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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:hypersensitivity reaction type III disease
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Accession:DOID:1557 term browser browse the term
Definition:A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury. (DO)
Synonyms:exact_synonym: Immune Complex Disease;   Immune Complex Diseases;   Type III Hypersensitivities;   Type III Hypersensitivity
 primary_id: MESH:D007105
For additional species annotation, visit the Alliance of Genome Resources.


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hypersensitivity reaction type III disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:8840296 NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,939 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:1825860 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752 		JBrowse link
G MASP2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
allergic cutaneous vasculitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF3 colony stimulating factor 3 treatment ISO associated with Severe Congenital Neutropenia; RGD PMID:20100783 RGD:11039037 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,445...22,342,163 		JBrowse link
arthus reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase treatment ISO RGD PMID:22228807 RGD:11040701 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G CFD complement factor D ISO RGD PMID:10605043 RGD:1624328 NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:23470165 RGD:9068463 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486 		JBrowse link
Henoch-Schoenlein purpura term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 disease_progression ISO DNA:deletion:intron:IVS16+1464-1751del (human) RGD PMID:15315169 RGD:11038920 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639 		JBrowse link
G AGT angiotensinogen severity ISO DNA:missense mutation:cds:p.M235T (human)
DNA:missense mutation:cds:p.T174M (human)		 RGD PMID:16521052 PMID:20702504 RGD:11039045 RGD:11039055 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1353212 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 susceptibility ISO DNA:snp:promoter:g.-2518C>T (human)
protein:increased expression:serum (human)		 RGD PMID:25839768 PMID:26234573 RGD:11522500 RGD:11528567 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028 		JBrowse link
G CD86 CD86 molecule treatment ISO protein:increased expression:venous blood, B cell (human) RGD PMID:27030970 RGD:11354986 NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,525...138,504,310 		JBrowse link
G HMOX1 heme oxygenase 1 ISO protein:increased expression:serum RGD PMID:20013271 RGD:10755701
G IGF1 insulin like growth factor 1 ISO protein:increased expression:serum RGD PMID:20013271 RGD:10755701 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human) RGD PMID:9186886 RGD:6909151
G IL27 interleukin 27 ISO mRNA,protein:decreased expression:peripheral blood mononuclear cell, blood serum (human)" RGD PMID:33280050 RGD:126790550 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915 		JBrowse link
G IL5 interleukin 5 ISO protein:increased expression:serum RGD PMID:16787590 RGD:11354946 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G KNG1 kininogen 1 ISO protein:increased expression:serum RGD PMID:26098644 RGD:11059888 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376 		JBrowse link
G MEFV MEFV innate immuity regulator, pyrin susceptibility ISO DNA:mutations:cds:
DNA:mutation:exon:p. E148Q (human)
DNA:mutations:exons:		 RGD PMID:20602240 PMID:22451026 PMID:25232290 RGD:11531116 RGD:7349346 RGD:7349347 NCBI chr 3:38,934,573...38,948,609 JBrowse link
G PLAT plasminogen activator, tissue type ISO protein:increased expression:plasma (human) RGD PMID:9543574 RGD:11541055 NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032 		JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:9002298 PMID:12671112 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172 		JBrowse link
G PON1 paraoxonase 1 susceptibility ISO DNA:missense mutations:cds:p.L55M, p.Q192R (human) RGD PMID:19967651 RGD:11552576 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,724 		JBrowse link
Serum Sickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:350256 PMID:9380243 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304 		JBrowse link
type I complement component 8 deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C8A complement C8 alpha chain ISO ClinVar Annotator: match by term: COMPLEMENT COMPONENT 8, ALPHA SUBUNIT, A/B POLYMORPHISM | ClinVar Annotator: match by term: Type I complement component 8 deficiency OMIM
ClinVar		 PMID:7649542 PMID:9759902 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 6:155,464,855...155,530,473
Ensembl chr 6:155,464,852...155,530,472 		JBrowse link
type II complement component 8 deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C8B complement C8 beta chain ISO ClinVar Annotator: match by term: Type II complement component 8 deficiency OMIM
ClinVar		 PMID:7594510 PMID:8098723 PMID:8365729 PMID:14767900 PMID:19434484 More... NCBI chr 6:155,411,982...155,453,034
Ensembl chr 6:155,387,142...155,458,586 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14378
    disease of anatomical entity 14096
      immune system disease 3936
        allergic disease 560
          hypersensitivity reaction type III disease 25
            Henoch-Schoenlein purpura + 15
            Serum Sickness 1
            arthus reaction 3
            hypersensitivity vasculitis + 16
            type I complement component 8 deficiency 1
            type II complement component 8 deficiency 1
Path 2
Term Annotations click to browse term
  disease 14378
    disease of anatomical entity 14096
      Immune & Inflammatory Diseases 4481
        immune system disease 3936
          hypersensitivity reaction disease 146
            hypersensitivity reaction type III disease 25
              Henoch-Schoenlein purpura + 15
              Serum Sickness 1
              arthus reaction 3
              hypersensitivity vasculitis + 16
              type I complement component 8 deficiency 1
              type II complement component 8 deficiency 1
paths to the root