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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:alcohol use disorder
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Accession:DOID:1574 term browser browse the term
Definition:A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (DO)
Synonyms:exact_synonym: alcohol abuse;   chronic alcoholic intoxication;   ethanol abuse
 related_synonym: Beta-glycopyranoside tasting
 primary_id: MESH:D000437
 xref: ICD10CM:F10.1;   ICD9CM:305.0;   NCI:C20701
For additional species annotation, visit the Alliance of Genome Resources.



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alcohol use disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-CoA dehydrogenase short chain susceptibility ISO DNA:SNP:: (rs1799958) (human) RGD PMID:20554694 RGD:401976551 NCBI chr12:41,493,650...41,502,897 JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:16404797 NCBI chr 2:226,797,303...226,808,892 JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide IMP RGD PMID:8462548 RGD:5129091 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment
onset
IEP
ISO
mRNA, protein:increased expression:orbitofrontal cortex, neurons
protein:increased expression:frontal cortex neuron
RGD PMID:33716687 PMID:23867237 PMID:23867237 PMID:23867237 RGD:597538457, RGD:597538460, RGD:597538460, RGD:597538460 NCBI chr20:4,152,758...4,155,956 JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16404797 PMID:17590986 PMID:10780266 RGD:734551 NCBI chr12:40,610,244...40,643,220 JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 severity ISO DNA:polymorphism: :rs1800497(human)
DNA:SNP,haplotype: :rs11604671, rs4938015 (human)
RGD PMID:32889058 PMID:21936764 RGD:401940151, RGD:401959296 NCBI chr 8:58,676,327...58,685,012 JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 ISO DNA, mRNA, protein:hypermethylation, decreased expression:brain RGD PMID:31239533 RGD:407987270 NCBI chr 7:10,043,010...10,065,037 JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 7:108,444,959...108,448,413 JBrowse link
G Avp arginine vasopressin IEP mRNA:altered expression:central amygdaloid nucleus, medial amygdaloid nucleus, medial zone of hypothalamus
protein:decreased expression:suprachiasmatic nucleus
RGD PMID:21575018 PMID:11709626 RGD:408364978, RGD:596933084 NCBI chr 3:138,246,544...138,248,522 JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
ISO
protein:decreased expression:plasma
protein:decreased expression:plasma (human)
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:altered expression:brain
protein:decreased expression:cerebellum, hippocampus
mRNA, protein:altered expression:brain
RGD PMID:32135570 PMID:30277635 PMID:30277635 PMID:15307153 PMID:19100286 More... RGD:35673317, RGD:401938665, RGD:401938665, RGD:401965482, RGD:401976492, RGD:596933362, RGD:596936412 NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Calb1 calbindin 1 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 5:29,375,624...29,402,532 JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:prefrontal cortex RGD PMID:28714806 RGD:18337277 NCBI chr 5:150,674,819...150,676,600 JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV IEP protein:decreased expression:brain, cingulate gyrus RGD PMID:11181917 RGD:401959326 NCBI chr18:24,857,152...25,076,054 JBrowse link
G Cast calpastatin IEP protein:increased expression:gastrocnemius (rat) RGD PMID:28800153 RGD:405100967 NCBI chr 2:5,707,633...5,817,213 JBrowse link
G Cat catalase treatment IEP associated with diabetes;protein:decreased activity:liver, kidney (rat)
associated with cognitive disorder; protein:altered activity:hippocampus (rat)
associated with cardiomyopathy
associated with diabetes; protein:decreased activity;testis, epididymis (rat)
RGD PMID:22596042 PMID:21713042 PMID:27367870 PMID:7195942 PMID:25541261 RGD:405255659, RGD:405255660, RGD:405255662, RGD:405255663, RGD:405255664 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cckar cholecystokinin A receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr14:57,292,397...57,300,747 JBrowse link
