RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Adrb2
adrenoceptor beta 2
susceptibility
ISO
DNA:polymorphism: :46A>G(human)
RGD
PMID:18159608
RGD:8548486
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8458210
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Bdnf
brain-derived neurotrophic factor
ISO
protein:increased expression:serum,skin:
RGD
PMID:21676041
RGD:8657027
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO
DNA:polymorphism,haplotype::190G>A(human)
RGD
PMID:23727176
RGD:8551831
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:15721839
RGD:6893392
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Ccr5
C-C motif chemokine receptor 5
ISO
DNA:frameshift mutation, haplotype: :p.S185_T195del (rs333) (human)
RGD
PMID:23727176
RGD:8551831
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Crp
C-reactive protein
ISO
protein:increased expression:serum
RGD
PMID:22348297
RGD:6482310
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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F12
coagulation factor XII
ISO
ClinVar Annotator: match by term: Urticaria
ClinVar
PMID:16638441 PMID:25741868
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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F2
coagulation factor II, thrombin
ISO
protein:increased expression:plasma
RGD
PMID:21488867
RGD:5147756
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fcer1a
Fc epsilon receptor Ia
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481 PMID:20485159
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
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Gstm1
glutathione S-transferase mu 1
ISO
DNA:deletion: : CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16433794 PMID:16433794
RGD:5490559
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Hnmt
histamine N-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20485159
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12121561
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il18
interleukin 18
ISO
DNA:SNPs, haplotype:promoter:-137G>C (rs187238), -607C>A (rs1946518) (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18204966 PMID:24490166 PMID:21692767
RGD:8655890 , RGD:8655894
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12121561
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18204966
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Ngfr
nerve growth factor receptor
ISO
protein:decreased expression:skin (human)
RGD
PMID:12653731
RGD:5508479
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nlrp3
NLR family, pyrin domain containing 3
susceptibility
ISO
familial cold autoinflammatory syndrome, OMIM:120100;DNA:missense mutations: :multiple
RGD
PMID:11687797
RGD:1600862
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
ISO
DNA:SNPs, haplotype: :rs1310182, rs2488457, rs3811021 (human)
RGD
PMID:22722472
RGD:7829761
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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RT1-Bb
RT1 class II, locus Bb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1
RT1 class II, locus Db1
ISO
DNA:polymorphism (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20485159 PMID:20559009
RGD:5147574
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Sele
selectin E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12121561
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Sod2
superoxide dismutase 2
ISO
protein:increased expression:skin
RGD
PMID:12780723
RGD:8547524
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19138248
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12121561 PMID:19250144 PMID:20485159
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vcam1
vascular cell adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12121561
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Nlrp12
NLR family, pyrin domain containing 12
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome
ClinVar
PMID:24033266 PMID:24064030 PMID:25741868 PMID:27314497 PMID:27633793 PMID:28492532 More...
NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934
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Nlrp3
NLR family, pyrin domain containing 3
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome
ClinVar
PMID:49161 PMID:11687797 PMID:11992256 PMID:12355493 PMID:14872505 PMID:15593220 PMID:17038455 PMID:17213252 PMID:17393462 PMID:20159265 PMID:22566169 PMID:23421920 PMID:24033266 PMID:24123366 PMID:24135410 PMID:25038238 PMID:25596455 PMID:25741868 PMID:26020059 PMID:26467025 PMID:26531310 PMID:27994174 PMID:28492532 PMID:28692792 PMID:29159471 PMID:29922587 PMID:30407166 PMID:30808881 More...
