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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pleural disease
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Accession:DOID:1532 term browser browse the term
Definition:A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. (DO)
Synonyms:exact_synonym: disorder of pleura;   non-neoplastic pleural disease;   pleural diseases
 primary_id: MESH:D010995
 xref: NCI:C26859
For additional species annotation, visit the Alliance of Genome Resources.



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pleural disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10923243 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cxcr3 chemokine (C-X-C motif) receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875
JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:alveolar macrophage RGD PMID:8325116 RGD:4143201 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Msln mesothelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23277285 NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,895...118,246,566
JBrowse link
G Tnc tenascin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:10950882 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
Chylothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 IMP RGD PMID:27899284 RGD:13592598 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO protein:increased expression:amniotic fluid RGD PMID:17295350 RGD:4891014 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
JBrowse link
congenital chylothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elk3 ELK3, member of ETS oncogene family IAGP OMIM:603523 MouseDO NCBI chr10:93,083,277...93,147,021
Ensembl chr10:93,083,276...93,146,997
JBrowse link
G Itga9 integrin alpha 9 IAGP OMIM:603523 MouseDO NCBI chr 9:118,435,777...118,730,071
Ensembl chr 9:118,435,758...118,730,071
JBrowse link
DICER1 syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asb2 ankyrin repeat and SOCS box-containing 2 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,287,401...103,322,260
Ensembl chr12:103,287,401...103,322,260
JBrowse link
G Btbd7 BTB (POZ) domain containing 7 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:102,747,056...102,844,733
Ensembl chr12:102,747,056...102,844,730
JBrowse link
G Cox8c cytochrome c oxidase subunit 8C ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:102,865,565...102,866,793
Ensembl chr12:102,865,575...102,866,785
JBrowse link
G Ddx24 DEAD box helicase 24 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,374,235...103,392,106
Ensembl chr12:103,374,241...103,392,089
JBrowse link
G Dicer1 dicer 1, ribonuclease type III ISO ClinVar Annotator: match by term: DICER1 syndrome OMIM
ClinVar
PMID:9295070 PMID:9345104 PMID:9536098 PMID:15987463 PMID:16095561 More... NCBI chr12:104,653,999...104,718,227
Ensembl chr12:104,654,001...104,718,211
JBrowse link
G Fam181a family with sequence similarity 181, member A ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,277,226...103,283,326
Ensembl chr12:103,277,234...103,283,324
JBrowse link
G Gsc goosecoid homeobox ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:104,437,468...104,439,495
Ensembl chr12:104,437,468...104,439,589
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,400,448...103,406,504
Ensembl chr12:103,400,470...103,406,498
JBrowse link
G Ifi27l2a interferon, alpha-inducible protein 27 like 2A ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,400,132...103,409,939
Ensembl chr12:103,408,426...103,409,939
JBrowse link
G Otub2 OTU domain, ubiquitin aldehyde binding 2 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,343,153...103,372,609
Ensembl chr12:103,354,941...103,372,609
JBrowse link
G Ppp4r4 protein phosphatase 4, regulatory subunit 4 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,498,509...103,580,098
Ensembl chr12:103,498,542...103,580,090
JBrowse link
G Prima1 proline rich membrane anchor 1 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,160,712...103,208,967
Ensembl chr12:103,163,167...103,208,409
JBrowse link
G Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,582,934...103,597,749
Ensembl chr12:103,581,045...103,597,703
JBrowse link
G Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,946,502...103,956,227
Ensembl chr12:103,946,502...103,956,216
JBrowse link
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,995,028...104,010,702
Ensembl chr12:103,995,028...104,010,702
JBrowse link
G Serpina1f serine (or cysteine) peptidase inhibitor, clade A, member 1F ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,654,303...103,661,788
Ensembl chr12:103,654,303...103,661,788
JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804
JBrowse link
G Serpina4-ps1 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:104,044,218...104,053,179
