|
G |
Acads |
acyl-CoA dehydrogenase short chain |
susceptibility |
ISO |
DNA:SNP:: (rs1799958) (human) |
RGD |
PMID:20554694 |
RGD:401976551 |
NCBI chr12:41,493,650...41,502,897
|
|
G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16404797 |
|
NCBI chr 2:226,797,303...226,808,892
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
|
IMP |
|
RGD |
PMID:8462548 |
RGD:5129091 |
NCBI chr 2:226,975,184...226,987,591
|
|
G |
Ager |
advanced glycosylation end product-specific receptor |
treatment onset |
IEP ISO |
mRNA, protein:increased expression:orbitofrontal cortex, neurons protein:increased expression:frontal cortex neuron |
RGD |
PMID:33716687 PMID:23867237 PMID:23867237 PMID:23867237 |
RGD:597538457, RGD:597538460, RGD:597538460, RGD:597538460 |
NCBI chr20:4,152,758...4,155,956
|
|
G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16404797 PMID:17590986 PMID:10780266 |
RGD:734551 |
NCBI chr12:40,610,244...40,643,220
|
|
G |
Ankk1 |
ankyrin repeat and kinase domain containing 1 |
severity |
ISO |
DNA:polymorphism: :rs1800497(human) DNA:SNP,haplotype: :rs11604671, rs4938015 (human) |
RGD |
PMID:32889058 PMID:21936764 |
RGD:401940151, RGD:401959296 |
NCBI chr 8:58,676,327...58,685,012
|
|
G |
Apc2 |
APC regulator of WNT signaling pathway 2 |
|
ISO |
DNA, mRNA, protein:hypermethylation, decreased expression:brain |
RGD |
PMID:31239533 |
RGD:407987270 |
NCBI chr 7:10,043,010...10,065,037
|
|
G |
Arc |
activity-regulated cytoskeleton-associated protein |
|
ISO |
associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter |
RGD |
PMID:30016666 |
RGD:401959614 |
NCBI chr 7:108,444,959...108,448,413
|
|
G |
Avp |
arginine vasopressin |
|
IEP |
mRNA:altered expression:central amygdaloid nucleus, medial amygdaloid nucleus, medial zone of hypothalamus protein:decreased expression:suprachiasmatic nucleus |
RGD |
PMID:21575018 PMID:11709626 |
RGD:408364978, RGD:596933084 |
NCBI chr 3:138,246,544...138,248,522
|
|
G |
Bdnf |
brain-derived neurotrophic factor |
treatment |
IEP ISO |
protein:decreased expression:plasma protein:decreased expression:plasma (human) mRNA,protein:decreased expression:hippocampus, plasma (rat) protein:altered expression:brain protein:decreased expression:cerebellum, hippocampus mRNA, protein:altered expression:brain |
RGD |
PMID:32135570 PMID:30277635 PMID:30277635 PMID:15307153 PMID:19100286 PMID:33919862 PMID:32330588 More...
|
RGD:35673317, RGD:401938665, RGD:401938665, RGD:401965482, RGD:401976492, RGD:596933362, RGD:596936412 |
NCBI chr 3:116,619,633...116,670,212
|
|
G |
Calb1 |
calbindin 1 |
|
IEP |
mRNA:decreased expression:hippocampus (rat) |
RGD |
PMID:30277635 |
RGD:401938665 |
NCBI chr 5:29,375,624...29,402,532
|
|
G |
Camk2n1 |
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
ISO |
mRNA:increased expression:prefrontal cortex |
RGD |
PMID:28714806 |
RGD:18337277 |
NCBI chr 5:150,674,819...150,676,600
|
|
G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
|
IEP |
protein:decreased expression:brain, cingulate gyrus |
RGD |
PMID:11181917 |
RGD:401959326 |
NCBI chr18:24,857,152...25,076,054
|
|
G |
Cast |
calpastatin |
|
IEP |
protein:increased expression:gastrocnemius (rat) |
RGD |
PMID:28800153 |
RGD:405100967 |
NCBI chr 2:5,707,633...5,817,213
|
|
G |
Cat |
catalase |
treatment |
IEP |
associated with diabetes;protein:decreased activity:liver, kidney (rat) associated with cognitive disorder; protein:altered activity:hippocampus (rat) associated with cardiomyopathy associated with diabetes; protein:decreased activity;testis, epididymis (rat) |
