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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.

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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chrNW_004624760:1,865,474...1,889,394
Ensembl chrNW_004624760:1,865,376...1,889,203 		JBrowse link
G Bsg basigin (Ok blood group) ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chrNW_004624828:7,913,297...7,920,891
Ensembl chrNW_004624828:7,913,099...7,920,804 		JBrowse link
G Cast calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chrNW_004624743:15,265,930...15,405,904
Ensembl chrNW_004624743:15,346,837...15,403,150 		JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chrNW_004624832:3,929,949...3,934,088
Ensembl chrNW_004624832:3,929,949...3,932,370 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chrNW_004624826:23,930...34,735 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G LOC101703821 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chrNW_004624754:23,895,509...23,902,487
Ensembl chrNW_004624754:23,895,607...23,906,713 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
G Tnf tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14170
    disease by infectious agent 1932
      parasitic infectious disease 265
        parasitic protozoa infectious disease 133
          malaria 62
            Plasmodium falciparum malaria 12
              Pregnancy-associated Malaria 1
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 14170
    disease of anatomical entity 13885
      Immune & Inflammatory Diseases 4763
        Inflammation 2275
          Systemic Inflammatory Response Syndrome 334
            Sepsis 332
              Parasitemia 62
                malaria 62
                  Plasmodium falciparum malaria 12
                    Pregnancy-associated Malaria 1
                    blackwater fever 0
paths to the root