Ensembl chr12:104,046,908...104,052,983
JBrowse link
G Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:104,065,572...104,072,397
Ensembl chr12:104,067,372...104,072,396
JBrowse link
G Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,612,889...103,623,477
Ensembl chr12:103,612,889...103,623,471
JBrowse link
G Serpina9 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:103,962,874...103,979,911
Ensembl chr12:103,961,002...103,980,014
JBrowse link
G Ubr7 ubiquitin protein ligase E3 component n-recognin 7 (putative) ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:102,724,234...102,743,960
Ensembl chr12:102,724,226...102,743,966
JBrowse link
G Unc79 unc-79 homolog ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr12:102,913,642...103,150,487
Ensembl chr12:102,915,118...103,150,324
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase disease_progression ISO protein:increased activity:serum:
protein:decreased expression:serum:
RGD PMID:27300446 PMID:1818842 PMID:1689629 RGD:152995272, RGD:152998934, RGD:152995292 NCBI chr 2:163,568,491...163,592,161
Ensembl chr 2:163,568,504...163,592,159
JBrowse link
G Il10 interleukin 10 IMP RGD PMID:30695099 RGD:14975123 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bap1 Brca1 associated protein 1 disease_progression ISO RGD PMID:27422796 RGD:127229946 NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 exacerbates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 (livin) ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 ameliorates ISO RGD PMID:18722110 RGD:151667912 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Emx2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr19:59,447,122...59,453,789
Ensembl chr19:59,446,804...59,453,789
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 6:47,507,208...47,572,309
Ensembl chr 6:47,507,073...47,572,275
JBrowse link
G Il7r interleukin 7 receptor disease_progression ISO RGD PMID:26155428 RGD:151347688 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262
JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A ISO mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:18,027,101...18,146,175
Ensembl chr  X:18,028,814...18,146,175
JBrowse link
G Mir192 microRNA 192 ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr19:6,314,874...6,314,962
Ensembl chr19:6,314,874...6,314,962
JBrowse link
G Mir193a microRNA 193a ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr11:79,602,795...79,602,860
Ensembl chr11:79,602,795...79,602,860
JBrowse link
G Mir200b microRNA 200b ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 4:156,140,138...156,140,207
Ensembl chr 4:156,140,138...156,140,207
JBrowse link
G Mlh1 mutL homolog 1 disease_progression ISO RGD PMID:23810210 RGD:126848799 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
JBrowse link
G Nf2 neurofibromin 2 disease_progression ISO DNA:loss of heterozygosity RGD PMID:27378628 PMID:26928227 PMID:26493618 RGD:150530638, RGD:150429647, RGD:11553131 NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536
JBrowse link
G Rad21 RAD21 cohesin complex component ISO RGD PMID:19380173 RGD:150520037 NCBI chr15:51,826,000...51,856,934
Ensembl chr15:51,825,636...51,855,143
JBrowse link
G Setd2 SET domain containing 2 disease_progression ISO DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647, RGD:150520202 NCBI chr 9:110,361,368...110,447,701
Ensembl chr 9:110,361,665...110,447,701
JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 disease_progression ISO protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201, RGD:151660330 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433
JBrowse link
G Smo smoothened, frizzled class receptor disease_progression ISO DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620, RGD:150521621 NCBI chr 6:29,735,496...29,761,365
Ensembl chr 6:29,735,502...29,761,364
JBrowse link
G Xiap X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
Pleural Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO associated with tuberculosis;protein:increased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 ISO associated with tuberculosis;protein:decreased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Ada adenosine deaminase treatment ISO RGD PMID:25547995 RGD:152995274 NCBI chr 2:163,568,491...163,592,161
Ensembl chr 2:163,568,504...163,592,159
JBrowse link
G Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 NCBI chr 2:73,393,625...73,410,682
Ensembl chr 2:73,393,559...73,410,682
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:15072171 RGD:4990458 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Lox lysyl oxidase ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
JBrowse link
G Srfbp1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr18:52,598,703...52,625,005
Ensembl chr18:52,598,765...52,625,003
