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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pleural disease
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Accession:DOID:1532 term browser browse the term
Definition:A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. (DO)
Synonyms:exact_synonym: disorder of pleura;   non-neoplastic pleural disease;   pleural diseases
 primary_id: MESH:D010995
 xref: NCI:C26859
For additional species annotation, visit the Alliance of Genome Resources.



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pleural disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10923243 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21357438 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LOC100969375 caspase recruitment domain-containing protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr19:45,204,735...45,256,481
Ensembl chr19:53,798,967...53,850,328
JBrowse link
G LOC100974383 mesothelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23277285 Ensembl chr16:777,146...783,449 JBrowse link
G LOC100977568 tenascin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10950882 NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO protein:increased expression:alveolar macrophage RGD PMID:8325116 RGD:4143201 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G TGFB1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649
JBrowse link
Chylothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 ISO RGD PMID:27899284 RGD:13592598 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G MIF macrophage migration inhibitory factor ISO protein:increased expression:amniotic fluid RGD PMID:17295350 RGD:4891014 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
congenital chylothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELK3 ETS transcription factor ELK3 ISO OMIM:603523 MouseDO NCBI chr12:93,781,034...93,863,042
Ensembl chr12:97,223,198...97,276,120
JBrowse link
G ITGA9 integrin subunit alpha 9 ISO OMIM:603523 MouseDO NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363
JBrowse link
DICER1 syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASB2 ankyrin repeat and SOCS box containing 2 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,566,607...74,608,905
Ensembl chr14:93,900,914...93,930,527
JBrowse link
G BTBD7 BTB domain containing 7 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:73,870,163...73,965,819
Ensembl chr14:93,211,207...93,264,835
JBrowse link
G DDX24 DEAD-box helicase 24 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,683,068...74,713,394
Ensembl chr14:94,016,438...94,046,635
JBrowse link
G DICER1 dicer 1, ribonuclease III ISO ClinVar Annotator: match by term: DICER1 syndrome OMIM
ClinVar
PMID:9295070 PMID:9345104 PMID:9536098 PMID:15987463 PMID:16095561 More... NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940
JBrowse link
G FAM181A family with sequence similarity 181 member A ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,549,016...74,562,068
Ensembl chr14:93,891,392...93,895,892
JBrowse link
G GSC goosecoid homeobox ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,390,119...75,392,050
Ensembl chr14:94,718,269...94,720,404
JBrowse link
G IFI27 interferon alpha inducible protein 27 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,742,775...74,748,820
Ensembl chr14:94,046,694...94,082,022
JBrowse link
G IFI27L1 interferon alpha inducible protein 27 like 1 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,713,459...74,734,835 JBrowse link
G IFI27L2 interferon alpha inducible protein 27 like 2 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,759,874...74,761,850 JBrowse link
G LOC100984553 cytochrome c oxidase subunit 8C, mitochondrial ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:73,979,629...73,984,116
Ensembl chr14:93,316,013...93,317,217
JBrowse link
G OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,658,535...74,681,084
Ensembl chr14:93,991,913...94,015,157
JBrowse link
G PPP4R4 protein phosphatase 4 regulatory subunit 4 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,806,877...74,912,209
Ensembl chr14:94,139,654...94,244,712
JBrowse link
G PRIMA1 proline rich membrane anchor 1 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,351,140...74,422,033
Ensembl chr14:93,685,784...93,756,139
JBrowse link
G SERPINA1 serpin family A member 1 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419
JBrowse link
G SERPINA10 serpin family A member 10 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,914,680...74,927,325
Ensembl chr14:94,248,362...94,257,835
JBrowse link
G SERPINA11 serpin family A member 11 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,065,755...75,076,662
Ensembl chr14:94,398,596...94,408,909
JBrowse link