G Cdk20 cyclin-dependent kinase 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr17:706,863...717,828 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 8:55,401,668...55,415,165 JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 8:55,369,794...55,398,526 JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit severity ISO DNA:haplotypes: : RGD PMID:19698703 RGD:405849410 NCBI chr16:64,697,741...64,704,441 JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:SNP:: (rs2412648) (human) RGD PMID:20554694 RGD:401976551 NCBI chr14:32,262,747...32,346,872 JBrowse link
G Cnr1 cannabinoid receptor 1 sexual_dimorphism IEP associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr 5:53,204,867...53,230,396 JBrowse link
G Comt catechol-O-methyltransferase disease_progression ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism::
DNA:polymorphism: :rs4680(human)
CTD
RGD
PMID:10395222 PMID:10395222 PMID:32889058 RGD:401940114, RGD:401940151 NCBI chr11:96,072,371...96,091,956 JBrowse link
G Creb1 cAMP responsive element binding protein 1 sexual_dimorphism IEP
IDA
mRNA, protein:decreased expression:amygdala
protein:altered expression, altered phosphorylation:liver, nucleus
protein:increased phosphorylation:liver
RGD PMID:29991681 PMID:22269225 PMID:31262967 RGD:401938626, RGD:401959317, RGD:401959334 NCBI chr 9:73,397,333...73,466,339 JBrowse link
G Crebbp CREB binding protein IEP mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr10:11,842,307...11,968,266 JBrowse link
G Crh corticotropin releasing hormone IEP mRNA:increased expression:central amygdaloid nucleus (rat) RGD PMID:20060104 RGD:5508173 NCBI chr 2:104,059,184...104,061,048 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:11988580 RGD:734822 NCBI chr10:89,540,192...89,583,466 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, extracellular exosome
CTD
RGD
PMID:20843640 PMID:29404485 PMID:29404485 PMID:23819932 RGD:14700911, RGD:14700911, RGD:14700915 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Dbh dopamine beta-hydroxylase no_association ISO DNA:polymorphism:5' utr:g.-1021C>T (human)
DNA:polymorphism:cds:g.444G>A (human)
RGD PMID:16133787 PMID:16252068 RGD:1625572, RGD:1625571 NCBI chr 3:30,886,313...30,903,313 JBrowse link
G Dbi diazepam binding inhibitor ISO mRNA,protein:increased expression:cerebral cortex (mouse) RGD PMID:9526063 RGD:408346747 NCBI chr13:33,794,231...33,802,632 JBrowse link
G Dcx doublecortin IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr  X:107,430,767...107,573,612 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) RGD PMID:30016666 RGD:401959614 NCBI chr10:55,239,397...55,267,780 JBrowse link
G Drd2 dopamine receptor D2 IEA GAD PMID:15118671 RGD:1331525 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Drd4 dopamine receptor D4 treatment
susceptibility
ISO DNA:repeats:exon:
associated with peer pressure;DNA:repeats:exon:
RGD PMID:25640830 PMID:26307243 RGD:11064848, RGD:401959598 NCBI chr 1:205,825,937...205,829,124 JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr 7:114,987,857...115,058,652 JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit IEP RGD PMID:23095216 RGD:10045658 NCBI chr 1:78,971,310...79,007,963 JBrowse link
G Fgf2 fibroblast growth factor 2 IMP RGD PMID:28821667 PMID:31375540 RGD:405855870, RGD:405855874 NCBI chr 2:122,164,454...122,218,796 JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IEP mRNA:increased expression:cerebellum RGD PMID:34453331 RGD:401938639 NCBI chr  X:147,240,239...147,278,057 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP
ISO
IDA
protein:increased expression:brain
protein:increased expression:parvocellular oculomotor nucleus
RGD PMID:14741756 PMID:11164784 PMID:29210146 RGD:405255650, RGD:405255652, RGD:405295495 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit treatment IEP
ISO
protein:increased expression:brain (mouse)
protein:increased expression:dorsal striatum (mouse)
RGD PMID:22792289 PMID:9835277 PMID:27380261 RGD:401851082, RGD:401901184, RGD:401901287 NCBI chr 1:88,082,324...88,089,506 JBrowse link
G Fshb follicle stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr20:1,469,779...1,499,352 JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility ISO DNA:SNP:intron: (rs2900512) (human) RGD PMID:28118741 RGD:401940105 NCBI chr 5:60,947,517...61,288,104 JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 susceptibility ISO DNA:SNPs:multiple:
