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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatic fever
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Accession:DOID:1586 term browser browse the term
Definition:A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has_symptom carditis, has_symptom polyarthritis, has_symptom chorea, has_symptom erythema marginatum, has_symptom subcutaneous nodules, has_symptom arthralgia, has_symptom prolonged PR interval, and/or has_symptom fever. (DO)
Synonyms:exact_synonym: Acute Articular Rheumatism;   Acute Articular Rheumatisms;   Acute Rheumatic Arthritides;   Acute Rheumatic Arthritis;   Acute Rheumatic Fever;   Acute Rheumatic Fevers;   Inflammatory Rheumatism;   Polyarthritis Rheumatica;   Polyarthritis Rheumaticas;   RhF - rheumatic fever;   Rheumatic Arthritis;   Rheumatic Fevers
 primary_id: MESH:D012213
 xref: EFO:1001160;   GARD:5699;   ICD10CM:I00;   ICD10CM:I00-I02;   ICD9CM:390;   ICD9CM:390-392.99;   NCI:C34984
For additional species annotation, visit the Alliance of Genome Resources.



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rheumatic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GC GC vitamin D binding protein ISO RGD PMID:2737695 RGD:5509933 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929
JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr12:2,151,409...2,164,564 JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:14567831 RGD:13702910 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
rheumatic heart disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD209 CD209 molecule ISO protein:increased expression:left cardiac atrium, dendritic cell (human) RGD PMID:30261069 RGD:41410815 NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942
JBrowse link
G CD36 CD36 molecule ISO mRNA:decreased expression:blood, mononuclear cell RGD PMID:16741676 RGD:6893529 NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639
JBrowse link
G FCN3 ficolin 3 ISO ClinVar Annotator: match by term: Rheumatic heart disease ClinVar
G HLA-DRB1 MHC class II DLA DRB1 beta chain susceptibility ISO DNA:polymorphism:cds:HLA-DRB1*13 (human)
DNA:polymorphism (human)
RGD PMID:16426242 PMID:17578051 RGD:5147630 RGD:5147643 NCBI chr12:2,151,409...2,164,564 JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:16406300 RGD:1582623 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IL10 interleukin 10 no_association ISO RGD PMID:16043936 RGD:1598626 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G LOC100688969 glyceraldehyde-3-phosphate dehydrogenase-like ISO RGD PMID:26823728 RGD:13792679 NCBI chr  X:51,925,654...51,926,724 JBrowse link
G MIR155 microRNA mir-155 ISO RGD PMID:31894293 RGD:151347417 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 treatment ISO RGD PMID:31894293 RGD:151347417 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557
JBrowse link
rheumatic myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
G SELE selectin E severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 7:28,888,503...28,898,787
Ensembl chr 7:28,888,197...28,898,786
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14860
    disease of anatomical entity 14527
      Skin and Connective Tissue Diseases 6142
        connective tissue disease 4683
          rheumatic disease 671
            rheumatic fever 14
              Rheumatic Nodule 0
              Wissler-Fanconi syndrome 0
              rheumatic heart disease + 13
Path 2
Term Annotations click to browse term
  disease 14860
    disease of anatomical entity 14527
      Skin and Connective Tissue Diseases 6142
        connective tissue disease 4683
          bone disease 3388
            bone inflammation disease 1131
              arthropathy 1115
                arthritis 831
                  rheumatic fever 14
                    Rheumatic Nodule 0
                    Wissler-Fanconi syndrome 0
                    rheumatic heart disease + 13
paths to the root