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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556;   RDO:0005308
 xref: ICD10CM:N30;   ICD10CM:N30.9;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
 
cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IEP mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I IEP mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
IEP		 RGD PMID:20079809, PMID:9631447 RGD:5684910, RGD:8657090 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Cat catalase IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Csf3 colony stimulating factor 3 IEP protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514 		JBrowse link
G Esr2 estrogen receptor 2 IEP protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il18 interleukin 18 IEP protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta IEP
IDA		 mRNA, protein:increased expression:urinary bladder RGD PMID:11948286, PMID:23000860 RGD:6907118, RGD:7175333 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Kdr kinase insert domain receptor IDA RGD PMID:21412823 RGD:5684428 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Lta lymphotoxin alpha IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677 		JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA, protein:increased expression:nervous system RGD PMID:12853844, PMID:19066630 RGD:1642002, RGD:4890977 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859 		JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Ngf nerve growth factor treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD PMID:16889433, PMID:20127836, PMID:19996110, PMID:11350415 RGD:7242782, RGD:7242802, RGD:7242808 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngfr nerve growth factor receptor IEP protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
Ensembl chr 9:101,307,764...101,319,845 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:20602232 RGD:5135058 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod1 superoxide dismutase 1 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17382773 RGD:2304340 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504 		JBrowse link
G Tlr5 toll-like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase IEP protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560 		JBrowse link
G Csf2 colony stimulating factor 2 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Ngf nerve growth factor treatment ISO protein:increased expression:serum, urine RGD PMID:23028581, PMID:18162370, PMID:20227820 RGD:7242773, RGD:7242805, RGD:7242781 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16918
    disease of anatomical entity 16286
      Urogenital Diseases 4203
        urinary system disease 2107
          bladder disease 403
            cystitis 44
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 14
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 0
paths to the root