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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:lacrimal duct obstruction
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Accession:DOID:13929 term browser browse the term
Definition:Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)
Synonyms:exact_synonym: LCDD;   Lacrimal Duct Obstructions;   NASOLACRIMAL DUCT OBSTRUCTION;   Tear Duct Obstruction;   blocked lacrimal canaliculus;   lacrimal duct defect;   obstruction of lacrimal canaliculus;   obstruction of lacrimal ducts;   tear duct obstructions
 primary_id: MESH:D007767
 alt_id: OMIM:149700
 xref: NCI:C34757
For additional species annotation, visit the Alliance of Genome Resources.



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lacrimal duct obstruction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igsf3 immunoglobulin superfamily, member 3 ISO ClinVar Annotator: match by term: Lacrimal duct defect OMIM
ClinVar
PMID:24372406 NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
ADULT syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp63 tumor protein p63 ISO ClinVar Annotator: match by term: Acro-dermato-ungual-lacrimal-tooth syndrome
ClinVar Annotator: match by term: ADULT syndrome
ClinVar Annotator: match by OMIM:103285
OMIM
ClinVar
PMID:8456838 PMID:8737655 PMID:9443880 PMID:11462173 PMID:11528512 More... NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    sensory system disease 5680
      eye disease 2766
        lacrimal apparatus disease 95
          lacrimal duct obstruction 2
            ADULT syndrome 1
            Chitty Hall Baraitser Syndrome 0
            HYPERTELORISM, PREAURICULAR SINUS, PUNCTAL PITS, AND DEAFNESS 0
            Lacrimal Puncta Agenesis 0
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      nervous system disease 12154
        sensory system disease 5680
          eye disease 2766
            lacrimal apparatus disease 95
              lacrimal duct obstruction 2
                ADULT syndrome 1
                Chitty Hall Baraitser Syndrome 0
                HYPERTELORISM, PREAURICULAR SINUS, PUNCTAL PITS, AND DEAFNESS 0
                Lacrimal Puncta Agenesis 0
paths to the root