RGD |
PMID:22596042 PMID:21713042 PMID:27367870 PMID:7195942 PMID:25541261 |
RGD:405255659, RGD:405255660, RGD:405255662, RGD:405255663, RGD:405255664 |
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Cckar |
cholecystokinin A receptor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9922984 |
|
NCBI chr14:57,292,397...57,300,747
|
|
G |
Cdk20 |
cyclin-dependent kinase 20 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18438686 |
|
NCBI chr17:706,863...717,828
|
|
G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18414406 |
|
NCBI chr 8:55,401,668...55,415,165
|
|
G |
Chrna5 |
cholinergic receptor nicotinic alpha 5 subunit |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18414406 |
|
NCBI chr 8:55,369,794...55,398,526
|
|
G |
Chrna6 |
cholinergic receptor nicotinic alpha 6 subunit |
severity |
ISO |
DNA:haplotypes: : |
RGD |
PMID:19698703 |
RGD:405849410 |
NCBI chr16:64,697,741...64,704,441
|
|
G |
Clock |
clock circadian regulator |
susceptibility |
ISO |
DNA:SNP:: (rs2412648) (human) |
RGD |
PMID:20554694 |
RGD:401976551 |
NCBI chr14:32,262,747...32,346,872
|
|
G |
Cnr1 |
cannabinoid receptor 1 |
sexual_dimorphism |
IEP |
associated with chronic stress in female rats |
RGD |
PMID:27894930 |
RGD:401959751 |
NCBI chr 5:53,204,867...53,230,396
|
|
G |
Comt |
catechol-O-methyltransferase |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism DNA:polymorphism:: DNA:polymorphism: :rs4680(human) |
CTD RGD |
PMID:10395222 PMID:10395222 PMID:32889058 |
RGD:401940114, RGD:401940151 |
NCBI chr11:96,072,371...96,091,956
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
sexual_dimorphism |
IEP IDA |
mRNA, protein:decreased expression:amygdala protein:altered expression, altered phosphorylation:liver, nucleus protein:increased phosphorylation:liver |
RGD |
PMID:29991681 PMID:22269225 PMID:31262967 |
RGD:401938626, RGD:401959317, RGD:401959334 |
NCBI chr 9:73,397,333...73,466,339
|
|
G |
Crebbp |
CREB binding protein |
|
IEP |
mRNA, protein:decreased expression:amygdala |
RGD |
PMID:29991681 |
RGD:401938626 |
NCBI chr10:11,842,307...11,968,266
|
|
G |
Crh |
corticotropin releasing hormone |
|
IEP |
mRNA:increased expression:central amygdaloid nucleus (rat) |
RGD |
PMID:20060104 |
RGD:5508173 |
NCBI chr 2:104,059,184...104,061,048
|
|
G |
Crhr1 |
corticotropin releasing hormone receptor 1 |
|
ISO |
|
RGD |
PMID:11988580 |
RGD:734822 |
NCBI chr10:89,540,192...89,583,466
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
ISO IEP |
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma, extracellular exosome |
CTD RGD |
PMID:20843640 PMID:29404485 PMID:29404485 PMID:23819932 |
RGD:14700911, RGD:14700911, RGD:14700915 |
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Dbh |
dopamine beta-hydroxylase |
no_association |
ISO |
DNA:polymorphism:5' utr:g.-1021C>T (human) DNA:polymorphism:cds:g.444G>A (human) |
RGD |
PMID:16133787 PMID:16252068 |
RGD:1625572, RGD:1625571 |
NCBI chr 3:30,886,313...30,903,313
|
|
G |
Dbi |
diazepam binding inhibitor |
|
ISO |
mRNA,protein:increased expression:cerebral cortex (mouse) |
RGD |
PMID:9526063 |
RGD:408346747 |
NCBI chr13:33,794,231...33,802,632
|
|
G |
Dcx |
doublecortin |
|
IEP |
mRNA:decreased expression:hippocampus (rat) |
RGD |
PMID:30277635 |
RGD:401938665 |
NCBI chr X:107,430,767...107,573,612
|
|
G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
|
ISO |
associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) |
RGD |
PMID:30016666 |
RGD:401959614 |
NCBI chr10:55,239,397...55,267,780
|
|
G |
