RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Diseases of the twelfth cranial (hypoglossal) nerve or nuclei. The nuclei and fascicles of the nerve are located in the medulla, and the nerve exits the skull via the hypoglossal foramen and innervates the muscles of the tongue. Lower brain stem diseases, including ischemia and MOTOR NEURON DISEASES may affect the nuclei or nerve fascicles. The nerve may also be injured by diseases of the posterior fossa or skull base. Clinical manifestations include unilateral weakness of tongue musculature and lingual dysarthria, with deviation of the tongue towards the side of weakness upon attempted protrusion.
Synonyms:
exact_synonym:
Cranial Nerve XII Diseases; Cranial Nerve XII Disorders; Hypoglossal Nerve Palsies; Hypoglossal Nerve Palsy; Hypoglossal Neuralgia; Hypoglossal Neuralgias; Hypoglossal Neuropathies; Hypoglossal Neuropathy; Twelfth Cranial Nerve Diseases; Twelfth Cranial Nerve Disorder; disorder of 12th nerve; disorder of XII nerve; disorder of hypoglossal [12th] nerve; disorder of hypoglossal nerve; hypoglossal nerve diseases
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