743,579
Ensembl chr  X:119,886,982...119,929,896 		JBrowse link
G LOC103786029 myosin-4 treatment ISO RGD PMID:14973145 RGD:9686059 NCBI chr17:41,183,808...41,209,774
Ensembl chr17:45,931,196...45,957,149 		JBrowse link
G LRP1 LDL receptor related protein 1 treatment ISO RGD PMID:18060043 PMID:26656067 RGD:13792690 RGD:13800561 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G MAG myelin associated glycoprotein treatment ISO RGD PMID:17705198 RGD:9685295 NCBI chr19:32,238,457...32,260,497
Ensembl chr19:40,975,763...40,997,401 		JBrowse link
G MAP2 microtubule associated protein 2 ISO protein:decrease expression:dorsal root ganglion RGD PMID:21933624 RGD:6483083 NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728 		JBrowse link
G MC4R melanocortin 4 receptor ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:21985621 RGD:6484557 NCBI chr18:53,744,172...53,747,282
Ensembl chr18:57,069,259...57,070,257 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO RGD PMID:25172308 RGD:13207330 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MPZ myelin protein zero treatment ISO RGD PMID:23545781 RGD:9685778 NCBI chr 1:136,691,245...136,720,958
Ensembl chr 1:140,626,039...140,631,273 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:20452291 RGD:10041037 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G NEFH neurofilament heavy chain treatment ISO RGD PMID:3135913 PMID:12445968 RGD:9693730 RGD:9743941 NCBI chr22:10,525,738...10,536,788 JBrowse link
G NEFL neurofilament light chain ISO associated with Diabetes Mellitus, Type 1 RGD PMID:3135913 PMID:12445968 PMID:12638730 RGD:9693730 RGD:9743941 RGD:9743948 NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694 		JBrowse link
G NEFM neurofilament medium chain treatment ISO associated with Diabetes Mellitus, Type 1 RGD PMID:3135913 PMID:12445968 PMID:12638730 RGD:9693730 RGD:9743941 RGD:9743948 NCBI chr 8:24,181,335...24,186,701
Ensembl chr 8:21,098,005...21,107,468 		JBrowse link
G NF1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:18938092 RGD:10413869 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NGF nerve growth factor treatment ISO protein:increased expression:sciatic nerve RGD PMID:22776032 PMID:32652504 RGD:401976543 RGD:7242913 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:17576803 PMID:23138653 RGD:10414078 RGD:5144067 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NLGN2 neuroligin 2 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr17:7,438,853...7,454,014 JBrowse link
G NLGN3 neuroligin 3 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr  X:60,413,098...60,439,359
Ensembl chr  X:70,469,764...70,496,526 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO mRNA:increased expression:dorsal root ganglion: RGD PMID:16914673 RGD:13781948 NCBI chr 1:8,712,798...8,753,027
Ensembl chr 1:9,942,491...9,982,364 		JBrowse link
G NRG1 neuregulin 1 treatment ISO RGD PMID:20957456 RGD:10449012 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G NTS neurotensin ISO RGD PMID:8518953 RGD:9743903 NCBI chr12:83,402,313...83,410,356
Ensembl chr12:86,640,720...86,648,745 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO mRNA:increased expression:brain: RGD PMID:15862535 RGD:9835022 Ensembl chr20:62,004,176...62,017,866 JBrowse link
G OPRM1 opioid receptor mu 1 ISO mRNA, protein:decreased expression:dorsal root ganglion RGD PMID:26917724 PMID:31836522 RGD:11531866 RGD:401842373 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251 		JBrowse link
G PCNA proliferating cell nuclear antigen ISO RGD PMID:23014974 RGD:10448976 NCBI chr20:5,134,930...5,146,603
Ensembl chr20:4,927,731...4,939,440 		JBrowse link
G PCSK5 proprotein convertase subtilisin/kexin type 5 ISO mRNA,protein:increased expression:nerve: RGD PMID:9729404 RGD:11556234 NCBI chr 9:48,480,607...48,943,331
Ensembl chr 9:74,745,761...75,220,502 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO RGD PMID:19909480 RGD:11080976 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:19909480 RGD:11080976 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PLAT plasminogen activator, tissue type ISO RGD PMID:18716863 RGD:6483827 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G PLAU plasminogen activator, urokinase treatment ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:18716863 PMID:21151668 RGD:6483827 RGD:7241585 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PMP22 peripheral myelin protein 22 ISO RGD PMID:1556154 RGD:1358785 NCBI chr17:36,389,549...36,425,161
