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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.


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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility IAGP DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr 9:133,250,401...133,275,201
Ensembl chr 9:133,233,278...133,276,024 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 IEP protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr 9:133,414,337...133,459,386
Ensembl chr 9:133,414,358...133,459,402 		JBrowse link
G BSG basigin (Ok blood group) EXP CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494 		JBrowse link
G CAST calpastatin IEP protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr 5:95,961,429...96,774,683
Ensembl chr 5:96,525,267...96,779,595
Ensembl chr 5:96,525,267...96,779,595 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 IEP mRNA, protein:increased expression:blood, RGD PMID:15972509 RGD:5683898 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CLEC11A C-type lectin domain containing 11A EXP CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr19:50,723,364...50,725,708
Ensembl chr19:50,723,364...50,725,708 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:9230440 PMID:11724985 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment IAGP DNA:polymorphisms:: RGD PMID:10471063 RGD:124713538 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G FAS Fas cell surface death receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FCGR2A Fc gamma receptor IIa severity IAGP DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase severity IAGP DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 severity IAGP RGD PMID:19635899 RGD:10450848 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HBB hemoglobin subunit beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:20305663 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395 		JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383 		JBrowse link
G HP haptoglobin severity IAGP DNA:missense mutation:cds:p.K54E (human) RGD PMID:24478401 RGD:11041793 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G IL13 interleukin 13 IEP protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility IAGP DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G TNF tumor necrosis factor severity IEP protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 IEP RGD PMID:24717969 RGD:11041890 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G MIR146A microRNA 146a susceptibility IAGP miRNA:SNP: (rs2910164) (human) RGD PMID:30642347 RGD:126925184 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97544
    disease by infectious agent 4419
      parasitic infectious disease 556
        parasitic protozoa infectious disease 367
          malaria 233
            Plasmodium falciparum malaria 20
              Pregnancy-associated Malaria 2
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 97544
    disease of anatomical entity 91158
      Immune & Inflammatory Diseases 18550
        Inflammation 11724
          Systemic Inflammatory Response Syndrome 591
            Sepsis 589
              Parasitemia 233
                malaria 233
                  Plasmodium falciparum malaria 20
                    Pregnancy-associated Malaria 2
                    blackwater fever 0
paths to the root