Drd2 |
dopamine receptor D2 |
|
IEA |
|
GAD |
PMID:15118671 |
RGD:1331525 |
NCBI chr 8:58,605,403...58,669,339
|
|
G |
Drd4 |
dopamine receptor D4 |
treatment susceptibility |
ISO |
DNA:repeats:exon: associated with peer pressure;DNA:repeats:exon: |
RGD |
PMID:25640830 PMID:26307243 |
RGD:11064848, RGD:401959598 |
NCBI chr 1:205,825,937...205,829,124
|
|
G |
Ep300 |
E1A binding protein p300 |
|
IEP |
mRNA, protein:decreased expression:amygdala |
RGD |
PMID:29991681 |
RGD:401938626 |
NCBI chr 7:114,987,857...115,058,652
|
|
G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
|
IEP |
|
RGD |
PMID:23095216 |
RGD:10045658 |
NCBI chr 1:78,971,310...79,007,963
|
|
G |
Fgf2 |
fibroblast growth factor 2 |
|
IMP |
|
RGD |
PMID:28821667 PMID:31375540 |
RGD:405855870, RGD:405855874 |
NCBI chr 2:122,164,454...122,218,796
|
|
G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
|
IEP |
mRNA:increased expression:cerebellum |
RGD |
PMID:34453331 |
RGD:401938639 |
NCBI chr X:147,240,239...147,278,057
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
treatment |
IEP ISO IDA |
protein:increased expression:brain protein:increased expression:parvocellular oculomotor nucleus |
RGD |
PMID:14741756 PMID:11164784 PMID:29210146 |
RGD:405255650, RGD:405255652, RGD:405295495 |
NCBI chr 6:110,852,188...110,855,054
|
|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
treatment |
IEP ISO |
protein:increased expression:brain (mouse) protein:increased expression:dorsal striatum (mouse) |
RGD |
PMID:22792289 PMID:9835277 PMID:27380261 |
RGD:401851082, RGD:401901184, RGD:401901287 |
NCBI chr 1:88,082,324...88,089,506
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8590623 |
|
NCBI chr 3:114,003,262...114,007,072
|
|
G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22253714 |
|
NCBI chr20:1,469,779...1,499,352
|
|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
susceptibility |
ISO |
DNA:SNP:intron: (rs2900512) (human) |
RGD |
PMID:28118741 |
RGD:401940105 |
NCBI chr 5:60,947,517...61,288,104
|
|
G |
Gabra2 |
gamma-aminobutyric acid type A receptor subunit alpha 2 |
susceptibility |
ISO |
DNA:SNPs:multiple: CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:22253714 PMID:15024690 |
RGD:6480257 |
NCBI chr14:37,451,218...37,587,458
|
|
G |
Gabrb3 |
gamma-aminobutyric acid type A receptor subunit beta 3 |
susceptibility |
ISO |
DNA:CA repeats: :(human) |
RGD |
PMID:9858031 |
RGD:405866342 |
NCBI chr 1:117,602,772...117,838,230
|
|
G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22253714 |
|
NCBI chr10:26,876,926...26,965,523
|
|
G |
Gata4 |
GATA binding protein 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20585342 |
|
NCBI chr15:41,635,572...41,707,252
|
|
G |
Gdnf |
glial cell derived neurotrophic factor |
treatment |
ISO IDA IEP |
protein:increased expression:serum DNA:hypomethylation:nucleus accumbens associated with Tobacco Use Disorder;mRNA:decreased expression:ventral tegmental area |
RGD |
PMID:25623403 PMID:31710958 PMID:22238721 PMID:28559549 |
RGD:401965480, RGD:405820205, RGD:405849387, RGD:405850249 |
NCBI chr 2:58,621,327...58,647,242
|
|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12747453 |
|
NCBI chr20:13,074,695...13,104,095
|
|
G |
Ghsr |
growth hormone secretagogue receptor |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:23977009 |
|
NCBI chr 2:110,268,489...110,271,865
|
|
G |
Gphn |
gephyrin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22253714 |
|
NCBI chr 6:96,954,365...97,483,617
|
|
G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