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:2518282 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
pleural empyema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plau plasminogen activator, urokinase ISO Gene product used in treatment of disease RGD PMID:20304453 RGD:4891955 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Tnc tenascin C ISO protein:increased expression:pleura RGD PMID:10950882 RGD:4889594 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment ISO RGD PMID:20819512 RGD:127284851 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952
JBrowse link
Pleural Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nf2 neurofibromin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23435014 NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16221779 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
pleural tuberculosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:increased activity:pleural fluid:
protein:increased activity:serum:
protein:increased expression:serum:
RGD PMID:21860532 PMID:1818842 PMID:1689629 PMID:18357489 RGD:152995280, RGD:152998934, RGD:152995292, RGD:152995288 NCBI chr 2:163,568,491...163,592,161
Ensembl chr 2:163,568,504...163,592,159
JBrowse link
G Ccl22 chemokine (C-C motif) ligand 22 ISO RGD PMID:20337996 RGD:4891473 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 ISO RGD PMID:19159432 RGD:4145106 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 ISO protein:increased expression:pleural fluid, natural killer cell (human) RGD PMID:19159432 RGD:4145106 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Foxp3 forkhead box P3 disease_progression ISO associated with human immunodeficiency virus infectious disease; RGD PMID:21303360 RGD:36947878 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Il1b interleukin 1 beta ISO DNA:polymorphism: :3953T>C (human) RGD PMID:10377182 RGD:4143226 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO DNA:repeat (human) RGD PMID:10377182 RGD:4143226 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il27 interleukin 27 exacerbates ISO associated with Pleural Effusion;protein:increased expression:pleural fluid (human)
protein:increased expression:alveolar system (human)
RGD PMID:25753767 PMID:31819557 PMID:23962500 PMID:28844060 RGD:126790505, RGD:126790549, RGD:126790523, RGD:126790517 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113
JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:pleural fluid: RGD PMID:23301222 RGD:39939042 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:pleura: RGD PMID:18715875 RGD:5129700 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:18295348 RGD:4144193 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnc tenascin C ISO protein:increased expression:pleura RGD PMID:10950882 RGD:4889594 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
pleurisy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase IDA RGD PMID:16860713 RGD:5128847 NCBI chr 2:163,568,491...163,592,161
Ensembl chr 2:163,568,504...163,592,159
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:9109363 RGD:4890429 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Anxa1 annexin A1 ISO RGD PMID:15784654 RGD:2306907 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 ISO RGD PMID:11853231 RGD:5129218 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 IMP
ISO
RGD PMID:15316088 PMID:9208140 RGD:4891029, RGD:4891041 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496
JBrowse link
G C3 complement component 3 IEP protein:increased activity:pleural cavity RGD PMID:18256172 RGD:5129520 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Cat catalase IEP RGD PMID:19778612 RGD:5130749 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl11 chemokine (C-C motif) ligand 11 IEP
ISO
protein:increased expression:pleural fluid RGD PMID:11877329 PMID:11564646 RGD:4145443, RGD:4145479 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccl25 chemokine (C-C motif) ligand 25 IEP protein:increased expression:pleural fluid RGD PMID:18056919 RGD:5130924 NCBI chr 8:4,375,207...4,410,020
Ensembl chr 8:4,375,210...4,410,020
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 IEP protein:increased secretion:lung (mouse) RGD PMID:18672096 RGD:4890016 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccr3 chemokine (C-C motif) receptor 3 IMP associated with Mycobacterium Infections RGD PMID:17158890 RGD:4145643 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) ISO RGD PMID:8841835 RGD:11039424 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 IEP RGD PMID:14527170 RGD:5135449 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 IEP RGD PMID:14527170 RGD:5135449 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 ISO
IEP
