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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:A bladder disease that is characterized by inflammation of the bladder. (DO)
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556;   RDO:0005308
 xref: ICD10CM:N30;   ICD10CM:N30.9;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.


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cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chrNW_004936672:3,461,387...3,468,053 JBrowse link
G Adcyap1r1 ADCYAP receptor type I ISO mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chrNW_004936478:7,278,081...7,322,970 JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:9631447 PMID:20079809 RGD:5684910 RGD:8657090 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Cat catalase ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Csf3 colony stimulating factor 3 ISO protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936490:15,142,526...15,146,375 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Esr2 estrogen receptor 2 ISO protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chrNW_004936886:617,531...620,661 JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118 RGD:7175333 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il2 interleukin 2 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:21412823 RGD:5684428 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Lta lymphotoxin alpha ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Mif macrophage migration inhibitory factor ISO mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002 RGD:4890977 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004936816:60,499...91,628 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Ngf nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11350415 PMID:16889433 PMID:19996110 PMID:20127836 RGD:7242782 RGD:7242802 RGD:7242808 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Ngfr nerve growth factor receptor ISO protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chrNW_004936745:152,571...163,712 JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chrNW_004936493:7,060,747...7,065,276 JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004936518:1,903,636...1,916,746 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20602232 RGD:5135058 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Sod1 superoxide dismutase 1 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17382773 RGD:2304340 NCBI chrNW_004936556:1,266,621...1,421,271 JBrowse link
G Tlr5 toll like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chrNW_004936526:383,490...387,007 JBrowse link
G Tnf tumor necrosis factor ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase ISO protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chrNW_004936792:531,076...579,083 JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chrNW_004936704:1,372,137...1,393,355 JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chrNW_004936676:72,383...73,697 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chrNW_004936676:33,580...40,323 JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G LOC101969640 C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chrNW_004936486:15,561,327...15,587,109 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Ngf nerve growth factor treatment ISO protein:increased expression:serum, urine RGD PMID:18162370 PMID:20227820 PMID:23028581 RGD:7242773 RGD:7242781 RGD:7242805 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chrNW_004936748:785,491...802,791 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13689
    disease of anatomical entity 13417
      Urogenital Diseases 3988
        urinary system disease 1845
          bladder disease 376
            cystitis 43
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 14
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 0
paths to the root