|
ISO IEP |
protein:increased phosphorylation:lumbar spinal cord (mouse) protein:increased expression:nucleus accumbens (rat) protein:increased expression:nucleus accumbens (mouse) protein:increased expression, increased phosphorylation:cingulate cortex (rat) protein:decreased expression:neocortex (rat) |
RGD |
PMID:28585190 PMID:21041654 PMID:21041654 PMID:34280506 PMID:12036520 |
RGD:405100727, RGD:405650686, RGD:405650686, RGD:405818275, RGD:405820203 |
NCBI chr10:41,710,540...42,030,105
|
|
G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
|
IEP |
protein:decreased expression:neocortex (rat) protein:increased expression:ventral CA1 field of hippocampus (rat) |
RGD |
PMID:12036520 PMID:30481568 |
RGD:405820203, RGD:596933081 |
NCBI chr 2:168,247,490...168,367,616
|
|
G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
|
ISO |
|
RGD |
PMID:14573320 |
RGD:1642372 |
NCBI chr 3:28,501,836...28,528,754
|
|
G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
|
ISO |
|
RGD |
PMID:14573320 PMID:16911840 |
RGD:1642372, RGD:1642200 |
NCBI chr 4:170,297,811...170,775,420
|
|
G |
Hdac2 |
histone deacetylase 2 |
|
IMP |
|
RGD |
PMID:23485013 |
RGD:9590265 |
NCBI chr20:42,101,815...42,126,486
|
|
G |
Hmgb1 |
high mobility group box 1 |
onset |
ISO IEP |
protein:increased expression:orbitofrontal cortex protein:increased expression:frontal cortex neuron |
RGD |
PMID:23867237 PMID:23867237 |
RGD:597538460, RGD:597538460 |
NCBI chr12:11,009,236...11,015,941
|
|
G |
Htr1a |
5-hydroxytryptamine receptor 1A |
treatment |
IMP |
|
RGD |
PMID:9631953 |
RGD:401900760 |
NCBI chr 2:38,427,169...38,431,733
|
|
G |
Htr1b |
5-hydroxytryptamine receptor 1B |
sexual_dimorphism no_association onset |
ISO |
associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human) DNA:SNPs: :multiples (human) DNA:SNP: :rs13212041 (human) |
RGD |
PMID:28923721 PMID:11496363 PMID:30774345 |
RGD:405650695, RGD:405818272, RGD:405847403 |
NCBI chr 8:91,395,405...91,414,815
|
|
G |
Htr2a |
5-hydroxytryptamine receptor 2A |
treatment |
ISO IEP IMP |
CTD Direct Evidence: marker/mechanism mRNA, protein:decreased expression:cerebral cortex, liver protein:increased expression:dorsal raphe, nucleus accumbens |
CTD RGD |
PMID:20501057 PMID:9347075 PMID:9347073 PMID:9631953 |
RGD:401900301, RGD:401900740, RGD:401900742, RGD:401900760 |
NCBI chr15:56,360,647...56,428,703
|
|
G |
Htr2c |
5-hydroxytryptamine receptor 2C |
treatment |
IDA |
|
RGD |
PMID:24041931 |
RGD:401900761 |
NCBI chr X:115,453,190...115,682,325
|
|
G |
Htr3a |
5-hydroxytryptamine receptor 3A |
|
ISO |
DNA:hypermethylation, hypomethylation:promoter: (mouse) |
RGD |
PMID:22834954 |
RGD:404976877 |
NCBI chr 8:58,138,514...58,150,960
|
|
G |
Htr3b |
5-hydroxytryptamine receptor 3B |
susceptibility |
ISO |
DNA:SNP:cds:rs1176744(human) |
RGD |
PMID:20838391 |
RGD:6480660 |
NCBI chr 8:49,279,291...49,308,444
|
|
G |
Htr7 |
5-hydroxytryptamine receptor 7 |
|
ISO |
DNA:SNP:intron: (rs7916403) (human) |
RGD |
PMID:21184583 |
RGD:150429835 |
NCBI chr 1:243,049,064...243,173,636
|
|
G |
Igf2 |
insulin-like growth factor 2 |
|
ISO |
protein:decreased expression:plasma (human) |
RGD |
PMID:30277635 |
RGD:401938665 |
NCBI chr 1:197,814,409...197,831,802
|
|
G |
Il10 |
interleukin 10 |
|
IEP |
mRNA:increased expression:liver |
RGD |
PMID:22269225 |
RGD:401959317 |
NCBI chr13:45,024,921...45,029,586
|
|
G |
Il6 |
interleukin 6 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:26208141 |
RGD:11342768 |
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Kcnj6 |