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:22253714 PMID:15024690 RGD:6480257 NCBI chr14:37,451,218...37,587,458 JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 susceptibility ISO DNA:CA repeats: :(human) RGD PMID:9858031 RGD:405866342 NCBI chr 1:117,602,772...117,838,230 JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr10:26,876,926...26,965,523 JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20585342 NCBI chr15:41,635,572...41,707,252 JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment ISO
IDA
IEP
protein:increased expression:serum
DNA:hypomethylation:nucleus accumbens
associated with Tobacco Use Disorder;mRNA:decreased expression:ventral tegmental area
RGD PMID:25623403 PMID:31710958 PMID:22238721 PMID:28559549 RGD:401965480, RGD:405820205, RGD:405849387, RGD:405850249 NCBI chr 2:58,621,327...58,647,242 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12747453 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Ghsr growth hormone secretagogue receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23977009 NCBI chr 2:110,268,489...110,271,865 JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 6:96,954,365...97,483,617 JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO
IEP
protein:increased phosphorylation:lumbar spinal cord (mouse)
protein:increased expression:nucleus accumbens (rat)
protein:increased expression:nucleus accumbens (mouse)
protein:increased expression, increased phosphorylation:cingulate cortex (rat)
protein:decreased expression:neocortex (rat)
RGD PMID:28585190 PMID:21041654 PMID:21041654 PMID:34280506 PMID:12036520 RGD:405100727, RGD:405650686, RGD:405650686, RGD:405818275, RGD:405820203 NCBI chr10:41,710,540...42,030,105 JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 IEP protein:decreased expression:neocortex (rat)
protein:increased expression:ventral CA1 field of hippocampus (rat)
RGD PMID:12036520 PMID:30481568 RGD:405820203, RGD:596933081 NCBI chr 2:168,247,490...168,367,616 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:14573320 RGD:1642372 NCBI chr 3:28,501,836...28,528,754 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:14573320 PMID:16911840 RGD:1642372, RGD:1642200 NCBI chr 4:170,297,811...170,775,420 JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:23485013 RGD:9590265 NCBI chr20:42,101,815...42,126,486 JBrowse link
G Hmgb1 high mobility group box 1 onset ISO
IEP
protein:increased expression:orbitofrontal cortex
protein:increased expression:frontal cortex neuron
RGD PMID:23867237 PMID:23867237 RGD:597538460, RGD:597538460 NCBI chr12:11,009,236...11,015,941 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A treatment IMP RGD PMID:9631953 RGD:401900760 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B sexual_dimorphism
no_association
onset
ISO associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human)
DNA:SNPs: :multiples (human)
DNA:SNP: :rs13212041 (human)
RGD PMID:28923721 PMID:11496363 PMID:30774345 RGD:405650695, RGD:405818272, RGD:405847403 NCBI chr 8:91,395,405...91,414,815 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO
IEP
IMP
CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:cerebral cortex, liver
protein:increased expression:dorsal raphe, nucleus accumbens
CTD
RGD
PMID:20501057 PMID:9347075 PMID:9347073 PMID:9631953 RGD:401900301, RGD:401900740, RGD:401900742, RGD:401900760 NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IDA RGD PMID:24041931 RGD:401900761 NCBI chr  X:115,453,190...115,682,325 JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DNA:hypermethylation, hypomethylation:promoter: (mouse) RGD PMID:22834954 RGD:404976877 NCBI chr 8:58,138,514...58,150,960 JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 8:49,279,291...49,308,444 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO DNA:SNP:intron: (rs7916403) (human) RGD PMID:21184583 RGD:150429835 NCBI chr 1:243,049,064...243,173,636 JBrowse link
G Igf2 insulin-like growth factor 2 ISO protein:decreased expression:plasma (human) RGD PMID:30277635 RGD:401938665 NCBI chr 1:197,814,409...197,831,802 JBrowse link