Ensembl chr17:41,038,302...41,073,872 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO associated with Diabetes Mellitus, Experimental RGD PMID:22996345 RGD:7242051 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212 		JBrowse link
G PTAFR platelet activating factor receptor ISO mRNA:increased expression:spinal cord, microglia (rat) RGD PMID:22296727 RGD:9999207 NCBI chr 1:27,405,880...27,436,184
Ensembl chr 1:28,447,833...28,448,861 		JBrowse link
G PTN pleiotrophin ISO mRNA:altered expression:dorsal root ganglia (rat) RGD PMID:18365878 RGD:9831453 NCBI chr 7:129,184,786...129,300,815
Ensembl chr 7:141,701,430...141,705,623 		JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr 3:49,020,310...49,029,443
Ensembl chr 3:50,100,216...50,125,112 		JBrowse link
G RAN RAN, member RAS oncogene family ISO RGD PMID:18667152 RGD:9835000 NCBI chr12:128,497,407...128,503,049
Ensembl chr12:132,694,498...132,699,668 		JBrowse link
G RANBP1 RAN binding protein 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:18667152 RGD:9835000 NCBI chr22:2,877,954...2,888,035
Ensembl chr22:18,549,055...18,560,573 		JBrowse link
G RANGAP1 Ran GTPase activating protein 1 ISO protein:increased expression:sciatic nerve, axon, cytoplasm (rat) RGD PMID:18667152 RGD:9835000 NCBI chr22:22,142,644...22,199,268
Ensembl chr22:40,233,357...40,272,671 		JBrowse link
G RARA retinoic acid receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr17:16,932,485...16,980,958 JBrowse link
G RARB retinoic acid receptor beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr 3:24,729,220...25,499,187
Ensembl chr 3:25,660,922...25,833,297 		JBrowse link
G RCHY1 ring finger and CHY zinc finger domain containing 1 ISO protein:increased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr 4:48,691,213...48,725,979
Ensembl chr 4:54,526,202...54,561,048 		JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a ISO RGD PMID:16863689 RGD:9850145 NCBI chr15:71,728,669...71,774,447
Ensembl chr15:90,922,199...90,956,179 		JBrowse link
G RPSA ribosomal protein SA ISO RGD PMID:19196078 RGD:11041651 NCBI chr 3:39,311,321...39,317,083
Ensembl chr 3:39,591,012...39,596,748 		JBrowse link
G RXRA retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO RGD PMID:21965668 RGD:6484251 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:25967608 RGD:11075075 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SERPINF1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:10441236 RGD:8554886 NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568 		JBrowse link
G SLC17A7 solute carrier family 17 member 7 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr19:46,443,076...46,455,195
Ensembl chr19:55,365,811...55,377,438 		JBrowse link
G SLC17A8 solute carrier family 17 member 8 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr12:97,935,177...98,001,240
Ensembl chr12:101,342,113...101,405,844 		JBrowse link
G SNW1 SNW domain containing 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:23389663 RGD:11035242 NCBI chr14:58,271,830...58,315,773
Ensembl chr14:77,472,387...77,517,315 		JBrowse link
G SOD1 superoxide dismutase 1 treatment
severity		 ISO human gene in a rat model;DNA:missense mutation:cds:p.G93A (human) RGD PMID:15707675 PMID:21489258 RGD:8655638 RGD:8655979 NCBI chr21:18,029,831...18,037,526 JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO RNA:decreased expression:dorsal root ganglion neuron RGD PMID:25484256 RGD:151893491 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:21125644 RGD:8553062 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:spinal cord:
mRNA,protein:increased expression:spinal cord:		 RGD PMID:18615568 PMID:22173123 RGD:7364836 RGD:7815041 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:9582261 PMID:11240015 RGD:5130898 RGD:5130963 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:11240015 RGD:5130963 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chr10:96,878,280...96,887,830
Ensembl chr10:100,358,095...100,368,640 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      nervous system disease 13293
        peripheral nervous system disease 4036
          neuritis 167
            Experimental Autoimmune Neuritis 36
            brachial plexus neuritis + 1
            mononeuritis + 137
            motor neuritis + 0
Path 2
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      nervous system disease 13293
        peripheral nervous system disease 4036
          neuropathy 3845
            neuritis 167
              Experimental Autoimmune Neuritis 36
              brachial plexus neuritis + 1
              mononeuritis + 137
              motor neuritis + 0
paths to the root