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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Plasmodium falciparum malaria
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Accession:DOID:14067 term browser browse the term
Definition:A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. (DO)
Synonyms:exact_synonym: falciparum malaria;   malaria fever, subtertian;   malignant tertian fever
 primary_id: MESH:D016778
 xref: EFO:0007444;   ICD10CM:B50;   ICD9CM:084.0;   NCI:C34798
For additional species annotation, visit the Alliance of Genome Resources.

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Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chrNW_004955513:2,761,386...2,786,447
Ensembl chrNW_004955513:2,764,186...2,786,187 		JBrowse link
G Bsg basigin (Ok blood group) ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chrNW_004955495:7,148,806...7,156,296 JBrowse link
G Cast calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chrNW_004955418:15,859,951...15,974,141
Ensembl chrNW_004955418:15,862,729...15,916,169 		JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chrNW_004955559:515,341...517,521
Ensembl chrNW_004955559:514,134...517,787 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Hbb hemoglobin subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20305663 NCBI chrNW_004955414:21,188,012...21,189,363 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006 		JBrowse link
G Tnf tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14278
    disease by infectious agent 1956
      parasitic infectious disease 265
        parasitic protozoa infectious disease 131
          malaria 59
            Plasmodium falciparum malaria 12
              Pregnancy-associated Malaria 1
              blackwater fever 0
Path 2
Term Annotations click to browse term
  disease 14278
    disease of anatomical entity 13984
      Immune & Inflammatory Diseases 4809
        Inflammation 2287
          Systemic Inflammatory Response Syndrome 332
            Sepsis 330
              Parasitemia 59
                malaria 59
                  Plasmodium falciparum malaria 12
                    Pregnancy-associated Malaria 1
                    blackwater fever 0
paths to the root