G Il10 interleukin 10 IEP mRNA:increased expression:liver RGD PMID:22269225 RGD:401959317 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:26208141 RGD:11342768 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP:promoter:rs2836016 (human) RGD PMID:21307845 RGD:6483053 NCBI chr11:47,531,312...47,778,348 JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 IEP protein:decreased expression:ventral CA1 field of hippocampus (rat) RGD PMID:30481568 RGD:596933081 NCBI chr18:40,004,693...40,445,043 JBrowse link
G Lhb luteinizing hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 1:105,037,457...105,038,446 JBrowse link
G Maoa monoamine oxidase A susceptibility ISO RGD PMID:15900229 RGD:1600720 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO protein:increased expression, increased phosphorylation:liver RGD PMID:31262967 RGD:401959334 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEP protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IDA RGD PMID:31262967 RGD:401959334 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mb myoglobin ISO protein:decreased expression:serum RGD PMID:3766421 RGD:458925288 NCBI chr 7:110,640,511...110,647,742 JBrowse link
G Mcm5 minichromosome maintenance complex component 5 IEP RGD PMID:23095216 RGD:10045658 NCBI chr19:13,488,813...13,510,131 JBrowse link
G Mir191 microRNA 191 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir195 microRNA 195 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr10:54,951,838...54,951,924 JBrowse link
G Mir206 microRNA 206 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 9:23,094,249...23,094,332 JBrowse link
G Mir30a microRNA 30a onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 9:25,737,600...25,737,670 JBrowse link
G Mki67 marker of proliferation Ki-67 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 1:199,926,150...199,952,847 JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP RGD PMID:24966898 RGD:13207311 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP RGD PMID:24966898 RGD:13207311 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Ncam1 neural cell adhesion molecule 1 treatment
sexual_dimorphism
IEP mRNA:decreased expression:hippocampus (rat)
associated with chronic stress in female rats
RGD PMID:30277635 PMID:16207289 PMID:27894930 RGD:401938665, RGD:401959613, RGD:401959751 NCBI chr 8:58,762,088...59,062,131 JBrowse link
G Ngf nerve growth factor ISO
IEP
protein:increased expression:serum
protein:decreased expression:brain
protein:decreased expression:cerebral cortex, hippocampus
RGD PMID:25623403 PMID:15307153 PMID:19100286 RGD:401965480, RGD:401965482, RGD:401976492 NCBI chr 2:192,589,580...192,642,971 JBrowse link
G Npy neuropeptide Y IAGP
ISO
DNA:deletion:intron:g.4666_4674del (rat)
DNA:missense mutation: :p.L7P (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17572454 PMID:15749341 PMID:12215082 RGD:1357412, RGD:10430830 NCBI chr 4:80,212,111...80,219,310 JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 2:167,901,999...167,912,165 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IDA
IMP
IEP
protein:decreased expression, decreased DNA binding:brain
mRNA, protein:decreased expression:placenta
RGD PMID:11961084 PMID:33920737 PMID:31756338 PMID:21143252 RGD:408345232, RGD:408345239, RGD:408345241, RGD:408345244 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment
sexual_dimorphism
IMP RGD PMID:29437012 PMID:33007359 PMID:30171933 RGD:401965466, RGD:401966865, RGD:401976281 NCBI chr19:47,619,853...47,964,089 JBrowse link
G Nrg1 neuregulin 1 sexual_dimorphism ISO in female, associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr16:65,954,084...67,007,484 JBrowse link
G Ntf3 neurotrophin 3 ISO
IEP
protein:decreased expression:plasma (human)
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:increased expression:brain
RGD PMID:30277635 PMID:30277635 PMID:15307153 RGD:401938665, RGD:401938665, RGD:401965482 NCBI chr 4:158,914,984...158,984,453 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment ISO
IEP
IDA
associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain RGD PMID:30016666 PMID:8840027 PMID:32206827 PMID:33919862 RGD:401959614, RGD:401965407, RGD:596933095, RGD:596933362 NCBI chr17:5,560,558...5,875,899 JBrowse link
G Oprd1 opioid receptor, delta 1 IEP
IMP
ISO
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNPs, haplotype:intron 1:multiple (human)