potassium inwardly-rectifying channel, subfamily J, member 6 |
|
ISO |
DNA:SNP:promoter:rs2836016 (human) |
RGD |
PMID:21307845 |
RGD:6483053 |
NCBI chr11:47,531,312...47,778,348
|
|
G |
Kcnn2 |
potassium calcium-activated channel subfamily N member 2 |
|
IEP |
protein:decreased expression:ventral CA1 field of hippocampus (rat) |
RGD |
PMID:30481568 |
RGD:596933081 |
NCBI chr18:40,004,693...40,445,043
|
|
G |
Lhb |
luteinizing hormone subunit beta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8590623 |
|
NCBI chr 1:105,037,457...105,038,446
|
|
G |
Maoa |
monoamine oxidase A |
susceptibility |
ISO |
|
RGD |
PMID:15900229 |
RGD:1600720 |
NCBI chr X:8,615,239...8,681,372
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
|
IEP |
protein:increased expression:liver |
RGD |
PMID:31262967 |
RGD:401959334 |
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
|
ISO |
protein:increased expression, increased phosphorylation:liver |
RGD |
PMID:31262967 |
RGD:401959334 |
NCBI chr20:6,751,288...6,812,294
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
|
IEP |
protein:increased expression:liver |
RGD |
PMID:31262967 |
RGD:401959334 |
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
|
IDA |
|
RGD |
PMID:31262967 |
RGD:401959334 |
NCBI chr16:8,645,171...8,728,225
|
|
G |
Mb |
myoglobin |
|
ISO |
protein:decreased expression:serum |
RGD |
PMID:3766421 |
RGD:458925288 |
NCBI chr 7:110,640,511...110,647,742
|
|
G |
Mcm5 |
minichromosome maintenance complex component 5 |
|
IEP |
|
RGD |
PMID:23095216 |
RGD:10045658 |
NCBI chr19:13,488,813...13,510,131
|
|
G |
Mir191 |
microRNA 191 |
onset |
IEP |
|
RGD |
PMID:32135570 |
RGD:35673317 |
NCBI chr 8:109,264,098...109,264,188
|
|
G |
Mir195 |
microRNA 195 |
onset |
IEP |
|
RGD |
PMID:32135570 |
RGD:35673317 |
NCBI chr10:54,951,838...54,951,924
|
|
G |
Mir206 |
microRNA 206 |
onset |
IEP |
|
RGD |
PMID:32135570 |
RGD:35673317 |
NCBI chr 9:23,094,249...23,094,332
|
|
G |
Mir30a |
microRNA 30a |
onset |
IEP |
|
RGD |
PMID:32135570 |
RGD:35673317 |
NCBI chr 9:25,737,600...25,737,670
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
|
IEP |
mRNA:decreased expression:hippocampus (rat) |
RGD |
PMID:30277635 |
RGD:401938665 |
NCBI chr 1:199,926,150...199,952,847
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
|
IEP |
|
RGD |
PMID:24966898 |
RGD:13207311 |
NCBI chr19:30,327,643...30,355,856
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
|
IEP |
|
RGD |
PMID:24966898 |
RGD:13207311 |
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Ncam1 |
neural cell adhesion molecule 1 |
treatment sexual_dimorphism |
IEP |
mRNA:decreased expression:hippocampus (rat) associated with chronic stress in female rats |
RGD |
PMID:30277635 PMID:16207289 PMID:27894930 |
RGD:401938665, RGD:401959613, RGD:401959751 |
NCBI chr 8:58,762,088...59,062,131
|
|
G |
Ngf |
nerve growth factor |
|
ISO IEP |
protein:increased expression:serum protein:decreased expression:brain protein:decreased expression:cerebral cortex, hippocampus |
RGD |
PMID:25623403 PMID:15307153 PMID:19100286 |
RGD:401965480, RGD:401965482, RGD:401976492 |
NCBI chr 2:192,589,580...192,642,971
|
|
G |
Npy |
neuropeptide Y |
|
IAGP ISO |
DNA:deletion:intron:g.4666_4674del (rat) DNA:missense mutation: :p.L7P (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:17572454 PMID:15749341 PMID:12215082 |
RGD:1357412, RGD:10430830 |
NCBI chr 4:80,212,111...80,219,310
|
|
G |
Npy2r |
neuropeptide Y receptor Y2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18828811 |
