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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.


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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr 9:49,839,252...49,867,295
Ensembl chr 9:49,839,252...49,867,295 		JBrowse link
G BSG basigin ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061 		JBrowse link
G CAST calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959 		JBrowse link
G CCL4 chemokine (C-C motif) ligand 4 ISO mRNA, protein:increased expression:blood, RGD PMID:15972509 RGD:5683898 NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G CLEC11A C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr 1:106,078,055...106,080,473
Ensembl chr 1:106,078,291...106,080,517 		JBrowse link
G DLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chr12:2,305,307...2,307,711 JBrowse link
G FAS Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G LOC490269 complement receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9230440 PMID:11724985 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G LOC609402 hemoglobin subunit beta-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20305663 NCBI chr21:28,187,535...28,188,991 JBrowse link
G MBL1 mannose binding lectin 1 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr 4:29,419,886...29,424,377 JBrowse link
G TNF tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15674
    disease by infectious agent 2163
      parasitic infectious disease 305
        parasitic protozoa infectious disease 158
          malaria 75
            Plasmodium falciparum malaria 16
              Pregnancy-associated Malaria 1
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 15674
    disease of anatomical entity 15315
      Immune & Inflammatory Diseases 5190
        Inflammation 2492
          Systemic Inflammatory Response Syndrome 381
            Sepsis 379
              Parasitemia 75
                malaria 75
                  Plasmodium falciparum malaria 16
                    Pregnancy-associated Malaria 1
                    blackwater fever 0
paths to the root