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Plcg2
phospholipase C, gamma 2
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome
ClinVar
PMID:25741868
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Nlrp3
NLR family, pyrin domain containing 3
ISO ISS
ClinVar Annotator: match by term: CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME 1 | ClinVar Annotator: match by term: FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1 | ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 1 OMIM:120100
OMIM ClinVar MouseDO
PMID:49161 PMID:447320 PMID:5173311 PMID:11687797 PMID:11992256 PMID:12032915 PMID:12355493 PMID:12483741 PMID:12522564 PMID:14630794 PMID:14872505 PMID:15020601 PMID:15231984 PMID:15334500 PMID:15593220 PMID:15724022 PMID:15801036 PMID:16081838 PMID:16100350 PMID:16255047 PMID:16449034 PMID:16646042 PMID:16802372 PMID:16871551 PMID:16920754 PMID:17038455 PMID:17178739 PMID:17213252 PMID:17284928 PMID:17393462 PMID:17509468 PMID:17513575 PMID:18063752 PMID:18080732 PMID:18174231 PMID:18263599 PMID:18311798 PMID:19319132 PMID:19501000 PMID:20131270 PMID:20159265 PMID:20182451 PMID:20472245 PMID:20506209 PMID:21058222 PMID:21109514 PMID:21245836 PMID:21356079 PMID:21621776 PMID:21637346 PMID:21702021 PMID:21810457 PMID:22128899 PMID:22146561 PMID:22193915 PMID:22403613 PMID:22512814 PMID:22524199 PMID:22529966 PMID:22566169 PMID:22661645 PMID:22843550 PMID:22935299 PMID:23015306 PMID:23421920 PMID:23442610 PMID:23703389 PMID:24033266 PMID:24098386 PMID:24123366 PMID:24135410 PMID:24158955 PMID:24365011 PMID:24431285 PMID:24517500 PMID:24649046 PMID:24759409 PMID:24773462 PMID:25038238 PMID:25584041 PMID:25586466 PMID:25596455 PMID:25639832 PMID:25730877 PMID:25741868 PMID:25766347 PMID:25821352 PMID:25979514 PMID:26020059 PMID:26033552 PMID:26178285 PMID:26218404 PMID:26245507 PMID:26273672 PMID:26386126 PMID:26467025 PMID:26531310 PMID:26535712 PMID:26590045 PMID:26848126 PMID:26931528 PMID:27036377 PMID:27060062 PMID:27134254 PMID:27191192 PMID:27548431 PMID:27612399 PMID:27650144 PMID:27692610 PMID:27819323 PMID:27943240 PMID:27943647 PMID:27994174 PMID:28028683 PMID:28079503 PMID:28137891 PMID:28185410 PMID:28421071 PMID:28492532 PMID:28501347 PMID:28692792 PMID:29047407 PMID:29102545 PMID:29117789 PMID:29148409 PMID:29152264 PMID:29159471 PMID:29163488 PMID:29322034 PMID:29922587 PMID:29977033 PMID:29988644 PMID:30069026 PMID:30214525 PMID:30311386 PMID:30338413 PMID:30407166 PMID:30431487 PMID:30772614 PMID:30808881 PMID:31172726 PMID:31442672 PMID:32082075 PMID:32199921 PMID:32477355 PMID:33020839 PMID:33329557 PMID:34099780 PMID:35668534 More...
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Myadm
myeloid-associated differentiation marker
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 2
ClinVar
PMID:28492532
NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
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Nlrp12
NLR family, pyrin domain containing 12
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 2 | ClinVar Annotator: match by term: NLRP12-related condition CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
PMID:9536098 PMID:16199547 PMID:17576681 PMID:18230725 PMID:21360512 PMID:21538323 PMID:24033266 PMID:24064030 PMID:25064839 PMID:25640679 PMID:25741868 PMID:25741909 PMID:26508570 PMID:27314497 PMID:27633793 PMID:28166811 PMID:28492532 PMID:29500522 PMID:30783801 PMID:30788684 PMID:30858956 PMID:31155445 PMID:31820221 PMID:32888943 PMID:33042144 PMID:34975878 More...
NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934
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Prkcg
protein kinase C, gamma
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 2
ClinVar
PMID:28492532
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
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Rapgefl1
Rap guanine nucleotide exchange factor like 1
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 2
ClinVar
NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371
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Plcg2
phospholipase C, gamma 2
ISO
ClinVar Annotator: match by term: FAMILIAL ATYPICAL COLD URTICARIA | ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 3
OMIM ClinVar
PMID:9536098 PMID:16199547 PMID:17576681 PMID:22236196 PMID:24033266 PMID:24869598 PMID:25640679 PMID:25741868 PMID:27577878 PMID:28166811 PMID:28492532 PMID:29590070 PMID:29921932 PMID:30273710 PMID:30344948 PMID:30619256 PMID:31853824 PMID:32047491 PMID:32185379 PMID:32671674 PMID:33859323 PMID:33936634 PMID:34329649 PMID:35753512 More...