G SERPINA12 serpin family A member 12 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,110,414...75,141,569
Ensembl chr14:94,442,931...94,473,779
JBrowse link
G SERPINA3 serpin family A member 3 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,220,252...75,247,996
Ensembl chr14:94,551,934...94,579,515
JBrowse link
G SERPINA4 serpin family A member 4 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,185,501...75,194,061
Ensembl chr14:94,517,341...94,525,820
JBrowse link
G SERPINA5 serpin family A member 5 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,205,446...75,217,114
Ensembl chr14:94,537,115...94,548,803
JBrowse link
G SERPINA6 serpin family A member 6 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:74,936,724...74,955,799
Ensembl chr14:94,269,299...94,288,391
JBrowse link
G SERPINA9 serpin family A member 9 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:75,085,874...75,099,381 JBrowse link
G UBR7 ubiquitin protein ligase E3 component n-recognin 7 ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:73,839,702...73,861,830
Ensembl chr14:93,176,149...93,198,150
JBrowse link
G UNC79 unc-79 homolog, NALCN channel complex subunit ISO ClinVar Annotator: match by term: DICER1 syndrome ClinVar PMID:28492532 NCBI chr14:73,965,908...74,340,573
Ensembl chr14:93,399,547...93,674,248
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase disease_progression ISO protein:decreased expression:serum:
protein:increased activity:serum:
RGD PMID:1689629 PMID:1818842 PMID:27300446 RGD:152995272 RGD:152995292 RGD:152998934 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G IL10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAP1 BRCA1 associated protein 1 disease_progression ISO RGD PMID:27422796 RGD:127229946 NCBI chr 3:52,344,067...52,352,187
Ensembl chr 3:53,573,785...53,581,943
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 exacerbates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159
JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr20:59,618,530...59,623,612
Ensembl chr20:61,157,302...61,161,932
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ameliorates ISO RGD PMID:18722110 RGD:151667912 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194
JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr 5:145,478,725...145,537,858
Ensembl chr 5:151,483,572...151,517,415
JBrowse link
G EMX2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr10:114,124,759...114,132,109
Ensembl chr10:117,551,451...117,557,972
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726
JBrowse link
G IL7R interleukin 7 receptor disease_progression ISO RGD PMID:26155428 RGD:151347688 NCBI chr 5:74,489,188...74,516,330
Ensembl chr 5:79,769,859...79,792,612
JBrowse link
G KDM6A lysine demethylase 6A ISO mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:37,313,000...37,548,630
Ensembl chr  X:45,127,382...45,362,029
JBrowse link
G MLH1 mutL homolog 1 disease_progression ISO RGD PMID:23810210 RGD:126848799 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801
JBrowse link
G NCOA2 nuclear receptor coactivator 2 ameliorates ISO protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 8:66,632,139...66,929,526
Ensembl chr 8:68,293,018...68,400,479
JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO DNA:loss of heterozygosity RGD PMID:26493618 PMID:26928227 PMID:27378628 RGD:11553131 RGD:150429647 RGD:150530638 NCBI chr22:10,648,022...10,738,167
Ensembl chr22:28,454,119...28,544,013
JBrowse link
G RAD21 RAD21 cohesin complex component ISO RGD PMID:19380173 RGD:150520037 NCBI chr 8:113,520,456...113,549,339
Ensembl chr 8:116,063,503...116,092,421
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase disease_progression ISO DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647 RGD:150520202 NCBI chr 3:46,916,615...47,064,046
Ensembl chr 3:48,018,517...48,163,999
JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201 RGD:151660330 NCBI chr16:68,512,407...68,552,763 JBrowse link
G SMO smoothened, frizzled class receptor disease_progression ISO DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620 RGD:150521621 NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048
JBrowse link
G XIAP X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:113,052,164...113,105,160
Ensembl chr  X:123,232,643...123,278,606
JBrowse link
Pleural Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO associated with tuberculosis;protein:increased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO associated with tuberculosis;protein:decreased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891
JBrowse link
G ADA adenosine deaminase treatment ISO RGD PMID:25547995 RGD:152995274 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763
JBrowse link
G IL15 interleukin 15 ISO RGD PMID:15072171 RGD:4990458 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
