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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:renovascular hypertension
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Accession:DOID:1591 term browser browse the term
Definition:Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Synonyms:exact_synonym: Goldblatt Hypertension;   Goldblatt Syndrome;   renal vascular hypertension
 primary_id: MESH:D006978
 xref: EFO:1001153;   ICD10CM:I15.0;   NCI:C85044
For additional species annotation, visit the Alliance of Genome Resources.


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renovascular hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:20630208 PMID:22342460 RGD:6893471 RGD:8157609 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADM adrenomedullin ISO protein:increased expression:plasma RGD PMID:15284680 RGD:1625303 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:15592645 PMID:17278011 RGD:7241568 RGD:7241580 NCBI chr10:110,642,491...110,646,595 JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO mRNA:decreased expression:kidney: RGD PMID:9644212 PMID:16796846 PMID:21326341 RGD:10047119 RGD:5129177 RGD:5147455 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:18158356 PMID:21189405 RGD:6903867 RGD:6903868 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G AVPR1A arginine vasopressin receptor 1A ISO mRNA:altered expression:brain RGD PMID:15613739 RGD:2300323 NCBI chr12:25,793,633...25,803,026
Ensembl chr12:26,065,882...26,075,972 		JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chr 4:105,957,773...106,271,887
Ensembl chr 4:116,523,850...116,835,387 		JBrowse link
G CCND2 cyclin D2 ISO protein:increased expression:left ventricle: RGD PMID:26300251 RGD:151664604 NCBI chr12:4,385,957...4,417,602
Ensembl chr12:4,309,272...4,335,551 		JBrowse link
G CMA1 chymase 1 ISO protein:increased activity:kidney (rat) RGD PMID:15869764 RGD:1581745 NCBI chr14:5,277,269...5,280,335
Ensembl chr14:23,400,345...23,403,548 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:17062848 RGD:2311383 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:17062848 RGD:2311383 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756 		JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987 		JBrowse link
G EIF4G2 eukaryotic translation initiation factor 4 gamma 2 ISO mRNA:increased expression:heart left ventricle RGD PMID:12708758 RGD:10755511 NCBI chr11:10,961,216...10,973,210
Ensembl chr11:10,656,795...10,668,956 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:17324142 RGD:7205461 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:22684021 RGD:10449172 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:11422751 RGD:7207851 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:11422751 RGD:7207851 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:22923545 RGD:7245500 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G HDAC8 histone deacetylase 8 treatment ISO RGD PMID:27673327 RGD:13208809 NCBI chr  X:61,565,790...61,811,588
Ensembl chr  X:71,649,341...71,894,896 		JBrowse link
G LAMA2 laminin subunit alpha 2 ISO mRNA:decreased expression:heart RGD PMID:10773239 RGD:1600206 NCBI chr 6:126,672,013...127,307,870
Ensembl chr 6:130,781,781...131,415,337 		JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:urine,plasma RGD PMID:22923545 RGD:7245500 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LOC100988373 LINE-1 retrotransposable element ORF2 protein treatment ISO RGD PMID:12218313 RGD:727424 NCBI chr 5:444,720...500,121
Ensembl chr 5:597,897...647,464 		JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:heart, brain, kidney RGD PMID:19549002 RGD:7174698 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:16788145 RGD:1642130 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:18641695 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G PDGFA platelet derived growth factor subunit A ISO mRNA:increased expression:vascular associated smooth muscle cell RGD PMID:17439406 RGD:2289672 NCBI chr 7:648,722...672,023 JBrowse link
G PRL prolactin ISO protein:increased expression:plasma RGD PMID:17316702 RGD:1642574 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO protein:increased expression:kidney (rat) RGD PMID:16788145 RGD:1642130 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO RGD PMID:17766473 RGD:2300258 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, kidney RGD PMID:18032469 RGD:2298840 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G REN renin ISO mRNA:increased expression:renal cortex (mouse)
protein:increased activity:blood plasma (human)		 RGD PMID:2240003 PMID:22378822 RGD:125097504 RGD:6892688 NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 treatment ISO RGD PMID:12218313 RGD:727424 NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:12620700 RGD:1581326 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935 		JBrowse link
G SRSF1 serine and arginine rich splicing factor 1 treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chr17:52,083,676...52,087,454
Ensembl chr17:56,937,295...56,944,425 		JBrowse link
G TRIP11 thyroid hormone receptor interactor 11 ISO ClinVar Annotator: match by term: Goldblatt syndrome ClinVar PMID:20089971 PMID:23956106 PMID:25741868 PMID:28492532 PMID:29872333 More... NCBI chr14:72,601,649...72,675,784
Ensembl chr14:91,945,392...92,019,231 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      Urogenital Diseases 4727
        urinary system disease 2403
          kidney disease 2174
            renal hypertension 76
              renovascular hypertension 35
Path 2
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      cardiovascular system disease 4333
        vascular disease 3043
          artery disease 2010
            hypertension 1003
              secondary hypertension 76
                renal hypertension 76
                  renovascular hypertension 35
paths to the root