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Dpy30
dpy-30 histone methyltransferase complex regulatory subunit
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,120,947...21,141,720
Ensembl chr 6:21,120,947...21,141,432
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Memo1
mediator of cell motility 1
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,144,525...21,234,363
Ensembl chr 6:21,125,639...21,234,561
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Nlrc4
NLR family, CARD domain containing 4
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
OMIM ClinVar
PMID:9536098 PMID:16199547 PMID:17576681 PMID:19763152 PMID:20307669 PMID:22406018 PMID:24033266 PMID:25217959 PMID:25217960 PMID:25385754 PMID:25741868 PMID:27974463 PMID:28492532 PMID:29326099 PMID:29778503 PMID:30783801 PMID:30864118 PMID:32081864 PMID:32529290 PMID:33822359 PMID:34248956 More...
NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
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Slc30a6
solute carrier family 30 member 6
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,020,931...21,050,785
Ensembl chr 6:21,020,931...21,050,785
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Spast
spastin
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954
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Srd5a2
steroid 5 alpha-reductase 2
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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Xdh
xanthine dehydrogenase
ISO
ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4
ClinVar
PMID:28492532
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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RT1-CE16
RT1 class I, locus CE16
ISO
protein:increased expression:peripheral blood (human)
RGD
PMID:32045706
RGD:329961316
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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Il1rn
interleukin 1 receptor antagonist
ISO
RGD
PMID:22146561
RGD:6906895
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Nlrp3
NLR family, pyrin domain containing 3
ISO
ClinVar Annotator: match by term: MUCKLE-WELLS SYNDROME | ClinVar Annotator: match by term: UDA syndrome CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
PMID:49161 PMID:11687797 PMID:11992256 PMID:12032915 PMID:12355493 PMID:12522564 PMID:14630794 PMID:14872505 PMID:15020601 PMID:15593220 PMID:16100350 PMID:16255047 PMID:16646042 PMID:17038455 PMID:17178739 PMID:17213252 PMID:17393462 PMID:17509468 PMID:18263599 PMID:18311798 PMID:19319132 PMID:19501000 PMID:20159265 PMID:20182451 PMID:20472245 PMID:21058222 PMID:21109514 PMID:21245836 PMID:21356079 PMID:21621776 PMID:21702021 PMID:21810457 PMID:22128899 PMID:22146561 PMID:22193915 PMID:22403613 PMID:22524199 PMID:22529966 PMID:22566169 PMID:22843550 PMID:22935299 PMID:23015306 PMID:23421920 PMID:23442610 PMID:23703389 PMID:24033266 PMID:24098386 PMID:24123366 PMID:24135410 PMID:24158955 PMID:24365011 PMID:24431285 PMID:24517500 PMID:24649046 PMID:24759409 PMID:24773462 PMID:25038238 PMID:25586466 PMID:25596455 PMID:25639832 PMID:25730877 PMID:25741868 PMID:25741909 PMID:25766347 PMID:25821352 PMID:25979514 PMID:26020059 PMID:26033552 PMID:26178285 PMID:26218404 PMID:26245507 PMID:26273672 PMID:26386126 PMID:26467025 PMID:26531310 PMID:26535712 PMID:26590045 PMID:26848126 PMID:26931528 PMID:27036377 PMID:27060062 PMID:27191192 PMID:27612399 PMID:27819323 PMID:27943240 PMID:27943647 PMID:27994174 PMID:28028683 PMID:28137891 PMID:28185410 PMID:28421071 PMID:28492532 PMID:28692792 PMID:29047407 PMID:29102545 PMID:29117789 PMID:29148409 PMID:29159471 PMID:29322034 PMID:29922587 PMID:29977033 PMID:30214525 PMID:30407166 PMID:30431487 PMID:30808881 PMID:32082075 PMID:32199921 PMID:33329557 More...
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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