|
NCBI chr 2:167,901,999...167,912,165
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
treatment |
IDA IMP IEP |
protein:decreased expression, decreased DNA binding:brain mRNA, protein:decreased expression:placenta |
RGD |
PMID:11961084 PMID:33920737 PMID:31756338 PMID:21143252 |
RGD:408345232, RGD:408345239, RGD:408345241, RGD:408345244 |
NCBI chr18:31,522,783...31,644,508
|
|
G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
treatment sexual_dimorphism |
IMP |
|
RGD |
PMID:29437012 PMID:33007359 PMID:30171933 |
RGD:401965466, RGD:401966865, RGD:401976281 |
NCBI chr19:47,619,853...47,964,089
|
|
G |
Nrg1 |
neuregulin 1 |
sexual_dimorphism |
ISO |
in female, associated with stressful life event;DNA:SNP: :rs6994992(human) |
RGD |
PMID:27353026 |
RGD:405100235 |
NCBI chr16:65,954,084...67,007,484
|
|
G |
Ntf3 |
neurotrophin 3 |
|
ISO IEP |
protein:decreased expression:plasma (human) mRNA,protein:decreased expression:hippocampus, plasma (rat) protein:increased expression:brain |
RGD |
PMID:30277635 PMID:30277635 PMID:15307153 |
RGD:401938665, RGD:401938665, RGD:401965482 |
NCBI chr 4:158,914,984...158,984,453
|
|
G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
treatment |
ISO IEP IDA |
associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain |
RGD |
PMID:30016666 PMID:8840027 PMID:32206827 PMID:33919862 |
RGD:401959614, RGD:401965407, RGD:596933095, RGD:596933362 |
NCBI chr17:5,560,558...5,875,899
|
|
G |
Oprd1 |
opioid receptor, delta 1 |
|
IEP IMP ISO |
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat) DNA:SNPs, haplotype:intron 1:multiple (human) |
RGD |
PMID:28511993 PMID:7501658 PMID:24533225 |
RGD:401976432, RGD:401976439, RGD:402525443 |
NCBI chr 5:149,590,244...149,624,999
|
|
G |
Oprk1 |
opioid receptor, kappa 1 |
severity no_association susceptibility |
ISO IEP |
DNA:SNP, haplotype: :rs6473797 (human) DNA:SNP: :rs997917 (human) DNA:SNP: :rs6473797 (human) associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat) |
RGD |
PMID:31004399 PMID:37177778 PMID:37177778 PMID:28511993 |
RGD:401831037, RGD:401850581, RGD:401850581, RGD:401976432 |
NCBI chr 5:18,657,866...18,675,671
|
|
G |
Oprl1 |
opioid related nociceptin receptor 1 |
|
IMP |
|
RGD |
PMID:11814626 |
RGD:9835016 |
NCBI chr 3:189,209,495...189,225,406
|
|
G |
Oprm1 |
opioid receptor, mu 1 |
no_association treatment |
ISO |
CTD Direct Evidence: marker/mechanism DNA:SNP: :rs510769 DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human) DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) |
CTD RGD |
PMID:12815747 PMID:26042510 PMID:9399694 PMID:32772383 |
RGD:401827930, RGD:401827934, RGD:401827947 |
NCBI chr 1:45,565,371...45,818,722
|
|
G |
Oxtr |
oxytocin receptor |
sexual_dimorphism |
ISO |
DNA:SNP:intron: (rs53576) (human) DNA:hypomethylation |
RGD |
PMID:27716573 PMID:35146961 |
RGD:597538589, RGD:597538605 |
NCBI chr 4:147,154,374...147,171,723
|
|
G |
Pde4b |
phosphodiesterase 4B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18438686 |
|
NCBI chr 5:122,028,956...122,598,267
|
|
G |
Pdyn |
prodynorphin |
susceptibility no_association |
ISO IEP |
CTD Direct Evidence: marker/mechanism associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human) DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human) DNA:SNP: :rs2281285 (human) DNA:SNPs: :rs2281285, rs2225749, rs910080 (human) mRNA, protein:decreased expression:hippocampus, granule cell |
CTD RGD |
PMID:17559549 PMID:18923396 PMID:18923396 PMID:29925858 PMID:36099111 PMID:37177778 PMID:1589146 More...
