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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.

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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chrNW_004936570:1,315,192...1,322,719 JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chrNW_004936669:3,449,259...3,478,471
Ensembl chrNW_004936669:3,456,494...3,478,512 		JBrowse link
G Bsg basigin (Ok blood group) ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chrNW_004936588:181,688...189,795
Ensembl chrNW_004936588:181,576...189,287 		JBrowse link
G Cast calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chrNW_004936523:6,688,153...6,798,184
Ensembl chrNW_004936523:6,686,519...6,798,321 		JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chrNW_004936889:476,439...478,620
Ensembl chrNW_004936889:476,133...478,711 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chrNW_004937131:15,542...22,099 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chrNW_004936809:1,269,900...1,285,853
Ensembl chrNW_004936809:1,269,914...1,285,889 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G LOC101964865 complement receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9230440 PMID:11724985 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G LOC101976500 haptoglobin severity ISO DNA:missense mutation:cds:p.K54E (human) RGD PMID:24478401 RGD:11041793 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Tnf tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14569
    disease by infectious agent 2001
      parasitic infectious disease 275
        parasitic protozoa infectious disease 139
          malaria 67
            Plasmodium falciparum malaria 14
              Pregnancy-associated Malaria 1
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 14569
    disease of anatomical entity 14271
      Immune & Inflammatory Diseases 4892
        Inflammation 2331
          Systemic Inflammatory Response Syndrome 348
            Sepsis 346
              Parasitemia 67
                malaria 67
                  Plasmodium falciparum malaria 14
                    Pregnancy-associated Malaria 1
                    blackwater fever 0
paths to the root