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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556;   RDO:0005308
 xref: ICD10CM:N30;   ICD10CM:N30.9;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.


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cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IEP mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I IEP mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
IEP		 RGD PMID:20079809 PMID:9631447 RGD:5684910, RGD:8657090 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Csf3 colony stimulating factor 3 IEP protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Esr2 estrogen receptor 2 IEP protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il18 interleukin 18 IEP protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta IEP
IDA		 mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118, RGD:7175333 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kdr kinase insert domain receptor IDA RGD PMID:21412823 RGD:5684428 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lta lymphotoxin alpha IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002, RGD:4890977 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:196,796,257...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ngf nerve growth factor treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16889433 PMID:20127836 PMID:19996110 PMID:11350415 RGD:7242782, RGD:7242802, RGD:7242808 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IEP protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:20602232 RGD:5135058 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17382773 RGD:2304340 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tlr5 toll-like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase IEP protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ngf nerve growth factor treatment ISO protein:increased expression:serum, urine RGD PMID:23028581 PMID:18162370 PMID:20227820 RGD:7242773, RGD:7242805, RGD:7242781 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17445
    disease of anatomical entity 16777
      Urogenital Diseases 4422
        urinary system disease 2169
          bladder disease 400
            cystitis 44
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 14
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 0
paths to the root