JBrowse link
G LOX lysyl oxidase ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717
JBrowse link
G SRFBP1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr 5:117,351,025...117,417,546
Ensembl chr 5:123,134,896...123,196,844
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:2518282 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
pleural empyema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100977568 tenascin ISO protein:increased expression:pleura RGD PMID:10950882 RGD:4889594 NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299
JBrowse link
G PLAU plasminogen activator, urokinase ISO Gene product used in treatment of disease RGD PMID:20304453 RGD:4891955 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 treatment ISO RGD PMID:20819512 RGD:127284851 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
JBrowse link
Pleural Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23435014 NCBI chr22:10,648,022...10,738,167
Ensembl chr22:28,454,119...28,544,013
JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16221779 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935
JBrowse link
pleural tuberculosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased activity:pleural fluid:
protein:increased activity:serum:
protein:increased expression:serum:
RGD PMID:1689629 PMID:1818842 PMID:18357489 PMID:21860532 RGD:152995280 RGD:152995288 RGD:152995292 RGD:152998934 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G ADA2 adenosine deaminase 2 treatment ISO RGD PMID:8656037 RGD:152995258 NCBI chr22:606,220...648,902
Ensembl chr22:16,042,295...16,081,949
JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO RGD PMID:20337996 RGD:4891473 NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:19159432 RGD:4145106 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO protein:increased expression:pleural fluid, natural killer cell (human) RGD PMID:19159432 RGD:4145106 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
JBrowse link
G FOXP3 forkhead box P3 disease_progression ISO associated with human immunodeficiency virus infectious disease; RGD PMID:21303360 RGD:36947878 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029
JBrowse link
G IL1B interleukin 1 beta ISO DNA:polymorphism: :3953T>C (human) RGD PMID:10377182 RGD:4143226 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL27 interleukin 27 exacerbates ISO associated with Pleural Effusion;protein:increased expression:pleural fluid (human)
protein:increased expression:alveolar system (human)
RGD PMID:23962500 PMID:25753767 PMID:28844060 PMID:31819557 RGD:126790505 RGD:126790517 RGD:126790523 RGD:126790549
G IL33 interleukin 33 ISO protein:increased expression:pleural fluid: RGD PMID:23301222 RGD:39939042 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
G LOC100977568 tenascin ISO protein:increased expression:pleura RGD PMID:10950882 RGD:4889594 NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO DNA:repeat (human) RGD PMID:10377182 RGD:4143226 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:pleura: RGD PMID:18715875 RGD:5129700 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:18295348 RGD:4144193 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
pleurisy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO RGD PMID:16860713 RGD:5128847 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:9109363 RGD:4890429 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
JBrowse link
G ANXA1 annexin A1 ISO RGD PMID:15784654 RGD:2306907 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:11853231 RGD:5129218 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:9208140 PMID:15316088 RGD:4891029 RGD:4891041 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253
JBrowse link
G C3 complement C3 ISO protein:increased activity:pleural cavity RGD PMID:18256172 RGD:5129520 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
JBrowse link
G CAT catalase ISO RGD PMID:19778612 RGD:5130749 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
JBrowse link
G CCL25 C-C motif chemokine ligand 25 ISO protein:increased expression:pleural fluid RGD PMID:18056919 RGD:5130924 NCBI chr19:7,307,109...7,363,983
Ensembl chr19:8,208,273...8,217,780
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung (mouse) RGD PMID:18672096 RGD:4890016 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO associated with Mycobacterium Infections RGD PMID:17158890 RGD:4145643 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630
JBrowse link
G CSF3 colony stimulating factor 3 ISO RGD PMID:8841835 RGD:11039424 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO RGD PMID:14527170 RGD:5135449 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14527170 RGD:5135449 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ISO RGD PMID:14527170 PMID:21549112 RGD:5135064 RGD:5135449 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14527170 RGD:5135449 NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502