RGD PMID:28511993 PMID:7501658 PMID:24533225 RGD:401976432, RGD:401976439, RGD:402525443 NCBI chr 5:149,590,244...149,624,999 JBrowse link
G Oprk1 opioid receptor, kappa 1 severity
no_association
susceptibility
ISO
IEP
DNA:SNP, haplotype: :rs6473797 (human)
DNA:SNP: :rs997917 (human)
DNA:SNP: :rs6473797 (human)
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
RGD PMID:31004399 PMID:37177778 PMID:37177778 PMID:28511993 RGD:401831037, RGD:401850581, RGD:401850581, RGD:401976432 NCBI chr 5:18,657,866...18,675,671 JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:11814626 RGD:9835016 NCBI chr 3:189,209,495...189,225,406 JBrowse link
G Oprm1 opioid receptor, mu 1 no_association
treatment
ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs510769
DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
CTD
RGD
PMID:12815747 PMID:26042510 PMID:9399694 PMID:32772383 RGD:401827930, RGD:401827934, RGD:401827947 NCBI chr 1:45,565,371...45,818,722 JBrowse link
G Oxtr oxytocin receptor sexual_dimorphism ISO DNA:SNP:intron: (rs53576) (human)
DNA:hypomethylation
RGD PMID:27716573 PMID:35146961 RGD:597538589, RGD:597538605 NCBI chr 4:147,154,374...147,171,723 JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 5:122,028,956...122,598,267 JBrowse link
G Pdyn prodynorphin susceptibility
no_association
ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)
DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human)
DNA:SNP: :rs2281285 (human)
DNA:SNPs: :rs2281285, rs2225749, rs910080 (human)
mRNA, protein:decreased expression:hippocampus, granule cell
CTD
RGD
PMID:17559549 PMID:18923396 PMID:18923396 PMID:29925858 PMID:36099111 More... RGD:401850550, RGD:401850559, RGD:401850566, RGD:401850581, RGD:401851059 NCBI chr 3:137,354,161...137,366,503 JBrowse link
G Penk proenkephalin IEP mRNA:increased expression:frontal lobe: RGD PMID:22703995 RGD:10003152 NCBI chr 5:21,981,381...21,987,074 JBrowse link
G Per1 period circadian regulator 1 IEP mRNA:altered expression: arcuate nucleus of hypothalamus RGD PMID:15009656 RGD:407572515 NCBI chr10:54,299,002...54,313,804 JBrowse link
G Per2 period circadian regulator 2 IEP mRNA:altered expression: arcuate nucleus of hypothalamus, suprachiasmatic nucleus RGD PMID:15009656 RGD:407572515 NCBI chr 9:99,454,828...99,497,069 JBrowse link
G Per3 period circadian regulator 3 IEP mRNA:altered expression:suprachiasmatic nucleus RGD PMID:15009656 RGD:407572515 NCBI chr 5:166,740,914...166,778,243 JBrowse link
G Pomc proopiomelanocortin sexual_dimorphism IEP
ISO
protein:decreased expression:brain (rat)
mRNA:increased expression: hypothalamus, pituitary gland, shell of nucleus accumbens
DNA, mRNA:deletion, decreased expression:enhancer, hypothalamus
mRNA, protein:increased expression:arcuate nucleus, hypothalamus, septum
protein:increased expression:plasma
associated with Prenatal Exposure Delayed Effects;mRNA:altered expression:adenohypophysis
mRNA:altered expression: arcuate nucleus of hypothalamus
RGD PMID:18162070 PMID:22724395 PMID:31339663 PMID:7925590 PMID:19912941 More... RGD:401976284, RGD:405878072, RGD:407550221, RGD:407571692, RGD:407572513, RGD:407572513, RGD:407572515 NCBI chr 6:32,659,137...32,665,175 JBrowse link
G Rest RE1-silencing transcription factor ISO protein:increased expression:basal forebrain RGD PMID:37402853 RGD:597538603 NCBI chr14:30,859,109...30,879,828 JBrowse link
G Rpl18a ribosomal protein L18A IEP mRNA:decreased expression:parietal cortex RGD PMID:11244494 RGD:11038708 NCBI chr16:18,576,467...18,578,653 JBrowse link
G Sell selectin L ISO protein:decreased expression:Tcell RGD PMID:7573774 RGD:597015763 NCBI chr13:78,950,100...78,969,604 JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:31,537,990...31,578,962 JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:15520362 PMID:17000009 PMID:20838391 RGD:6480660 NCBI chr10:62,322,688...62,357,060 JBrowse link
G Snca synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18055133 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Sod1 superoxide dismutase 1 IEP associated with diabetes; protein:decreased activity;testis, epididymis (rat) RGD PMID:25541261 RGD:405255664 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sox2 SRY-box transcription factor 2 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 2:117,536,929...117,539,340 JBrowse link