|
RGD:401850550, RGD:401850559, RGD:401850566, RGD:401850581, RGD:401851059 |
NCBI chr 3:137,354,161...137,366,503
|
|
G |
Penk |
proenkephalin |
|
IEP |
mRNA:increased expression:frontal lobe: |
RGD |
PMID:22703995 |
RGD:10003152 |
NCBI chr 5:21,981,381...21,987,074
|
|
G |
Per1 |
period circadian regulator 1 |
|
IEP |
mRNA:altered expression: arcuate nucleus of hypothalamus |
RGD |
PMID:15009656 |
RGD:407572515 |
NCBI chr10:54,299,002...54,313,804
|
|
G |
Per2 |
period circadian regulator 2 |
|
IEP |
mRNA:altered expression: arcuate nucleus of hypothalamus, suprachiasmatic nucleus |
RGD |
PMID:15009656 |
RGD:407572515 |
NCBI chr 9:99,454,828...99,497,069
|
|
G |
Per3 |
period circadian regulator 3 |
|
IEP |
mRNA:altered expression:suprachiasmatic nucleus |
RGD |
PMID:15009656 |
RGD:407572515 |
NCBI chr 5:166,740,914...166,778,243
|
|
G |
Pomc |
proopiomelanocortin |
sexual_dimorphism |
IEP ISO |
protein:decreased expression:brain (rat) mRNA:increased expression: hypothalamus, pituitary gland, shell of nucleus accumbens DNA, mRNA:deletion, decreased expression:enhancer, hypothalamus mRNA, protein:increased expression:arcuate nucleus, hypothalamus, septum protein:increased expression:plasma associated with Prenatal Exposure Delayed Effects;mRNA:altered expression:adenohypophysis mRNA:altered expression: arcuate nucleus of hypothalamus |
RGD |
PMID:18162070 PMID:22724395 PMID:31339663 PMID:7925590 PMID:19912941 PMID:19912941 PMID:15009656 More...
|
RGD:401976284, RGD:405878072, RGD:407550221, RGD:407571692, RGD:407572513, RGD:407572513, RGD:407572515 |
NCBI chr 6:32,659,137...32,665,175
|
|
G |
Rest |
RE1-silencing transcription factor |
|
ISO |
protein:increased expression:basal forebrain |
RGD |
PMID:37402853 |
RGD:597538603 |
NCBI chr14:30,859,109...30,879,828
|
|
G |
Rpl18a |
ribosomal protein L18A |
|
IEP |
mRNA:decreased expression:parietal cortex |
RGD |
PMID:11244494 |
RGD:11038708 |
NCBI chr16:18,576,467...18,578,653
|
|
G |
Sell |
selectin L |
|
ISO |
protein:decreased expression:Tcell |
RGD |
PMID:7573774 |
RGD:597015763 |
NCBI chr13:78,950,100...78,969,604
|
|
G |
Shbg |
sex hormone binding globulin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8590623 |
|
NCBI chr10:54,332,939...54,350,409
|
|
G |
Slc6a3 |
solute carrier family 6 member 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27219321 |
|
NCBI chr 1:31,537,990...31,578,962
|
|
G |
Slc6a4 |
solute carrier family 6 member 4 |
susceptibility |
ISO |
protein:decreased activity: : CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:15520362 PMID:17000009 PMID:20838391 |
RGD:6480660 |
NCBI chr10:62,322,688...62,357,060
|
|
G |
Snca |
synuclein alpha |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18055133 |
|
NCBI chr 4:91,026,474...91,127,444
|
|
G |
Sod1 |
superoxide dismutase 1 |
|
IEP |
associated with diabetes; protein:decreased activity;testis, epididymis (rat) |
RGD |
PMID:25541261 |
RGD:405255664 |
NCBI chr11:42,942,742...42,948,399
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
|
IEP |
mRNA:decreased expression:hippocampus (rat) |
RGD |
PMID:30277635 |
RGD:401938665 |
NCBI chr 2:117,536,929...117,539,340
|
|
G |
Spi1 |
Spi-1 proto-oncogene |
treatment |
IEP IDA |
protein:decreased expression:alveolar macrophage |
RGD |
PMID:16272341 PMID:21447000 |
RGD:9586723, RGD:9586725 |
NCBI chr 3:77,059,744...77,093,730
|
|
G |
Spn |
sialophorin |
|
ISO |
associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter |
RGD |
PMID:30016666 |
RGD:401959614 |
NCBI chr 1:181,746,937...181,759,564
|
|
G |
St6gal1 |
ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
severity |
ISO |
mRNA,protein:decreased expression:liver: |
RGD |
PMID:17697868 |
RGD:10043133 |
NCBI chr11:77,526,837...77,653,474
|
|
G |
Syp |
synaptophysin |
sexual_dimorphism |
IEP |
associated with chronic stress in female rats |
RGD |
PMID:27894930 |
RGD:401959751 |
NCBI chr X:17,521,348...17,536,449
|
|
G |
Tacr1 |
tachykinin receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19204064 |
|
NCBI chr 4:116,478,617...116,647,492
|
|
G |
Tacr3 |
tachykinin receptor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18422838 |
|
NCBI chr 2:223,266,536...223,363,791
|
|
G |
Tas2r118 |
taste receptor, type 2, member 118 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16385453 PMID:17250611 |
|
NCBI chr 4:52,449,208...52,450,107
|
|
G |
Tas2r138 |
taste receptor, type 2, member 138 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17250611 |
|
NCBI chr 4:69,428,344...69,429,339
|
|
G |
Tbx19 |
T-box transcription factor 19 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18438686 |
|
NCBI chr13:77,450,848...77,484,475
|
|
G |
Tf |
transferrin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:11000917 PMID:21792595 |
|
NCBI chr 8:103,789,780...103,816,487
|
|
G |
Timeless |
timeless circadian regulator |
susceptibility |
ISO |
DNA:SNP:: (rs2291738) (human) |
RGD |
PMID:20554694 |
RGD:401976551 |
NCBI chr 7:654,804...678,769
|
|
G |
Tlr2 |
toll-like receptor 2 |
|
IEP ISO |
protein:decreased expression:alveolar macrophage mRNA:increased expression:respiratory system fluid/secretion protein:decreased expression:blood, monocyte mRNA:increased expression:liver mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:36281822 PMID:26208141 PMID:27256567 PMID:30756376 PMID:34415075 |
RGD:597538461, RGD:11342768, RGD:597538485, RGD:597538493, RGD:597538499 |
NCBI chr 2:171,499,189...171,504,831
|
|
G |
Tlr3 |
toll-like receptor 3 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr16:53,554,916...53,572,321
|
|
G |
Tlr4 |
toll-like receptor 4 |
onset |
ISO IEP |
mRNA:decreased expression:respiratory system fluid/secretion protein:decreased expression:blood, monocyte protein:increased expression:liver mRNA:increased expression:liver mRNA:increased expression:orbitofrontal cortex protein:increased expression:orbitofrontal cortex protein:increased expression:frontal cortex neuron |
RGD |
PMID:26208141 PMID:27256567 PMID:21276439 PMID:30756376 PMID:34415075 PMID:23867237 PMID:23867237 More...
|
RGD:11342768, RGD:597538485, RGD:150540306, RGD:597538493, RGD:597538499, RGD:597538460, RGD:597538460 |
NCBI chr 5:85,161,247...85,174,882
|
|
G |
Tlr5 |
toll-like receptor 5 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr13:97,166,430...97,190,642
|
|
G |
Tlr6 |
toll-like receptor 6 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr14:43,715,809...43,727,019
|
|
G |
Tlr7 |
toll-like receptor 7 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr X:30,644,324...30,670,796
|
|
G |
Tlr8 |
toll-like receptor 8 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr X:30,708,714...30,733,104
|
|
G |
Tlr9 |
toll-like receptor 9 |
|
ISO |
mRNA:increased expression:orbitofrontal cortex |
RGD |
PMID:34415075 |
RGD:597538499 |
NCBI chr 8:115,743,407...115,747,523
|
|
G |
Tph1 |
tryptophan hydroxylase 1 |
|
ISO |
|
RGD |
PMID:15654285 |
RGD:1580464 |
NCBI chr 1:97,157,375...97,178,415
|
|
G |
Vip |
vasoactive intestinal peptide |
susceptibility |
ISO |
DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) |
RGD |
PMID:20554694 |
RGD:401976551 |
NCBI chr 1:44,470,232...44,478,561
|
|