JBrowse link
G EDNRA endothelin receptor type A ISO RGD PMID:15107459 RGD:4892325 NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497
JBrowse link
G ELANE elastase, neutrophil expressed ISO RGD PMID:20860667 RGD:10450565 NCBI chr19:276,499...280,598 JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:17035596 RGD:4892303 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)
protein:increased expression:bronchial epithelium (mouse)
CTD
RGD
PMID:11181422 PMID:19056932 PMID:19714575 RGD:4145510 RGD:4145519 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL15 interleukin 15 ISO RGD PMID:10823416 RGD:4990464 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
JBrowse link
G IL17A interleukin 17A treatment ISO RGD PMID:21898269 RGD:7175307 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
protein:increased expression:pleural cavity, exudate (rat)
RGD
CTD
PMID:11181422 PMID:20141620 PMID:20175894 PMID:21898269 RGD:4142808 RGD:4142826 RGD:7175307 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO RGD PMID:8491511 RGD:4143233 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:lung RGD PMID:11577999 RGD:5130991 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:14673141 RGD:6893408 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:pleural cavity (rat) RGD PMID:20141620 PMID:21898269 RGD:4142808 RGD:7175307 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:15003994 RGD:6482741 NCBI chr22:18,998,060...19,094,507
Ensembl chr22:36,849,794...36,919,509
Ensembl chr22:36,849,794...36,919,509
JBrowse link
G PTAFR platelet activating factor receptor treatment ISO RGD PMID:8395390 RGD:10043147 NCBI chr 1:27,405,880...27,436,184
Ensembl chr 1:28,447,833...28,448,861
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:15740981 PMID:20141620 RGD:4142808 RGD:5143929 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G SELP selectin P ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
CTD
RGD
PMID:11181422 PMID:21147071 RGD:6219005 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SERPINE1 serpin family E member 1 susceptibility ISO associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): RGD PMID:23052617 RGD:13207414 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11161459 PMID:11181422 PMID:15380531 PMID:20141620 RGD:4142808 RGD:4143474 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15380531 NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822
JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:12773506 RGD:4890419 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
JBrowse link
pleuropulmonary blastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DICER1 dicer 1, ribonuclease III ISO ClinVar Annotator: match by term: DICER1-related pleuropulmonary blastoma cancer predisposition syndrome | ClinVar Annotator: match by term: Pleuropulmonary blastoma ClinVar PMID:19556464 PMID:21036787 PMID:21266384 PMID:21501861 PMID:23728841 More... NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940
JBrowse link
G FGF9 fibroblast growth factor 9 ISO OMIM:601200 MouseDO NCBI chr13:2,967,713...3,000,554
Ensembl chr13:21,273,333...21,307,198
JBrowse link
G YY1 YY1 transcription factor ISO OMIM:601200 MouseDO NCBI chr14:80,859,491...80,903,651 JBrowse link
pneumothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLCN folliculin ISO ClinVar Annotator: match by term: Spontaneous pneumothorax ClinVar PMID:25741868 PMID:28492532 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G HMOX1 heme oxygenase 1 ISO protein:increased expression:lung RGD PMID:20526373 RGD:4145332 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
JBrowse link
primary spontaneous pneumothorax term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLCN folliculin ISO ClinVar Annotator: match by term: Pneumothorax, primary spontaneous OMIM
ClinVar
PMID:12204536 PMID:12471204 PMID:12843323 PMID:14627671 PMID:15657874 More... NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14685
    disease of anatomical entity 14400
      respiratory system disease 3110
        lower respiratory tract disease 2069
          pleural disease 111
            Chylothorax + 4
            Hemothorax + 0
            Hydropneumothorax 0
            Hydrothorax 0
            Pleural Effusion + 11
            Pleural Neoplasms + 22
            benign pleural mesothelioma 0
            neurilemmoma of the pleura 0
            pleural empyema + 3
            pleural tuberculosis + 13
            pleurisy + 35
            pneumothorax + 2
            pulmonary blastoma + 26
paths to the root