RGD PMID:21549112 PMID:14527170 RGD:5135064, RGD:5135449 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 IEP RGD PMID:14527170 RGD:5135449 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:15107459 RGD:4892325 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Elane elastase, neutrophil expressed ISO RGD PMID:20860667 RGD:10450565 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049
JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO RGD PMID:17035596 RGD:4892303 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO
IEP
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:bronchial epithelium (mouse)
CTD
RGD
PMID:11181422 PMID:19714575 PMID:19056932 RGD:4145510, RGD:4145519 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:10823416 RGD:4990464 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:21898269 RGD:7175307 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il1b interleukin 1 beta ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased expression:pleural cavity, exudate (rat)
protein:increased expression:lung
CTD
RGD
PMID:11181422 PMID:20141620 PMID:21898269 PMID:20175894 RGD:4142808, RGD:7175307, RGD:4142826 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8491511 RGD:4143233 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:lung RGD PMID:11577999 RGD:5130991 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IMP RGD PMID:14673141 RGD:6893408 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO protein:increased expression:pleural cavity (rat) RGD PMID:21898269 PMID:20141620 RGD:7175307, RGD:4142808 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pla2g6 phospholipase A2, group VI ISO RGD PMID:15003994 RGD:6482741 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590
JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:8395390 RGD:10043147 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20141620 PMID:15740981 RGD:4142808, RGD:5143929 NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Selp selectin, platelet IEP
ISO
protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11181422 PMID:21147071 RGD:6219005 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 susceptibility ISO associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): RGD PMID:23052617 RGD:13207414 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Tnf tumor necrosis factor IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11181422 PMID:15380531 PMID:11161459 PMID:20141620 RGD:4143474, RGD:4142808 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15380531 NCBI chr 4:63,749,439...63,779,745
Ensembl chr 4:63,749,545...63,779,584
JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:12773506 RGD:4890419 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
pleuropulmonary blastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1, ribonuclease type III IMP
ISO
ClinVar Annotator: match by term: DICER1-related pleuropulmonary blastoma cancer predisposition syndrome | ClinVar Annotator: match by term: Pleuropulmonary blastoma
CTD Direct Evidence: marker/mechanism
DNA:mutations:cds
ClinVar
CTD
RGD
PMID:19556464 PMID:21036787 PMID:21266384 PMID:21501861 PMID:23728841 More... RGD:149735200, RGD:11552609 NCBI chr12:104,653,999...104,718,227
Ensembl chr12:104,654,001...104,718,211
JBrowse link
G Fgf9 fibroblast growth factor 9 IAGP OMIM:601200 MouseDO NCBI chr14:58,308,131...58,350,311
Ensembl chr14:58,308,004...58,350,177
JBrowse link
G Yy1 YY1 transcription factor IAGP OMIM:601200 MouseDO NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
JBrowse link
pneumothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flcn folliculin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Spontaneous pneumothorax
CTD
ClinVar
PMID:12204536 PMID:25741868 PMID:28492532 NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842
JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:lung RGD PMID:20526373 RGD:4145332 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
primary spontaneous pneumothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flcn folliculin ISO ClinVar Annotator: match by term: Pneumothorax, primary spontaneous OMIM
ClinVar
PMID:12204536 PMID:12471204 PMID:12843323 PMID:14627671 PMID:15657874 More... NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15283
    disease of anatomical entity 14937
      respiratory system disease 3294
        lower respiratory tract disease 2234
          pleural disease 112
            Chylothorax + 4
            Hemothorax + 0
            Hydropneumothorax 0
            Hydrothorax 0
            Pleural Effusion + 11
            Pleural Neoplasms + 25
            benign pleural mesothelioma 0
            neurilemmoma of the pleura 0
            pleural empyema + 3
            pleural tuberculosis + 12
            pleurisy + 36
            pneumothorax + 2
            pulmonary blastoma + 25
paths to the root