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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.

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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr12:4,863,100...4,892,204
Ensembl chr12:4,863,165...4,885,849 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr12:4,677,237...4,718,825
Ensembl chr12:4,677,229...4,714,386 		JBrowse link
G BSG basigin (Ok blood group) ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chr 6:309,579...320,209
Ensembl chr 6:309,506...321,785 		JBrowse link
G CAST calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr 4:90,496,867...90,607,019
Ensembl chr 4:90,497,754...90,605,481 		JBrowse link
G CLEC11A C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr 6:43,780,151...43,782,780 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:9230440 PMID:11724985 NCBI chr25:21,787,237...21,909,462 JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment ISO DNA:polymorphisms:: RGD PMID:10471063 RGD:124713538 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chr20:2,480,710...2,512,429 JBrowse link
G G6PD glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:128,768,028...128,788,366
Ensembl chr  X:128,770,268...128,786,961 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chr 1:6,676,897...6,679,936 JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G TNF tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15342
    disease by infectious agent 2089
      parasitic infectious disease 275
        parasitic protozoa infectious disease 146
          malaria 68
            Plasmodium falciparum malaria 14
              Pregnancy-associated Malaria 1
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 15342
    disease of anatomical entity 15027
      Immune & Inflammatory Diseases 5115
        Inflammation 2431
          Systemic Inflammatory Response Syndrome 369
            Sepsis 367
              Parasitemia 68
                malaria 68
                  Plasmodium falciparum malaria 14
                    Pregnancy-associated Malaria 1
                    blackwater fever 0
paths to the root