G Spi1 Spi-1 proto-oncogene treatment IEP
IDA
protein:decreased expression:alveolar macrophage RGD PMID:16272341 PMID:21447000 RGD:9586723, RGD:9586725 NCBI chr 3:77,059,744...77,093,730 JBrowse link
G Spn sialophorin ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 1:181,746,937...181,759,564 JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 severity ISO mRNA,protein:decreased expression:liver: RGD PMID:17697868 RGD:10043133 NCBI chr11:77,526,837...77,653,474 JBrowse link
G Syp synaptophysin sexual_dimorphism IEP associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr  X:17,521,348...17,536,449 JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 4:116,478,617...116,647,492 JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 2:223,266,536...223,363,791 JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16385453 PMID:17250611 NCBI chr 4:52,449,208...52,450,107 JBrowse link
G Tas2r138 taste receptor, type 2, member 138 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17250611 NCBI chr 4:69,428,344...69,429,339 JBrowse link
G Tbx19 T-box transcription factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr13:77,450,848...77,484,475 JBrowse link
G Tf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11000917 PMID:21792595 NCBI chr 8:103,789,780...103,816,487 JBrowse link
G Timeless timeless circadian regulator susceptibility ISO DNA:SNP:: (rs2291738) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 7:654,804...678,769 JBrowse link
G Tlr2 toll-like receptor 2 IEP
ISO
protein:decreased expression:alveolar macrophage
mRNA:increased expression:respiratory system fluid/secretion
protein:decreased expression:blood, monocyte
mRNA:increased expression:liver
mRNA:increased expression:orbitofrontal cortex
RGD PMID:36281822 PMID:26208141 PMID:27256567 PMID:30756376 PMID:34415075 RGD:597538461, RGD:11342768, RGD:597538485, RGD:597538493, RGD:597538499 NCBI chr 2:171,499,189...171,504,831 JBrowse link
G Tlr3 toll-like receptor 3 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr16:53,554,916...53,572,321 JBrowse link
G Tlr4 toll-like receptor 4 onset ISO
IEP
mRNA:decreased expression:respiratory system fluid/secretion
protein:decreased expression:blood, monocyte
protein:increased expression:liver
mRNA:increased expression:liver
mRNA:increased expression:orbitofrontal cortex
protein:increased expression:orbitofrontal cortex
protein:increased expression:frontal cortex neuron
RGD PMID:26208141 PMID:27256567 PMID:21276439 PMID:30756376 PMID:34415075 More... RGD:11342768, RGD:597538485, RGD:150540306, RGD:597538493, RGD:597538499, RGD:597538460, RGD:597538460 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Tlr5 toll-like receptor 5 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr13:97,166,430...97,190,642 JBrowse link
G Tlr6 toll-like receptor 6 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr14:43,715,809...43,727,019 JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr  X:30,644,324...30,670,796 JBrowse link
G Tlr8 toll-like receptor 8 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr  X:30,708,714...30,733,104 JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:34415075 RGD:597538499 NCBI chr 8:115,743,407...115,747,523 JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15654285 RGD:1580464 NCBI chr 1:97,157,375...97,178,415 JBrowse link
G Vip vasoactive intestinal peptide susceptibility ISO DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 1:44,470,232...44,478,561 JBrowse link

Term paths to the root
Path 1
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  disease 19139
    Chemically-Induced Disorders 1443
      substance-related disorder 776
        substance abuse 266
          alcohol use disorder 176
Path 2
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  disease 19139
    disease of anatomical entity 18450
      nervous system disease 14359
        central nervous system disease 12634
          brain disease 11853
            disease of mental health 8450
              substance-related disorder 776
                Alcohol-Related Disorders 475
                  alcohol use disorder 176
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