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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:dental fluorosis
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Accession:DOID:13711 term browser browse the term
Definition:A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)
Synonyms:exact_synonym: Dental Fluoroses;   Intrinsic enamel discolouration of fluorosis;   Mottled Enamel;   Mottled Enamels;   Mottled teeth;   Mottling of enamel
 primary_id: MESH:D009050;   RDO:0006140
 xref: ICD10CM:K00.3;   ICD9CM:520.3;   NCI:C85059
For additional species annotation, visit the Alliance of Genome Resources.

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dental fluorosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm1l dynamin 1-like IEP mRNA, protein:increased expression:frontal cortex (rat) RGD PMID:23007560 RGD:12738230 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Fis1 fission, mitochondrial 1 IEP mRNA, protein:increased expression:kidney (rat) RGD PMID:24958380 RGD:12437081 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Mfn1 mitofusin 1 IEP mRNA, protein:decreased expression:frontal cortex (rat) RGD PMID:23007560 RGD:12738230 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    Stomatognathic Diseases 967
      tooth disease 282
        dental fluorosis 3
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      nervous system disease 10977
        sensory system disease 5248
          mouth disease 748
            tooth disease 282
              dental fluorosis 3
paths to the root